Matija Peterlin, MD

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(415) 502-1902

513 Parnassus Ave, MSB
San Francisco, CA 94117

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  • Professor, School of Medicine

Biography

Welcome to B. Matija Peterlin Laboratory:

We use molecular biology, immunology, virology and genetics to tackle intractable immunodeficiencies, be they the bare lymphocyte syndrome or AIDS. These approaches also find resonance in autoimmunity and cancer. In the process, these diseases and their pathogens educate us about human biology and evolution. Indeed, new paradigms in genomic stability, transcription, transport and intracellular traffic have been forthcoming from these studies. Our ultimate goals are to use this knowledge of basic molecular mechanisms to cure human diseases.

Displaying 1 - 144 of 144

  1. Cary DC, Rheinberger M, Rojc A, Peterlin BM. HIV Transcription Is Independent of Mediator Kinases. AIDS Res Hum Retroviruses. 2019 Aug; 35(8):710-717. View on Pubmed
  2. Cary DC, Peterlin BM. Procyanidin trimer C1 reactivates latent HIV as a triple combination therapy with kansui and JQ1. PLoS One. 2018; 13(11):e0208055. View on Pubmed
  3. Leoz M, Kukanja P, Luo Z, Huang F, Cary DC, Peterlin BM, Fujinaga K. HEXIM1-Tat chimera inhibits HIV-1 replication. PLoS Pathog. 2018 11; 14(11):e1007402. View on Pubmed
  4. Huang F, Shao W, Fujinaga K, Peterlin BM. Bromodomain-containing protein 4-independent transcriptional activation by autoimmune regulator (AIRE) and NF-?B. J Biol Chem. 2018 04 06; 293(14):4993-5004. View on Pubmed
  5. Ferdin J, Goricar K, Dolžan V, Plemenitaš A, Martin JN, Peterlin BM, Deeks SG, Lenassi M. Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA. PLoS One. 2018; 13(1):e0191613. View on Pubmed
  6. Cary DC, Peterlin BM. Natural Products and HIV/AIDS. AIDS Res Hum Retroviruses. 2018 01; 34(1):31-38. View on Pubmed
  7. Binning JM, Smith AM, Hultquist JF, Craik CS, Caretta Cartozo N, Campbell MG, Burton L, La Greca F, McGregor MJ, Ta HM, Bartholomeeusen K, Peterlin BM, Krogan NJ, Sevillano N, Cheng Y, Gross JD. Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors. PLoS Pathog. 2018 01; 14(1):e1006830. View on Pubmed
  8. Pužar Dominkuš P, Ferdin J, Plemenitaš A, Peterlin BM, Lenassi M. Nef is secreted in exosomes from Nef.GFP-expressing and HIV-1-infected human astrocytes. J Neurovirol. 2017 10; 23(5):713-724. View on Pubmed
  9. Peterlin BM, Liu P, Wang X, Cary D, Shao W, Leoz M, Hong T, Pan T, Fujinaga K. Hili Inhibits HIV Replication in Activated T Cells. J Virol. 2017 06 01; 91(11). View on Pubmed
  10. Cary DC, Fujinaga K, Peterlin BM. Euphorbia Kansui Reactivates Latent HIV. PLoS One. 2016; 11(12):e0168027. View on Pubmed
  11. Shao W, Zumer K, Fujinaga K, Peterlin BM. FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator). J Biol Chem. 2016 08 19; 291(34):17953-63. View on Pubmed
  12. Cary DC, Peterlin BM. Targeting the latent reservoir to achieve functional HIV cure. F1000Res. 2016; 5. View on Pubmed
  13. Pak V, Eifler TT, Jäger S, Krogan NJ, Fujinaga K, Peterlin BM. CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing. Cell Host Microbe. 2015 Nov 11; 18(5):560-70. View on Pubmed
  14. Eifler TT, Shao W, Bartholomeeusen K, Fujinaga K, Jäger S, Johnson JR, Luo Z, Krogan NJ, Peterlin BM. Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts. Mol Cell Biol. 2015 Jan; 35(2):468-78. View on Pubmed
