Note: Beginning with Fall 2016, The Basic Science program has been combined into the Mentored Scientist Award mechanism - which now has three scientific priority areas for funding: Basic Science, Clinical/ Translational/ Epidemiological/ Behavioral, and Implementation Science.
Below are the awards made under the Basic Science program from 1994 to 2016.
58 Awards
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Evaluation of Thymic Mass in HIV-1 Infected Patients
Evaluation of Thymic Mass in HIV-1 Infected Patients
Abstract
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Development and Validation of a Cytokine Flow Cytometry Assay to Detect T Cell Immune Responses Against Pneumocystis Carinii
Development and Validation of a Cytokine Flow Cytometry Assay to Detect T Cell Immune Responses Against Pneumocystis Carinii
Abstract
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Molecular Interactions Between HIV and HPV
Molecular Interactions Between HIV and HPV
Abstract
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The Role of P Bodies and Stress Granules in the HIV-1 Replicative Cycles
The Role of P Bodies and Stress Granules in the HIV-1 Replicative Cycles
Abstract
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Characterization and Inhibition of Kaposi's Sarcoma Herpesvirus Protease
Characterization and Inhibition of Kaposi's Sarcoma Herpesvirus Protease
Abstract
Publications:
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Pilot Study of HIV-1-Specific Immunity Following Antiretroviral Treatment Interruption
Pilot Study of HIV-1-Specific Immunity Following Antiretroviral Treatment Interruption
Abstract
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Biochemical and Clinical Consequences of Antiviral Resistance Mutations in HIV-1 Protease
Biochemical and Clinical Consequences of Antiviral Resistance Mutations in HIV-1 Protease
Abstract
Publications:
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Lymphocyte Apoptosis and Disease Progression Following HIV Infection
Lymphocyte Apoptosis and Disease Progression Following HIV Infection
Abstract
Publications:
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Do HIV Neutralizing Antibodies Recognize Inflammatory-mimetic Modifications of the HIV gp41 MPR?
Do HIV Neutralizing Antibodies Recognize Inflammatory-mimetic Modifications of the HIV gp41 MPR?
Abstract
Two broadly neutralizing HIV monoclonal antibodies (mAB; 2F5 and 4E10) that bind to the membrane external proximal region (MPR) of gp41 were isolated from patient material but scientist have been unable to identify immunogens that induce broadly neutralizing antibodies to MPR in mice, rabbits or primates. We think they failed because they used the wrong epitopes as immunogens. We hypothesize that post-translational modifications such as phosphorylation of MPR are critical to the induction of neutralizing antibodies against MPR. Post-translational modifications (e.g.
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pDC Activation and Chronic Immune Activation in AIDS
pDC Activation and Chronic Immune Activation in AIDS
Abstract
HIV infection causes widespread persistent inflammation that leads to the progressive loss of function in the immune system and the onset of AIDS. The objective of this proposal is to investigate the interaction of HIV with the innate immune system and how this interaction impacts persistent inflammation during HIV infection. We will dissect the molecular events subsequent to activation of pDC by HIV and the impact that this sequence has on T cell function and differentiation.