Lynda Frassetto, MD

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Lynda Frassetto, MD

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Professor, School of Medicine
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Lynda Frassetto, MD, is a Professor Emeritus of Medicine in the Division of Nephrology at the University of California, San Francisco (USCF). She grew up in the greater New York metropolitan area and attended college and medical school in Connecticut. She trained as a nephrologist at UCSF and was in private practice in San Francisco before returning to UCSF to start her research career with Drs. Anthony Sebastian and R. Curtis Morris Jr. Over approximately 20 years, the group published papers on regulation of acid base balance in healthy and aging people and dietary influences on acid-base balance in healthy people and those with diabetes. Dr. Frassetto also collaborates with Dr. Leslie Z Benet, past chair of the Department of Biopharmaceutical Sciences at UCSF. Dr. Benet has pioneered a novel model predicting drug interactions in vivo, depending on the degree of in vitro membrane transporter and intracellular metabolizing enzyme interactions with a specific drug, xenobiotic or toxin. These predictions are then tested in clinical trials in healthy people and those with kidney disease, diabetes or HIV before and after transplantation. In addition to research, Dr. Frassetto was the director of the adult Clinical Research Center at the Parnassus Campus in UCSF’s Clinical and Translational Science Institute, and still supervises inpatient and outpatient care at three of the University’s hospital campuses. For the last several years, she has also been participating in and teaching programs that teach UC students and faculty better communication and behavioral stress modification techniques.
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  1. Banerjee T, Sebastian A, Frassetto L. Association of diet-dependent systemic acid load, renal function, and serum albumin concentration. J Ren Nutr. 2023 Jan 31.
  2. Frassetto L, Remer T, Banerjee T. Dietary Contributions to Metabolic Acidosis. Adv Chronic Kidney Dis. 2022 07; 29(4):373-380.
  3. Sirch C, Khanna N, Frassetto L, Bianco F, Artero ML. Diagnosis of acute intermittent porphyria in a renal transplant patient: A case report. World J Transplant. 2022 Jan 18; 12(1):8-14.
  4. Banerjee T, Sebastian A, Frassetto L. Diet-dependent acid load is associated with mean arterial pressure in a cohort of non-obese, non-black, postmenopausal women. Appl Physiol Nutr Metab. 2022 Mar; 47(3):227-233.
  5. Xiang Y, Okochi H, Kozachenko I, Sodhi JK, Frassetto LA, Benet LZ. Effects of Single Dose Rifampin on the Pharmacokinetics of Fluvastatin in Healthy Volunteers. Clin Pharmacol Ther. 2021 08; 110(2):480-485.
  6. Angeloco LRN, Arces de Souza GC, Romão EA, Frassetto L, Chiarello PG. Association of dietary acid load with serum bicarbonate in chronic kidney disease (CKD) patients. Eur J Clin Nutr. 2020 08; 74(Suppl 1):69-75.
  7. Frassetto LA, Sebastian A, DuBose TD. How metabolic acidosis and kidney disease may accelerate the aging process. Eur J Clin Nutr. 2020 08; 74(Suppl 1):27-32.
  8. Parmenter BH, Dymock M, Banerjee T, Sebastian A, Slater GJ, Frassetto LA. Performance of Predictive Equations and Biochemical Measures Quantifying Net Endogenous Acid Production and the Potential Renal Acid Load. Kidney Int Rep. 2020 Oct; 5(10):1738-1745.
  9. Surofchy DD, Frassetto LA, Benet LZ. Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial. Pharm Res. 2019 Sep 04; 36(11):155.
  10. Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frassetto L, Gower BA, McFarlane SI, Nielsen JV, Krarup T, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, Dahlqvist A, Sundberg R, Childers A, Morrison K, Manninen AH, Dashti HM, Wood RJ, Wortman J, Worm N. Corrigendum to "Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base" [Nutrition 31 (2015) 1-13]. Nutrition. 2019 Jun; 62:213.
  11. Frassetto LA, Sebastian A. Aging, metabolic acidosis and renal failure: Interactive accelerating processes. Med Hypotheses. 2019 Mar; 124:95-97.
  12. Frassetto LA, Sebastian A. . . Med Hypotheses. Aging, metabolic acidosis and renal failure: Interactive accelerating processes. 2019; 124:95-97.
  13. Frassetto LA, Sebastian A. . . Med Hypotheses. Aging, metabolic acidosis and renal failure: Interactive accelerating processes. 2019; 124:95-97.
  14. Jayachandran P, Okochi H, Frassetto LA, Park W, Fang L, Zhao L, Benet LZ. Evaluating Within-Subject Variability for Narrow Therapeutic Index Drugs. Clin Pharmacol Ther. 2019 02; 105(2):411-416.
  15. Sebastian A, Cordain L, Frassetto L, Banerjee T, Morris RC. Postulating the major environmental condition resulting in the expression of essential hypertension and its associated cardiovascular diseases: Dietary imprudence in daily selection of foods in respect of their potassium and sodium content resulting in oxidative stress-induced dysfunction of the vascular endothelium, vascular smooth muscle, and perivascular tissues. Med Hypotheses. 2018 Oct; 119:110-119.
  16. Frassetto L. Another strategy to help counter the effects of low gravity? Am J Clin Nutr. 2018 05 01; 107(5):681-682.
  17. Frassetto L, Banerjee T, Powe N, Sebastian A. Acid Balance, Dietary Acid Load, and Bone Effects-A Controversial Subject. Nutrients. 2018 Apr 21; 10(4).
  18. Hietavala EM, Ihalainen JK, Frassetto LA, Schumann M, Eklund D, Pitkänen H, Häkkinen K, Mero AA. Effects of 12-Week Low or Moderate Dietary Acid Intake on Acid-Base Status and Kidney Function at Rest and during Submaximal Cycling. Nutrients. 2018 Mar 08; 10(3).
  19. Hietavala EM, Stout JR, Frassetto LA, Puurtinen R, Pitkänen H, Selänne H, Suominen H, Mero AA. Dietary acid load and renal function have varying effects on blood acid-base status and exercise performance across age and sex. Appl Physiol Nutr Metab. 2017 Dec; 42(12):1330-1340.
  20. Wu HF, Hristeva N, Chang J, Liang X, Li R, Frassetto L, Benet LZ. Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions. J Pharm Sci. 2017 09; 106(9):2751-2757.
  21. Arentson-Lantz EJ, Saeed IH, Frassetto LA, Masharani U, Harnish RJ, Seo Y, VanBrocklin HF, Hawkins RA, Mari-Aparici C, Pampaloni MH, Slater J, Paddon-Jones D, Lang TF. 11C-L-methyl methionine dynamic PET/CT of skeletal muscle: response to protein supplementation compared to L-[ring 13C6] phenylalanine infusion with serial muscle biopsy. Ann Nucl Med. 2017 May; 31(4):295-303.
  22. Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ. Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption. Pharm Res. 2017 03; 34(3):619-628.
  23. Parmenter BH, Slater GJ, Frassetto LA. Accuracy and precision of estimation equations to predict net endogenous acid excretion using the Australian food database. Nutr Diet. 2017 Jul; 74(3):308-312.
  24. Parmenter BH, Slater GJ, Frassetto LA. Spot-testing urine pH, a novel dietary biomarker? A randomised cross-over trial. Nutr Diet. 2017 Jul; 74(3):313-319.
  25. Frassetto LA, Gibson S. Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a Hemodialysis Patient. Case Rep Nephrol. 2016; 2016:9106935.