Dynamics of T Cell Dysfunction in Primary HIV-1 Infection
Recipient
Award type
Award date
2008
Award cycle
Spring
Award amount - Direct
40,000.00
Abstract
We propose that during the evolution of primary HIV-1 infection an expansion in the proportion of CD8 T cells expressing the inhibitory receptor, Tim-3, will result in failure to control viral replication. In those who initiate HAART we predict they will experience greater declines in Tim-3 expression. Accordingly, over a one year timeline, the approach will involve the use of sophisticated multiparameteric flow cytometry to assess the phenotype and function of such a CD8 T cell repertoire and assess for statistical significant differences between and within subjects.