Adithya Cattamanchi, MD, MAS

CTSI Profile Photo

Adithya Cattamanchi, MD, MAS

User Profile Name
Professor, School of Medicine
CTSI Profile Title
User Profile Email


My research is focused on two thematic areas: 1) Development and evaluation of tuberculosis (TB) diagnostics and 2) Implementation and dissemination of evidence-based preventative, diagnostic, and treatment interventions for TB. I have considerable experience with the evaluation of TB diagnostics in low-income countries, including studying the impact of new diagnostics on patient- and public health-important outcomes. I have served on several World Health Organization (WHO) Expert Group panels to develop new policies related to TB diagnostics and serve as a faculty member for the Advanced Tuberculosis Diagnostics Research workshop sponsored by the WHO Stop TB Partnership. I have initiated a number of collaborations with engineers in industry and academia to develop and evaluate new diagnostic platforms for TB including: 1) mobile phone-based microscopy; 2) mobile phone-based molecular diagnostic platforms; and 3) single-particle aerosol mass spectrometry. We are currently evaluating the mobile phone-based microscopy platform and health centers in Hanoi, Vietnam in a demonstration project funded by the TB REACH initiative.

In addition to research on TB diagnostics, I have developed an active research agenda related to implementation science. I helped establish a platform for monitoring the quality of TB care at 6 rural health centers in Uganda (Uganda Tuberculosis Surveillance Project). My current work, supported through an NIH/NIAID R21 in Implementation and Dissemination Science, is focused on improving the quality of TB suspect evaluation at these health centers.

