Phyllis Tien, MD

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Phyllis Tien, MD

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Professor, School of Medicine
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Dr. Tien is Professor of Medicine at the University of California, San Francisco and Chief of the Infectious Diseases Division at the San Francisco Veterans Affairs Health Care System. Her research program examines the mechanisms by which chronic viral infections (specifically HIV and HCV) and their associated metabolic and immune perturbations impact long term organ injury in adults. She has served in several leadership positions including Co-Chair of the Executive Committee of the Multicenter AIDS Cohort Study (MACS)/Women's Interagency HIV Study (WIHS) Combined Cohort Study (MWCCS) and the MWCCS Steering Committee. The MWCCS integrates two of the largest and longest running NIH-funded prospective cohorts of adult men and women with and at risk for HIV in the U.S. She also serves as Chair of the Inter-CFAR Collaboration on HIV Research in Women and previously served as Chair of the NIH AIDS Clinical Epidemiology Study Section. She was a member of the Department of Health and Human Services Antiretroviral Guidelines Panel, and is currently a member of the NIAID AIDS Research Study Section and the NIH COVID-19 Treatment Guidelines Panel.
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  1. Mirmirani P, Maurer T, Cohen M, D'Souza G, Karim R, Plankey M, Robison E, Sharma A, Tien PC, Hessol NA. Investigating the effects of metabolic dysregulation on hair follicles: a comparison of HIV-infected women with and without central lipohypertrophy. Int J Dermatol. 2014 Oct; 53(10):e443-8.
    http://www.ncbi.nlm.nih.gov/pubmed/23786579
  2. David B Hanna, Wendy S Post, Jennifer A Deal, Howard N Hodis, Kathryn Anastos, Jason M Lazar, Frank J Palella, Phyllis C Tien, Mallory D Witt, Robert C Kaplan, Lawrence A Kingsley. Abstract 28: HIV Infection Is Associated With Greater Risk of Carotid Artery Lesions Over Seven Years. Circulation. 2014 Mar 25; 129(suppl_1).
    http://www.ncbi.nlm.nih.gov/pubmed/23945505
  3. David B Hanna, Iftach Shaked, Daniel Tracy, Kathryn Anastos, Mardge H Cohen, Elizabeth T Golub, Roksana Karim, Jason M Lazar, Vinayaka R Prasad, Phyllis C Tien, Mary Young, Alan L Landay, Klaus Ley, Robert C Kaplan. Abstract P342: Macrophage Markers are Associated with Atherosclerotic Plaque and Distensibility in the Women’s Interagency HIV Study. Circulation. 2014 Mar 25; 129(suppl_1).
    http://www.ncbi.nlm.nih.gov/pubmed/23435295
  4. Schwartz JB, Moore KL, Yin M, Sharma A, Merenstein D, Islam T, Golub ET, Tien PC, Adeyemi OM. Relationship of vitamin D, HIV, HIV treatment, and lipid levels in the Women's Interagency HIV Study of HIV-infected and uninfected women in the United States. J Int Assoc Provid AIDS Care. 2014 May-Jun; 13(3):250-9.
    http://www.ncbi.nlm.nih.gov/pubmed/23343914
  5. Shaked I, Hanna DB, Gleißner C, Marsh B, Plants J, Tracy D, Anastos K, Cohen M, Golub ET, Karim R, Lazar J, Prasad V, Tien PC, Young MA, Landay AL, Kaplan RC, Ley K. Macrophage inflammatory markers are associated with subclinical carotid artery disease in women with human immunodeficiency virus or hepatitis C virus infection. Arterioscler Thromb Vasc Biol. 2014 May; 34(5):1085-92.
    http://www.ncbi.nlm.nih.gov/pubmed/23675750
  6. Marks KM, Kitch D, Chung RT, Hadigan C, Andersen J, Tien P, Luetkemeyer A, Alston-Smith B, Glesby MJ, A5239 Team . Pilot study of pioglitazone before HCV retreatment in HIV/HCV genotype 1-infected subjects with insulin resistance and previous nonresponse to peginterferon and ribavirin therapy: A5239. . 2014 Mar 01; 65(3):345-9.