  15. Pandeló José D, Bartholomeeusen K, da Cunha RD, Abreu CM, Glinski J, da Costa TB, Bacchi Rabay AF, Pianowski Filho LF, Dudycz LW, Ranga U, Peterlin BM, Pianowski LF, Tanuri A, Aguiar RS. Reactivation of latent HIV-1 by new semi-synthetic ingenol esters. Virology. 2014 Aug; 462-463:328-39. View on Pubmed
  16. Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson KA, Price DH, Peterlin BM. Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription. J Biol Chem. 2014 Apr 04; 289(14):9918-25. View on Pubmed
  17. Bartholomeeusen K, Fujinaga K, Xiang Y, Peterlin BM. Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcription. J Biol Chem. 2013 May 17; 288(20):14400-7. View on Pubmed
  18. Stanley DJ, Bartholomeeusen K, Crosby DC, Kim DY, Kwon E, Yen L, Cartozo NC, Li M, Jäger S, Mason-Herr J, Hayashi F, Yokoyama S, Krogan NJ, Harris RS, Peterlin BM, Gross JD. Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G. PLoS Pathog. 2012 Dec; 8(12):e1003085. View on Pubmed
  19. Bartholomeeusen K, Xiang Y, Fujinaga K, Peterlin BM. Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein. J Biol Chem. 2012 Oct 19; 287(43):36609-16. View on Pubmed
  20. Fujinaga K, Barboric M, Li Q, Luo Z, Price DH, Peterlin BM. PKC phosphorylates HEXIM1 and regulates P-TEFb activity. Nucleic Acids Res. 2012 Oct; 40(18):9160-70. View on Pubmed
  21. Lu C, Luo Z, Jäger S, Krogan NJ, Peterlin BM. Moloney leukemia virus type 10 inhibits reverse transcription and retrotransposition of intracisternal a particles. J Virol. 2012 Oct; 86(19):10517-23. View on Pubmed
  22. Blazek D, Kohoutek J, Bartholomeeusen K, Johansen E, Hulinkova P, Luo Z, Cimermancic P, Ule J, Peterlin BM. The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Genes Dev. 2011 Oct 15; 25(20):2158-72. View on Pubmed
  23. Peterlin BM, Brogie JE, Price DH. 7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription. Wiley Interdiscip Rev RNA. 2012 Jan-Feb; 3(1):92-103. View on Pubmed
  24. Lu C, Contreras X, Peterlin BM. P bodies inhibit retrotransposition of endogenous intracisternal a particles. J Virol. 2011 Jul; 85(13):6244-51. View on Pubmed
  25. Peterlin BM. Transcription elongation takes central stage: the P-TEFb connection. Cell Cycle. 2010 Aug 01; 9(15):2933-4. View on Pubmed
  26. Lenassi M, Cagney G, Liao M, Vaupotic T, Bartholomeeusen K, Cheng Y, Krogan NJ, Plemenitas A, Peterlin BM. HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells. Traffic. 2010 Jan; 11(1):110-22. View on Pubmed
  27. Chen H, Contreras X, Yamaguchi Y, Handa H, Peterlin BM, Guo S. Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5. PLoS One. 2009 Sep 09; 4(9):e6918. View on Pubmed
  28. Li Q, Peterlin BM. Genetic analysis of P-TEFb function via heterologous nucleic acid tethering systems. Methods. 2009 Aug; 48(4):375-80. View on Pubmed
  29. Barboric M, Lenasi T, Chen H, Johansen EB, Guo S, Peterlin BM. 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7798-803. View on Pubmed
  30. Contreras X, Schweneker M, Chen CS, McCune JM, Deeks SG, Martin J, Peterlin BM. Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells. J Biol Chem. 2009 Mar 13; 284(11):6782-9. View on Pubmed
