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Francis Szoka, PhD
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Professor, School of Pharmacy
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Email: frank.szoka@ucsf.edu
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Biography
The Szoka group applies chemical, biophysical and molecular biology approaches to devise vaccine, drug and nucleic acid delivery systems to treat cancer or infectious diseases. These systems can incorporate lipids, peptides, polymers and proteins. These drug carriers are composed of lipids, polymers, peptides or proteins. His group has extensively investigated the role of lipids in membrane fusion and his designed, synthesized and studied the mechanism of fusogenic peptides. With group members, he has published over 220 manuscripts and has received 35 U.S. patents. One FDA approved drug product Amphotec™ and one biotechnology product Superfect™ have been commercialized from the patents. In addition to his University commitments, Dr. Szoka is a founder of Sequus Pharmaceuticals, Inc., GeneMedicine, Inc., and ZoneOne Pharma, Inc. Sequus introduced sterically stabilized liposomes for anti-cancer drug delivery (Doxil™).
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Displaying 176 - 200 of 209
- Bentz J, Ellens H, Szoka FC. Destabilization of phosphatidylethanolamine-containing liposomes: hexagonal phase and asymmetric membranes. Biochemistry. 1987 Apr 21; 26(8):2105-16.
- Dijkstra J, Mellors JW, Ryan JL, Szoka FC. Modulation of the biological activity of bacterial endotoxin by incorporation into liposomes. J Immunol. 1987 Apr 15; 138(8):2663-70.
- Szoka FC, Milholland D, Barza M. Effect of lipid composition and liposome size on toxicity and in vitro fungicidal activity of liposome-intercalated amphotericin B. Antimicrob Agents Chemother. 1987 Mar; 31(3):421-9.
- Szoka FC, Jones CS. Uptake of liposome-encapsulated agents. Methods Enzymol. 1987; 149:143-7.
- Ellens H, Bentz J, Szoka FC. Fusion of phosphatidylethanolamine-containing liposomes and mechanism of the L alpha-HII phase transition. Biochemistry. 1986 Jul 15; 25(14):4141-7.
- Ellens H, Bentz J, Szoka FC. Destabilization of phosphatidylethanolamine liposomes at the hexagonal phase transition temperature. Biochemistry. 1986 Jan 28; 25(2):285-94.
- Bentz J, Ellens H, Lai MZ, Szoka FC. On the correlation between HII phase and the contact-induced destabilization of phosphatidylethanolamine-containing membranes. Proc Natl Acad Sci U S A. 1985 Sep; 82(17):5742-5.
- Barza M, Baum J, Tremblay C, Szoka F, D'Amico DJ. Ocular toxicity of intravitreally injected liposomal amphotericin B in rhesus monkeys. Am J Ophthalmol. 1985 Aug 15; 100(2):259-63.
- Ellens H, Bentz J, Szoka FC. H+- and Ca2+-induced fusion and destabilization of liposomes. Biochemistry. 1985 Jun 18; 24(13):3099-106.
- Tremblay C, Barza M, Szoka F, Lahav M, Baum J. Reduced toxicity of liposome-associated amphotericin B injected intravitreally in rabbits. Invest Ophthalmol Vis Sci. 1985 May; 26(5):711-8.
- Lai MZ, Vail WJ, Szoka FC. Acid- and calcium-induced structural changes in phosphatidylethanolamine membranes stabilized by cholesteryl hemisuccinate. Biochemistry. 1985 Mar 26; 24(7):1654-61.
- Lai MZ, Düzgünes N, Szoka FC. Effects of replacement of the hydroxyl group of cholesterol and tocopherol on the thermotropic behavior of phospholipid membranes. Biochemistry. 1985 Mar 26; 24(7):1646-53.
- Tremblay C, Barza M, Fiore C, Szoka F. Efficacy of liposome-intercalated amphotericin B in the treatment of systemic candidiasis in mice. Antimicrob Agents Chemother. 1984 Aug; 26(2):170-3.
- Panosian CB, Barza M, Szoka F, Wyler DJ. Treatment of experimental cutaneous leishmaniasis with liposome-intercalated amphotericin B. Antimicrob Agents Chemother. 1984 May; 25(5):655-6.
- Barza M, Baum J, Szoka F. Pharmacokinetics of subconjunctival liposome-encapsulated gentamicin in normal rabbit eyes. Invest Ophthalmol Vis Sci. 1984 Apr; 25(4):486-90.
- Ellens H, Bentz J, Szoka FC. pH-induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact. Biochemistry. 1984 Mar 27; 23(7):1532-8.
- Szoka FC, Mayhew E. Alteration of liposome disposition in vivo by bilayer situated carbohydrates. Biochem Biophys Res Commun. 1983 Jan 14; 110(1):140-6.
- Abra RM, Schreier H, Szoka FC. The use of a new radioactive-iodine labeled lipid marker to follow in vivo disposition of liposomes: comparison with an encapsulated aqueous space marker. Res Commun Chem Pathol Pharmacol. 1982 Aug; 37(2):199-213.
- Alroy J, Szoka FC, Heaney JA, Ucci AA. Lectins as a probe for carbohydrate residues in non-neoplastic urothelium of human urinary bladder. J Urol. 1982 Jul; 128(1):189-93.
- Olson F, Mayhew E, Maslow D, Rustum Y, Szoka F. Characterization, toxicity and therapeutic efficacy of adriamycin encapsulated in liposomes. Eur J Cancer Clin Oncol. 1982 Feb; 18(2):167-76.
- Kirkland JJ, Yau WW, Szoka FC. Sedimentation field flow fractionation of liposomes. Science. 1982 Jan 15; 215(4530):296-8.
- Rustum YM, Mayhew E, Szoka F, Campbell J. Inability of liposome encapsulated 1-beta-D-arabinofuranosylcytosine nucleotides to overcome drug resistance in L1210 cells. Eur J Cancer Clin Oncol. 1981 Jul; 17(7):809-17.
- Szoka F, Magnusson KE, Wojcieszyn J, Hou Y, Derzko Z, Jacobson K. Use of lectins and polyethylene glycol for fusion of glycolipid-containing liposomes with eukaryotic cells. Proc Natl Acad Sci U S A. 1981 Mar; 78(3):1685-9.
- Szoka F, Olson F, Heath T, Vail W, Mayhew E, Papahadjopoulos D. Preparation of unilamellar liposomes of intermediate size (0.1-0.2 mumol) by a combination of reverse phase evaporation and extrusion through polycarbonate membranes. Biochim Biophys Acta. 1980 Oct 02; 601(3):559-71.
- Szoka F, Jacobson K, Derzko Z, Papahadjopoulos D. Fluorescence studies on the mechanism of liposome-cell interactions in vitro. Biochim Biophys Acta. 1980 Jul 16; 600(1):1-18.