Mike McCune, MD, PhD
Head, HIV Frontiers Global Health Innovative Technology Solutions Bill & Melinda Gates Foundation
Professor, School of Medicine
Email: mike.mccune@ucsf.edu
Biography
Joseph ("Mike") McCune is a professor of medicine at the University of California, San Francisco (UCSF). He received his AB degree from Harvard College in 1975, his PhD degree from Rockefeller University in 1981, and his MD degree from Cornell University Medical College in 1982. He completed his residency in internal medicine in 1984 and did fellowship training in infectious diseases at UCSF. He is board certified in internal medicine.
The McCune lab has been involved for many years in the analysis of HIV pathogenesis, prevention, treatment, and cure. Dr. McCune started to treat patients with HIV disease as a resident in internal medicine at UCSF in 1982 and has been involved in the HIV/AIDS research field ever since. This work included postdoctoral studies at Stanford, exploring the fusogenic properties of the HIV envelope protein and developing the first humanized mouse model (the SCID-hu mouse) capable of multilineage human hematopoiesis and receptive to infection with primary isolates of HIV. He then co-founded the companies SyStemix (in 1988) and Progenesys (and 1991), serving as Scientific Director and leading research efforts to find better ways – including antiviral medications and hematopoietic stem cell-based gene therapy – to treat HIV disease. In 1995, Dr. McCune returned to academia, first as an investigator at the Gladstone Institute of Virology and Immunology and then (from 2006-2016) as the Chief of the Division of Experimental Medicine (which he founded) at UCSF. Concomitantly, he was the founding PI (and Senior Associate Dean) of the Clinical and Translational Sciences Institute at UCSF (from 2005-08). In recent years, he has helped to form multidisciplinary, collaborative research teams to find a cure for HIV disease. Throughout this time, he has actively mentored graduate students and postdoctoral fellows, many of whom have gone on to successful careers in academia or biotech/pharma.
Dr. McCune’s studies have led to the publication of over 200 peer-reviewed articles, and he is the holder of 20 patents and inventions. He is a member of many scientific and professional societies, including the American Society for Clinical Investigation, the American Association of Physicians, and the Henry Kunkel Society. He has served on the editorial boards of Virology and the Journal of the Acquired Immune Deficiency Syndrome. He was awarded the Elizabeth Glaser Pediatric AIDS Foundation Scientist Award in 1996, the Burroughs Wellcome Fund Clinical Scientist Award in Translational Research in 2000, a MERIT Award from the NIH in 2001, the NIH Director’s Pioneer Award in 2004, and the Holly Smith Award for Exceptional Service to the School of Medicine in 2016. He was also selected to give the UCSF Academic Senate Faculty Research Lecture (on Translational Science) in 2013.
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- Péault B, Weissman IL, Baum C, McCune JM, Tsukamoto A. Lymphoid reconstitution of the human fetal thymus in SCID mice with CD34+ precursor cells. J Exp Med. 1991 Nov 01; 174(5):1283-6.
- Vandekerckhove BA, Krowka JF, McCune JM, de Vries JE, Spits H, Roncarolo MG. Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse. J Immunol. 1991 Jun 15; 146(12):4173-9.
- Krowka JF, Sarin S, Namikawa R, McCune JM, Kaneshima H. Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent. J Immunol. 1991 Jun 01; 146(11):3751-6.
- Kaneshima H, Shih CC, Namikawa R, Rabin L, Outzen H, Machado SG, McCune JM. Human immunodeficiency virus infection of human lymph nodes in the SCID-hu mouse. Proc Natl Acad Sci U S A. 1991 May 15; 88(10):4523-7.
- McCune JM. SCID mice as immune system models. Curr Opin Immunol. 1991 Apr; 3(2):224-8.
- Shih CC, Kaneshima H, Rabin L, Namikawa R, Sager P, McGowan J, McCune JM. Postexposure prophylaxis with zidovudine suppresses human immunodeficiency virus type 1 infection in SCID-hu mice in a time-dependent manner. J Infect Dis. 1991 Mar; 163(3):625-7.
- McCune JM. HIV-1: the infective process in vivo. Cell. 1991 Jan 25; 64(2):351-63.
