Adithya Cattamanchi, MD, MAS

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Adithya Cattamanchi, MD, MAS

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Professor, School of Medicine
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Biography

My research is focused on two thematic areas: 1) Development and evaluation of tuberculosis (TB) diagnostics and 2) Implementation and dissemination of evidence-based preventative, diagnostic, and treatment interventions for TB. I have considerable experience with the evaluation of TB diagnostics in low-income countries, including studying the impact of new diagnostics on patient- and public health-important outcomes. I have served on several World Health Organization (WHO) Expert Group panels to develop new policies related to TB diagnostics and serve as a faculty member for the Advanced Tuberculosis Diagnostics Research workshop sponsored by the WHO Stop TB Partnership. I have initiated a number of collaborations with engineers in industry and academia to develop and evaluate new diagnostic platforms for TB including: 1) mobile phone-based microscopy; 2) mobile phone-based molecular diagnostic platforms; and 3) single-particle aerosol mass spectrometry. We are currently evaluating the mobile phone-based microscopy platform and health centers in Hanoi, Vietnam in a demonstration project funded by the TB REACH initiative.

In addition to research on TB diagnostics, I have developed an active research agenda related to implementation science. I helped establish a platform for monitoring the quality of TB care at 6 rural health centers in Uganda (Uganda Tuberculosis Surveillance Project). My current work, supported through an NIH/NIAID R21 in Implementation and Dissemination Science, is focused on improving the quality of TB suspect evaluation at these health centers.