User Profile Bio

Displaying 1 - 25 of 202

  1. Yerlikaya S, Holtgrewe LM, Broger T, Isaacs C, Nahid P, Cattamanchi A, Denkinger CM. Innovative COVID-19 point-of-care diagnostics suitable for tuberculosis diagnosis: a scoping review protocol. BMJ Open. 2023 02 08; 13(2):e065194.
  2. Thompson RR, Nalugwa T, Oyuku D, Tucker A, Nantale M, Nakaweesa A, Musinguzi J, Reza TF, Zimmer AJ, Ferguson O, Turyahabwe S, Joloba M, Cattamanchi A, Katamba A, Dowdy DW, Sohn H. Multicomponent strategy with decentralised molecular testing for tuberculosis in Uganda: a cost and cost-effectiveness analysis. Lancet Glob Health. 2023 Feb; 11(2):e278-e286.
  3. Chang A, Loy CJ, Lenz JS, Steadman A, Andama A, Nhung NV, Yu C, Worodria W, Denkinger CM, Nahid P, Cattamanchi A, De Vlaminck I. Circulating Cell-Free RNA in Blood as a Host Response Biomarker for the Detection of Tuberculosis. medRxiv. 2023 Jan 11.
  4. Huddart S, Geocaniga-Gaviola DM, Crowder R, Lim AR, Lopez E, Valdez CL, Berger CA, Destura R, Kato-Maeda M, Cattamanchi A, Garfin AMC. Adherence trajectory as an on-treatment risk indicator among drug-resistant TB patients in the Philippines. PLoS One. 2022; 17(11):e0277078.
  5. Dowdy DW, Thompson RR, Kityamuwesi A, Crowder R, Cattamanchi A, Katamba A, Sohn H. Analyzing Pragmatic Trials to Inform Cost-Effectiveness Analyses. Value Health. 2022 Oct 29.
  6. Chang A, Mzava O, Djomnang LK, Lenz JS, Burnham P, Kaplinsky P, Andama A, Connelly J, Bachman CM, Cattamanchi A, Steadman A, De Vlaminck I. Metagenomic DNA sequencing to quantify Mycobacterium tuberculosis DNA and diagnose tuberculosis. Sci Rep. 2022 10 10; 12(1):16972.
  7. Jaganath D, Reza TF, Wambi P, Nakafeero J, Kiconco E, Nanyonga G, Oumo EA, Nsereko MC, Sekadde MP, Nabukenya-Mudiope MG, Kato-Maeda M, Andama A, Yoon C, Mohanty S, Wobudeya E, Cattamanchi A. The Role of C-Reactive Protein as a Triage Tool for Pulmonary Tuberculosis in Children. J Pediatric Infect Dis Soc. 2022 Jul 21; 11(7):316-321.
  8. Zimmer AJ, Ugarte-Gil C, Pathri R, Dewan P, Jaganath D, Cattamanchi A, Pai M, Grandjean Lapierre S. Making cough count in tuberculosis care. Commun Med (Lond). 2022; 2:83.
  9. Zawedde-Muyanja S, Manabe YC, Cattamanchi A, Castelnuovo B, Katamba A. Patient and health system level barriers to and facilitators for tuberculosis treatment initiation in Uganda: a qualitative study. BMC Health Serv Res. 2022 Jun 28; 22(1):831.
  10. Andama A, Whitman GR, Crowder R, Reza TF, Jaganath D, Mulondo J, Nalugwa TK, Semitala FC, Worodria W, Cook C, Wood RC, Weigel KM, Olson AM, Lohmiller Shaw J, Kato-Maeda M, Denkinger CM, Nahid P, Cangelosi GA, Cattamanchi A. Accuracy of Tongue Swab Testing Using Xpert MTB-RIF Ultra for Tuberculosis Diagnosis. J Clin Microbiol. 2022 07 20; 60(7):e0042122.
  11. Chaisson LH, Semitala FC, Mwebe S, Katende J, Asege L, Nakaye M, Andama AO, Atuhumuza E, Kamya M, Cattamanchi A, Yoon C. Transaminitis prevalence among HIV-infected adults eligible for tuberculosis preventive therapy. AIDS. 2022 Sep 01; 36(11):1591-1595.
  12. Zawedde-Muyanja S, Musaazi J, Castelnuovo B, Cattamanchi A, Katamba A, Manabe YC. Feasibility of a multifaceted intervention to improve treatment initiation among patients diagnosed with TB using Xpert MTB/RIF testing in Uganda. PLoS One. 2022; 17(6):e0265035.
  13. de Groot LM, Straetemans M, Maraba N, Jennings L, Gler MT, Marcelo D, Mekoro M, Steenkamp P, Gavioli R, Spaulding A, Prophete E, Bury M, Banu S, Sultana S, Onjare B, Efo E, Alacapa J, Levy J, Morales MLL, Katamba A, Bogdanov A, Gamazina K, Kumarkul D, Ekaterina OL, Cattamanchi A, Khan A, Bakker MI. Time Trend Analysis of Tuberculosis Treatment While Using Digital Adherence Technologies-An Individual Patient Data Meta-Analysis of Eleven Projects across Ten High Tuberculosis-Burden Countries. Trop Med Infect Dis. 2022 Apr 22; 7(5).
  14. Ayakaka I, Armstrong-Hough M, Hannaford A, Ggita JM, Turimumahoro P, Katamba A, Katahoire A, Cattamanchi A, Shenoi SV, Davis JL. Perceptions, preferences, and experiences of tuberculosis education and counselling among patients and providers in Kampala, Uganda: A qualitative study. Glob Public Health. 2022 11; 17(11):2911-2928.