- McCune J, Kaneshima H, Krowka J, Namikawa R, Outzen H, Peault B, Rabin L, Shih CC, Yee E, Lieberman M. The SCID-hu mouse: a small animal model for HIV infection and pathogenesis. Annu Rev Immunol. 1991; 9:399-429.
- Kaneshima H, Baum C, Chen B, Namikawa R, Outzen H, Rabin L, Tsukamoto A, McCune JM. Today's SCID-hu mouse. Nature. 1990 Dec 06; 348(6301):561-2.
- McCune JM, Namikawa R, Shih CC, Rabin L, Kaneshima H. Pseudotypes in HIV-infected mice. Science. 1990 Nov 23; 250(4984):1152-4.
- Namikawa R, Weilbaecher KN, Kaneshima H, Yee EJ, McCune JM. Long-term human hematopoiesis in the SCID-hu mouse. J Exp Med. 1990 Oct 01; 172(4):1055-63.
- McCune JM, Namikawa R, Shih CC, Rabin L, Kaneshima H. Suppression of HIV infection in AZT-treated SCID-hu mice. Science. 1990 Feb 02; 247(4942):564-6.
- McCune JM, Kaneshima H, Rabin L, Shih CC, Namikawa R. Preclinical evaluation of antiviral compounds in the SCID-hu mouse. Ann N Y Acad Sci. 1990; 616:281-6.
- McCune JM, Kaneshima H, Lieberman M, Weissman IL, Namikawa R. The scid-hu mouse: current status and potential applications. Curr Top Microbiol Immunol. 1989; 152:183-93.
- Namikawa R, Kaneshima H, Lieberman M, Weissman IL, McCune JM. Infection of the SCID-hu mouse by HIV-1. Science. 1988 Dec 23; 242(4886):1684-6.
- McCune JM, Namikawa R, Kaneshima H, Shultz LD, Lieberman M, Weissman IL. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science. 1988 Sep 23; 241(4873):1632-9.
- McCune JM, Rabin LB, Feinberg MB, Lieberman M, Kosek JC, Reyes GR, Weissman IL. Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus. Cell. 1988 Apr 08; 53(1):55-67.
- Lieberman M, Hansteen GA, McCune JM, Scott ML, White JH, Weissman IL. Indirect induction of radiation lymphomas in mice. Evidence for a novel, transmissible leukemogen. J Exp Med. 1987 Dec 01; 166(6):1883-93.
- McCune JM, Fu SM. Ig biosynthesis in a human pre-B cell line. J Immunol. 1981 Dec; 127(6):2609-11.
- McCune JM, Fu SM, Kunkel HG. J chain biosynthesis in pre-B cells and other possible precursor B cells. J Exp Med. 1981 Jul 01; 154(1):138-45.
- McCune JM, Fu SM, Blobel G, Kunkel HG. Biogenesis of membrane-bound and secreted immunoglobulins. II. Two forms of the human alpha chain translated in vitro and processed in vivo as distinct polypeptide chains. J Exp Med. 1981 Jun 01; 153(6):1684-9.
- Fu SM, Hurley JN, McCune JM, Kunkel HG, Good RA. Pre-B cells and other possible precursor lymphoid cell lines derived from patients with X-linked agammaglobulinemia. J Exp Med. 1980 Dec 01; 152(6):1519-26.
- McCune JM, Lingappa VR, Fu SM, Blobel G, Kunkel HG. Biogenesis of membrane-bound and secreted immunoglobulins. I. Two distinct translation products of human mu-chain, with identical N-termini and different C-termini. J Exp Med. 1980 Aug 01; 152(2):463-8.
- Yu DT, McCune JM, Fu SM, Winchester RJ, Kunkel HG. Two types of Ia-positive T cells. Synthesis and exchange of Ia antigens. J Exp Med. 1980 Aug 01; 152(2 Pt 2):89s-98s.
- Humphreys RE, McCune JM, Chess L, Herrman HC, Malenka DJ, Mann DL, Parham P, Schlossman SF, Strominger JL. Isolation and immunologic characterization of a human. B-lymphocyte-specific, cell surface antigen. J Exp Med. 1976 Jul 01; 144(1):98-112.