Phyllis Tien, MD

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Phyllis Tien, MD

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Professor, School of Medicine
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Dr. Tien is Professor of Medicine at the University of California, San Francisco and Chief of the Infectious Diseases Division at the San Francisco Veterans Affairs Health Care System. Her research program examines the mechanisms by which chronic viral infections (specifically HIV and HCV) and their associated metabolic and immune perturbations impact long term organ injury in adults. She has served in several leadership positions including Co-Chair of the Executive Committee of the Multicenter AIDS Cohort Study (MACS)/Women's Interagency HIV Study (WIHS) Combined Cohort Study (MWCCS) and the MWCCS Steering Committee. The MWCCS integrates two of the largest and longest running NIH-funded prospective cohorts of adult men and women with and at risk for HIV in the U.S. She also serves as Chair of the Inter-CFAR Collaboration on HIV Research in Women and previously served as Chair of the NIH AIDS Clinical Epidemiology Study Section. She was a member of the Department of Health and Human Services Antiretroviral Guidelines Panel, and is currently a member of the NIAID AIDS Research Study Section and the NIH COVID-19 Treatment Guidelines Panel.
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  1. Womack J, Richman S, Tien PC, Grey M, Williams A. Hormonal contraception and HIV-positive women: metabolic concerns and management strategies. J Midwifery Womens Health. 2008 Jul-Aug; 53(4):362-75.
    http://www.ncbi.nlm.nih.gov/pubmed/17356466
  2. Anastos K, Lu D, Shi Q, Tien PC, Kaplan RC, Hessol NA, Cole S, Vigen C, Cohen M, Young M, Justman J. Association of serum lipid levels with HIV serostatus, specific antiretroviral agents, and treatment regimens. . 2007 May 01; 45(1):34-42.
    http://www.ncbi.nlm.nih.gov/pubmed/17460470
  3. French AL, Operskalski E, Peters M, Strickler HD, Tien PC, Sharp GB, Glesby MJ, Young M, Augenbraun M, Seaberg E, Kovacs A. Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US women. J Infect Dis. 2007 May 15; 195(10):1437-42.
    http://www.ncbi.nlm.nih.gov/pubmed/17436223
  4. Currier J, Scherzer R, Bacchetti P, Heymsfield S, Lee D, Sidney S, Tien PC, Fat Redistribution and Metabolic Changes in HIV Infection Study Investigators . Regional adipose tissue and lipid and lipoprotein levels in HIV-infected women. . 2008 May 01; 48(1):35-43.
    http://www.ncbi.nlm.nih.gov/pubmed/17243063
  5. Shah T, Lampiris H, Vu M, Monto A, Tien PC. Resolution of hepatitis C virus-induced steatosis improves tolerability of antiretroviral drugs associated with hepatotoxicity in an HIV-infected individual. J Infect Dis. 2008 Mar 15; 197(6):932-3.
    http://www.ncbi.nlm.nih.gov/pubmed/17091021
  6. Anastos K, Lu D, Shi O, Mulligan K, Tien PC, Freeman R, Cohen MH, Justman J, Hessol NA. The association of bone mineral density with HIV infection and antiretroviral treatment in women. Antivir Ther. 2007; 12(7):1049-58.
    http://www.ncbi.nlm.nih.gov/pubmed/18018763
  7. Tien PC, Benson C, Zolopa AR, Sidney S, Osmond D, Grunfeld C. The study of fat redistribution and metabolic change in HIV infection (FRAM): methods, design, and sample characteristics. Am J Epidemiol. 2006 May 01; 163(9):860-9.
    http://www.ncbi.nlm.nih.gov/pubmed/16524955
  8. Luetkemeyer A, Hare CB, Stansell J, Tien PC, Charlesbois E, Lum P, Havlir D, Peters M. Clinical presentation and course of acute hepatitis C infection in HIV-infected patients. . 2006 Jan 01; 41(1):31-6.
    http://www.ncbi.nlm.nih.gov/pubmed/16340470
  9. Bacchetti P, Gripshover B, Grunfeld C, Heymsfield S, McCreath H, Osmond D, Saag M, Scherzer R, Shlipak M, Tien P, Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM) . Fat distribution in men with HIV infection. . 2005 Oct 01; 40(2):121-31.
    http://www.ncbi.nlm.nih.gov/pubmed/16186728
  10. Khalsa A, Karim R, Mack WJ, Minkoff H, Cohen M, Young M, Anastos K, Tien PC, Seaberg E, Levine AM. Correlates of prevalent hypertension in a large cohort of HIV-infected women: Women's Interagency HIV Study. AIDS. 2007 Nov 30; 21(18):2539-41.
