Paul Ogongo, PhD
Postdoctoral Scholar, Division of Experimental Medicine
Postdoctoral Scholar, School of Medicine
Email: Paul.ogongo@ucsf.edu
Biography
My research interests are in understanding the role of Mycobacterium tuberculosis antigen-specific human T cell responses and how they determine infection outcome, that is, progression to active TB disease or non-progression in latent TB (LTBI). My current work is characterizing TB-specific T cell signatures in LTBI individuals at the highest risk of developing active TB disease and we hope that changes in T cell signatures between progressors and non-progressors will yield novel and insightful data that can inform better vaccination strategies or identify correlates of protection.
Previously, I worked on human lung tissue resident memory T cells in people infected with TB where we showed that T cells response to TB in the lung and blood are fundamentally different because it involves cells that do not recirculate and TB-antigen specific T cells are highly enriched at the site of disease. I am also keen on understanding the impact of HIV coinfection on the TB-antigen specific signatures as HIV is a key driver of TB related deaths.
CFAR Awards
- Mentored Scientist Award, SpringAward Mentor:PeterHunt, MD
Displaying 1 - 23 of 23
- Ogongo P, Tran A, Marzan F, Gingrich D, Krone M, Aweeka F, Lindestam Arlehamn CS, Martin JN, Deeks SG, Hunt PW, Ernst JD. M. tuberculosis antigen-responsive IL17 + CD4 T cells are disproportionately spared in ART-suppressed HIV. bioRxiv. 2023 Jan 07.
- Ogongo P, Ernst JD. Finding antigens for TB vaccines: the good, the bad and the useless. Nat Med. 2023 Jan; 29(1):35-36.
- Obiero JA, Ogongo P, Mwethera PG, Wiysonge CS. Do vaginal microbicides reduce the risk of HIV acquisition in women? Pan Afr Med J. 2022; 43:96.
- Ogongo P, Nyakundi RK, Chege GK, Ochola L. The Road to Elimination: Current State of Schistosomiasis Research and Progress Towards the End Game. Front Immunol. 2022; 13:846108.
- Nyakundi RK, Hau J, Ogongo P, Nyamongo O, Jeneby M, Akinyi M, Mulei I, Nyundo F, Farah I, Malhotra I, Ozwara H, King CL, Kariuki T. Acquired Clinical Immunity to Malaria in Nonhuman Primates Coinfected with Schistosoma and Plasmodium Parasites. Infect Immun. 2022 02 17; 90(2):e0046421.
- von Borstel A, Chevour P, Arsovski D, Krol JMM, Howson LJ, Berry AA, Day CL, Ogongo P, Ernst JD, Nomicos EYH, Boddey JA, Giles EM, Rossjohn J, Traore B, Lyke KE, Williamson KC, Crompton PD, Davey MS. Repeated Plasmodium falciparum infection in humans drives the clonal expansion of an adaptive γδ T cell repertoire. Sci Transl Med. 2021 12; 13(622):eabe7430.
- Ceglia V, Kelley EJ, Boyle AS, Zurawski S, Mead HL, Harms CE, Blanck JP, Flamar AL, Kirschman JH, Ogongo P, Ernst JD, Levy Y, Zurawski G, Altin JA. A Framework to Identify Antigen-Expanded T Cell Receptor Clusters Within Complex Repertoires. Front Immunol. 2021; 12:735584.
- Ochola L, Ogongo P, Mungai S, Gitaka J, Suliman S. Performance Evaluation of Lateral Flow Assays for Coronavirus Disease-19 Serology. Clin Lab Med. 2022 03; 42(1):31-56.
- Lucy Ochola, Paul Ogongo, Samuel Mungai, Jesse Gitaka, Sara Suliman. Performance evaluation of lateral flow assays for COVID-19 serology. Clinics in Laboratory Medicine. 2021 Nov 3.
- Ogongo P, Tezera LB, Ardain A, Nhamoyebonde S, Ramsuran D, Singh A, Ng'oepe A, Karim F, Naidoo T, Khan K, Dullabh KJ, Fehlings M, Lee BH, Nardin A, Lindestam Arlehamn CS, Sette A, Behar SM, Steyn AJ, Madansein R, Kl?verpris HN, Elkington PT, Leslie A. Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung. J Clin Invest. 2021 05 17; 131(10).
- Obiero J, Ogongo P, Mwethera PG, Wiysonge CS. Topical microbicides for preventing sexually transmitted infections. Cochrane Database Syst Rev. 2021 03 13; 3:CD007961.