  31. Lenasi T, Contreras X, Peterlin BM. Transcriptional interference antagonizes proviral gene expression to promote HIV latency. Cell Host Microbe. 2008 Aug 14; 4(2):123-33. View on Pubmed
  32. Su MA, Giang K, Zumer K, Jiang H, Oven I, Rinn JL, Devoss JJ, Johannes KP, Lu W, Gardner J, Chang A, Bubulya P, Chang HY, Peterlin BM, Anderson MS. Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. J Clin Invest. 2008 May; 118(5):1712-26. View on Pubmed
  33. Blazek D, Peterlin BM. Tat-SIRT1 tango. Mol Cell. 2008 Mar 14; 29(5):539-40. View on Pubmed
  34. Aguiar RS, Peterlin BM. APOBEC3 proteins and reverse transcription. Virus Res. 2008 Jun; 134(1-2):74-85. View on Pubmed
  35. Aguiar RS, Lovsin N, Tanuri A, Peterlin BM. Vpr.A3A chimera inhibits HIV replication. J Biol Chem. 2008 Feb 01; 283(5):2518-25. View on Pubmed
  36. Jiang H, Peterlin BM. Differential chromatin looping regulates CD4 expression in immature thymocytes. Mol Cell Biol. 2008 Feb; 28(3):907-12. View on Pubmed
  37. Oven I, Brdicková N, Kohoutek J, Vaupotic T, Narat M, Peterlin BM. AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells. Mol Cell Biol. 2007 Dec; 27(24):8815-23. View on Pubmed
  38. Contreras X, Barboric M, Lenasi T, Peterlin BM. HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription. PLoS Pathog. 2007 Oct 12; 3(10):1459-69. View on Pubmed
  39. Drozina G, Kohoutek J, Nishiya T, Peterlin BM. Sequential modifications in class II transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class II transcription in macrophages. J Biol Chem. 2006 Dec 29; 281(52):39963-70. View on Pubmed
  40. Kohoutek J, Blazek D, Peterlin BM. Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17349-54. View on Pubmed
  41. Peterlin BM, Price DH. Controlling the elongation phase of transcription with P-TEFb. Mol Cell. 2006 Aug 04; 23(3):297-305. View on Pubmed
  42. Lenasi T, Peterlin BM, Dovc P. Distal regulation of alternative splicing by splicing enhancer in equine beta-casein intron 1. RNA. 2006 Mar; 12(3):498-507. View on Pubmed
  43. Contreras X, Lenasi T, Peterlin BM. HIV latency: present knowledge, future directions. Future Virol. 2006; 1(6):733-745. View on Pubmed
  44. Blazek D, Barboric M, Kohoutek J, Oven I, Peterlin BM. Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb. Nucleic Acids Res. 2005; 33(22):7000-10. View on Pubmed
  45. Barboric M, Kohoutek J, Price JP, Blazek D, Price DH, Peterlin BM. Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb. EMBO J. 2005 Dec 21; 24(24):4291-303. View on Pubmed
  46. Jiang H, Zhang F, Kurosu T, Peterlin BM. Runx1 binds positive transcription elongation factor b and represses transcriptional elongation by RNA polymerase II: possible mechanism of CD4 silencing. Mol Cell Biol. 2005 Dec; 25(24):10675-83. View on Pubmed
  47. Barboric M, Zhang F, Besenicar M, Plemenitas A, Peterlin BM. Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation. J Virol. 2005 Sep; 79(17):11135-41. View on Pubmed
  48. Zheng YH, Peterlin BM. Intracellular immunity to HIV-1: newly defined retroviral battles inside infected cells. Retrovirology. 2005 Apr 13; 2:25. View on Pubmed
  49. Barboric M, Peterlin BM. A new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongation. PLoS Biol. 2005 Feb; 3(2):e76. View on Pubmed
  50. Zheng YH, Lovsin N, Peterlin BM. Newly identified host factors modulate HIV replication. Immunol Lett. 2005 Mar 15; 97(2):225-34. View on Pubmed
