Creative and Novel Ideas in HIV Research (CNIHR) Program

The intent of the Creative and Novel Ideas in HIV Research (CNIHR) program is to attract both international and U.S.-based early stage investigators from outside the field of HIV research to help address key scientific questions in HIV research, including emerging issues of long-term survival with HIV infection, prevention of HIV transmission and research towards a cure.

  • Term: Up to 2 years
  • Up to $150,000 direct cost per year, (the amount of the award will vary depending on the proposal)

11 Awards

Award Recipient Award date Award Type
Defining and Eliminating the Macrophage Reservoir Jonah Sacha, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Impact of Integration Site Selection on HIV Persistence Rik Gijsbers, MD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Impact of CMV replication on the HIV-1 latent reservoir Sara Gianella Weibel, MD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Bridges Within the HIV-human Hosthogen Genome JJ Miranda, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Targeting NK cell activity to eradicate the HIV-1 reservoir Eileen Scully, MD, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Development of a diagnostic T cell assay to confirm disruption of latent HIV-1 infection Nilu Goonetilleke, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
A Super-agonistic antibody to human IL-21 to boost immunity for HIV cure Di Yu, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Targeting Tim-3 for elimination of HIV reservoirs Lishomwa Ndhlovu, MD, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Sampling and Analysis of Thoracic Duct Lymphocytes in HIV+ Patients Matthew Callaghan, MD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Gut Barrier Dysfunction and Dysbiosis on HIV Persistence and Immune Activation Ma Somsouk, MD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Targeting Antiapoptotic Signaling for Eradication of HIV Latent Reservoir Haishan Li, MD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Contacts

  • Defining and Eliminating the Macrophage Reservoir

    Defining and Eliminating the Macrophage Reservoir

    Abstract

    With 34 million people currently living with HIV, stopping the HIV epidemic remains imperative. Highly active antiretroviral therapy (HAART) limits viral replication, but is not curative. Thus, there is an urgent need to define and eliminate the viral reservoir. While the role of resting memory CD4+ T cells is well established, little is known about other cells as reservoirs. Macrophages are a major target of both HIV and SIV infection.

  • Targeting NK cell activity to eradicate the HIV-1 reservoir

    Targeting NK cell activity to eradicate the HIV-1 reservoir

    Headshot of

    Abstract

    Antiretroviral therapy (ART) has been effective in the suppression of HIV-1 viremia, but does not eliminate the reservoir of cells with latent HIV-1 infection, obligating lifelong therapy. Recent work has identified mechanisms for activating HIV-1 transcription in latently infected cells without inducing cellular activation, including the use of histone deacetylase (HDAC) inhibitors. This offers a pathway towards potential eradication of the viral reservoir and cure of the infection.

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