Phyllis Tien, MD

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Phyllis Tien, MD

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Professor, School of Medicine
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Dr. Tien is Professor of Medicine at the University of California, San Francisco and Chief of the Infectious Diseases Division at the San Francisco Veterans Affairs Health Care System. Her research program examines the mechanisms by which chronic viral infections (specifically HIV and HCV) and their associated metabolic and immune perturbations impact long term organ injury in adults. She has served in several leadership positions including Co-Chair of the Executive Committee of the Multicenter AIDS Cohort Study (MACS)/Women's Interagency HIV Study (WIHS) Combined Cohort Study (MWCCS) and the MWCCS Steering Committee. The MWCCS integrates two of the largest and longest running NIH-funded prospective cohorts of adult men and women with and at risk for HIV in the U.S. She also serves as Chair of the Inter-CFAR Collaboration on HIV Research in Women and previously served as Chair of the NIH AIDS Clinical Epidemiology Study Section. She was a member of the Department of Health and Human Services Antiretroviral Guidelines Panel, and is currently a member of the NIAID AIDS Research Study Section and the NIH COVID-19 Treatment Guidelines Panel.
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  1. Kassaye S, Li Y, Huhn G, Peters MG, French AL, Tien PC, Luxon B, Plankey MW. Direct and Indirect Serum Markers of Liver Fibrosis Compared with Transient Elastography among Women in the Women's Interagency HIV Study. J AIDS Clin Res. 2015 Apr; 6(4).
    http://www.ncbi.nlm.nih.gov/pubmed/26251759
  2. Valcour V, Rubin LH, Tien P, Anastos K, Young M, Mack W, Cohen M, Golub ET, Crystal H, Maki PM. Human immunodeficiency virus (HIV) modulates the associations between insulin resistance and cognition in the current combination antiretroviral therapy (cART) era: a study of the Women's Interagency HIV Study (WIHS). J Neurovirol. 2015 Aug; 21(4):415-21.
    http://www.ncbi.nlm.nih.gov/pubmed/25740539
  3. Scherzer R, Lin H, Abraham A, Thiessen-Philbrook H, Parikh CR, Bennett M, Cohen MH, Nowicki M, Gustafson DR, Sharma A, Young M, Tien P, Jotwani V, Shlipak MG. Use of urine biomarker-derived clusters to predict the risk of chronic kidney disease and all-cause mortality in HIV-infected women. Nephrol Dial Transplant. 2016 09; 31(9):1478-85.
    http://www.ncbi.nlm.nih.gov/pubmed/25699995
  4. E.M. Kelly, J. Dodge, P. Bacchetti, M. Sarkar, A. French, P. Tien, M. Glesby, E. Golub, M. Augenbraun, M. Plankey, M. Peters. PS073 Light to Moderate Alcohol Use is not Associated with Long-Term Progression of Liver Fibrosis in Hiv Hcv Coinfected Women. Journal of Hepatology. 2016 Jan 1; 64(2):s171-s172.
    http://www.ncbi.nlm.nih.gov/pubmed/25532609
  5. Sharma A, Hoover DR, Shi Q, Gustafson D, Plankey MW, Hershow RC, Tien PC, Golub ET, Anastos K. Relationship between Body Mass Index and Mortality in HIV-Infected HAART Users in the Women's Interagency HIV Study. PLoS One. 2015; 10(12):e0143740.
    http://www.ncbi.nlm.nih.gov/pubmed/25370597
  6. Tien PC. Novel Approaches to Targeting Visceral and Hepatic Adiposities in HIV-Associated Lipodystrophy. Curr Atheroscler Rep. 2015 Dec; 17(12):73.
    http://www.ncbi.nlm.nih.gov/pubmed/25314249
  7. Swanson S, Ma Y, Scherzer R, Huhn G, French AL, Plankey MW, Grunfeld C, Rosenberg WM, Peters MG, Tien PC. Association of HIV, Hepatitis C Virus, and Liver Fibrosis Severity With the Enhanced Liver Fibrosis Score. J Infect Dis. 2016 Apr 01; 213(7):1079-86.