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Displaying 126 - 150 of 202

  1. Hanrahan CF, Haguma P, Ochom E, Kinera I, Cobelens F, Cattamanchi A, Davis L, Katamba A, Dowdy D. Implementation of Xpert MTB/RIF in Uganda: Missed Opportunities to Improve Diagnosis of Tuberculosis. Open Forum Infect Dis. 2016 Mar; 3(2):ofw068.
  2. Handley MA, Gorukanti A, Cattamanchi A. Strategies for implementing implementation science: a methodological overview. Emerg Med J. 2016 Sep; 33(9):660-4.
  3. Gonzales R, Cattamanchi A. Changing Clinician Behavior When Less Is More. JAMA Intern Med. 2015 Dec; 175(12):1921-2.
  4. Walter ND, Miller MA, Vasquez J, Weiner M, Chapman A, Engle M, Higgins M, Quinones AM, Rosselli V, Canono E, Yoon C, Cattamanchi A, Davis JL, Phang T, Stearman RS, Datta G, Garcia BJ, Daley CL, Strong M, Kechris K, Fingerlin TE, Reves R, Geraci MW. Blood Transcriptional Biomarkers for Active Tuberculosis among Patients in the United States: a Case-Control Study with Systematic Cross-Classifier Evaluation. J Clin Microbiol. 2016 Feb; 54(2):274-82.
  5. Moses MW, Zwerling A, Cattamanchi A, Denkinger CM, Banaei N, Kik SV, Metcalfe J, Pai M, Dowdy D. Serial testing for latent tuberculosis using QuantiFERON-TB Gold In-Tube: A Markov model. Sci Rep. 2016 07 29; 6:30781.
  6. Katagira W, Walter ND, Den Boon S, Kalema N, Ayakaka I, Vittinghoff E, Worodria W, Cattamanchi A, Huang L, Davis JL. Empiric TB Treatment of Severely Ill Patients With HIV and Presumed Pulmonary TB Improves Survival. . 2016 07 01; 72(3):297-303.
  7. Ross JM, Cattamanchi A, Miller CR, Tatem AJ, Katamba A, Haguma P, Handley MA, Davis JL. Investigating Barriers to Tuberculosis Evaluation in Uganda Using Geographic Information Systems. Am J Trop Med Hyg. 2015 Oct; 93(4):733-8.
  8. Chaisson LH, Katamba A, Haguma P, Ochom E, Ayakaka I, Mugabe F, Miller C, Vittinghoff E, Davis JL, Handley MA, Cattamanchi A. Theory-Informed Interventions to Improve the Quality of Tuberculosis Evaluation at Ugandan Health Centers: A Quasi-Experimental Study. PLoS One. 2015; 10(7):e0132573.
  9. Gonzales R, Cattamanchi A. Changing Clinician Behavior When Less Is More. JAMA Intern Med. 2015 Dec; 175(12):1921-2.
  10. Slater M, Tran MC, Platt L, Luu LT, Phan HT, Pham PT, Do TB, Nguyen HT, Gaur RL, Parsonnet J, Cattamanchi A, Luo R, Nahid P, Banaei N. In vitro immunomodulation for enhancing T cell-based diagnosis of Mycobacterium tuberculosis infection. Diagn Microbiol Infect Dis. 2015 Sep; 83(1):41-5.
  11. Koss CA, Jarlsberg LG, den Boon S, Cattamanchi A, Davis JL, Worodria W, Ayakaka I, Sanyu I, Huang L. A Clinical Predictor Score for 30-Day Mortality among HIV-Infected Adults Hospitalized with Pneumonia in Uganda. PLoS One. 2015; 10(5):e0126591.
  12. Semitala FC, Chaisson LH, den Boon S, Walter N, Cattamanchi A, Awor M, Katende J, Huang L, Joloba M, Albert H, Kamya MR, Davis JL. Impact of mycobacterial culture among HIV-infected adults with presumed TB in Uganda: a prospective cohort study. Public Health Action. 2015 Jun 21; 5(2):106-11.
  13. Walter ND, Dolganov GM, Garcia BJ, Worodria W, Andama A, Musisi E, Ayakaka I, Van TT, Voskuil MI, de Jong BC, Davidson RM, Fingerlin TE, Kechris K, Palmer C, Nahid P, Daley CL, Geraci M, Huang L, Cattamanchi A, Strong M, Schoolnik GK, Davis JL. Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis. J Infect Dis. 2015 Sep 15; 212(6):990-8.
  14. Zellweger JP, Cattamanchi A, Sotgiu G. Tobacco and tuberculosis: could we improve tuberculosis outcomes by helping patients to stop smoking? Eur Respir J. 2015 Mar; 45(3):583-5.
  15. Cattamanchi A, Miller CR, Tapley A, Haguma P, Ochom E, Ackerman S, Davis JL, Katamba A, Handley MA. Health worker perspectives on barriers to delivery of routine tuberculosis diagnostic evaluation services in Uganda: a qualitative study to guide clinic-based interventions. BMC Health Serv Res. 2015 Jan 22; 15:10.
  16. Lambdin BH, Cheng B, Peter T, Mbwambo J, Apollo T, Dunbar M, Udoh IC, Cattamanchi A, Geng EH, Volberding P. Implementing Implementation Science: An Approach for HIV Prevention, Care and Treatment Programs. Curr HIV Res. 2015; 13(3):244-9.
  17. Koss CA, Jarlsberg LG, den Boon S, Cattamanchi A, Davis JL, Worodria W, Ayakaka I, Sanyu I, Huang L, International HIV-associated Opportunistic Pneumonias (IHOP) Study . A Clinical Predictor Score for 30-Day Mortality among HIV-Infected Adults Hospitalized with Pneumonia in Uganda. PLoS One. 2015; 10(5):e0126591.
  18. Tagmouti S, Slater M, Benedetti A, Kik SV, Banaei N, Cattamanchi A, Metcalfe J, Dowdy D, van Zyl Smit R, Dendukuri N, Pai M, Denkinger C. Reproducibility of interferon gamma (IFN-?) release Assays. A systematic review. Ann Am Thorac Soc. 2014 Oct; 11(8):1267-76.
  19. Marquez C, Davis JL, Katamba A, Haguma P, Ochom E, Ayakaka I, Chamie G, Dorsey G, Kamya MR, Charlebois E, Havlir DV, Cattamanchi A. Assessing the quality of tuberculosis evaluation for children with prolonged cough presenting to routine community health care settings in rural Uganda. PLoS One. 2014; 9(8):e105935.
  20. Chaisson LH, Roemer M, Cantu D, Haller B, Millman AJ, Cattamanchi A, Davis JL. Impact of GeneXpert MTB/RIF assay on triage of respiratory isolation rooms for inpatients with presumed tuberculosis: a hypothetical trial. Clin Infect Dis. 2014 Nov 15; 59(10):1353-60.
  21. Davis JL, Kawamura LM, Chaisson LH, Grinsdale J, Benhammou J, Ho C, Babst A, Banouvong H, Metcalfe JZ, Pandori M, Hopewell PC, Cattamanchi A. Impact of GeneXpert MTB/RIF on patients and tuberculosis programs in a low-burden setting. a hypothetical trial. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1551-9.
  22. Iwai S, Huang D, Fong S, Jarlsberg LG, Worodria W, Yoo S, Cattamanchi A, Davis JL, Kaswabuli S, Segal M, Huang L, Lynch SV. The lung microbiome of Ugandan HIV-infected pneumonia patients is compositionally and functionally distinct from that of San Franciscan patients. PLoS One. 2014; 9(4):e95726.
  23. Yoon C, Davis JL, Huang L, Muzoora C, Byakwaga H, Scibetta C, Bangsberg DR, Nahid P, Semitala FC, Hunt PW, Martin JN, Cattamanchi A. Point-of-care C-reactive protein testing to facilitate implementation of isoniazid preventive therapy for people living with HIV. J Acquir Immune Defic Syndr. 2014 Apr 15; 65(5):551-6.
  24. Tagmouti S, Slater M, Benedetti A, Kik SV, Banaei N, Cattamanchi A, Metcalfe J, Dowdy D, van Zyl Smit R, Dendukuri N, Pai M, Denkinger C. Reproducibility of interferon gamma (IFN-γ) release Assays. A systematic review. Ann Am Thorac Soc. 2014 Oct; 11(8):1267-76.
  25. Tokman S, Barnett CF, Jarlsberg LG, Taub PR, den Boon S, Davis JL, Cattamanchi A, Worodria W, Maisel A, Huang L. Procalcitonin predicts mortality in HIV-infected Ugandan adults with lower respiratory tract infections. Respirology. 2014 Apr; 19(3):382-8.