Laurence Huang, MD

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Laurence Huang, MD

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Professor, School of Medicine
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Biography

I am a pulmonary and critical care medicine specialist with a research focus on pulmonary diseases affecting persons with HIV with a global perspective. I am a clinical-translational researcher with clinical cohorts in San Francisco, CA and in Kampala, Uganda. Currently, I am PI/Co-PI on these main studies: I AM OLD and I AM OLD-DA (renewal): The Inflammation, Aging, Microbes and Obstructive Lung Disease (I AM OLD) Study and The Inflammation, Aging, Microbes, Obstructive Lung Disease, and Diffusion Abnormalities (I AM OLD-DA) Study is a multi-cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to examine potential mechanisms for development of obstructive lung disease and progression of airflow obstruction and diffusion abnormalities in a multi-national cohort of HIV-infected subjects with opportunistic pneumonia. I AM GOLD: The Integrated Analysis of Microbial and Genomic data in Obstructive Lung Disease (I AM GOLD) Study is a multi-cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to examine airway microbial communities (the lung microbiome) and inflammatory gene expression markers at the time of acute infection and during chronic stable disease that are associated with HIV-associated COPD and lung function decline in HIV and to perform integrative analyses of the airway microbiome, microbial and human transcriptome, metabolome and lung radiographic changes in HIV-associated COPD. Recent, former studies: IHOP: The International HIV-associated Opportunistic Pneumonias (IHOP) Study is a multi-national cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to improve our understanding of the epidemiology, etiology, and outcome of pneumonias in persons with HIV infection. IHOP was part of the Lung HIV Study, a collaborative multi-R01 consortium established by the National Heart, Lung, and Blood Institute (NHLBI) to examine a diverse range of infectious and non-infectious pulmonary diseases in HIV-infected persons. Lung MicroCHIP: The Lung Microbiome in Cohorts of HIV-Infected Persons (Lung MicroChip) Study is a multi-cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to examine the composition and function of the lung microbiome in persons with HIV. Lung MicroChip was part of the Lung HIV Microbiome Project, a collaborative multi-U01 consortium established by the NHLBI to study the lung microbiome in HIV infection. I am also involved in training the next generation of clinical and translational researchers at both fellowship and junior faculty levels, including through the following NIH-funded training programs: Multidisciplinary Training Program in Lung Disease (NIH T32 HL007185): This is a continuation of the UCSF Multidisciplinary Training Program in Lung Disease, which provides training in basic and clinical sciences important to the respiratory system. The program draws on the basic and clinical research skills of the broad group of faculty at UCSF addressing questions directly relevant to lung biology and disease. The grant is to accommodate a total of 13 postdoctoral trainees, including both MDs and PhDs. The main program is an actual research experience under the close supervision of a Preceptor and a review committee selected on the basis of the experimental approaches of the trainee. These approaches include disciplines applicable at the molecular, cellular, tissue, organ, whole animal, clinical, or population levels. CHIC (NIH K12 HL143961): The UCSF Career Development Program in Cardiopulmonary, Hematologic, and Immunologic Comorbidities of HIV (CHIC) is a K12 training grant whose goals are: (1) To recruit MD, MD/PhD and PhD scholars dedicated to independent research careers conducting clinical and translational research in HIV-related heart, lung, and blood research; (2) To design, implement, and monitor individualized and tailored research training and career development of these scholars using an interdisciplinary, team-science, and team-mentoring approach that combines didactic training in research methods with supervised research under the mentorship of an experienced faculty mentor and mentoring team; (3) To produce the ‘next generation’ of researchers in HIV-associated heart, lung and blood diseases.
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Displaying 201 - 225 of 226

