Basic Science Award

Note: Beginning with Fall 2016, The Basic Science program has been combined into the Mentored Scientist Award mechanism - which now has three scientific priority areas for funding: Basic Science, Clinical/ Translational/ Epidemiological/ Behavioral, and Implementation Science.

Below are the awards made under the Basic Science program from 1994 to 2016.

58 Awards

Year

Award type

Award	Recipient	Award date	Award Type
Transcriptome analysis of HIV latently infected cells	Koh Fujinaga , PhD	Spring 2016	Basic Science Award
The Role of LEDGF in establishing HIV latency in primary CD4 T cells	Judd Hultquist, PhD	Spring 2016	Basic Science Award
Rapid Genetic Interaction Mapping of HIV-1 Host Factors in Cultured T-Cells	David Gordon, PhD	Fall 2015	Basic Science Award
Genetic Interaction Analysis of HIV-1 Rev Host Regulatory Networks	Jason Wojcechowskyj, PhD	Spring 2015	Basic Science Award
Quantifying the Role of Stochastic Gene Expression in HIV-1 Latency Establishment and Reactivation	Anand Pai, PhD	Spring 2015	Basic Science Award
A Novel Dual Florescent HIV-1 to Study Latency	Emily Battivelli, PhD	Fall 2014	Basic Science Award
Mechanistic and Phenotypic Characterization of Semen Amyloid Disassembler as Novel Approach to HIV Microbicide Development	Nadia Roan, PhD	Spring 2014	Basic Science Award
Mucosal Natural Killer T (NKT) cells and the Gut Microbiome in HIV-1 Infection	Devi SenGupta, MD	Spring 2014	Basic Science Award
Exploring the Role of Caspase-1-Mediated-Pyroptosis in Promoting Chronic Inflammation in HIV Patients	Gilad Doitsh, PhD	Spring 2014	Basic Science Award
Mechanisms Underlying CD4 T-Cell Depletion and Inflammation During Aids Progression	Xin Geng, PhD	Fall 2013	Basic Science Award
The Anti-HIV mechanism of human Piwil2	Pingyang Liu, PhD	Fall 2013	Basic Science Award
Intrapatient Coevolution Between the Antibody Repertoire and HIV Populations	Ryan Hernandez, PhD	Fall 2013	Basic Science Award
Investigating the interface between HIV-1 proteins and the host cellular ubiquitin machinery	Ruth Huettenhain, PhD	Fall 2013	Basic Science Award
Structure-Function Study of Semen-Derived HIV Enhancing Amyloids and Their Interactors	Haichuan Liu, PhD	Spring 2013	Basic Science Award
Human Macrophage Heterogeneity in HIV-1 Infection	Wes Yonemoto, PhD	Spring 2013	Basic Science Award
Detection of HIV Transcription in Individual Cells by Flow Cytometry	Elizabeth Sinclair, PhD	Spring 2013	Basic Science Award
Cytokine Responses in Elite Controllers of HIV	Evan Jacobs, PhD	Spring 2013	Basic Science Award
Identifying the Killing Pathway that Mediates CD4 T-cell Depletion in HIV-Infected Lymphoid Tissues	Zhiyuan Yang, PhD	Spring 2013	Basic Science Award
Study of Tat Lysine 41 Post-translational Modification in HIV Transcription	Gregory Camus, PhD	Fall 2012	Basic Science Award
Hyperthermia and HSP90AB1 Facilitate HIV Infection	Pheroze Joshi, PhD	Fall 2012	Basic Science Award
Identification of Anti-HIV Factor(s) from CD8+ Cell Antiviral Factor Gene Candidates	Lianxing Liu, PhD	Fall 2012	Basic Science Award
HIV Transcription Inhibition by Newly Identified p300 Inhibitors	Kotaro Shirakawa, MD, PhD	Fall 2011	Basic Science Award
Understanding the Role of Inflamasome Activation in AIDS Progression	Kathryn Monroe, PhD	Fall 2011	Basic Science Award
Role of Telomere maintenance in HIV-Associated Cardiovascular Disease	Jue Lin, PhD	Spring 2011	Basic Science Award
Do HIV Neutralizing Antibodies Recognize Inflammatory-mimetic Modifications of the HIV gp41 MPR?	Vincent Venditto, PhD	Spring 2010	Basic Science Award
pDC Activation and Chronic Immune Activation in AIDS	Richard Dunham, PhD	Spring 2010	Basic Science Award
Differential Regulation of Basal and Tat-mediated HIV Transcription by Acetylation of P-TEFb	Sungyoo Cho, PhD	Fall 2009	Basic Science Award
SAHA Induced Mechanism of HIV Reactivation from Latency	Koen Bartholomeeusen, PhD	Fall 2009	Basic Science Award
