Image
Brenda Sanchez
Former Developmental Core Manager (2002-2025)
CFAR offered a general Pilot Award program from 1994 to 2017 and funded 82 early stage investigators.
In 2022, CFAR initiated a new program: Pilot Award for Investigators New to HIV.
82 Awards
-
Prevalence and Predictors of Skin Disease in a Cohort of Women with HIV
Prevalence and Predictors of Skin Disease in a Cohort of Women with HIV
Abstract
-
Alcohol Use and HIV Treatment Failure in Mbarara, Uganda
Alcohol Use and HIV Treatment Failure in Mbarara, Uganda
Abstract
Alcohol is the most commonly used recreational drug in sub-Saharan Africa, and Uganda has the highest rate of per capita alcohol consumption in the world. Alcohol consumption is recognized as a predictor of sexual risk behavior and thus HIV transmission and acquisition in sub-Saharan Africa, yet the effect of alcohol on HIV treatment success has not been studied in this setting. HIV antiretroviral therapy (ART) is increasing rapidly in sub-Saharan Africa, and has greatly decreased HIV morbidity and mortality.
-
Dynamics of T Cell Dysfunction in Primary HIV-1 Infection
Dynamics of T Cell Dysfunction in Primary HIV-1 Infection
Abstract
We propose that during the evolution of primary HIV-1 infection an expansion in the proportion of CD8 T cells expressing the inhibitory receptor, Tim-3, will result in failure to control viral replication. In those who initiate HAART we predict they will experience greater declines in Tim-3 expression. Accordingly, over a one year timeline, the approach will involve the use of sophisticated multiparameteric flow cytometry to assess the phenotype and function of such a CD8 T cell repertoire and assess for statistical significant differences between and within subjects.
-
Valganciclovir to Reduce T Cell Activation in HIV Infection
Valganciclovir to Reduce T Cell Activation in HIV Infection
Abstract
-
Alcohol Use and HIV Treatment Failure in Mbarara, Uganda
Alcohol Use and HIV Treatment Failure in Mbarara, Uganda
Abstract
Alcohol is the most commonly used recreational drug in sub-Saharan Africa, and Uganda has the highest rate of per capita alcohol consumption in the world. Alcohol consumption is recognized as a predictor of sexual risk behavior and thus HIV transmission and acquisition in sub-Saharan Africa, yet the effect of alcohol on HIV treatment success has not been studied in this setting. HIV antiretroviral therapy (ART) is increasing rapidly in sub-Saharan Africa, and has greatly decreased HIV morbidity and mortality.
-
Dynamics of T Cell Dysfunction in Primary HIV-1 Infection
Dynamics of T Cell Dysfunction in Primary HIV-1 Infection
Abstract
We propose that during the evolution of primary HIV-1 infection an expansion in the proportion of CD8 T cells expressing the inhibitory receptor, Tim-3, will result in failure to control viral replication. In those who initiate HAART we predict they will experience greater declines in Tim-3 expression. Accordingly, over a one year timeline, the approach will involve the use of sophisticated multiparameteric flow cytometry to assess the phenotype and function of such a CD8 T cell repertoire and assess for statistical significant differences between and within subjects.
-
Valganciclovir to Reduce T Cell Activation in HIV Infection
Valganciclovir to Reduce T Cell Activation in HIV Infection
Abstract
-
The Diagnostic Utility of Bone Marrow Aspirate Cultures Versus Blood Cultures for Detection of Mycobacterium Avium Complex in AIDS Patients
The Diagnostic Utility of Bone Marrow Aspirate Cultures Versus Blood Cultures for Detection of Mycobacterium Avium Complex in AIDS Patients
Abstract
-
Functional Characterization of a Novel Counteregulator CD4 T cell in Primary HIV-1 Infection
Functional Characterization of a Novel Counteregulator CD4 T cell in Primary HIV-1 Infection
Abstract
Natural occurring CD4+CD25+ regulatory T (T-reg) cells have broad immunotherapeutic applications and a greater understanding of the factors influencing their function is important. During untreated early HIV-1 infection there is a progressive and preferential expansion of circulating T-reg cells and such accumulation plays an important role in the inability of the immune system to control viral replication. Despite renewed focus on suppressive T-reg cells, the existence of a reciprocal pathway of immune "contrasuppression" has been suggested by clonal studies in mice.
-
The Diagnostic Utility of Bone Marrow Aspirate Cultures Versus Blood Cultures for Detection of Mycobacterium Avium Complex in AIDS Patients
The Diagnostic Utility of Bone Marrow Aspirate Cultures Versus Blood Cultures for Detection of Mycobacterium Avium Complex in AIDS Patients
Abstract