CFAR offered a general Pilot Award program from 1994 to 2017 and funded 82 early stage investigators.
In 2022, CFAR initiated a new program: Pilot Award for Investigators New to HIV.
82 Awards
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Prevalence and Predictors of Skin Disease in a Cohort of Women with HIV
Prevalence and Predictors of Skin Disease in a Cohort of Women with HIV
Abstract
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Non-Commercial Culture Methods for Rapid Screening of Patients at Risk of Drug-Resistant Tuberculosis in Zimbabwe
Non-Commercial Culture Methods for Rapid Screening of Patients at Risk of Drug-Resistant Tuberculosis in Zimbabwe
Abstract
Between 2000 and 2009, the estimated global incidence of multidrug-resistant tuberculosis (MDR TB) more than doubled, and extensively drug-resistant tuberculosis (XDR TB) was newly verified in 57 countries. The lack of rapid drug susceptibility testing (DST) has been a major impediment to effective prevention, treatment and epidemiologic research of drug resistant TB.
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Intra-familial Transmission of Kaposi's Sarcoma Associated Herpesvirus in Sub-Saharan Africa
Intra-familial Transmission of Kaposi's Sarcoma Associated Herpesvirus in Sub-Saharan Africa
Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV) is the viral etiologic agent of Kaposi's sarcoma (KS). In sub-Saharan Africa, the catastrophic intersection between underlying endemic infection with KSHV and the HIV epidemic has resulted in KS becoming the most common malignancy among adults in many countries and a growing cause of cancer in children.
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Prevalence and Predictors of Skin Disease in a Cohort of Women with HIV
Prevalence and Predictors of Skin Disease in a Cohort of Women with HIV
Abstract
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Alcohol Use and HIV Treatment Failure in Mbarara, Uganda
Alcohol Use and HIV Treatment Failure in Mbarara, Uganda
Abstract
Alcohol is the most commonly used recreational drug in sub-Saharan Africa, and Uganda has the highest rate of per capita alcohol consumption in the world. Alcohol consumption is recognized as a predictor of sexual risk behavior and thus HIV transmission and acquisition in sub-Saharan Africa, yet the effect of alcohol on HIV treatment success has not been studied in this setting. HIV antiretroviral therapy (ART) is increasing rapidly in sub-Saharan Africa, and has greatly decreased HIV morbidity and mortality.
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Dynamics of T Cell Dysfunction in Primary HIV-1 Infection
Dynamics of T Cell Dysfunction in Primary HIV-1 Infection
Abstract
We propose that during the evolution of primary HIV-1 infection an expansion in the proportion of CD8 T cells expressing the inhibitory receptor, Tim-3, will result in failure to control viral replication. In those who initiate HAART we predict they will experience greater declines in Tim-3 expression. Accordingly, over a one year timeline, the approach will involve the use of sophisticated multiparameteric flow cytometry to assess the phenotype and function of such a CD8 T cell repertoire and assess for statistical significant differences between and within subjects.
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Valganciclovir to Reduce T Cell Activation in HIV Infection
Valganciclovir to Reduce T Cell Activation in HIV Infection
Abstract
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Alcohol Use and HIV Treatment Failure in Mbarara, Uganda
Alcohol Use and HIV Treatment Failure in Mbarara, Uganda
Abstract
Alcohol is the most commonly used recreational drug in sub-Saharan Africa, and Uganda has the highest rate of per capita alcohol consumption in the world. Alcohol consumption is recognized as a predictor of sexual risk behavior and thus HIV transmission and acquisition in sub-Saharan Africa, yet the effect of alcohol on HIV treatment success has not been studied in this setting. HIV antiretroviral therapy (ART) is increasing rapidly in sub-Saharan Africa, and has greatly decreased HIV morbidity and mortality.
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Dynamics of T Cell Dysfunction in Primary HIV-1 Infection
Dynamics of T Cell Dysfunction in Primary HIV-1 Infection
Abstract
We propose that during the evolution of primary HIV-1 infection an expansion in the proportion of CD8 T cells expressing the inhibitory receptor, Tim-3, will result in failure to control viral replication. In those who initiate HAART we predict they will experience greater declines in Tim-3 expression. Accordingly, over a one year timeline, the approach will involve the use of sophisticated multiparameteric flow cytometry to assess the phenotype and function of such a CD8 T cell repertoire and assess for statistical significant differences between and within subjects.
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Valganciclovir to Reduce T Cell Activation in HIV Infection
Valganciclovir to Reduce T Cell Activation in HIV Infection
Abstract