HPV-associated Disruption of Anal Epithelium may Facilitate HIV Mucosal Transmission	Sharof Tugizov, PhD	Fall 2009	Basic Science Award
Investigation of the Effects of IL-2 on the Frequency of FcRL3+ Tregs and T cell Activation in HIV-infected Patients	Louise Swainson, PhD	Fall 2009	Basic Science Award
Do Human Natural Killer Cells Acquire Immune Memory to Viral Infections?	Lewis Lanier, PhD	Spring 2009	Basic Science Award
The Role of P Bodies and Stress Granules in the HIV-1 Replicative Cycles	Chunye Lu, PhD	Fall 2008	Basic Science Award
Role of Double Modified Tat Protein in HIV-1 Transcription	Sara Pagans, PhD	Fall 2008	Basic Science Award
The Role of Autophagy in HIV Infection	Michael Killian, PhD, MPH	Spring 2008	Basic Science Award
Activation of transcriptional elongation in HIV latently infected cells by SAHA	Xavier Contreras, PhD	Spring 2008	Basic Science Award
Activation of the SIRT1 Deacetylase as a Therapeutic Concept in HIV-induced T Cell Hyperactivation	Xavier Contreras, PhD	Spring 2008	Basic Science Award
Role of Chromatin Remodeling in HIV Transcriptional Regulation	Shweta Hakre, PhD	Spring 2008	Basic Science Award
The role of transcriptional interference and inhibition of transcriptional elongation in HIV latency	Valentina Lenasi, PhD	Spring 2007	Basic Science Award
Defining the role of lysine methylation in HIV-1 Tat transactivation	Melanie Ott, MD, PhD	Spring 2007	Basic Science Award
High CD8+ T cell Activation Associates with HIV Disease Outcome	Jason Barbour, PhD, MHS	Spring 2006	Basic Science Award
BRD4 Overexpression Increases the Propensity for Proviral Latency and Determine how this Relates to HIV Latency in vivo.	Dwayne Bisgrove, PhD	Spring 2006	Basic Science Award
Genetic Diversity of HIV-1 in vivo During Very Early Primary Infection	Eric Delwart, PhD	Spring 2000	Basic Science Award
Evaluation of Thymic Mass in HIV-1 Infected Patients	Mike McCune, MD, PhD	Fall 1999	Basic Science Award
Optimization of Cytokine Flow Cytometry (CFC) for Trans-Shipped Specimens	Mike McCune, MD, PhD	Fall 1999	Basic Science Award
Development and Validation of a Cytokine Flow Cytometry Assay to Detect T Cell Immune Responses Against Pneumocystis Carinii	Laurence Huang, MD	Fall 1999	Basic Science Award
Expanded Cellular Tropism of Human Immunodeficiency Virus 1 by a Trans-Receptor Mechanism	Roberto Speck, MD	Spring 1999	Basic Science Award
Identification of Novel HIV Co-Receptors and Characterization of Their Role in Viral Transmission	Laura Digilio, MD	Spring 1998	Basic Science Award
The Biology of Coreceptors for HIV and Chemokine Receptors in vivo as a Factor in Regulating HIV Disease Progression	Mark Goldsmith, MD, PhD	Fall 1997	Basic Science Award
Transgenic Rabbits and HIV Infection	Mark Goldsmith, MD, PhD	Spring 1997	Basic Science Award
Molecular Interactions Between HIV and HPV	Joel Palefsky, MD	Spring 1997	Basic Science Award
Characterization of the Epstein Barr Virus BMRF-2 Gene and its Role in the Pathogenesis of Hairy Leukoplakia	Laurel Lagenaur, PhD	Spring 1997	Basic Science Award
Characterization and Inhibition of Kaposi's Sarcoma Herpesvirus Protease	Charles Craik	Spring 1997	Basic Science Award
Pilot Study of HIV-1-Specific Immunity Following Antiretroviral Treatment Interruption	Mike McCune, MD, PhD	Spring 1995	Basic Science Award
Biochemical and Clinical Consequences of Antiviral Resistance Mutations in HIV-1 Protease	Charles Craik	Spring 1995	Basic Science Award
The Kinetics of Primary Viremia in Macaques and Sooty Mangabeys Infected with Simian Immunodeficiency Virus	Mark Feinberg, MD, PhD	Spring 1995	Basic Science Award
Molecular Biology of HIV Macrophage Infection	Kathleen Page, PhD	Spring 1995	Basic Science Award
Direct Measurement of Rate of Synthesis and Removal of Circulating HIV in Infected Humans	Marc Hellerstein, MD, PhD	Fall 1994	Basic Science Award
Lymphocyte Apoptosis and Disease Progression Following HIV Infection	Teri Liegler, PhD	Fall 1994	Basic Science Award