    http://www.ncbi.nlm.nih.gov/pubmed/16025515
  11. Tien PC, Kovacs A, Bacchetti P, French AL, Augenbraun M, Cole SR, Hessol N, Justman J, Women's Interagency HIV Study . Association between syphilis, antibodies to herpes simplex virus type 2, and recreational drug use and hepatitis B virus infection in the Women's Interagency HIV Study. Clin Infect Dis. 2004 Nov 01; 39(9):1363-70.
    http://www.ncbi.nlm.nih.gov/pubmed/15494914
  12. Mafong DD, Lee GA, Yu S, Tien P, Mauro T, Grunfeld C. Development of multiple lipomas during treatment with rosiglitazone in a patient with HIV-associated lipoatrophy. AIDS. 2004 Aug 20; 18(12):1742-4.
    http://www.ncbi.nlm.nih.gov/pubmed/15280791
  13. Kaplan RC, Tien PC, Lazar J. Antiretroviral drugs and the risk of myocardial infarction. N Engl J Med. 2007 Aug 16; 357(7):715; author reply 716-7.
    http://www.ncbi.nlm.nih.gov/pubmed/15226135
  14. Tien PC, Grunfeld C. What is HIV-associated lipodystrophy? Defining fat distribution changes in HIV infection. Curr Opin Infect Dis. 2004 Feb; 17(1):27-32.
    http://www.ncbi.nlm.nih.gov/pubmed/15090886
  15. Tien PC, Cole SR, Williams CM, Li R, Justman JE, Cohen MH, Young M, Rubin N, Augenbraun M, Grunfeld C. Incidence of lipoatrophy and lipohypertrophy in the women's interagency HIV study. . 2003 Dec 15; 34(5):461-6.
    http://www.ncbi.nlm.nih.gov/pubmed/14657755
  16. Grunfeld C, Tien P. Difficulties in understanding the metabolic complications of acquired immune deficiency syndrome. Clin Infect Dis. 2003; 37 Suppl 2:S43-6.
    http://www.ncbi.nlm.nih.gov/pubmed/12942373
  17. Tien PC, Bacchetti P, Gripshover B, Overton ET, Rimland D, Kotler D, Fat Redistribution and Metabolic Change in HIV Infection Study Investigators . Association between hepatitis C virus coinfection and regional adipose tissue volume in HIV-infected men and women. . 2007 May 01; 45(1):60-5.
    http://www.ncbi.nlm.nih.gov/pubmed/12439806
  18. Tien PC, Grunfeld C. The fatty liver in AIDS. Semin Gastrointest Dis. 2002 Jan; 13(1):47-54.
    http://www.ncbi.nlm.nih.gov/pubmed/11944634
  19. Carl Grunfeld, Peter Jensen, Phyllis C. Tien. Metabolic Manifestations. Atlas of AIDS. 2001 Jan 1; 154-165.
  20. French AL, Operskalski E, Peters M, Strickler HD, Tien PC, Sharp GB, Glesby MJ, Young M, Augenbraun M, Seaberg E, Kovacs A. Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US women. J Infect Dis. 2007 May 15; 195(10):1437-42.
    http://www.ncbi.nlm.nih.gov/pubmed/10890359
  21. Han S, Wu Z, Yang H, Wang R, Yie Y, Xie L, Tien P. Ribozyme-mediated resistance to rice dwarf virus and the transgene silencing in the progeny of transgenic rice plants. Transgenic Res. 2000 Jun; 9(3):195-203.
    http://www.ncbi.nlm.nih.gov/pubmed/11032368
  22. Tien PC, Chiu T, Latif A, Ray S, Batra M, Contag CH, Zejena L, Mbizvo M, Delwart EL, Mullins JI, Katzenstein DA. Primary subtype C HIV-1 infection in Harare, Zimbabwe. J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Feb 01; 20(2):147-53.
    http://www.ncbi.nlm.nih.gov/pubmed/10048901
  23. Tien PC, Schneider MF, Cole SR, Justman JE, French AL, Young M, DeHovitz J, Nathwani N, Brown TT. Relation of stavudine discontinuation to anthropometric changes among HIV-infected women. . 2007 Jan 01; 44(1):43-8.
    http://www.ncbi.nlm.nih.gov/pubmed/8933546
  24. Anastos K, Lu D, Shi O, Mulligan K, Tien PC, Freeman R, Cohen MH, Justman J, Hessol NA. The association of bone mineral density with HIV infection and antiretroviral treatment in women. Antivir Ther. 2007; 12(7):1049-58.
    http://www.ncbi.nlm.nih.gov/pubmed/8793830
  25. Tien PC, Benson C, Zolopa AR, Sidney S, Osmond D, Grunfeld C. The study of fat redistribution and metabolic change in HIV infection (FRAM): methods, design, and sample characteristics. Am J Epidemiol. 2006 May 01; 163(9):860-9.
    http://www.ncbi.nlm.nih.gov/pubmed/3973534