Joel Ernst, MD
Professor of Medicine, UCSF
Professor, School of Medicine
Email: Joel.Ernst@ucsf.edu
Biography
Our laboratory studies the mechanisms of protective and pathological immunity to Mycobacterium tuberculosis, the bacteria that cause tuberculosis (TB). Even though TB can be treated and potentially cured, it still causes more human mortality than any other infectious disease, including HIV. Our goal is to inform development of effective TB vaccines, and for this we use mouse models and human translational immunology studies.
We use mouse models to discover and characterize mechanisms of immune evasion employed by M. tuberculosis to prevent immune responses from clearing the infection and establishing sterile immunity and memory.
Displaying 101 - 125 of 126
- Zimmerli S, Edwards S, Ernst JD. Selective receptor blockade during phagocytosis does not alter the survival and growth of Mycobacterium tuberculosis in human macrophages. Am J Respir Cell Mol Biol. 1996 Dec; 15(6):760-70.
- Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. J Clin Invest. 1996 Nov 01; 98(9):2050-9.
- Read RC, Zimmerli S, Broaddus C, Sanan DA, Stephens DS, Ernst JD. The (alpha2-->8)-linked polysialic acid capsule of group B Neisseria meningitidis modifies multiple steps during interaction with human macrophages. Infect Immun. 1996 Aug; 64(8):3210-7.
- Kuypers FA, Lewis RA, Hua M, Schott MA, Discher D, Ernst JD, Lubin BH. Detection of altered membrane phospholipid asymmetry in subpopulations of human red blood cells using fluorescently labeled annexin V. Blood. 1996 Feb 01; 87(3):1179-87.
- Zimmerli S, Majeed M, Gustavsson M, Stendahl O, Sanan DA, Ernst JD. Phagosome-lysosome fusion is a calcium-independent event in macrophages. J Cell Biol. 1996 Jan; 132(1-2):49-61.
- Larsson M, Majeed M, Stendahl O, Magnusson KE, Ernst JD, Forsum U. Mobilization of annexin V during the uptake of DNP-albumin by human dendritic cells. APMIS. 1995 Dec; 103(12):855-61.
- Schmidt DM, Ernst JD. A fluorometric assay for the quantification of RNA in solution with nanogram sensitivity. Anal Biochem. 1995 Nov 20; 232(1):144-6.
- Ernst JD, Rosales JL, Zimmerli S. Calcium signalling initiated by CR1 (CD35) crosslinking is mediated by phagocyte Fc gamma receptors in cis. Biochem Biophys Res Commun. 1995 Apr 26; 209(3):1032-8.
- Larsson M, Majeed M, Stendahl O, Magnusson KE, Ernst JD, Forsum U. Annexin expression in human dendritic cells. Adv Exp Med Biol. 1995; 378:191-3.
- Majeed M, Ernst JD, Magnusson KE, Kihlström E, Stendahl O. Selective translocation of annexins III, IV, and V during intracellular redistribution of Chlamydia trachomatis serovar L2 in HeLa and McCoy cells. Ann N Y Acad Sci. 1994 Aug 15; 730:326-8.
- Ernst JD, Mall A, Chew G. Annexins possess functionally distinguishable Ca2+ and phospholipid binding domains. Biochem Biophys Res Commun. 1994 Apr 29; 200(2):867-76.
- Majeed M, Ernst JD, Magnusson KE, Kihlström E, Stendahl O. Selective translocation of annexins during intracellular redistribution of Chlamydia trachomatis in HeLa and McCoy cells. Infect Immun. 1994 Jan; 62(1):126-34.
- Ernst JD. Epitope mapping of annexin I: antibodies that compete with phospholipids and calcium recognize amino acids 42-99. Biochem J. 1993 Jan 15; 289 ( Pt 2):539-42.
- Ernst JD. Annexin III translocates to the periphagosomal region when neutrophils ingest opsonized yeast. J Immunol. 1991 May 01; 146(9):3110-4.
- Ernst JD, Hoye E, Blackwood RA, Mok TL. Identification of a domain that mediates vesicle aggregation reveals functional diversity of annexin repeats. J Biol Chem. 1991 Apr 15; 266(11):6670-3.
- Ernst JD, Hoye E, Blackwood RA, Jaye D. Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules. J Clin Invest. 1990 Apr; 85(4):1065-71.
- Blackwood RA, Ernst JD. Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins. Biochem J. 1990 Feb 15; 266(1):195-200.
- Ernst JD, Hoye E, Blackwood RA. Use of a novel strategy for the preparation and characterization of an antipeptide antibody capable of recognizing members of the annexin family. Biochem Biophys Res Commun. 1989 Jun 30; 161(3):959-64.
- Meers P, Ernst JD, Düzgünes N, Hong KL, Fedor J, Goldstein IM, Papahadjopoulos D. Synexin-like proteins from human polymorphonuclear leukocytes. Identification and characterization of granule-aggregating and membrane-fusing activities. J Biol Chem. 1987 Jun 05; 262(16):7850-8.
- Ernst JD, Meers P, Hong K, Duzgunes N, Papahadjopoulos D, Goldstein IM. Human polymorphonuclear leukocytes contain synexin, a calcium-binding protein that mediates membrane fusion. Trans Assoc Am Physicians. 1986; 99:58-66.
- Ernst JD, Hartiala KT, Goldstein IM, Sande MA. Complement (C5)-derived chemotactic activity accounts for accumulation of polymorphonuclear leukocytes in cerebrospinal fluid of rabbits with pneumococcal meningitis. Infect Immun. 1984 Oct; 46(1):81-6.
- Decazes JM, Ernst JD, Sande MA. Correlation of in vitro time-kill curves and kinetics of bacterial killing in cerebrospinal fluid during ceftriaxone therapy of experimental Escherichia coli meningitis. Antimicrob Agents Chemother. 1983 Oct; 24(4):463-7.
- Ernst JD, Rusnak M, Sande MA. Combination antifungal chemotherapy for experimental disseminated candidiasis: lack of correlation between in vitro and in vivo observations with amphotericin B and rifampin. Rev Infect Dis. 1983 Jul-Aug; 5 Suppl 3:S626-30.
- Ernst JD, Decazes JM, Sande MA. Experimental pneumococcal meningitis: role of leukocytes in pathogenesis. Infect Immun. 1983 Jul; 41(1):275-9.
- Hackbarth CJ, Ernst JD, Sande MA. Inhibition of isolation of Escherichia coli in blood cultures by trimethoprim-sulfamethoxazole. J Infect Dis. 1983 May; 147(5):964-5.