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Francis Szoka, PhD
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Professor, School of Pharmacy
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Email: frank.szoka@ucsf.edu
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Biography
The Szoka group applies chemical, biophysical and molecular biology approaches to devise vaccine, drug and nucleic acid delivery systems to treat cancer or infectious diseases. These systems can incorporate lipids, peptides, polymers and proteins. These drug carriers are composed of lipids, polymers, peptides or proteins. His group has extensively investigated the role of lipids in membrane fusion and his designed, synthesized and studied the mechanism of fusogenic peptides. With group members, he has published over 220 manuscripts and has received 35 U.S. patents. One FDA approved drug product Amphotec™ and one biotechnology product Superfect™ have been commercialized from the patents. In addition to his University commitments, Dr. Szoka is a founder of Sequus Pharmaceuticals, Inc., GeneMedicine, Inc., and ZoneOne Pharma, Inc. Sequus introduced sterically stabilized liposomes for anti-cancer drug delivery (Doxil™).
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- Szoka F, Papahadjopoulos D. Comparative properties and methods of preparation of lipid vesicles (liposomes). Annu Rev Biophys Bioeng. 1980; 9:467-508.
- Near JA, Szoka FC, Olsen R, Ettinger MJ. Photoaffinity labeling of three renal cyclic 3',5'-adenosine monophosphate-binding proteins. Biochim Biophys Acta. 1979 Nov 01; 587(4):522-39.
- Mayhew E, Rustum YM, Szoka F, Papahadjopoulos D. Role of cholesterol in enhancing the antitumor activity of cytosine arabinoside entrapped in liposomes. Cancer Treat Rep. 1979 Nov-Dec; 63(11-12):1923-8.
- Olson F, Hunt CA, Szoka FC, Vail WJ, Papahadjopoulos D. Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes. Biochim Biophys Acta. 1979 Oct 19; 557(1):9-23.
- Saffran M, Franco-Saenz R, Kong A, Papahadjopoulos D, Szoka F. A model for the study of the oral administration of peptide hormones. Can J Biochem. 1979 Jun; 57(6):548-53.
- Szoka FC, Jacobson K, Papahadjopoulos D. The use of aqueous space markers to determine the mechanism of interaction between phospholipid vesicles and cells. Biochim Biophys Acta. 1979 Mar 08; 551(2):295-303.
- Wu ES, Jacobson K, Szoka F, Portis A. Lateral diffusion of a hydrophobic peptide, N-4-nitrobenz-2-oxa-1,3-diazole gramicidin S, in phospholipid multibilayers. Biochemistry. 1978 Dec 12; 17(25):5543-50.
- Szoka FC, Ettinger MJ. Adenosine 3' :5' -monophosphate-dependnet phosphorylations of renal subcellular fractions. Differences between cortical and medullary membrane preparations. J Biol Chem. 1978 Sep 25; 253(18):6536-43.
- Szoka F, Papahadjopoulos D. Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc Natl Acad Sci U S A. 1978 Sep; 75(9):4194-8.