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Francis Szoka, PhD
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Professor, School of Pharmacy
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Email: frank.szoka@ucsf.edu
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Biography
The Szoka group applies chemical, biophysical and molecular biology approaches to devise vaccine, drug and nucleic acid delivery systems to treat cancer or infectious diseases. These systems can incorporate lipids, peptides, polymers and proteins. These drug carriers are composed of lipids, polymers, peptides or proteins. His group has extensively investigated the role of lipids in membrane fusion and his designed, synthesized and studied the mechanism of fusogenic peptides. With group members, he has published over 220 manuscripts and has received 35 U.S. patents. One FDA approved drug product Amphotec™ and one biotechnology product Superfect™ have been commercialized from the patents. In addition to his University commitments, Dr. Szoka is a founder of Sequus Pharmaceuticals, Inc., GeneMedicine, Inc., and ZoneOne Pharma, Inc. Sequus introduced sterically stabilized liposomes for anti-cancer drug delivery (Doxil™).
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Displaying 151 - 175 of 209
- Haensler J, Szoka FC. Synthesis and characterization of a trigalactosylated bisacridine compound to target DNA to hepatocytes. Bioconjug Chem. 1993 Jan-Feb; 4(1):85-93.
- Legendre JY, Szoka FC. Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: comparison with cationic liposomes. Pharm Res. 1992 Oct; 9(10):1235-42.
- Stull RA, Taylor LA, Szoka FC. Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices. Nucleic Acids Res. 1992 Jul 11; 20(13):3501-8.
- Kim A, Szoka FC. Amino acid side-chain contributions to free energy of transfer of tripeptides from water to octanol. Pharm Res. 1992 Apr; 9(4):504-14.
- Woodle MC, Storm G, Newman MS, Jekot JJ, Collins LR, Martin FJ, Szoka FC. Prolonged systemic delivery of peptide drugs by long-circulating liposomes: illustration with vasopressin in the Brattleboro rat. Pharm Res. 1992 Feb; 9(2):260-5.
- Szoka FC. The macrophage as the principal antigen-presenting cell for liposome-encapsulated antigen. Res Immunol. 1992 Feb; 143(2):186-8.
- Green PG, Hinz RS, Kim A, Szoka FC, Guy RH. Iontophoretic delivery of a series of tripeptides across the skin in vitro. Pharm Res. 1991 Sep; 8(9):1121-7.
- Goormaghtigh E, De Meutter J, Szoka F, Cabiaux V, Parente RA, Ruysschaert JM. Secondary structure and orientation of the amphipathic peptide GALA in lipid structures. An infrared-spectroscopic approach. Eur J Biochem. 1991 Jan 30; 195(2):421-9.
- Chin DJ, Green GA, Zon G, Szoka FC, Straubinger RM. Rapid nuclear accumulation of injected oligodeoxyribonucleotides. New Biol. 1990 Dec; 2(12):1091-100.
- Szoka FC. The future of liposomal drug delivery. Biotechnol Appl Biochem. 1990 Oct; 12(5):496-500.
- Parente RA, Nadasdi L, Subbarao NK, Szoka FC. Association of a pH-sensitive peptide with membrane vesicles: role of amino acid sequence. Biochemistry. 1990 Sep 18; 29(37):8713-9.
- Parente RA, Nir S, Szoka FC. Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA. Biochemistry. 1990 Sep 18; 29(37):8720-8.
- Chu CJ, Dijkstra J, Lai MZ, Hong K, Szoka FC. Efficiency of cytoplasmic delivery by pH-sensitive liposomes to cells in culture. Pharm Res. 1990 Aug; 7(8):824-34.
- Roe JN, Szoka FC, Verkman AS. Fibre optic sensor for the detection of potassium using fluorescence energy transfer. Analyst. 1990 Apr; 115(4):353-8.
- Dal Monte PR, Szoka FC. Antigen presentation by B cells and macrophages of cytochrome c and its antigenic fragment when conjugated to the surface of liposomes. Vaccine. 1989 Oct; 7(5):401-8.
- Roe JN, Szoka FC, Verkman AS. Optical measurement of aqueous potassium concentration by a hydrophobic indicator in lipid vesicles. Biophys Chem. 1989 Jul; 33(3):295-302.
- Patterson TF, Miniter P, Dijkstra J, Szoka FC, Ryan JL, Andriole VT. Treatment of experimental invasive aspergillosis with novel amphotericin B/cholesterol-sulfate complexes. J Infect Dis. 1989 Apr; 159(4):717-24.
- Dal Monte P, Szoka FC. Effect of liposome encapsulation on antigen presentation in vitro. Comparison of presentation by peritoneal macrophages and B cell tumors. J Immunol. 1989 Mar 01; 142(5):1437-43.
- Dijkstra J, Ryan JL, Szoka FC. A procedure for the efficient incorporation of wild-type lipopolysaccharide into liposomes for use in immunological studies. J Immunol Methods. 1988 Nov 10; 114(1-2):197-205.
- Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR. An evaluation of the sensitivity of MRI at detecting hepatocellular carcinoma in cirrhotic patients utilizing an explant reference standard. Clin Imaging. 2014 Sep-Oct; 38(5):693-7.
- Dijkstra J, Larrick JW, Ryan JL, Szoka FC. Incorporation of LPS in liposomes diminishes its ability to induce tumoricidal activity and tumor necrosis factor secretion in murine macrophages. J Leukoc Biol. 1988 May; 43(5):436-44.
- Parente RA, Nir S, Szoka FC. pH-dependent fusion of phosphatidylcholine small vesicles. Induction by a synthetic amphipathic peptide. J Biol Chem. 1988 Apr 05; 263(10):4724-30.
- Subbarao NK, Fielding CJ, Hamilton RL, Szoka FC. Lecithin:cholesterol acyltransferase activation by synthetic amphipathic peptides. Proteins. 1988; 3(3):187-98.
- Subbarao NK, Parente RA, Szoka FC, Nadasdi L, Pongracz K. pH-dependent bilayer destabilization by an amphipathic peptide. Biochemistry. 1987 Jun 02; 26(11):2964-72.
- Barza M, Stuart M, Szoka F. Effect of size and lipid composition on the pharmacokinetics of intravitreal liposomes. Invest Ophthalmol Vis Sci. 1987 May; 28(5):893-900.