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Brenda Sanchez
Former Developmental Core Manager (2002-2025)
CFAR offered a general Pilot Award program from 1994 to 2017 and funded 82 early stage investigators.
In 2022, CFAR initiated a new program: Pilot Award for Investigators New to HIV.
82 Awards
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The Diagnostic Utility of Bone Marrow Aspirate Cultures Versus Blood Cultures for Detection of Mycobacterium Avium Complex in AIDS Patients
The Diagnostic Utility of Bone Marrow Aspirate Cultures Versus Blood Cultures for Detection of Mycobacterium Avium Complex in AIDS Patients
Abstract
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Functional Characterization of a Novel Counteregulator CD4 T cell in Primary HIV-1 Infection
Functional Characterization of a Novel Counteregulator CD4 T cell in Primary HIV-1 Infection
Abstract
Natural occurring CD4+CD25+ regulatory T (T-reg) cells have broad immunotherapeutic applications and a greater understanding of the factors influencing their function is important. During untreated early HIV-1 infection there is a progressive and preferential expansion of circulating T-reg cells and such accumulation plays an important role in the inability of the immune system to control viral replication. Despite renewed focus on suppressive T-reg cells, the existence of a reciprocal pathway of immune "contrasuppression" has been suggested by clonal studies in mice.
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The Diagnostic Utility of Bone Marrow Aspirate Cultures Versus Blood Cultures for Detection of Mycobacterium Avium Complex in AIDS Patients
The Diagnostic Utility of Bone Marrow Aspirate Cultures Versus Blood Cultures for Detection of Mycobacterium Avium Complex in AIDS Patients
Abstract
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Functional Characterization of a Novel Counteregulator CD4 T cell in Primary HIV-1 Infection
Functional Characterization of a Novel Counteregulator CD4 T cell in Primary HIV-1 Infection
Abstract
Natural occurring CD4+CD25+ regulatory T (T-reg) cells have broad immunotherapeutic applications and a greater understanding of the factors influencing their function is important. During untreated early HIV-1 infection there is a progressive and preferential expansion of circulating T-reg cells and such accumulation plays an important role in the inability of the immune system to control viral replication. Despite renewed focus on suppressive T-reg cells, the existence of a reciprocal pathway of immune "contrasuppression" has been suggested by clonal studies in mice.
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Discontinuation of Antifungal Therapy for Cryptococcal Meningitis Following Immunologic Response to Antiretroviral Therapy
Discontinuation of Antifungal Therapy for Cryptococcal Meningitis Following Immunologic Response to Antiretroviral Therapy
Abstract
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Telemedicine Screening for Cytomegalovirus Retinitis Among HIV Patients in Developing Countries: A Pilot Study
Telemedicine Screening for Cytomegalovirus Retinitis Among HIV Patients in Developing Countries: A Pilot Study
Abstract
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Implementing a Sampling-based Approach to Measuring Patient Outcomes Among HIV-infected Patients Lost to Follow-up in East Africa: the I-SAMPOLE Study
Implementing a Sampling-based Approach to Measuring Patient Outcomes Among HIV-infected Patients Lost to Follow-up in East Africa: the I-SAMPOLE Study
Abstract
The science of implementation begins with the ability to measure important occurrences in routine, day-to-day clinical care. Although the provision of care and treatment for HIV-infected patients in Africa over the last five years has scaled up rapidly, loss to follow-up (i.e., unknown outcomes) commonly exceeds 40% at 1 year. By precluding knowledge of key events, such as mortality and retention in care, losses systematically impair our ability to measure occurrences in clinical care for the conduct implementation science.
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REACH Cohort Adherence-Pharmacokinetic Substudy
REACH Cohort Adherence-Pharmacokinetic Substudy
Abstract
Publications:
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A Placebo-Controlled Pilot Study of Chinese Herbs in HIV Associated Cryptosporidium-Negative Diarrhea
A Placebo-Controlled Pilot Study of Chinese Herbs in HIV Associated Cryptosporidium-Negative Diarrhea
Abstract
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Biomarkers of Atherosclerosis Risk in HIV-1 Infection
Biomarkers of Atherosclerosis Risk in HIV-1 Infection
Abstract
HIV-infected individuals are prone to accelerated atherosclerosis (ATH)1. The objective of this pilot award is to identify biomarkers that can be used to predict and monitor ATH in the setting of HIV infection. Circulating endothelial progenitor cells (EPCs) repair damaged vascular endothelium2, while circulating endothelial microparticles (EMPs) are derived from activated or apoptotic endothelial cells3.