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Lauren Sterling
Associate Director, UCSF-Bay Area CFAR
Note: Beginning with Fall 2016, The Basic Science program has been combined into the Mentored Scientist Award mechanism - which now has three scientific priority areas for funding: Basic Science, Clinical/ Translational/ Epidemiological/ Behavioral, and Implementation Science.
Below are the awards made under the Basic Science program from 1994 to 2016.
58 Awards
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Role of Chromatin Remodeling in HIV Transcriptional Regulation
Role of Chromatin Remodeling in HIV Transcriptional Regulation
Abstract
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Differential Regulation of Basal and Tat-mediated HIV Transcription by Acetylation of P-TEFb
Differential Regulation of Basal and Tat-mediated HIV Transcription by Acetylation of P-TEFb
Abstract
We try to understand the mechanisms of HIV transcriptional regulation as target for therapy. The viral transactivator Tat and its interacting cofactors play an important role in HIV transcription. Tat binds to an RNA structure called TAR and recruits the positive elongation factor b (P-TEFb) to HIV-1 transcripts. P-TEFb is composed of the cyclin T1 and cyclin-dependent kinase 9 (CDK9). We identified four acetylation sites in cyclin T1.
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Differential Regulation of Basal and Tat-mediated HIV Transcription by Acetylation of P-TEFb
Differential Regulation of Basal and Tat-mediated HIV Transcription by Acetylation of P-TEFb
Abstract
We try to understand the mechanisms of HIV transcriptional regulation as target for therapy. The viral transactivator Tat and its interacting cofactors play an important role in HIV transcription. Tat binds to an RNA structure called TAR and recruits the positive elongation factor b (P-TEFb) to HIV-1 transcripts. P-TEFb is composed of the cyclin T1 and cyclin-dependent kinase 9 (CDK9). We identified four acetylation sites in cyclin T1.
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The role of transcriptional interference and inhibition of transcriptional elongation in HIV latency
The role of transcriptional interference and inhibition of transcriptional elongation in HIV latency
Abstract
Publications:
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The role of transcriptional interference and inhibition of transcriptional elongation in HIV latency
The role of transcriptional interference and inhibition of transcriptional elongation in HIV latency
Abstract
Publications:
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HPV-associated Disruption of Anal Epithelium may Facilitate HIV Mucosal Transmission
HPV-associated Disruption of Anal Epithelium may Facilitate HIV Mucosal Transmission
Abstract
Mucosal epithelia are the first tissue sites of contact of HIV with the human body during the course of infection, and these play a critical role in determining its success in establishing systemic infection. We have shown that experimental disruption of tight junctions of mucosal epithelium may facilitate HIV transmission across mucosal epithelia by paracellular penetration, which requires no viral replication and, therefore, antiretroviral therapy would not be expected to block such transmission.
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HPV-associated Disruption of Anal Epithelium may Facilitate HIV Mucosal Transmission
HPV-associated Disruption of Anal Epithelium may Facilitate HIV Mucosal Transmission
Abstract
Mucosal epithelia are the first tissue sites of contact of HIV with the human body during the course of infection, and these play a critical role in determining its success in establishing systemic infection. We have shown that experimental disruption of tight junctions of mucosal epithelium may facilitate HIV transmission across mucosal epithelia by paracellular penetration, which requires no viral replication and, therefore, antiretroviral therapy would not be expected to block such transmission.
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Activation of transcriptional elongation in HIV latently infected cells by SAHA
Activation of transcriptional elongation in HIV latently infected cells by SAHA
Abstract
Publications:
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Identification of Novel HIV Co-Receptors and Characterization of Their Role in Viral Transmission
Identification of Novel HIV Co-Receptors and Characterization of Their Role in Viral Transmission
Abstract
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The Role of Autophagy in HIV Infection