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Brenda Sanchez
Former Developmental Core Manager (2002-2025)
CFAR offered a general Pilot Award program from 1994 to 2017 and funded 82 early stage investigators.
In 2022, CFAR initiated a new program: Pilot Award for Investigators New to HIV.
82 Awards
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Non-Commercial Culture Methods for Rapid Screening of Patients at Risk of Drug-Resistant Tuberculosis in Zimbabwe
Non-Commercial Culture Methods for Rapid Screening of Patients at Risk of Drug-Resistant Tuberculosis in Zimbabwe
Abstract
Between 2000 and 2009, the estimated global incidence of multidrug-resistant tuberculosis (MDR TB) more than doubled, and extensively drug-resistant tuberculosis (XDR TB) was newly verified in 57 countries. The lack of rapid drug susceptibility testing (DST) has been a major impediment to effective prevention, treatment and epidemiologic research of drug resistant TB.
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Intra-familial Transmission of Kaposi's Sarcoma Associated Herpesvirus in Sub-Saharan Africa
Intra-familial Transmission of Kaposi's Sarcoma Associated Herpesvirus in Sub-Saharan Africa
Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV) is the viral etiologic agent of Kaposi's sarcoma (KS). In sub-Saharan Africa, the catastrophic intersection between underlying endemic infection with KSHV and the HIV epidemic has resulted in KS becoming the most common malignancy among adults in many countries and a growing cause of cancer in children.
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Prevalence and Predictors of Skin Disease in a Cohort of Women with HIV
Prevalence and Predictors of Skin Disease in a Cohort of Women with HIV
Abstract
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Alcohol Use and HIV Treatment Failure in Mbarara, Uganda
Alcohol Use and HIV Treatment Failure in Mbarara, Uganda
Abstract
Alcohol is the most commonly used recreational drug in sub-Saharan Africa, and Uganda has the highest rate of per capita alcohol consumption in the world. Alcohol consumption is recognized as a predictor of sexual risk behavior and thus HIV transmission and acquisition in sub-Saharan Africa, yet the effect of alcohol on HIV treatment success has not been studied in this setting. HIV antiretroviral therapy (ART) is increasing rapidly in sub-Saharan Africa, and has greatly decreased HIV morbidity and mortality.
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Dynamics of T Cell Dysfunction in Primary HIV-1 Infection
Dynamics of T Cell Dysfunction in Primary HIV-1 Infection
Abstract
We propose that during the evolution of primary HIV-1 infection an expansion in the proportion of CD8 T cells expressing the inhibitory receptor, Tim-3, will result in failure to control viral replication. In those who initiate HAART we predict they will experience greater declines in Tim-3 expression. Accordingly, over a one year timeline, the approach will involve the use of sophisticated multiparameteric flow cytometry to assess the phenotype and function of such a CD8 T cell repertoire and assess for statistical significant differences between and within subjects.
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Valganciclovir to Reduce T Cell Activation in HIV Infection
Valganciclovir to Reduce T Cell Activation in HIV Infection
Abstract
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Effect of Malaria Chemoprevention on Naturally Acquired T-Cell Mediated Immunity to Malaria
Effect of Malaria Chemoprevention on Naturally Acquired T-Cell Mediated Immunity to Malaria
Abstract
Malaria is the leading cause of morbidity and mortality among children in Uganda. The clinical presentation of malaria is modulated by the natural development of acquired immunity, which develops slowly, wanes rapidly, and is poorly understood. A more thorough understanding of natural immunity to malaria and its development during early childhood is needed to inform development of an effective vaccine.
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Highly Active Antiretroviral Therapy and Lymphoid Irradiation, with Thymic Shielding, in Subjects with HIV Disease
Highly Active Antiretroviral Therapy and Lymphoid Irradiation, with Thymic Shielding, in Subjects with HIV Disease
Abstract
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Cohort Study: Study on the Consequences of the Protease-Inhibitor Era (SCOPE)
Cohort Study: Study on the Consequences of the Protease-Inhibitor Era (SCOPE)
Abstract
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Property Rights and HIVIAIDS Prevention: Examining the Impact of a Community Land and Property WatchDog Model In Nyanza and Western Provinces, Kenya
Property Rights and HIVIAIDS Prevention: Examining the Impact of a Community Land and Property WatchDog Model In Nyanza and Western Provinces, Kenya
Abstract
Poverty and gender inequality are two core structural factors that shape women's vulnerability to HIV/AIDS. Recent research demonstrates that access to and control over assets such as property can empower women, provide them with a secure means of livelihood, prevent food insecurity, and improve household bargaining power, all of which mitigate the negative effects of HIV/AIDS. However, little work has intervened at the intersection of property rights and HIV/AIDS prevention.