  1. Beck JM, Rosen MJ, Peavy HH. Pulmonary complications of HIV infection. Report of the Fourth NHLBI Workshop. Am J Respir Crit Care Med. 2001 Dec 01; 164(11):2120-6.
  2. Navin TR, Beard CB, Huang L, del Rio C, Lee S, Pieniazek NJ, Carter JL, Le T, Hightower A, Rimland D. Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P carinii pneumonia in patients with HIV-1: a prospective study. Lancet. 2001 Aug 18; 358(9281):545-9.
  3. Soumelis V, Scott I, Gheyas F, Bouhour D, Cozon G, Cotte L, Huang L, Levy JA, Liu YJ. Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients. Blood. 2001 Aug 15; 98(4):906-12.
  4. Kazanjian P, Armstrong W, Hossler PA, Lee CH, Huang L, Beard CB, Carter J, Crane L, Duchin J, Burman W, Richardson J, Meshnick SR. Pneumocystis carinii cytochrome b mutations are associated with atovaquone exposure in patients with AIDS. J Infect Dis. 2001 Mar 01; 183(5):819-22.
  5. Meshnick SR, Hossler PA, Enger KS, Kazanjian P, Rest JS, Mindell D, Li B, Lee CH, Nimri LF, Carter JL, Beard CB, Huang L. Distribution of DHPS mutations among ITS subtypes of P. carinii f. sp. hominis. J Eukaryot Microbiol. 2001; Suppl:126S-128S.
  6. Huang L, Hecht FM. Why does Pneumocystis carinii pneumonia still occur? AIDS. 2000 Nov 10; 14(16):2611-2.
  7. Huang L, Morris AM, Beard CB. Pneumocystis carinii dihydropteroate synthase mutations and treatment with sulfa or sulfone regimens: a proposal for standardized definitions for clinical evaluation. J Eukaryot Microbiol. 2001; Suppl:180S-181S.
  8. Huang L, Hecht FM. Why does Pneumocystis carinii pneumonia still occur? AIDS. 2000 Nov 10; 14(16):2611-2.
  9. Morris AM, Swanson M, Ha H, Huang L. Geographic distribution of human immunodeficiency virus-associated Pneumocystis carinii pneumonia in San Francisco. Am J Respir Crit Care Med. 2000 Nov; 162(5):1622-6.
  10. Huang L, Beard CB, Creasman J, Levy D, Duchin JS, Lee S, Pieniazek N, Carter JL, del Rio C, Rimland D, Navin TR. Sulfa or sulfone prophylaxis and geographic region predict mutations in the Pneumocystis carinii dihydropteroate synthase gene. J Infect Dis. 2000 Oct; 182(4):1192-8.
  11. Morris AM, Huang L, Bacchetti P, Turner J, Hopewell PC, Wallace JM, Kvale PA, Rosen MJ, Glassroth J, Reichman LB, Stansell JD. Permanent declines in pulmonary function following pneumonia in human immunodeficiency virus-infected persons. The Pulmonary Complications of HIV Infection Study Group. Am J Respir Crit Care Med. 2000 Aug; 162(2 Pt 1):612-6.
  12. Morris AM, Nishimura S, Huang L. Subacute hypersensitivity pneumonitis in an HIV infected patient receiving antiretroviral therapy. Thorax. 2000 Jul; 55(7):625-7.
  13. Beard CB, Carter JL, Keely SP, Huang L, Pieniazek NJ, Moura IN, Roberts JM, Hightower AW, Bens MS, Freeman AR, Lee S, Stringer JR, Duchin JS, del Rio C, Rimland D, Baughman RP, Levy DA, Dietz VJ, Simon P, Navin TR. Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission. Emerg Infect Dis. 2000 May-Jun; 6(3):265-72.
  14. Jasmer RM, Edinburgh KJ, Thompson A, Gotway MB, Creasman JM, Webb WR, Huang L. Clinical and radiographic predictors of the etiology of pulmonary nodules in HIV-infected patients. Chest. 2000 Apr; 117(4):1023-30.
  15. Edinburgh KJ, Jasmer RM, Huang L, Reddy GP, Chung MH, Thompson A, Halvorsen RA, Webb RA. Multiple pulmonary nodules in AIDS: usefulness of CT in distinguishing among potential causes. Radiology. 2000 Feb; 214(2):427-32.
  16. Huang, L. . Definitive diagnosis or empiric therapy of Pneumocystis carinii pneumonia. Pulmonary Infections Forum. 1999; 3(3):4-5.
  17. Huang L, Stansell J, Osmond D, Turner J, Shafer KP, Fulkerson W, Kvale P, Wallace J, Rosen M, Glassroth J, Reichman L, Hopewell P. Performance of an algorithm to detect Pneumocystis carinii pneumonia in symptomatic HIV-infected persons. Pulmonary Complications of HIV Infection Study Group. Chest. 1999 Apr; 115(4):1025-32.
  18. Huang L,
    Hopewell PC. Bronchoscopy versus sputum induction as the initial procedure for the diagnosis of Pneumocystis carinii pneumonia in patients infected with HIV. Journal of Bronchology. 1998; 5:163-168.
  19. Horton CK, Huang L, Goozé L. Pseudallescheria boydii infection in AIDS. J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Feb 01; 20(2):209-11.
  20. Jasmer, R
    Huang, L. TB or not TB. AIDS Care. 1997; 5(1):70-73.
  21. Jasmer, R
    Huang, L. The challenge of multidrug-resistant tuberculosis: the clinical features, diagnosis, and treatment of TB in patients with HIV infection. HIV Newsline. 1997; 5(3):108-112.
  22. Huang, L. . Definitive diagnosis or empiric therapy of Pneumocystis carinii pneumonia. Pulmonary Infections Forum. 1999; 3(3):4-5.
  23. Holtzer CD, Jacobson MA, Hadley WK, Huang L, Stanley HD, Montanti R, Wong MK, Stansell JD. Decline in the rate of specific opportunistic infections at San Francisco General Hospital, 1994-1997. AIDS. 1998 Oct 01; 12(14):1931-3.
  24. Huang, L. Pneumocystis carinii pneumonia: who to prophylax, who to evaluate, who to treat empirically. HIV Newsline. 1996; 5(2):116-121.
  25. Huang L, Hecht FM, Stansell JD, Montanti R, Hadley WK, Hopewell PC. Suspected Pneumocystis carinii pneumonia with a negative induced sputum examination. Is early bronchoscopy useful? Am J Respir Crit Care Med. 1995 Jun; 151(6):1866-71.