Melanie Ott, PhD

Headshot of Melanie Ott
User Profile Photo

Melanie Ott, PhD

User Profile Name
Senior Investigator, The Ott Lab, Gladstone Institute of Virology and Immunology
Professor, School of Medicine
User Profile Title
User Profile Email

Biography

My laboratory is interested in the molecular mechanisms of viral pathogenesis. We focus on a variety of viruses including HIV-1, Hepatitis B and C Virus (HBV and HCV), Zika and SARS-CoV-2. We believe that identifying common host pathways involved in different viruses can lead to the discovery of panviral therapeutics. All are important public health problems and with HCV and HIV sharing common traits including high propensities to establish chronic infections and a lack of efficient vaccines, and Zika and SARS-CoV-2 causing global pandemics leading to death and disability. In recent years, we have established four main technologies to study these viruses—rapid quantitative tests, human organoids, a viral protein library and transcriptomics and chromatin biology. We recently applied these technologies to the studies of SARS-CoV-2, leading to the development of a new direct detection CRISPR diagnostic and the identification of shared host factors necessary for the replication of SARS-CoV-2 and common cold coronaviruses. SARS-CoV-2, HCV and HIV research in my laboratory includes replication studies with infectious viral clones, which are performed in the BSL3 laboratory. Recent rotation projects in the lab: • characterizing influenza B infection in human airway organoids • developing a new hepatitis B clone to screen for host factors regulating cccDNA formation
CTSI Profile Bio

Displaying 101 - 125 of 149

  1. Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M. The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets. J Biol Chem. 2014 Dec 26; 289(52):35770-80.
  2. Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell. 2013 Nov 07; 52(3):314-24.
  3. Webster B, Ott M, Greene WC. Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus. J Virol. 2013 Dec; 87(24):13354-69.
  4. Verdin E, Ott M. Acetylphosphate: a novel link between lysine acetylation and intermediary metabolism in bacteria. Mol Cell. 2013 Jul 25; 51(2):132-4.
  5. Boehm D, Conrad RJ, Ott M. Bromodomain proteins in HIV infection. Viruses. 2013 Jun 21; 5(6):1571-86.
  6. Ott M, Verdin E. Three rules for HIV latency: location, location, and location. . 2013 Jun 12; 13(6):625-6.
  7. Camus G, Ott M. How the antiviral immune response boosts liver fat. Nat Med. 2013 Jun; 19(6):671-2.
  8. Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M. Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. PLoS Pathog. 2013; 9(4):e1003302.
  9. Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Ott M. Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. J Biol Chem. 2013 Apr 05; 288(14):9915-9923.
  10. Knipe DM, Lieberman PM, Jung JU, McBride AA, Morris KV, Ott M, Margolis D, Nieto A, Nevels M, Parks RJ, Kristie TM. Snapshots: chromatin control of viral infection. Virology. 2013 Jan 05; 435(1):141-56.
  11. Camus G, Vogt DA, Kondratowicz AS, Ott M. Lipid droplets and viral infections. Methods Cell Biol. 2013; 116:167-90.
  12. Webster B, Wissing S, Herker E, Ott M, Greene WC. Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis. J Virol. 2013 Jan; 87(1):581-96.
  13. Kwon HS, Lim HW, Wu J, Schnölzer M, Verdin E, Ott M. Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol. 2012 Mar 15; 188(6):2712-21.
  14. Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li PC, Planelles V, Bradner JE, Zhou MM, Siliciano RF, Weinberger L, Verdin E, Ott M. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. . 2013 Feb 01; 12(3):452-62.
  15. Ott M, Geyer M, Zhou Q. The control of HIV transcription: keeping RNA polymerase II on track. . 2011 Nov 17; 10(5):426-35.
  16. Herker E, Ott M. Emerging role of lipid droplets in host/pathogen interactions. J Biol Chem. 2012 Jan 20; 287(4):2280-7.
  17. Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M. Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem. 2012 Jan 06; 287(2):1090-9.
  18. Harris C, Herker E, Farese RV, Ott M. Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis. J Biol Chem. 2011 Dec 09; 286(49):42615-42625.
  19. Sakane N, Kwon HS, Pagans S, Kaehlcke K, Mizusawa Y, Kamada M, Lassen KG, Chan J, Greene WC, Schnoelzer M, Ott M. Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). PLoS Pathog. 2011 Aug; 7(8):e1002184.
  20. Ott M, Tascher G, Haßdenteufel S, Zimmermann R, Haas J, Bailer SM. Functional characterization of the essential tail anchor of the herpes simplex virus type 1 nuclear egress protein pUL34. J Gen Virol. 2011 Dec; 92(Pt 12):2734-2745.
  21. Herker E, Ott M. Unique ties between hepatitis C virus replication and intracellular lipids. Trends Endocrinol Metab. 2011 Jun; 22(6):241-8.
  22. Ott M. HIV never ceases to surprise: Innovative methods in the quest for a cure. Methods. 2011 Jan; 53(1):1-2.
  23. Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV, Ott M. Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nat Med. 2010 Nov; 16(11):1295-8.
  24. Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010 Sep 23; 67(6):953-66.
  25. Pagans S, Sakane N, Schnölzer M, Ott M. Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies. Methods. 2011 Jan; 53(1):91-6.