- Magnoumba M, Singh A, Ogongo P, Roider J, Asowata O, Fehlings M, Karim F, Ndung'u T, Anderson F, Leslie A, Kl?verpris H. Unbiased Profiling Reveals Compartmentalization of Unconventional T-Cells Within the Intestinal Mucosa Irrespective of HIV Infection. Front Immunol. 2020; 11:579743.
- Tezera LB, Bielecka MK, Ogongo P, Walker NF, Ellis M, Garay-Baquero DJ, Thomas K, Reichmann MT, Johnston DA, Wilkinson KA, Ahmed M, Jogai S, Jayasinghe SN, Wilkinson RJ, Mansour S, Thomas GJ, Ottensmeier CH, Leslie A, Elkington PT. Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-a. Elife. 2020 02 24; 9.
- Ogongo P, Steyn AJ, Karim F, Dullabh KJ, Awala I, Madansein R, Leslie A, Behar SM. Differential skewing of donor-unrestricted and ?d T cell repertoires in tuberculosis-infected human lungs. J Clin Invest. 2020 01 02; 130(1):214-230.
- Ardain A, Domingo-Gonzalez R, Das S, Kazer SW, Howard NC, Singh A, Ahmed M, Nhamoyebonde S, Rangel-Moreno J, Ogongo P, Lu L, Ramsuran D, de la Luz Garcia-Hernandez M, Ulland TK, Darby M, Park E, Karim F, Melocchi L, Madansein R, Dullabh KJ, Dunlap M, Marin-Agudelo N, Ebihara T, Ndung'u T, Kaushal D, Pym AS, Kolls JK, Steyn A, Z??iga J, Horsnell W, Yokoyama WM, Shalek AK, Kl?verpris HN, Colonna M, Leslie A, Khader SA. Publisher Correction: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis. Nature. 2019 Aug; 572(7768):E10.
- Roider J, Porterfield JZ, Ogongo P, Muenchhoff M, Adland E, Groll A, Morris L, Moore PL, Ndung'u T, Kl?verpris H, Goulder PJR, Leslie A. Plasma IL-5 but Not CXCL13 Correlates With Neutralization Breadth in HIV-Infected Children. Front Immunol. 2019; 10:1497.
- Ardain A, Domingo-Gonzalez R, Das S, Kazer SW, Howard NC, Singh A, Ahmed M, Nhamoyebonde S, Rangel-Moreno J, Ogongo P, Lu L, Ramsuran D, de la Luz Garcia-Hernandez M, K Ulland T, Darby M, Park E, Karim F, Melocchi L, Madansein R, Dullabh KJ, Dunlap M, Marin-Agudelo N, Ebihara T, Ndung'u T, Kaushal D, Pym AS, Kolls JK, Steyn A, Zúñiga J, Horsnell W, Yokoyama WM, Shalek AK, Kløverpris HN, Colonna M, Leslie A, Khader SA. Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis. Nature. 2019 06; 570(7762):528-532.
- Ogongo P, Porterfield JZ, Leslie A. Lung Tissue Resident Memory T-Cells in the Immune Response to Mycobacterium tuberculosis. Front Immunol. 2019; 10:992.
- Attaf M, Malik A, Severinsen MC, Roider J, Ogongo P, Buus S, Ndung'u T, Leslie A, Kløverpris HN, Matthews PC, Sewell AK, Goulder P. Major TCR Repertoire Perturbation by Immunodominant HLA-B*44:03-Restricted CMV-Specific T Cells. Front Immunol. 2018; 9:2539.
- Jael Obrero, Stephen Rulisa, Paul Ogongo and Charles S Wiysonge. Nifuratel‐Nystatin combination for the treatment of mixed infections of bacterial vaginosis, vulvovaginal candidiasis, and trichomonal vaginitis. Cochrane Database Systematic Reviews. 2018; (4).
- Ogongo P, Kariuki TM, Wilson RA. Diagnosis of schistosomiasis mansoni: an evaluation of existing methods and research towards single worm pair detection. Parasitology. 2018 09; 145(11):1355-1366.
- Carvalho-Queiroz C, Nyakundi R, Ogongo P, Rikoi H, Egilmez NK, Farah IO, Kariuki TM, LoVerde PT. Protective Potential of Antioxidant Enzymes as Vaccines for Schistosomiasis in a Non-Human Primate Model. Front Immunol. 2015; 6:273.
- P. Ogongo. Identification and evaluation of Schistosoma mansoni proteins as diagnostic targets for schistosomiasis. International Journal of Infectious Diseases. 2014 Apr 1; 21:365.