I am a Staff Research Scientist, and the head of HIV Pathogenesis Group at the Gladstone Institute of Virology and Immunology, UCSF. My group focuses on two of the most fundamental questions in AIDS: How HIV causes the depletion of CD4 T cells, and the role of inflammation as a driver of HIV pathogenesis. We explore this question using a unique, physiological relevant experimental system formed of fresh human lymphoid cultures. In many regards, this system is one of the most powerful experimental approaches to modeling molecular and cellular events during HIV infection in human patients. More about our finding could be found in our papers: Doitsh, G., et al. Cell. 143, 789-801, (2010); Doitsh, G., et al. Nature 505, 509-514, (2014); Monroe, K.M., et al. Science 343, 428-432, (2014).
- Exploring the Role of Caspase-1-Mediated-Pyroptosis in Promoting Chronic Inflammation in HIV PatientsBasic Science Award , Spring