  51. Drozina G, Kohoutek J, Jabrane-Ferrat N, Peterlin BM. Expression of MHC II genes. Curr Top Microbiol Immunol. 2005; 290:147-70. View on Pubmed
  52. Kurosu T, Zhang F, Peterlin BM. Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb. Gene. 2004 Dec 08; 343(1):173-9. View on Pubmed
  53. Kurosu T, Peterlin BM. VP16 and ubiquitin; binding of P-TEFb via its activation domain and ubiquitin facilitates elongation of transcription of target genes. Curr Biol. 2004 Jun 22; 14(12):1112-6. View on Pubmed
  54. Zheng YH, Irwin D, Kurosu T, Tokunaga K, Sata T, Peterlin BM. Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication. J Virol. 2004 Jun; 78(11):6073-6. View on Pubmed
  55. Costa LJ, Zheng YH, Sabotic J, Mak J, Fackler OT, Peterlin BM. Nef binds p6* in GagPol during replication of human immunodeficiency virus type 1. J Virol. 2004 May; 78(10):5311-23. View on Pubmed
  56. Fujinaga K, Irwin D, Huang Y, Taube R, Kurosu T, Peterlin BM. Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element. Mol Cell Biol. 2004 Jan; 24(2):787-95. View on Pubmed
  57. Kanazawa S, Soucek L, Evan G, Okamoto T, Peterlin BM. c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis. Oncogene. 2003 Aug 28; 22(36):5707-11. View on Pubmed
  58. Lin X, Irwin D, Kanazawa S, Huang L, Romeo J, Yen TS, Peterlin BM. Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir. J Virol. 2003 Aug; 77(15):8227-36. View on Pubmed
  59. Uematsu K, Kanazawa S, You L, He B, Xu Z, Li K, Peterlin BM, McCormick F, Jablons DM. Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin. Cancer Res. 2003 Aug 01; 63(15):4547-51. View on Pubmed
  60. Zheng YH, Yu HF, Peterlin BM. Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells. Nat Cell Biol. 2003 Jul; 5(7):611-8. View on Pubmed
  61. Zheng YH, Plemenitas A, Fielding CJ, Peterlin BM. Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8460-5. View on Pubmed
  62. Jabrane-Ferrat N, Nekrep N, Tosi G, Esserman L, Peterlin BM. MHC class II enhanceosome: how is the class II transactivator recruited to DNA-bound activators? Int Immunol. 2003 Apr; 15(4):467-75. View on Pubmed
  63. Zhang F, Barboric M, Blackwell TK, Peterlin BM. A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb. Genes Dev. 2003 Mar 15; 17(6):748-58. View on Pubmed
  64. Peterlin BM, Trono D. Hide, shield and strike back: how HIV-infected cells avoid immune eradication. Nat Rev Immunol. 2003 Feb; 3(2):97-107. View on Pubmed
  65. Fujinaga K, Irwin D, Taube R, Zhang F, Geyer M, Peterlin BM. A minimal chimera of human cyclin T1 and tat binds TAR and activates human immunodeficiency virus transcription in murine cells. J Virol. 2002 Dec; 76(24):12934-9. View on Pubmed
  66. Fujinaga K, Irwin D, Geyer M, Peterlin BM. Optimized chimeras between kinase-inactive mutant Cdk9 and truncated cyclin T1 proteins efficiently inhibit Tat transactivation and human immunodeficiency virus gene expression. J Virol. 2002 Nov; 76(21):10873-81. View on Pubmed
  67. Tosi G, Jabrane-Ferrat N, Peterlin BM. Phosphorylation of CIITA directs its oligomerization, accumulation and increased activity on MHCII promoters. EMBO J. 2002 Oct 15; 21(20):5467-76. View on Pubmed
  68. Nekrep N, Jabrane-Ferrat N, Wolf HM, Eibl MM, Geyer M, Peterlin BM. Mutation in a winged-helix DNA-binding motif causes atypical bare lymphocyte syndrome. Nat Immunol. 2002 Nov; 3(11):1075-81. View on Pubmed
