Joel Ernst, MD
Professor of Medicine, UCSF
Professor, School of Medicine
Email: Joel.Ernst@ucsf.edu
Biography
Our laboratory studies the mechanisms of protective and pathological immunity to Mycobacterium tuberculosis, the bacteria that cause tuberculosis (TB). Even though TB can be treated and potentially cured, it still causes more human mortality than any other infectious disease, including HIV. Our goal is to inform development of effective TB vaccines, and for this we use mouse models and human translational immunology studies.
We use mouse models to discover and characterize mechanisms of immune evasion employed by M. tuberculosis to prevent immune responses from clearing the infection and establishing sterile immunity and memory.
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- Ernst JD. Antigenic Variation and Immune Escape in the MTBC. Adv Exp Med Biol. 2017; 1019:171-190.
- Copin R, Wang X, Louie E, Escuyer V, Coscolla M, Gagneux S, Palmer GH, Ernst JD. Within Host Evolution Selects for a Dominant Genotype of Mycobacterium tuberculosis while T Cells Increase Pathogen Genetic Diversity. PLoS Pathog. 2016 Dec; 12(12):e1006111.
- Portal-Celhay C, Tufariello JM, Srivastava S, Zahra A, Klevorn T, Grace PS, Mehra A, Park HS, Ernst JD, Jacobs WR, Philips JA. Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T-cell activation. Nat Microbiol. 2016 Dec 05; 2:16232.
- Wiens KE, Ernst JD. Type I Interferon is Pathogenic During Chronic Mycobacterium africanum Infection. J Infect Dis. 2016 Dec 15; 214(12):1893-1896.
- Blumberg HM, Ernst JD. The Challenge of Latent TB Infection. JAMA. 2016 Sep 06; 316(9):931-3.
- Wiens KE, Ernst JD. The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent. PLoS Pathog. 2016 08; 12(8):e1005809.
- Lindestam Arlehamn CS, McKinney DM, Carpenter C, Paul S, Rozot V, Makgotlho E, Gregg Y, van Rooyen M, Ernst JD, Hatherill M, Hanekom WA, Peters B, Scriba TJ, Sette A. A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans. PLoS Pathog. 2016 07; 12(7):e1005760.
- Srivastava S, Grace PS, Ernst JD. Antigen Export Reduces Antigen Presentation and Limits T Cell Control of M. tuberculosis. . 2016 Jan 13; 19(1):44-54.
- Gaur RL, Ren K, Blumenthal A, Bhamidi S, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst JD, Banaei N. Correction: LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis. PLoS Pathog. 2015 Dec; 11(12):e1005336.
- Grace PS, Ernst JD. Suboptimal Antigen Presentation Contributes to Virulence of Mycobacterium tuberculosis In Vivo. J Immunol. 2016 Jan 01; 196(1):357-64.
- Coscolla M, Copin R, Sutherland J, Gehre F, de Jong B, Owolabi O, Mbayo G, Giardina F, Ernst JD, Gagneux S. M. tuberculosis T Cell Epitope Analysis Reveals Paucity of Antigenic Variation and Identifies Rare Variable TB Antigens. . 2015 Nov 11; 18(5):538-48.
- Desvignes L, Weidinger C, Shaw P, Vaeth M, Ribierre T, Liu M, Fergus T, Kozhaya L, McVoy L, Unutmaz D, Ernst JD, Feske S. STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection. J Clin Invest. 2015 Jun; 125(6):2347-62.
- Young DC, Layre E, Pan SJ, Tapley A, Adamson J, Seshadri C, Wu Z, Buter J, Minnaard AJ, Coscolla M, Gagneux S, Copin R, Ernst JD, Bishai WR, Snider BB, Moody DB. In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection. Chem Biol. 2015 Apr 23; 22(4):516-526.
- Srivastava S, Ernst JD, Desvignes L. Beyond macrophages: the diversity of mononuclear cells in tuberculosis. Immunol Rev. 2014 Nov; 262(1):179-92.
- Gaur RL, Ren K, Blumenthal A, Bhamidi S, González-Nilo FD, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst JD, Banaei N. LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis. PLoS Pathog. 2014 Sep; 10(9):e1004376.
- Copin R, Coscollá M, Efstathiadis E, Gagneux S, Ernst JD. Impact of in vitro evolution on antigenic diversity of Mycobacterium bovis bacillus Calmette-Guerin (BCG). Vaccine. 2014 Oct 14; 32(45):5998-6004.
- Srivastava S, Ernst JD. Cell-to-cell transfer of M. tuberculosis antigens optimizes CD4 T cell priming. . 2014 Jun 11; 15(6):741-52.
- Copin R, Coscollá M, Seiffert SN, Bothamley G, Sutherland J, Mbayo G, Gagneux S, Ernst JD. Sequence diversity in the pe_pgrs genes of Mycobacterium tuberculosis is independent of human T cell recognition. mBio. 2014 Jan 14; 5(1):e00960-13.
- Wiens KE, Swaminathan H, Copin R, Lun DS, Ernst JD. Equivalent T cell epitope promiscuity in ecologically diverse human pathogens. PLoS One. 2013; 8(8):e73124.
- Srivastava S, Ernst JD. Cutting edge: Direct recognition of infected cells by CD4 T cells is required for control of intracellular Mycobacterium tuberculosis in vivo. J Immunol. 2013 Aug 01; 191(3):1016-20.
- Desvignes LP, Ernst JD. Taking sides: interferons in leprosy. . 2013 Apr 17; 13(4):377-8.
- Fan L, Xiao HP, Hu ZY, Ernst JD. Variation of Mycobacterium tuberculosis antigen-specific IFN-γ and IL-17 responses in healthy tuberculin skin test (TST)-positive human subjects. PLoS One. 2012; 7(8):e42716.
- Bold TD, Ernst JD. CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection. J Immunol. 2012 Sep 01; 189(5):2530-6.
- Ernst JD. The immunological life cycle of tuberculosis. Nat Rev Immunol. 2012 Jul 13; 12(8):581-91.
- Ernst JD, Hanekom W, Hawn T, Kampmann B, Rengarajan J. Meeting report: The International Conference on Human Immunity to Tuberculosis. Tuberculosis (Edinb). 2012 Sep; 92(5):440-4.