Warner Greene, MD, PhD

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Warner Greene, MD, PhD

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Director, Gladstone Center for HIV Cure Research
Professor, School of Medicine
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Biography

Warner C. Greene, MD, PhD is Director of the Gladstone Center for HIV Cure Research, Senior Investigator, and Nick and Sue Hellmann Distinguished Professor of Translational Medicine at the Gladstone Institute of Virology and Immunology (GIVI). He is the Founding and Emeritus Director of GIVI. Dr. Greene is also Professor of Medicine, Microbiology and of Immunology at UCSF. Dr. Greene is a member of the Institute of Medicine of the National Academies and a fellow of the American Academy for the Advancement of Science. He also serves as Co-Director of the UCSF-Gladstone Center for AIDS Research, and has served as a Councilor and President of the Association of American Physicians. Dr. Greene earned a bachelor’s degree at Stanford University and an MD/PhD at Washington University School of Medicine. He took his internship and residency training in Medicine at the Massachusetts General Hospital at Harvard. After serving as a Senior Investigator at the National Cancer Institute and a Professor of Medicine and Howard Hughes Investigator at Duke University Medical Center, Dr. Greene accepted his current position as the Founding Director of the Gladstone Institute of Virology and Immunology in 1991. The ongoing research in Dr. Greene’s laboratory focuses on the molecular mechanisms underlying HIV pathogenesis, latency, and transmission. He is the author of more than 380 scientific papers and has been recognized as one of the 100 Most Cited Scientists in the world. In 2007, Dr. Greene expanded his work to include global health in sub-Saharan Africa in his service as president and executive chairman of the Accordia Global Health Foundation. Accordia established the Infectious Diseases Institute at Makerere University in Uganda, which has trained thousands of African health care workers, is caring for 30,000 HIV-infected patients, and has brought health care to nearly 500,000 people living in remote rural regions of Uganda. In 2016, Accordia merged with Africare.
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  1. Kehrl JH, Dukovich M, Whalen G, Katz P, Fauci AS, Greene WC. Novel interleukin 2 (IL-2) receptor appears to mediate IL-2-induced activation of natural killer cells. J Clin Invest. 1988 Jan; 81(1):200-5.
  2. Greene WC, Böhnlein E, Siekevitz M, Franza BR, Lowenthal J. The human interleukin-2 receptor. Recent studies of structure and regulation. Ann N Y Acad Sci. 1988; 546:116-21.
  3. Siekevitz M, Josephs SF, Dukovich M, Peffer N, Wong-Staal F, Greene WC. Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I. Science. 1987 Dec 11; 238(4833):1575-8.
  4. Lowenthal JW, Greene WC. Contrasting interleukin 2 binding properties of the alpha (p55) and beta (p70) protein subunits of the human high-affinity interleukin 2 receptor. J Exp Med. 1987 Oct 01; 166(4):1156-61.
  5. Rubin LA, Hoekzema GS, Nelson DL, Greene WC, Jay G. Reconstitution of a functional interleukin 2 receptor in a nonlymphoid cell. J Immunol. 1987 Oct 01; 139(7):2355-60.
  6. Bich-Thuy LT, Dukovich M, Peffer NJ, Fauci AS, Kehrl JH, Greene WC. Direct activation of human resting T cells by IL 2: the role of an IL 2 receptor distinct from the Tac protein. J Immunol. 1987 Sep 01; 139(5):1550-6.