    http://www.ncbi.nlm.nih.gov/pubmed/25314253
  8. Peralta CA, McClure LA, Scherzer R, Odden MC, White CL, Shlipak M, Benavente O, Pergola P. Effect of Intensive Versus Usual Blood Pressure Control on Kidney Function Among Individuals With Prior Lacunar Stroke: A Post Hoc Analysis of the Secondary Prevention of Small Subcortical Strokes (SPS3) Randomized Trial. Circulation. 2016 Feb 09; 133(6):584-91.
    http://www.ncbi.nlm.nih.gov/pubmed/25251910
  9. Shah S, Ma Y, Scherzer R, Huhn G, French AL, Plankey M, Peters MG, Grunfeld C, Tien PC. Association of HIV, hepatitis C virus and liver fibrosis severity with interleukin-6 and C-reactive protein levels. AIDS. 2015 Jul 17; 29(11):1325-33.
    http://www.ncbi.nlm.nih.gov/pubmed/25027062
  10. Marcus JL, Leyden WA, Chao CR, Xu L, Quesenberry CP, Tien PC, Klein DB, Towner WJ, Horberg MA, Silverberg MJ. Differences in Response to Antiretroviral Therapy by Sex and Hepatitis C Infection Status. AIDS Patient Care STDS. 2015 Jul; 29(7):370-8.
    http://www.ncbi.nlm.nih.gov/pubmed/24932614
  11. Jotwani V, Shlipak MG, Scherzer R, Parekh RS, Kao WH, Bennett M, Cohen MH, Nowicki M, Sharma A, Young M, Tien PC, Parikh CR, Estrella MM. APOL1 Genotype and Glomerular and Tubular Kidney Injury in Women With HIV. Am J Kidney Dis. 2015 Jun; 65(6):889-98.
    http://www.ncbi.nlm.nih.gov/pubmed/25059222
  12. Rakhi P. Naik, Marguerite R. Irvin, Suzanne Judd, Orlando Gutierrez, Neil A Zakai, Vimal K. Derebail, Carmen Peralta, Michael Lewis, Degui Zhi, Donna Arnett, William McClellan, James G. Wilson, Alexander Reiner, Jeffrey Kopp, Cheryl Winkler, Mary Cushman. Association of Hemoglobin S and C Traits with Kidney Disease in African Americans in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. Blood. 2015 Dec 3; 126(23):70-70.
    http://www.ncbi.nlm.nih.gov/pubmed/24922479
  13. David B Hanna, Wendy S Post, Jennifer A Deal, Howard N Hodis, Kathryn Anastos, Jason M Lazar, Frank J Palella, Phyllis C Tien, Mallory D Witt, Robert C Kaplan, Lawrence A Kingsley. Abstract 28: HIV Infection Is Associated With Greater Risk of Carotid Artery Lesions Over Seven Years. Circulation. 2014 Mar 25; 129(suppl_1).
  14. David B Hanna, Iftach Shaked, Daniel Tracy, Kathryn Anastos, Mardge H Cohen, Elizabeth T Golub, Roksana Karim, Jason M Lazar, Vinayaka R Prasad, Phyllis C Tien, Mary Young, Alan L Landay, Klaus Ley, Robert C Kaplan. Abstract P342: Macrophage Markers are Associated with Atherosclerotic Plaque and Distensibility in the Women’s Interagency HIV Study. Circulation. 2014 Mar 25; 129(suppl_1).
