The Role of LEDGF in establishing HIV latency in primary CD4 T cells
The Role of LEDGF in establishing HIV latency in primary CD4 T cells

Abstract
One of the most promising strategies for curing HIV infection is referred to as “shock and kill,” whereby latently infected cells are induced to express the virus and subsequently cleared from the body. Understanding how certain cells become latently infected, however, has been a major hurdle towards realizing this strategy. It is known that certain host factors, such as the chromatin bound protein LEDGF, can influence latency by dictating the site of HIV integration and recruiting epigenetic factors.