  69. Jabrane-Ferrat N, Nekrep N, Tosi G, Esserman LJ, Peterlin BM. Major histocompatibility complex class II transcriptional platform: assembly of nuclear factor Y and regulatory factor X (RFX) on DNA requires RFX5 dimers. Mol Cell Biol. 2002 Aug; 22(15):5616-25. View on Pubmed
  70. Greene WC, Peterlin BM. Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy. Nat Med. 2002 Jul; 8(7):673-80. View on Pubmed
  71. Geyer M, Fackler OT, Peterlin BM. Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptins. Mol Biol Cell. 2002 Jun; 13(6):2045-56. View on Pubmed
  72. Geyer M, Yu H, Mandic R, Linnemann T, Zheng YH, Fackler OT, Peterlin BM. Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery. J Biol Chem. 2002 Aug 09; 277(32):28521-9. View on Pubmed
  73. Linnemann T, Zheng YH, Mandic R, Peterlin BM. Interaction between Nef and phosphatidylinositol-3-kinase leads to activation of p21-activated kinase and increased production of HIV. Virology. 2002 Mar 15; 294(2):246-55. View on Pubmed
  74. Lin X, Taube R, Fujinaga K, Peterlin BM. P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. J Biol Chem. 2002 May 10; 277(19):16873-8. View on Pubmed
  75. Lind KE, Du Z, Fujinaga K, Peterlin BM, James TL. Structure-based computational database screening, in vitro assay, and NMR assessment of compounds that target TAR RNA. Chem Biol. 2002 Feb; 9(2):185-93. View on Pubmed
  76. Taube R, Lin X, Irwin D, Fujinaga K, Peterlin BM. Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes. Mol Cell Biol. 2002 Jan; 22(1):321-31. View on Pubmed
  77. Nekrep N, Geyer M, Jabrane-Ferrat N, Peterlin BM. Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndrome. Mol Cell Biol. 2001 Aug; 21(16):5566-76. View on Pubmed
  78. Barboric M, Nissen RM, Kanazawa S, Jabrane-Ferrat N, Peterlin BM. NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II. Mol Cell. 2001 Aug; 8(2):327-37. View on Pubmed
  79. Kanazawa S, Peterlin BM. Combinations of dominant-negative class II transactivator, p300 or CDK9 proteins block the expression of MHC II genes. Int Immunol. 2001 Jul; 13(7):951-8. View on Pubmed
  80. Fackler OT, d'Aloja P, Baur AS, Federico M, Peterlin BM. Nef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivity. J Virol. 2001 Jul; 75(14):6601-8. View on Pubmed
  81. Geyer M, Fackler OT, Peterlin BM. Structure--function relationships in HIV-1 Nef. EMBO Rep. 2001 Jul; 2(7):580-5. View on Pubmed
  82. Zheng YH, Plemenitas A, Linnemann T, Fackler OT, Peterlin BM. Nef increases infectivity of HIV via lipid rafts. Curr Biol. 2001 Jun 05; 11(11):875-9. View on Pubmed
  83. Geyer M, Peterlin BM. Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef. FEBS Lett. 2001 May 11; 496(2-3):91-5. View on Pubmed
  84. Fackler OT, Peterlin BM, Weis K. Lessons from HIV: movement of macromolecules inside the cell. Curr Mol Med. 2001 Mar; 1(1):1-7. View on Pubmed
  85. Mandic R, Fackler OT, Geyer M, Linnemann T, Zheng YH, Peterlin BM. Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivity. Mol Biol Cell. 2001 Feb; 12(2):463-73. View on Pubmed
  86. Fackler OT, Peterlin BM. Endocytic entry of HIV-1. Curr Biol. 2000 Aug 24; 10(16):1005-8. View on Pubmed
  87. Barboric M, Taube R, Nekrep N, Fujinaga K, Peterlin BM. Binding of Tat to TAR and recruitment of positive transcription elongation factor b occur independently in bovine immunodeficiency virus. J Virol. 2000 Jul; 74(13):6039-44. View on Pubmed