    http://www.ncbi.nlm.nih.gov/pubmed/23656440
  7. Wheeler AL, Scherzer R, Lee D, Delaney JA, Bacchetti P, Shlipak MG, Sidney S, Grunfeld C, Tien PC, Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM) . HIV/hepatitis C virus coinfection ameliorates the atherogenic lipoprotein abnormalities of HIV infection. AIDS. 2014 Jan 02; 28(1):49-58.
    http://www.ncbi.nlm.nih.gov/pubmed/23221984
  8. Sharma A, Bynum SA, Schneider MF, Cox C, Tien PC, Hershow RC, Gustafson D, Plankey MW. Changes in Body Mass Index Following HAART Initiation among HIV-Infected Women in the Women's Interagency HIV Study. J AIDS Clin Res. 2014; 5.
    http://www.ncbi.nlm.nih.gov/pubmed/23095316
  9. Karim R, Mack WJ, Kono N, Tien PC, Anastos K, Lazar J, Young M, Cohen M, Golub E, Greenblatt RM, Kaplan RC, Hodis HN. Gonadotropin and sex steroid levels in HIV-infected premenopausal women and their association with subclinical atherosclerosis in HIV-infected and -uninfected women in the women's interagency HIV study (WIHS). J Clin Endocrinol Metab. 2013 Apr; 98(4):E610-8.
    http://www.ncbi.nlm.nih.gov/pubmed/23418313
  10. Peralta C, Scherzer R, Grunfeld C, Abraham A, Tien P, Devarajan P, Bennett M, Butch A, Anastos K, Cohen M, Nowicki M, Sharma A, Young M, Sarnak M, Parikh C, Shlipak M. Urinary biomarkers of kidney injury are associated with all-cause mortality in the Women's Interagency HIV Study (WIHS). HIV Med. 2014 May; 15(5):291-300.
    http://www.ncbi.nlm.nih.gov/pubmed/23273313
  11. Hessol NA, Ameli N, Cohen MH, Urwin S, Weber KM, Tien PC. The association between diet and physical activity on insulin resistance in the Women's Interagency HIV Study. . 2013 Jan 01; 62(1):74-80.
    http://www.ncbi.nlm.nih.gov/pubmed/23075914
  12. López L, Peralta CA, Lee A, Zeki Al Hazzouri A, Haan MN. Impact of acculturation on cardiovascular risk factors among elderly Mexican Americans. Ann Epidemiol. 2014 Oct; 24(10):714-9.
    http://www.ncbi.nlm.nih.gov/pubmed/23023103
  13. Jotwani V, Scherzer R, Abraham A, Estrella MM, Bennett M, Devarajan P, Anastos K, Cohen MH, Nowicki M, Sharma A, Young M, Tien PC, Grunfeld C, Parikh CR, Shlipak MG. Does HIV infection promote early kidney injury in women? Antivir Ther. 2014; 19(1):79-87.
    http://www.ncbi.nlm.nih.gov/pubmed/22895436
  14. Sarkar M, Bacchetti P, Tien P, Mileti E, French AL, Edlin BR, Keller M, Seaberg E, Nowicki MJ, Young M, Peters MG. Racial/ethnic differences in spontaneous HCV clearance in HIV infected and uninfected women. Dig Dis Sci. 2013 May; 58(5):1341-8.
    http://www.ncbi.nlm.nih.gov/pubmed/23179159
  15. Mirmirani P, Maurer T, Cohen M, D'Souza G, Karim R, Plankey M, Robison E, Sharma A, Tien PC, Hessol NA. Investigating the effects of metabolic dysregulation on hair follicles: a comparison of HIV-infected women with and without central lipohypertrophy. Int J Dermatol. 2014 Oct; 53(10):e443-8.
    http://www.ncbi.nlm.nih.gov/pubmed/22878421
  16. Karim R, Mack WJ, Stiller T, Operskalski E, Frederick T, Landay A, Young MA, Tien PC, Augenbraun M, Strickler HD, Kovacs A. Association of HIV clinical disease progression with profiles of early immune activation: results from a cluster analysis approach. AIDS. 2013 Jun 01; 27(9):1473-81.