  15. Kassaye S, Li Y, Huhn G, Peters MG, French AL, Tien PC, Luxon B, Plankey MW. Direct and Indirect Serum Markers of Liver Fibrosis Compared with Transient Elastography among Women in the Women's Interagency HIV Study. J AIDS Clin Res. 2015 Apr; 6(4).
    http://www.ncbi.nlm.nih.gov/pubmed/24668135
  16. Valcour V, Rubin LH, Tien P, Anastos K, Young M, Mack W, Cohen M, Golub ET, Crystal H, Maki PM. Human immunodeficiency virus (HIV) modulates the associations between insulin resistance and cognition in the current combination antiretroviral therapy (cART) era: a study of the Women's Interagency HIV Study (WIHS). J Neurovirol. 2015 Aug; 21(4):415-21.
    http://www.ncbi.nlm.nih.gov/pubmed/24651679
  17. Jung M, Parrinello CM, Xue X, Mack WJ, Anastos K, Lazar JM, Selzer RH, Shircore AM, Plankey M, Tien P, Cohen M, Gange SJ, Hodis HN, Kaplan RC. Echolucency of the carotid artery intima-media complex and intima-media thickness have different cardiovascular risk factor relationships: the Women's Interagency HIV Study. J Am Heart Assoc. 2015 Feb 19; 4(2).
    http://www.ncbi.nlm.nih.gov/pubmed/24525470
  18. Wheeler AL, Tien PC, Grunfeld C, Schafer AL. Teriparatide treatment of osteoporosis in an HIV-infected man: a case report and literature review. AIDS. 2015 Jan 14; 29(2):245-6.
    http://www.ncbi.nlm.nih.gov/pubmed/24136113
  19. Jotwani V, Scherzer R, Abraham A, Estrella MM, Bennett M, Cohen MH, Nowicki M, Sharma A, Young M, Tien PC, Ix JH, Sarnak MJ, Parikh CR, Shlipak MG. Association of urine α1-microglobulin with kidney function decline and mortality in HIV-infected women. Clin J Am Soc Nephrol. 2015 Jan 07; 10(1):63-73.
    http://www.ncbi.nlm.nih.gov/pubmed/25580365
  20. Gustafson DR, Mielke MM, Tien PC, Valcour V, Cohen M, Anastos K, Liu C, Pearce L, Golub ET, Minkoff H, Crystal HA. Anthropometric measures and cognition in middle-aged HIV-infected and uninfected women. The Women's Interagency HIV Study. J Neurovirol. 2013 Dec; 19(6):574-85.
    http://www.ncbi.nlm.nih.gov/pubmed/24338243
  21. Peralta CA, Muntner P, Scherzer R, Judd S, Cushman M, Shlipak MG. A Risk Score to Guide Cystatin C Testing to Detect Occult-Reduced Estimated Glomerular Filtration Rate. Am J Nephrol. 2015; 42(2):141-7.
    http://www.ncbi.nlm.nih.gov/pubmed/24313986
  22. Malkina A, Scherzer R, Shlipak MG, Bacchetti P, Tien PC, Grunfeld C, Kosmiski L, Peralta CA. The association of adiposity with kidney function decline among HIV-infected adults: findings from the Fat Redistribution and Metabolic Changes in HIV Infection (FRAM) study. HIV Med. 2015 Mar; 16(3):184-90.
    http://www.ncbi.nlm.nih.gov/pubmed/24415610
  23. Sanchez OA, Jacobs DR, Bahrami H, Peralta CA, Daniels LB, Lima JA, Maisel A, Duprez DA. Increasing aminoterminal-pro-B-type natriuretic peptide precedes the development of arterial hypertension: the multiethnic study of atherosclerosis. J Hypertens. 2015 May; 33(5):966-74.
    http://www.ncbi.nlm.nih.gov/pubmed/23669156
  24. Frasco MA, Karim R, Van Den Berg D, Watanabe RM, Anastos K, Cohen M, Gange SJ, Gustafson DR, Liu C, Tien PC, Mack WJ, Pearce CL. Antiretroviral therapy modifies the genetic effect of known type 2 diabetes-associated risk variants in HIV-infected women. AIDS. 2014 Jul 31; 28(12):1815-23.
    http://www.ncbi.nlm.nih.gov/pubmed/23970313
  25. Bailony MR, Scherzer R, Huhn G, Plankey MW, Peters MG, Tien PC. Association of HIV infection, hepatitis C virus infection, and metabolic factors with liver stiffness measured by transient elastography. J Infect Dis. 2013 Dec 01; 208(11):1776-83.
    http://www.ncbi.nlm.nih.gov/pubmed/23901097