Warner Greene, MD, PhD

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Warner Greene, MD, PhD

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Director, Gladstone Center for HIV Cure Research
Professor, School of Medicine
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Biography

Warner C. Greene, MD, PhD is Director of the Gladstone Center for HIV Cure Research, Senior Investigator, and Nick and Sue Hellmann Distinguished Professor of Translational Medicine at the Gladstone Institute of Virology and Immunology (GIVI). He is the Founding and Emeritus Director of GIVI. Dr. Greene is also Professor of Medicine, Microbiology and of Immunology at UCSF. Dr. Greene is a member of the Institute of Medicine of the National Academies and a fellow of the American Academy for the Advancement of Science. He also serves as Co-Director of the UCSF-Gladstone Center for AIDS Research, and has served as a Councilor and President of the Association of American Physicians. Dr. Greene earned a bachelor’s degree at Stanford University and an MD/PhD at Washington University School of Medicine. He took his internship and residency training in Medicine at the Massachusetts General Hospital at Harvard. After serving as a Senior Investigator at the National Cancer Institute and a Professor of Medicine and Howard Hughes Investigator at Duke University Medical Center, Dr. Greene accepted his current position as the Founding Director of the Gladstone Institute of Virology and Immunology in 1991. The ongoing research in Dr. Greene’s laboratory focuses on the molecular mechanisms underlying HIV pathogenesis, latency, and transmission. He is the author of more than 380 scientific papers and has been recognized as one of the 100 Most Cited Scientists in the world. In 2007, Dr. Greene expanded his work to include global health in sub-Saharan Africa in his service as president and executive chairman of the Accordia Global Health Foundation. Accordia established the Infectious Diseases Institute at Makerere University in Uganda, which has trained thousands of African health care workers, is caring for 30,000 HIV-infected patients, and has brought health care to nearly 500,000 people living in remote rural regions of Uganda. In 2016, Accordia merged with Africare.
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  1. Waldmann TA, Leonard WJ, Depper JM, Kronke M, Goldman CK, Sharrow S, Greene WC. In: Pinchera A, Doria G, Dammacco F, Bargellesi A (Eds.), Monoclonal Antibodies 1984: Biological and Clinical Applications. Interleukin-2 receptors on lymphocytes. 1985; 329-338.
  2. Kronke M, Depper JM, Leonard WJ, Wong-Staal F, Gallo RC, Waldmann TA, Greene WC. In: Sorg C, Schimple A (Eds.), Cellular and molecular biology of lymphokines. Cyclosporin A inhibits expression of select T-cell activation genes. 1985; 647-652.
  3. Leonard WJ, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Kronke M, Svetlik P, Peffer NJ, Waldmann TA, Greene WC. In: Sorg C, Schimple A (Eds.), Cellular and molecular biology of lymphokines. Cloning of cDNAs for the human interleukin-2 receptor and determination of its complete protein sequence. 1985; 623-633.
  4. Depper JM, Leonard WJ, Kronke M, Waldmann TA, Greene WC. In: Sorg P, Schimple A (Eds.), Cellular and molecular biology of lymphokines. The role of protein kinase C, and effects of 5-azacytidine on regulation on interleukin-2 receptor expression. 1985; 151-156.
  5. Greene WC, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Krönke M, Svetlik P, Peffer NJ, Waldmann TA. Molecular cloning of cDNA for the human interleukin-2 receptor. Haematol Blood Transfus. 1985; 29:388-95.
  6. Greene WC, Robb RJ. Receptors for T-cell growth factor: structure, function and expression on normal and neoplastic cells. Contemp Top Mol Immunol. 1985; 10:1-34.
  7. Greene WC, Depper JM, Krönke M, Leonard WJ. The human interleukin-2 receptor. J Cell Sci Suppl. 1985; 3:97-106.
