Warner Greene, MD, PhD

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Warner Greene, MD, PhD

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Director, Gladstone Center for HIV Cure Research
Professor, School of Medicine
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Biography

Warner C. Greene, MD, PhD is Director of the Gladstone Center for HIV Cure Research, Senior Investigator, and Nick and Sue Hellmann Distinguished Professor of Translational Medicine at the Gladstone Institute of Virology and Immunology (GIVI). He is the Founding and Emeritus Director of GIVI. Dr. Greene is also Professor of Medicine, Microbiology and of Immunology at UCSF. Dr. Greene is a member of the Institute of Medicine of the National Academies and a fellow of the American Academy for the Advancement of Science. He also serves as Co-Director of the UCSF-Gladstone Center for AIDS Research, and has served as a Councilor and President of the Association of American Physicians. Dr. Greene earned a bachelor’s degree at Stanford University and an MD/PhD at Washington University School of Medicine. He took his internship and residency training in Medicine at the Massachusetts General Hospital at Harvard. After serving as a Senior Investigator at the National Cancer Institute and a Professor of Medicine and Howard Hughes Investigator at Duke University Medical Center, Dr. Greene accepted his current position as the Founding Director of the Gladstone Institute of Virology and Immunology in 1991. The ongoing research in Dr. Greene’s laboratory focuses on the molecular mechanisms underlying HIV pathogenesis, latency, and transmission. He is the author of more than 380 scientific papers and has been recognized as one of the 100 Most Cited Scientists in the world. In 2007, Dr. Greene expanded his work to include global health in sub-Saharan Africa in his service as president and executive chairman of the Accordia Global Health Foundation. Accordia established the Infectious Diseases Institute at Makerere University in Uganda, which has trained thousands of African health care workers, is caring for 30,000 HIV-infected patients, and has brought health care to nearly 500,000 people living in remote rural regions of Uganda. In 2016, Accordia merged with Africare.
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  1. Greene WC, Robb RJ, Svetlik PB, Rusk CM, Depper JM, Leonard WJ. Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells. J Exp Med. 1985 Jul 01; 162(1):363-8.
  2. Waldmann TA, Leonard WJ, Depper JM, Kronke M, Kozak R, Greene WC. In: Cancer Cells 3: Growth factors and transformation. Structure, function, and expression of the receptor for interleukin-2 on normal and malignant lymphocytes. 1985; 221-226.
  3. Waldmann TA, Leonard WJ, Depper JM, Kronke M, Goldman CK, Bongiovani KF, Greene WC.. In: Feldman M (Ed.), Human T cell clones: An approach to immune regulation. Interleukin-2 receptors. 1985; 285-300.
  4. Leonard WJ, Depper JM, Crabtee GM, Rudikoff S, Pumphrey J, Robb RJ, Kronke M, Svetlik P, Peffer NJ, Waldmann TA, Greene WC. In: Feldmann M, Mitchison NA (Eds.), Immune Regulation. Molecular cloning and expression of cDNAs encoding the human interleukin-2 receptor. 1985; 185-195.
  5. Greene WC, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Kronke M, Svetlik P, Peffer NJ, Waldmann TA, Leonard WJ. In: Pattengale PK, Lukes RJ, Taylor CR (Eds.), Lymphoproliferative Diseases: Pathogenesis, Diagnosis, and Therapy. Molecular analysis of the human interleukin-2 receptor. 1985; 8-20.
  6. Waldmann TA, Leonard WJ, Depper JM, Kronke M, Goldman CK, Sharrow S, Greene WC. In: Pinchera A, Doria G, Dammacco F, Bargellesi A (Eds.), Monoclonal Antibodies 1984: Biological and Clinical Applications. Interleukin-2 receptors on lymphocytes. 1985; 329-338.
  7. Kronke M, Depper JM, Leonard WJ, Wong-Staal F, Gallo RC, Waldmann TA, Greene WC. In: Sorg C, Schimple A (Eds.), Cellular and molecular biology of lymphokines. Cyclosporin A inhibits expression of select T-cell activation genes. 1985; 647-652.