  15. Davis JL, Ayakaka I, Ggita JM, Ochom E, Babirye D, Turimumahoro P, Gupta AJ, Mugabe FR, Armstrong-Hough M, Cattamanchi A, Katamba A. Theory-Informed Design of a Tailored Strategy for Implementing Household TB Contact Investigation in Uganda. Front Public Health. 2022; 10:837211.
  16. Nalugwa T, Handley M, Shete P, Ojok C, Nantale M, Reza T, Katamba A, Cattamanchi A, Ackerman S. Readiness to implement on-site molecular testing for tuberculosis in community health centers in Uganda. Implement Sci Commun. 2022 Feb 02; 3(1):9.
  17. Kerkhoff AD, Farrand E, Marquez C, Cattamanchi A, Handley MA. Addressing health disparities through implementation science-a need to integrate an equity lens from the outset. Implement Sci. 2022 01 31; 17(1):13.
  18. Thompson RR, Kityamuwesi A, Kuan A, Oyuku D, Tucker A, Ferguson O, Kunihira Tinka L, Crowder R, Turyahabwe S, Cattamanchi A, Dowdy DW, Katamba A, Sohn H. Cost and Cost-Effectiveness of a Digital Adherence Technology for Tuberculosis Treatment Support in Uganda. Value Health. 2022 06; 25(6):924-930.
  19. Cattamanchi A, Reza TF, Nalugwa T, Adams K, Nantale M, Oyuku D, Nabwire S, Babirye D, Turyahabwe S, Tucker A, Sohn H, Ferguson O, Thompson R, Shete PB, Handley MA, Ackerman S, Joloba M, Moore DAJ, Davis JL, Dowdy DW, Fielding K, Katamba A. Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis. N Engl J Med. 2021 12 23; 385(26):2441-2450.
  20. Semitala FC, Kadota JL, Musinguzi A, Nabunje J, Welishe F, Nakitende A, Akello L, Bishop O, Patel D, Sammann A, Nahid P, Belknap R, Kamya MR, Handley MA, Phillips PPJ, Katahoire A, Berger CA, Kiwanuka N, Katamba A, Dowdy DW, Cattamanchi A. Completion of isoniazid-rifapentine (3HP) for tuberculosis prevention among people living with HIV: Interim analysis of a hybrid type 3 effectiveness-implementation randomized trial. PLoS Med. 2021 12; 18(12):e1003875.
  21. Dhana A, Hamada Y, Kengne AP, Kerkhoff AD, Rangaka MX, Kredo T, Baddeley A, Miller C, Singh S, Hanifa Y, Grant AD, Fielding K, Affolabi D, Merle CS, Wachinou AP, Yoon C, Cattamanchi A, Hoffmann CJ, Martinson N, Mbu ET, Sander MS, Balcha TT, Skogmar S, Reeve BWP, Theron G, Ndlangalavu G, Modi S, Cavanaugh J, Swindells S, Chaisson RE, Ahmad Khan F, Howard AA, Wood R, Thit SS, Kyi MM, Hanson J, Drain PK, Shapiro AE, Kufa T, Churchyard G, Nguyen DT, Graviss EA, Bjerrum S, Johansen IS, Gersh JK, Horne DJ, LaCourse SM, Al-Darraji HAA, Kamarulzaman A, Kempker RR, Tukvadze N, Barr DA, Meintjes G, Maartens G. Tuberculosis screening among ambulatory people living with HIV: a systematic review and individual participant data meta-analysis. Lancet Infect Dis. 2022 04; 22(4):507-518.
  22. Christina N. Willis, Shaylee R. Larson, Alfred Andama, Devan Jaganath, Manoranjan Misra, Adithya Cattamanchi, Swomitra K. Mohanty. Engineered Electroactive Solutions for Electrochemical Detection of Tuberculosis-Associated Volatile Organic Biomarkers. IEEE Sensors Journal. 2021 Nov 1; PP(99):1-1.
  23. Crowder R, Geocaniga-Gaviola DM, Fabella RA, Lim A, Lopez E, Kadota JL, Reza TF, Cattamanchi A, Garfin AMC. Impact of shelter-in-place orders on TB case notifications and mortality in the Philippines during the COVID-19 pandemic. J Clin Tuberc Other Mycobact Dis. 2021 Dec; 25:100282.
  24. Magni R, Rruga F, Alsaab FM, Sharif S, Howard M, Espina V, Kim B, Lepene B, Lee G, Alayouni MA, Steinberg H, Araujo R, Kashanchi F, Riccardi F, Morreira S, Araujo A, Poli F, Jaganath D, Semitala FC, Worodria W, Andama A, Choudhary A, Honnen WJ, Petricoin EF, Cattamanchi A, Colombatti R, de Waard JH, Oberhelman R, Pinter A, Gilman RH, Liotta LA, Luchini A. Author Correction: Lipoarabinomannan antigenic epitope differences in tuberculosis disease subtypes. Sci Rep. 2021 Sep 27; 11(1):19546.
  25. Kerkhoff AD, Cattamanchi A, Muyoyeta M, Denkinger CM, Dowdy DW. Validating novel diagnostic assays for tuberculosis in the context of existing tools. Lancet Glob Health. 2021 09; 9(9):e1209.