    http://www.ncbi.nlm.nih.gov/pubmed/23089369
  17. Sarkar M, Bacchetti P, French AL, Tien P, Glesby MJ, Nowicki M, Plankey M, Gange S, Sharp G, Minkoff H, Peters MG, Women's Interagency HIV Study (WIHS) . Lower liver-related death in African-American women with human immunodeficiency virus/hepatitis C virus coinfection, compared to Caucasian and Hispanic women. Hepatology. 2012 Nov; 56(5):1699-705.
    http://www.ncbi.nlm.nih.gov/pubmed/22618868
  18. Lang J, Scherzer R, Weekley CC, Tien PC, Grunfeld C, Shlipak MG. Serum albumin and short-term risk for mortality and cardiovascular disease among HIV-infected veterans. AIDS. 2013 May 15; 27(8):1339-43.
    http://www.ncbi.nlm.nih.gov/pubmed/22592585
  19. Adeyemi OM, Livak B, Orsi J, Glesby MJ, Villacres MC, Weber KM, Sharma A, Golub E, Young M, Cohen M, Tien PC. Vitamin D and insulin resistance in non-diabetic women's interagency HIV study participants. AIDS Patient Care STDS. 2013 Jun; 27(6):320-5.
    http://www.ncbi.nlm.nih.gov/pubmed/22495733
  20. Roksana Karim, Naoko Kono, Robert Kaplan, Wendy J Mack, Howard N Hodis, Kathy Anastos, Jason Lazar, Mary Young, Phyllis Tien, Seema Desai, Elizabeth Golub, Andrea Kovacs. Abstract P167: Title: Prediction of Arterial Stiffness from Early T-cell Activation among HIV and HCV Co-infected Women in the Women's Interagency HIV Study (WIHS). Circulation. 2012 Mar 13; 125(suppl_10).
  21. Bambha K, Pierce C, Cox C, French AL, Tien PC, Sharp GB, Augenbraun M, Glesby MJ, Villacres MC, Plankey M, Strickler HD, Gange SJ, Peters MG. Assessing mortality in women with hepatitis C virus and HIV using indirect markers of fibrosis. AIDS. 2012 Mar 13; 26(5):599-607.
    http://www.ncbi.nlm.nih.gov/pubmed/22156972
  22. Kiefer EM, Shi Q, Hoover DR, Kaplan R, Tracy R, Augenbraun M, Liu C, Nowicki M, Tien PC, Cohen M, Golub ET, Anastos K. Association of hepatitis C with markers of hemostasis in HIV-infected and uninfected women in the women's interagency HIV study (WIHS). . 2013 Mar 01; 62(3):301-10.
    http://www.ncbi.nlm.nih.gov/pubmed/22302074
  23. Weiser SD, Young SL, Cohen CR, Kushel MB, Tsai AC, Tien PC, Hatcher AM, Frongillo EA, Bangsberg DR. Conceptual framework for understanding the bidirectional links between food insecurity and HIV/AIDS. Am J Clin Nutr. 2011 Dec; 94(6):1729S-1739S.
    http://www.ncbi.nlm.nih.gov/pubmed/22089434
  24. Karim R, Mack WJ, Kono N, Tien PC, Anastos K, Lazar J, Young M, Cohen M, Golub E, Greenblatt RM, Kaplan RC, Hodis HN. Gonadotropin and sex steroid levels in HIV-infected premenopausal women and their association with subclinical atherosclerosis in HIV-infected and -uninfected women in the women's interagency HIV study (WIHS). J Clin Endocrinol Metab. 2013 Apr; 98(4):E610-8.
    http://www.ncbi.nlm.nih.gov/pubmed/22073156
  25. Estrella MM, Abraham AG, Jing Y, Parekh RS, Tien PC, Merenstein D, Pearce CL, Anastos K, Cohen MH, Dehovitz JA, Gange SJ. Antiretroviral-treated HIV-infected women have similar long-term kidney function trajectories as HIV-uninfected women. AIDS Res Hum Retroviruses. 2013 May; 29(5):755-60.
    http://www.ncbi.nlm.nih.gov/pubmed/22034200