Creative and Novel Ideas in HIV Research (CNIHR) Program

The intent of the Creative and Novel Ideas in HIV Research (CNIHR) program is to attract both international and U.S.-based early stage investigators from outside the field of HIV research to help address key scientific questions in HIV research, including emerging issues of long-term survival with HIV infection, prevention of HIV transmission and research towards a cure.

  • Term: Up to 2 years
  • Up to $150,000 direct cost per year, (the amount of the award will vary depending on the proposal)

11 Awards

Award Recipient Award date Award Type
Defining and Eliminating the Macrophage Reservoir Jonah Sacha, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Impact of Integration Site Selection on HIV Persistence Rik Gijsbers, MD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Impact of CMV replication on the HIV-1 latent reservoir Sara Gianella Weibel, MD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Bridges Within the HIV-human Hosthogen Genome JJ Miranda, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Targeting NK cell activity to eradicate the HIV-1 reservoir Eileen Scully, MD, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Development of a diagnostic T cell assay to confirm disruption of latent HIV-1 infection Nilu Goonetilleke, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
A Super-agonistic antibody to human IL-21 to boost immunity for HIV cure Di Yu, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Targeting Tim-3 for elimination of HIV reservoirs Lishomwa Ndhlovu, MD, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Sampling and Analysis of Thoracic Duct Lymphocytes in HIV+ Patients Matthew Callaghan, MD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Gut Barrier Dysfunction and Dysbiosis on HIV Persistence and Immune Activation Ma Somsouk, MD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Targeting Antiapoptotic Signaling for Eradication of HIV Latent Reservoir Haishan Li, MD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Contacts

  • Bridges Within the HIV-human Hosthogen Genome

    Bridges Within the HIV-human Hosthogen Genome

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    Abstract

    The human genome is not a linear sequence, but rather a contorted knot of chromosomes in the three-dimensional space of the nucleus. The transcription community is now starting to realize that chromosomes do not work in isolation. Interchromosomal associations regulate gene expression. This innovation, however, has not been applied to retroviral infections. We still talk of host and pathogen genomes as if they only interact locally.

  • Targeting Tim-3 for elimination of HIV reservoirs

    Targeting Tim-3 for elimination of HIV reservoirs

    Abstract

    This study is aimed at determining whether targeting a novel immune-inhibitory pathway can deplete latently HIV infected CD4 memory T cells in HIV virally suppressed patients. Although antiretroviral therapy (ART) can suppress HIV replication and significantly improve the long-term health of the patient, it is unable to permanently remove latent reservoirs of virus. Therefore, novel strategies are needed to specifically target and destroy latently infected cells.

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