Joel Ernst, MD
Professor of Medicine, UCSF
Professor, School of Medicine
Email: Joel.Ernst@ucsf.edu
Biography
Our laboratory studies the mechanisms of protective and pathological immunity to Mycobacterium tuberculosis, the bacteria that cause tuberculosis (TB). Even though TB can be treated and potentially cured, it still causes more human mortality than any other infectious disease, including HIV. Our goal is to inform development of effective TB vaccines, and for this we use mouse models and human translational immunology studies.
We use mouse models to discover and characterize mechanisms of immune evasion employed by M. tuberculosis to prevent immune responses from clearing the infection and establishing sterile immunity and memory.
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- Banaiee N, Jacobs WR, Ernst JD. LspA-independent action of globomycin on Mycobacterium tuberculosis. J Antimicrob Chemother. 2007 Aug; 60(2):414-6.
- Banaiee N, Jacobs WR, Ernst JD. Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages. Infect Immun. 2006 Nov; 74(11):6449-57.
- Banaiee N, Kincaid EZ, Buchwald U, Jacobs WR, Ernst JD. Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2. J Immunol. 2006 Mar 01; 176(5):3019-27.
- Rosales JL, Ernst JD, Hallows J, Lee KY. GTP-dependent secretion from neutrophils is regulated by Cdk5. J Biol Chem. 2004 Dec 24; 279(52):53932-6.
- Peters W, Cyster JG, Mack M, Schlöndorff D, Wolf AJ, Ernst JD, Charo IF. CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis. J Immunol. 2004 Jun 15; 172(12):7647-53.
- Fortune SM, Solache A, Jaeger A, Hill PJ, Belisle JT, Bloom BR, Rubin EJ, Ernst JD. Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms. J Immunol. 2004 May 15; 172(10):6272-80.
- Nagabhushanam V, Solache A, Ting LM, Escaron CJ, Zhang JY, Ernst JD. Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma. J Immunol. 2003 Nov 01; 171(9):4750-7.
- Kincaid EZ, Ernst JD. Mycobacterium tuberculosis exerts gene-selective inhibition of transcriptional responses to IFN-gamma without inhibiting STAT1 function. J Immunol. 2003 Aug 15; 171(4):2042-9.
- Peters W, Ernst JD. Mechanisms of cell recruitment in the immune response to Mycobacterium tuberculosis. Microbes Infect. 2003 Feb; 5(2):151-8.
- Sonda S, Ting LM, Novak S, Kim K, Maher JJ, Farese RV, Ernst JD. Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii. J Biol Chem. 2001 Sep 14; 276(37):34434-40.
- Peters W, Scott HM, Chambers HF, Flynn JL, Charo IF, Ernst JD. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2001 Jul 03; 98(14):7958-63.
- Ernst JD. Bacterial inhibition of phagocytosis. Cell Microbiol. 2000 Oct; 2(5):379-86.
- Rosales JL, Ernst JD. GTP-dependent permeabilized neutrophil secretion requires a freely diffusible cytosolic protein. J Cell Biochem. 2000 Sep 18; 80(1):37-45.
- Liu W, Ernst JD, Broaddus VC. Phagocytosis of crocidolite asbestos induces oxidative stress, DNA damage, and apoptosis in mesothelial cells. Am J Respir Cell Mol Biol. 2000 Sep; 23(3):371-8.
- Flynn JL, Ernst JD. Immune responses in tuberculosis. Curr Opin Immunol. 2000 Aug; 12(4):432-6.
- Ernst JD. Toward the development of antibacterial vaccines: report of a symposium and workshop. Organizing Committee. Clin Infect Dis. 1999 Nov; 29(5):1295-302.
- Ting LM, Kim AC, Cattamanchi A, Ernst JD. Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1. J Immunol. 1999 Oct 01; 163(7):3898-906.
- Ernst JD. Editorial response: variation in clinical and immune responses to bacille Calmette-Guérin--implications for an improved tuberculosis vaccine. Clin Infect Dis. 1999 Apr; 28(4):791-3.
- Ernst JD, Yang L, Rosales JL, Broaddus VC. Preparation and characterization of an endogenously fluorescent annexin for detection of apoptotic cells. Anal Biochem. 1998 Jun 15; 260(1):18-23.
- Majeed M, Perskvist N, Ernst JD, Orselius K, Stendahl O. Roles of calcium and annexins in phagocytosis and elimination of an attenuated strain of Mycobacterium tuberculosis in human neutrophils. Microb Pathog. 1998 May; 24(5):309-20.
- Ernst JD. Macrophage receptors for Mycobacterium tuberculosis. Infect Immun. 1998 Apr; 66(4):1277-81.
- Rosales JL, Ernst JD. Calcium-dependent neutrophil secretion: characterization and regulation by annexins. J Immunol. 1997 Dec 15; 159(12):6195-202.
- Larsson M, Majeed M, Ernst JD, Magnusson KE, Stendahl O, Forsum U. Role of annexins in endocytosis of antigens in immature human dendritic cells. Immunology. 1997 Dec; 92(4):501-11.
- Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. Crocidolite asbestos induces apoptosis of pleural mesothelial cells: role of reactive oxygen species and poly(ADP-ribosyl) polymerase. Environ Health Perspect. 1997 Sep; 105 Suppl 5:1147-52.
- Collins HL, Schaible UE, Ernst JD, Russell DG. Transfer of phagocytosed particles to the parasitophorous vacuole of Leishmania mexicana is a transient phenomenon preceding the acquisition of annexin I by the phagosome. J Cell Sci. 1997 Jan; 110 ( Pt 2):191-200.