  88. Nekrep N, Jabrane-Ferrat N, Peterlin BM. Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex. Mol Cell Biol. 2000 Jun; 20(12):4455-61. View on Pubmed
  89. Taube R, Fujinaga K, Irwin D, Wimmer J, Geyer M, Peterlin BM. Interactions between equine cyclin T1, Tat, and TAR are disrupted by a leucine-to-valine substitution found in human cyclin T1. J Virol. 2000 Jan; 74(2):892-8. View on Pubmed
  90. Kanazawa S, Okamoto T, Peterlin BM. Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection. Immunity. 2000 Jan; 12(1):61-70. View on Pubmed
  91. Taube R, Fujinaga K, Wimmer J, Barboric M, Peterlin BM. Tat transactivation: a model for the regulation of eukaryotic transcriptional elongation. Virology. 1999 Nov 25; 264(2):245-53. View on Pubmed
  92. Fontes JD, Kanazawa S, Nekrep N, Peterlin BM. The class II transactivator CIITA is a transcriptional integrator. Microbes Infect. 1999 Sep; 1(11):863-9. View on Pubmed
  93. Fackler OT, Luo W, Geyer M, Alberts AS, Peterlin BM. Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions. Mol Cell. 1999 Jun; 3(6):729-39. View on Pubmed
  94. Wimmer J, Fujinaga K, Taube R, Cujec TP, Zhu Y, Peng J, Price DH, Peterlin BM. Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b. Virology. 1999 Mar 01; 255(1):182-9. View on Pubmed
  95. Fujinaga K, Taube R, Wimmer J, Cujec TP, Peterlin BM. Interactions between human cyclin T, Tat, and the transactivation response element (TAR) are disrupted by a cysteine to tyrosine substitution found in mouse cyclin T. Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1285-90. View on Pubmed
  96. Fontes JD, Kanazawa S, Jean D, Peterlin BM. Interactions between the class II transactivator and CREB binding protein increase transcription of major histocompatibility complex class II genes. Mol Cell Biol. 1999 Jan; 19(1):941-7. View on Pubmed
  97. Fujinaga K, Cujec TP, Peng J, Garriga J, Price DH, Graña X, Peterlin BM. The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat. J Virol. 1998 Sep; 72(9):7154-9. View on Pubmed
  98. Lu X, Yu H, Liu SH, Brodsky FM, Peterlin BM. Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4. Immunity. 1998 May; 8(5):647-56. View on Pubmed
  99. Luo W, Peterlin BM. Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus. J Virol. 1997 Dec; 71(12):9531-7. View on Pubmed
  100. Cujec TP, Okamoto H, Fujinaga K, Meyer J, Chamberlin H, Morgan DO, Peterlin BM. The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II. Genes Dev. 1997 Oct 15; 11(20):2645-57. View on Pubmed
  101. Fontes JD, Jabrane-Ferrat N, Peterlin BM. Assembly of functional regulatory complexes on MHC class II promoters in vivo. J Mol Biol. 1997 Jul 18; 270(3):336-45. View on Pubmed
  102. Fontes JD, Jiang B, Peterlin BM. The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32. Nucleic Acids Res. 1997 Jun 15; 25(12):2522-8. View on Pubmed
  103. Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM. The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. Mol Cell Biol. 1997 Apr; 17(4):1817-23. View on Pubmed
  104. Lim CS, Jabrane-Ferrat N, Fontes JD, Okamoto H, Garovoy MR, Peterlin BM, Hunt CA. Sequence-independent inhibition of RNA transcription by DNA dumbbells and other decoys. Nucleic Acids Res. 1997 Feb 01; 25(3):575-81. View on Pubmed