  8. Korsmeyer SJ, Greene WC, Waldmann TA. Cellular origin of hairy cell leukemia: malignant B cells that express receptors for T cell growth factor. Semin Oncol. 1984 Dec; 11(4):394-400.
  9. Depper JM, Leonard WJ, Krönke M, Noguchi PD, Cunningham RE, Waldmann TA, Greene WC. Regulation of interleukin 2 receptor expression: effects of phorbol diester, phospholipase C, and reexposure to lectin or antigen. J Immunol. 1984 Dec; 133(6):3054-61.
  10. Waldmann TA, Goldman CK, Robb RJ, Depper JM, Leonard WJ, Sharrow SO, Bongiovanni KF, Korsmeyer SJ, Greene WC. Expression of interleukin 2 receptors on activated human B cells. J Exp Med. 1984 Nov 01; 160(5):1450-66.
  11. Depper JM, Leonard WJ, Krönke M, Waldmann TA, Greene WC. Augmented T cell growth factor receptor expression in HTLV-1-infected human leukemic T cells. J Immunol. 1984 Oct; 133(4):1691-5.
  12. Greene WC, Cossman J, Leonard WJ, Bakshi A, Waldmann TA, Korsmeyer SJ. In: Golde DW, Marks PA (Eds.), Normal and Neoplastic Hematopoiesis, UCLA Symposia on Molecular and Cellular Biology. Hairy cell leukemia: A malignant expansion of B cells that express Tac antigen. 1983; 9:491-500.
  13. Robb RJ, Greene WC, Rusk CM. Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen. J Exp Med. 1984 Oct 01; 160(4):1126-46.
  14. Leonard WJ, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Krönke M, Svetlik PB, Peffer NJ, Waldmann TA. Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature. 1984 Oct 18-24; 311(5987):626-31.
  15. Krönke M, Leonard WJ, Depper JM, Arya SK, Wong-Staal F, Gallo RC, Waldmann TA, Greene WC. Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc Natl Acad Sci U S A. 1984 Aug; 81(16):5214-8.
  16. Greene WC, Robb RJ, Depper JM, Leonard WJ, Drogula C, Svetlik PB, Wong-Staal F, Gallo RC, Waldmann TA. Phorbol diester induces expression of Tac antigen on human acute T lymphocytic leukemic cells. J Immunol. 1984 Aug; 133(2):1042-7.
  17. Waldmann TA, Greene WC, Sarin PS, Saxinger C, Blayney DW, Blattner WA, Goldman CK, Bongiovanni K, Sharrow S, Depper JM. Functional and phenotypic comparison of human T cell leukemia/lymphoma virus positive adult T cell leukemia with human T cell leukemia/lymphoma virus negative Sézary leukemia, and their distinction using anti-Tac. Monoclonal antibody identifying the human receptor for T cell growth factor. J Clin Invest. 1984 Jun; 73(6):1711-8.
  18. Depper JM, Leonard WJ, Smith KA, Waldmann TA, Greene WC. In: Oppenheim JJ, Cohen S (Eds.), Interleukins, lymphokines, and cytokines. Monoclonal anti-Tac blocks the action of human interleukin-2. 1982; 19-24.
  19. Lipkowitz S, Greene WC, Rubin AL, Novogrodsky A, Stenzel KH. Expression of receptors for interleukin 2: Role in the commitment of T lymphocytes to proliferate. J Immunol. 1984 Jan; 132(1):31-7.
  20. Leonard WJ, Depper JM, Waldmann TA, Greene WC. In: Greaves M (Ed.), Receptors and Recognition. A monoclonal antibody to the human receptor for T cell growth factor. 1984; 17:45-66.
  21. Depper JM, Leonard WJ, Waldmann TA, Greene WC. In: Pick E (Ed.), Lymphokines. A monoclonal antibody which recognizes the human receptor for T cell growth factor: Functional effects and use as a probe to investigate receptor regulation. 1984; 9:127-152.
  22. Waldmann TA, Broder S, Greene WC. In: Sasazuki T (Ed.), Immunogenetics: Its application to clinical medicine. Cell-cell interactions in the human immune response: Analysis of leukemic T calls with immunoregulatory functions. 1984; 137-142.
  23. Waldmann TA, Leonard WJ, Depper JM, Krönke M, Goldman CK, Oh T, Greene WC. Interleukin-2 receptor expression in retrovirus associated adult T-cell leukemia. Princess Takamatsu Symp. 1984; 15:259-68.
  24. Waldmann TA, Goldman CK, Leonard WJ, Depper JM, Robb RJ, Korsmeyer SJ, Greene WC. Interleukin-2 receptors on activated malignant and normal B-cells. Curr Top Microbiol Immunol. 1984; 113:96-101.
  25. Parker CW, Greene WC. In: Cramer H, Schultz J (Eds.), Mechanism of Action. Cyclic nucleotides in the immune response. 1977; 161-187.