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Lauren Sterling
Associate Director, UCSF-Bay Area CFAR
Note: Beginning with Fall 2016, The Basic Science program has been combined into the Mentored Scientist Award mechanism - which now has three scientific priority areas for funding: Basic Science, Clinical/ Translational/ Epidemiological/ Behavioral, and Implementation Science.
Below are the awards made under the Basic Science program from 1994 to 2016.
58 Awards
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Do HIV Neutralizing Antibodies Recognize Inflammatory-mimetic Modifications of the HIV gp41 MPR?
Do HIV Neutralizing Antibodies Recognize Inflammatory-mimetic Modifications of the HIV gp41 MPR?
Abstract
Two broadly neutralizing HIV monoclonal antibodies (mAB; 2F5 and 4E10) that bind to the membrane external proximal region (MPR) of gp41 were isolated from patient material but scientist have been unable to identify immunogens that induce broadly neutralizing antibodies to MPR in mice, rabbits or primates. We think they failed because they used the wrong epitopes as immunogens. We hypothesize that post-translational modifications such as phosphorylation of MPR are critical to the induction of neutralizing antibodies against MPR. Post-translational modifications (e.g.
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Evaluation of Thymic Mass in HIV-1 Infected Patients
Evaluation of Thymic Mass in HIV-1 Infected Patients
Abstract
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Do HIV Neutralizing Antibodies Recognize Inflammatory-mimetic Modifications of the HIV gp41 MPR?
Do HIV Neutralizing Antibodies Recognize Inflammatory-mimetic Modifications of the HIV gp41 MPR?
Abstract
Two broadly neutralizing HIV monoclonal antibodies (mAB; 2F5 and 4E10) that bind to the membrane external proximal region (MPR) of gp41 were isolated from patient material but scientist have been unable to identify immunogens that induce broadly neutralizing antibodies to MPR in mice, rabbits or primates. We think they failed because they used the wrong epitopes as immunogens. We hypothesize that post-translational modifications such as phosphorylation of MPR are critical to the induction of neutralizing antibodies against MPR. Post-translational modifications (e.g.
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Evaluation of Thymic Mass in HIV-1 Infected Patients
Evaluation of Thymic Mass in HIV-1 Infected Patients
Abstract
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Lymphocyte Apoptosis and Disease Progression Following HIV Infection
Lymphocyte Apoptosis and Disease Progression Following HIV Infection
Abstract
Publications:
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Optimization of Cytokine Flow Cytometry (CFC) for Trans-Shipped Specimens
Optimization of Cytokine Flow Cytometry (CFC) for Trans-Shipped Specimens
Abstract
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Lymphocyte Apoptosis and Disease Progression Following HIV Infection
Lymphocyte Apoptosis and Disease Progression Following HIV Infection
Abstract
Publications:
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Optimization of Cytokine Flow Cytometry (CFC) for Trans-Shipped Specimens
Optimization of Cytokine Flow Cytometry (CFC) for Trans-Shipped Specimens
Abstract
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Biochemical and Clinical Consequences of Antiviral Resistance Mutations in HIV-1 Protease
Biochemical and Clinical Consequences of Antiviral Resistance Mutations in HIV-1 Protease
Abstract
Publications:
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BRD4 Overexpression Increases the Propensity for Proviral Latency and Determine how this Relates to HIV Latency in vivo.
BRD4 Overexpression Increases the Propensity for Proviral Latency and Determine how this Relates to HIV Latency in vivo.
Abstract