  7. Wano Y, Hattori T, Matsuoka M, Takatsuki K, Chua AO, Gubler U, Greene WC. Interleukin 1 gene expression in adult T cell leukemia. J Clin Invest. 1987 Sep; 80(3):911-6.
  8. Greene WC. The human interleukin-2 receptor: a molecular and biochemical analysis of structure and function. Clin Res. 1987 Sep; 35(5):439-50.
  9. Siekevitz M, Feinberg MB, Holbrook N, Wong-Staal F, Greene WC. Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I. Proc Natl Acad Sci U S A. 1987 Aug; 84(15):5389-93.
  10. Dukovich M, Wano Y, Le thi Bich Thuy , Katz P, Cullen BR, Kehrl JH, Greene WC. A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors. Nature. 1987 Jun 11-17; 327(6122):518-22.
  11. Holter W, Goldman CK, Casabo L, Nelson DL, Greene WC, Waldmann TA. Expression of functional IL 2 receptors by lipopolysaccharide and interferon-gamma stimulated human monocytes. J Immunol. 1987 May 01; 138(9):2917-22.
  12. Bernard O, Fazekas de St Groth B, Ullrich A, Green W, Schlessinger J. High-affinity interleukin 2 binding by an oncogenic hybrid interleukin 2-epidermal growth factor receptor molecule. Proc Natl Acad Sci U S A. 1987 Apr; 84(8):2125-9.
  13. Robb RJ, Rusk CM, Yodoi J, Greene WC. Interleukin 2 binding molecule distinct from the Tac protein: analysis of its role in formation of high-affinity receptors. Proc Natl Acad Sci U S A. 1987 Apr; 84(7):2002-6.
  14. Robb RJ, Greene WC. Internalization of interleukin 2 is mediated by the beta chain of the high-affinity interleukin 2 receptor. J Exp Med. 1987 Apr 01; 165(4):1201-6.
  15. Wano Y, Cullen BR, Svetlik PA, Peffer NJ, Greene WC. Reconstitution of high affinity IL-2 receptor expression in a human T-cell line using a retroviral cDNA expression vector. Mol Biol Med. 1987 Apr; 4(2):95-109.
  16. Greene WC, Leonard WJ, Wano Y, Svetlik PB, Peffer NJ, Sodroski JG, Rosen CA, Goh WC, Haseltine WA. Trans-activator gene of HTLV-II: interpretation. Science. 1987 Feb 27; 235(4792):1073.
  17. Greene WC, Leonard WJ, Wano Y, Sodroski JG, Rosen CA, Haseltine WA. In: Pruzanki W, Seligmann M (Eds.), Clinical Immunology. The transactivator (tat) gene of HTLV-II induces the expression of cellular genes involved in T cell growth. 1987; 213-216.
  18. Greene WC, Dukovich M, Wano Y, Kehrl JH, Robb RJ. In: Webb DR, Pierce CW, Cohen S (Eds.), Proceedings of the Fifth International Lymphokine Workshop. The human high affinity for interleukin-2 receptor. 1987; 171-179.
  19. Greene WC. Int. J. Immunother. III. Expression of interleukin-2 receptors in normal and neoplastic T cells. 1987; 3:171-175.
  20. Greene WC. Proceedings of the AACR 1987. IL-2, IL-2 receptors and human retroviruses. 1987; 469-470.
  21. Greene WC. An overview of the human interleukin-2 receptor: molecular, biochemical, and functional properties. Cancer Invest. 1987; 5(4):369-76.
  22. Greene WC, Leonard WJ. Human interleukin 2 receptor (Tac antigen). Methods Enzymol. 1987; 150:682-700.
  23. Greene WC, Leonard WJ, Wano Y, Sodroski JG, Rosen CA, Haseltine WA. In: Pruzanki W, Seligmann M (Eds.), Clinical Immunology. The transactivator (tat) gene of HTLV-II induces the expression of cellular genes involved in T cell growth. 1987; 213-216.
  24. Greene WC, Dukovich M, Wano Y, Kehrl JH, Robb RJ. In: Webb DR, Pierce CW, Cohen S (Eds.), Proceedings of the Fifth International Lymphokine Workshop. The human high affinity for interleukin-2 receptor. 1987; 171-179.
  25. Greene WC. Int. J. Immunother. III. Expression of interleukin-2 receptors in normal and neoplastic T cells. 1987; 3:171-175.