Contacts

Lauren Sterling

Associate Director, UCSF-Bay Area CFAR

Brenda Sanchez

Former Developmental Core Manager (2002-2025)

SAHA Induced Mechanism of HIV Reactivation from Latency

SAHA Induced Mechanism of HIV Reactivation from Latency

Abstract

Despite heroic efforts and better highly active antiretroviral therapy (HAART), HIV remains a lifelong infection that interferes with productivity, decreases lifespan, and is ultimately fatal. Wide-ranging vaccine trials have failed. Thus, this is an opportune time to turn to the persistent infection, and develop new therapies to purge the reservoir of HIV from the infected host.
Defining the role of lysine methylation in HIV-1 Tat transactivation

Defining the role of lysine methylation in HIV-1 Tat transactivation

Abstract
SAHA Induced Mechanism of HIV Reactivation from Latency

SAHA Induced Mechanism of HIV Reactivation from Latency

Abstract

Despite heroic efforts and better highly active antiretroviral therapy (HAART), HIV remains a lifelong infection that interferes with productivity, decreases lifespan, and is ultimately fatal. Wide-ranging vaccine trials have failed. Thus, this is an opportune time to turn to the persistent infection, and develop new therapies to purge the reservoir of HIV from the infected host.
Defining the role of lysine methylation in HIV-1 Tat transactivation

Defining the role of lysine methylation in HIV-1 Tat transactivation

Abstract
Identification of Novel HIV Co-Receptors and Characterization of Their Role in Viral Transmission

Identification of Novel HIV Co-Receptors and Characterization of Their Role in Viral Transmission

Abstract
The Role of Autophagy in HIV Infection
The Role of Autophagy in HIV Infection

Abstract
Publications:
- PubMed# 19189205
Identification of Novel HIV Co-Receptors and Characterization of Their Role in Viral Transmission

Identification of Novel HIV Co-Receptors and Characterization of Their Role in Viral Transmission

Abstract
The Role of Autophagy in HIV Infection
The Role of Autophagy in HIV Infection

Abstract
Publications:
- PubMed# 19189205
Characterization of the Epstein Barr Virus BMRF-2 Gene and its Role in the Pathogenesis of Hairy Leukoplakia

Characterization of the Epstein Barr Virus BMRF-2 Gene and its Role in the Pathogenesis of Hairy Leukoplakia

Abstract
Characterization of the Epstein Barr Virus BMRF-2 Gene and its Role in the Pathogenesis of Hairy Leukoplakia

Characterization of the Epstein Barr Virus BMRF-2 Gene and its Role in the Pathogenesis of Hairy Leukoplakia

Abstract

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58 Awards

SAHA Induced Mechanism of HIV Reactivation from Latency

Abstract

Defining the role of lysine methylation in HIV-1 Tat transactivation

Abstract

SAHA Induced Mechanism of HIV Reactivation from Latency

Abstract

Defining the role of lysine methylation in HIV-1 Tat transactivation

Abstract

Identification of Novel HIV Co-Receptors and Characterization of Their Role in Viral Transmission

Abstract

The Role of Autophagy in HIV Infection

Abstract

Publications:

Identification of Novel HIV Co-Receptors and Characterization of Their Role in Viral Transmission

Abstract

The Role of Autophagy in HIV Infection

Abstract

Publications:

Characterization of the Epstein Barr Virus BMRF-2 Gene and its Role in the Pathogenesis of Hairy Leukoplakia

Abstract

Characterization of the Epstein Barr Virus BMRF-2 Gene and its Role in the Pathogenesis of Hairy Leukoplakia

Abstract