  105. Lu X, Wu X, Plemenitas A, Yu H, Sawai ET, Abo A, Peterlin BM. CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1. Curr Biol. 1996 Dec 01; 6(12):1677-84. View on Pubmed
  106. Okamoto H, Sheline CT, Corden JL, Jones KA, Peterlin BM. Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11575-9. View on Pubmed
  107. Jabrane-Ferrat N, Fontes JD, Boss JM, Peterlin BM. Complex architecture of major histocompatibility complex class II promoters: reiterated motifs and conserved protein-protein interactions. Mol Cell Biol. 1996 Sep; 16(9):4683-90. View on Pubmed
  108. Fontes JD, Jabrane-Ferrat N, Toth CR, Peterlin BM. Binding and cooperative interactions between two B cell-specific transcriptional coactivators. J Exp Med. 1996 Jun 01; 183(6):2517-21. View on Pubmed
  109. Sawai ET, Baur AS, Peterlin BM, Levy JA, Cheng-Mayer C. A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity. J Biol Chem. 1995 Jun 23; 270(25):15307-14. View on Pubmed
  110. Jabrane-Ferrat N, Peterlin BM. Ets-1 activates the DRA promoter in B cells. Mol Cell Biol. 1994 Nov; 14(11):7314-21. View on Pubmed
  111. Alonso A, Cujec TP, Peterlin BM. Effects of human chromosome 12 on interactions between Tat and TAR of human immunodeficiency virus type 1. J Virol. 1994 Oct; 68(10):6505-13. View on Pubmed
  112. Mujeeb A, Bishop K, Peterlin BM, Turck C, Parslow TG, James TL. NMR structure of a biologically active peptide containing the RNA-binding domain of human immunodeficiency virus type 1 Tat. Proc Natl Acad Sci U S A. 1994 Aug 16; 91(17):8248-52. View on Pubmed
  113. Adams M, Sharmeen L, Kimpton J, Romeo JM, Garcia JV, Peterlin BM, Groudine M, Emerman M. Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3862-6. View on Pubmed
  114. Sawai ET, Baur A, Struble H, Peterlin BM, Levy JA, Cheng-Mayer C. Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes. Proc Natl Acad Sci U S A. 1994 Feb 15; 91(4):1539-43. View on Pubmed
  115. Baur A, Garber S, Peterlin BM. Effects of CD45 on NF-kappa B. Implications for replication of HIV-1. J Immunol. 1994 Feb 01; 152(3):976-83. View on Pubmed
  116. Ghosh S, Selby MJ, Peterlin BM. Synergism between Tat and VP16 in trans-activation of HIV-1 LTR. J Mol Biol. 1993 Dec 05; 234(3):610-9. View on Pubmed
  117. Luo Y, Madore SJ, Parslow TG, Cullen BR, Peterlin BM. Functional analysis of interactions between Tat and the trans-activation response element of human immunodeficiency virus type 1 in cells. J Virol. 1993 Sep; 67(9):5617-22. View on Pubmed
  118. Tong-Starksen SE, Baur A, Lu XB, Peck E, Peterlin BM. Second exon of Tat of HIV-2 is required for optimal trans-activation of HIV-1 and HIV-2 LTRs. Virology. 1993 Aug; 195(2):826-30. View on Pubmed
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  120. Voliva CF, Tsang S, Peterlin BM. Mapping cis-acting defects in promoters of transcriptionally silent DQA2, DQB2, and DOB genes. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3408-12. View on Pubmed
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  122. Alonso A, Derse D, Peterlin BM. Human chromosome 12 is required for optimal interactions between Tat and TAR of human immunodeficiency virus type 1 in rodent cells. J Virol. 1992 Jul; 66(7):4617-21. View on Pubmed
