Creative and Novel Ideas in HIV Research (CNIHR) Program

The intent of the Creative and Novel Ideas in HIV Research (CNIHR) program is to attract both international and U.S.-based early stage investigators from outside the field of HIV research to help address key scientific questions in HIV research, including emerging issues of long-term survival with HIV infection, prevention of HIV transmission and research towards a cure.

  • Term: Up to 2 years
  • Up to $150,000 direct cost per year, (the amount of the award will vary depending on the proposal)

11 Awards

Award Recipient Award date Award Type
Defining and Eliminating the Macrophage Reservoir Jonah Sacha, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Impact of Integration Site Selection on HIV Persistence Rik Gijsbers, MD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Impact of CMV replication on the HIV-1 latent reservoir Sara Gianella Weibel, MD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Bridges Within the HIV-human Hosthogen Genome JJ Miranda, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Targeting NK cell activity to eradicate the HIV-1 reservoir Eileen Scully, MD, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Development of a diagnostic T cell assay to confirm disruption of latent HIV-1 infection Nilu Goonetilleke, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
A Super-agonistic antibody to human IL-21 to boost immunity for HIV cure Di Yu, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Targeting Tim-3 for elimination of HIV reservoirs Lishomwa Ndhlovu, MD, PhD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Sampling and Analysis of Thoracic Duct Lymphocytes in HIV+ Patients Matthew Callaghan, MD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Gut Barrier Dysfunction and Dysbiosis on HIV Persistence and Immune Activation Ma Somsouk, MD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Targeting Antiapoptotic Signaling for Eradication of HIV Latent Reservoir Haishan Li, MD Fall Creative and Novel Ideas in HIV Research (CNIHR) Program
Contacts

  • Sampling and Analysis of Thoracic Duct Lymphocytes in HIV+ Patients

    Sampling and Analysis of Thoracic Duct Lymphocytes in HIV+ Patients

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    Abstract

    A major contributor to HIV persistence despite antiretroviral therapy (ART) is latent infection in long-lived CD4+ cell populations. Subsets of these cells have been shown to harbor virus and activate to re-establish infection when ART is stopped. Classification of discreet cell types and the mechanism by which reservoirs are maintained has been limited by lack of access to these cells, which are found in very small numbers in circulating blood.

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