CFAR offered a general Pilot Award program from 1994 to 2017 and funded 82 early stage investigators.
In 2022, CFAR initiated a new program: Pilot Award for Investigators New to HIV.
82 Awards
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Biomarkers of Atherosclerosis Risk in HIV-1 Infection
Biomarkers of Atherosclerosis Risk in HIV-1 Infection
Abstract
HIV-infected individuals are prone to accelerated atherosclerosis (ATH)1. The objective of this pilot award is to identify biomarkers that can be used to predict and monitor ATH in the setting of HIV infection. Circulating endothelial progenitor cells (EPCs) repair damaged vascular endothelium2, while circulating endothelial microparticles (EMPs) are derived from activated or apoptotic endothelial cells3.
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REACH Cohort Adherence-Pharmacokinetics Substudy (continuation from 2000)
REACH Cohort Adherence-Pharmacokinetics Substudy (continuation from 2000)
Abstract
Publications:
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Biomarkers of Atherosclerosis Risk in HIV-1 Infection
Biomarkers of Atherosclerosis Risk in HIV-1 Infection
Abstract
HIV-infected individuals are prone to accelerated atherosclerosis (ATH)1. The objective of this pilot award is to identify biomarkers that can be used to predict and monitor ATH in the setting of HIV infection. Circulating endothelial progenitor cells (EPCs) repair damaged vascular endothelium2, while circulating endothelial microparticles (EMPs) are derived from activated or apoptotic endothelial cells3.
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REACH Cohort Adherence-Pharmacokinetics Substudy (continuation from 2000)
REACH Cohort Adherence-Pharmacokinetics Substudy (continuation from 2000)
Abstract
Publications:
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Immunodiagnosis of Active Tuberculosis in HIV Co-infected Patients: Local versus Peripheral T-cell Interferon Gamma Responses
Immunodiagnosis of Active Tuberculosis in HIV Co-infected Patients: Local versus Peripheral T-cell Interferon Gamma Responses
Abstract
Publications:
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A Randomized Controlled Trial of Routinely Offering HIV and Hepatitis C Testing to Hospitalized Patients
A Randomized Controlled Trial of Routinely Offering HIV and Hepatitis C Testing to Hospitalized Patients
Abstract
Publications:
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Cellular Determinants of Anti-rebound to Malaria in HIV-Exposed Children Discontinuing Chemoprophylaxis
Cellular Determinants of Anti-rebound to Malaria in HIV-Exposed Children Discontinuing Chemoprophylaxis
Abstract
Antimalarial chemoprevention is an emerging modality to prevent deaths and morbidity from malaria in children living in highly endemic areas, but there are concerns that it will delay the natural acquisition of antimalarial immunity. Recent studies in mice and humans have challenged this paradigm, and suggest that selective blockade of blood stage infection with antimalarial drugs may paradoxically enhance the development of sterilizing antimalarial immunity, but this has not been tested in field settings.
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The Clinical and Public Health Impact of Automated Nucleic Acid Testing for TB in San Francisco
The Clinical and Public Health Impact of Automated Nucleic Acid Testing for TB in San Francisco
Abstract
Standard diagnostic strategies for tuberculosis (TB) are inadequate, and result in misuse of resources in public health programs; overutilization of hospital isolation facilities; and anxiety for patients. The reason for this waste is that standard diagnostic tests for TB are either inaccurate (smear microscopy) or slow (mycobacterial culture).
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Household HIV Testing During Tuberculosis Contact Investigation in Tanzania
Household HIV Testing During Tuberculosis Contact Investigation in Tanzania
Abstract
The overall objective of this study is to determine if active tuberculosis (TB) case finding among persons residing in the same household as a person with active pulmonary TB (household contact investigation) is an effective TB control intervention in a low-income setting with a high incidence of TB and a high prevalence of HIV infection.
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Acceptability, Feasibility, and Efficacy of Vaginal Insemination for Conception in Human Immunodeficiency Virus (HIV) Discordant Couples (Female Positive, Male Negative) Seeking Pregnancy in Kenya
Acceptability, Feasibility, and Efficacy of Vaginal Insemination for Conception in Human Immunodeficiency Virus (HIV) Discordant Couples (Female Positive, Male Negative) Seeking Pregnancy in Kenya
Abstract
In sub-Saharan Africa, HIV is predominantly transmitted via discordant sexual relationships. With the availability of antiretroviral (ARV) medications, individuals infected with HIV can live relatively normal productive lives. Societal and cultural expectations as well as personal reproductive intentions drive HIV positive women in discordant relationships to conceive. Approximately 50% of HIV infected couples desire children.