  123. Voliva CF, Aronheim A, Walker MD, Peterlin BM. B-cell factor 1 is required for optimal expression of the DRA promoter in B cells. Mol Cell Biol. 1992 May; 12(5):2383-90. View on Pubmed
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  126. Tong-Starksen SE, Welsh TM, Peterlin BM. Differences in transcriptional enhancers of HIV-1 and HIV-2. Response to T cell activation signals. J Immunol. 1990 Dec 15; 145(12):4348-54. View on Pubmed
  127. Andersson G, Peterlin BM. NF-X2 that binds to the DRA X2-box is activator protein 1. Expression cloning of c-Jun. J Immunol. 1990 Nov 15; 145(10):3456-62. View on Pubmed
  128. Selby MJ, Peterlin BM. Trans-activation by HIV-1 Tat via a heterologous RNA binding protein. Cell. 1990 Aug 24; 62(4):769-76. View on Pubmed
  129. Tsang SY, Nakanishi M, Peterlin BM. Mutational analysis of the DRA promoter: cis-acting sequences and trans-acting factors. Mol Cell Biol. 1990 Feb; 10(2):711-9. View on Pubmed
  130. Peterlin BM, Andersson G, Lötscher E, Tsang S. Transcriptional regulation of HLA class-II genes. Immunol Res. 1990; 9(3):164-77. View on Pubmed
  131. Seto E, Zhou DX, Peterlin BM, Yen TS. trans-activation by the hepatitis B virus X protein shows cell-type specificity. Virology. 1989 Dec; 173(2):764-6. View on Pubmed
  132. Selby MJ, Bain ES, Luciw PA, Peterlin BM. Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat. Genes Dev. 1989 Apr; 3(4):547-58. View on Pubmed
  133. Calman AF, Peterlin BM. Evidence for a trans-acting factor that regulates the transcription of class II major histocompatibility complex genes: genetic and functional analysis. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):8830-4. View on Pubmed
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  135. Seto E, Yen TS, Peterlin BM, Ou JH. Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):8286-90. View on Pubmed
  136. Calman AF, Busch MP, Vyas GN, McHugh TM, Stites DP, Peterlin BM. Transcription and replication of human immunodeficiency virus-1 in B lymphocytes in vitro. AIDS. 1988 Jun; 2(3):185-93. View on Pubmed
  137. Peltz G, Frederick K, Anderson CL, Peterlin BM. Characterization of the human monocyte high affinity Fc receptor (hu FcRI). Mol Immunol. 1988 Mar; 25(3):243-50. View on Pubmed
  138. Peterlin BM, Luciw PA. Molecular biology of HIV. AIDS. 1988; 2 Suppl 1:S29-40. View on Pubmed
  139. Kao SY, Calman AF, Luciw PA, Peterlin BM. Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product. Nature. 1987 Dec 3-9; 330(6147):489-93. View on Pubmed
  140. Peltz GA, Gallis B, Peterlin BM. Monoclonal antibody immunoprecipitation of cell membrane glycoproteins. Anal Biochem. 1987 Dec; 167(2):239-44. View on Pubmed
  141. Tong-Starksen SE, Luciw PA, Peterlin BM. Human immunodeficiency virus long terminal repeat responds to T-cell activation signals. Proc Natl Acad Sci U S A. 1987 Oct; 84(19):6845-9. View on Pubmed
  142. Calman AF, Peterlin BM. Mutant human B cell lines deficient in class II major histocompatibility complex transcription. J Immunol. 1987 Oct 01; 139(7):2489-95. View on Pubmed
  143. Sullivan KE, Peterlin BM. Transcriptional enhancers in the HLA-DQ subregion. Mol Cell Biol. 1987 Sep; 7(9):3315-9. View on Pubmed
  144. Sullivan KE, Calman AF, Nakanishi M, Tsang SY, Wang Y, Peterlin BM. A model for the transcriptional regulation of MHC class II genes. Immunol Today. 1987; 8(10):289-93. View on Pubmed