  8. Leonard WJ, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Kronke M, Svetlik P, Peffer NJ, Waldmann TA, Greene WC. In: Sorg C, Schimple A (Eds.), Cellular and molecular biology of lymphokines. Cloning of cDNAs for the human interleukin-2 receptor and determination of its complete protein sequence. 1985; 623-633.
  9. Depper JM, Leonard WJ, Kronke M, Waldmann TA, Greene WC. In: Sorg P, Schimple A (Eds.), Cellular and molecular biology of lymphokines. The role of protein kinase C, and effects of 5-azacytidine on regulation on interleukin-2 receptor expression. 1985; 151-156.
  10. Leonard WJ, Donlon TA, Lebo RV, Greene WC. Localization of the gene encoding the human interleukin-2 receptor on chromosome 10. Science. 1985 Jun 28; 228(4707):1547-9.
  11. Krönke M, Leonard WJ, Depper JM, Greene WC. Deregulation of interleukin-2 receptor gene expression in HTLV-I-induced adult T-cell leukemia. Science. 1985 Jun 07; 228(4704):1215-7.
  12. Krönke M, Depper JM, Leonard WJ, Vitetta ES, Waldmann TA, Greene WC. Adult T cell leukemia: a potential target for ricin A chain immunotoxins. Blood. 1985 Jun; 65(6):1416-21.
  13. Depper JM, Leonard WJ, Drogula C, Krönke M, Waldmann TA, Greene WC. Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene. Proc Natl Acad Sci U S A. 1985 Jun; 82(12):4230-4.
  14. Miller J, Malek TR, Leonard WJ, Greene WC, Shevach EM, Germain RN. Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA. J Immunol. 1985 Jun; 134(6):4212-7.
  15. Krönke M, Leonard WJ, Depper JM, Greene WC. Sequential expression of genes involved in human T lymphocyte growth and differentiation. J Exp Med. 1985 Jun 01; 161(6):1593-8.
  16. Leonard WJ, Depper JM, Krönke M, Robb RJ, Waldmann TA, Greene WC. The human receptor for T-cell growth factor. Evidence for variable post-translational processing, phosphorylation, sulfation, and the ability of precursor forms of the receptor to bind T-cell growth factor. J Biol Chem. 1985 Feb 10; 260(3):1872-80.
  17. Depper JM, Leonard WJ, Drogula CL, Krönke M, Waldmann TA, Greene WC. Activators of protein kinase C and 5-azacytidine induce IL-2 receptor expression on human T lymphocytes. J Cell Biochem. 1985; 27(3):267-76.
  18. Reed JC, Robb RJ, Greene WC, Nowell PC. Effect of wheat germ agglutinin on the interleukin pathway of human T lymphocyte activation. J Immunol. 1985 Jan; 134(1):314-23.
  19. Waldmann TA, Leonard WJ, Depper JM, Kronke M, Kozak R, Greene WC. In: Cancer Cells 3: Growth factors and transformation. Structure, function, and expression of the receptor for interleukin-2 on normal and malignant lymphocytes. 1985; 221-226.
  20. Waldmann TA, Leonard WJ, Depper JM, Kronke M, Goldman CK, Bongiovani KF, Greene WC.. In: Feldman M (Ed.), Human T cell clones: An approach to immune regulation. Interleukin-2 receptors. 1985; 285-300.
  21. Leonard WJ, Depper JM, Crabtee GM, Rudikoff S, Pumphrey J, Robb RJ, Kronke M, Svetlik P, Peffer NJ, Waldmann TA, Greene WC. In: Feldmann M, Mitchison NA (Eds.), Immune Regulation. Molecular cloning and expression of cDNAs encoding the human interleukin-2 receptor. 1985; 185-195.
  22. Greene WC, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Kronke M, Svetlik P, Peffer NJ, Waldmann TA, Leonard WJ. In: Pattengale PK, Lukes RJ, Taylor CR (Eds.), Lymphoproliferative Diseases: Pathogenesis, Diagnosis, and Therapy. Molecular analysis of the human interleukin-2 receptor. 1985; 8-20.
  23. Leonard WJ, Depper JM, Waldmann TA, Greene WC. In: Greaves M (Ed.), Receptors and Recognition. A monoclonal antibody to the human receptor for T cell growth factor. 1984; 17:45-66.
  24. Depper JM, Leonard WJ, Waldmann TA, Greene WC. In: Pick E (Ed.), Lymphokines. A monoclonal antibody which recognizes the human receptor for T cell growth factor: Functional effects and use as a probe to investigate receptor regulation. 1984; 9:127-152.
  25. Waldmann TA, Broder S, Greene WC. In: Sasazuki T (Ed.), Immunogenetics: Its application to clinical medicine. Cell-cell interactions in the human immune response: Analysis of leukemic T calls with immunoregulatory functions. 1984; 137-142.