Laurence Huang, MD

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Laurence Huang, MD

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Professor, School of Medicine
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I am a pulmonary and critical care medicine specialist with a research focus on pulmonary diseases affecting persons with HIV with a global perspective. I am a clinical-translational researcher with clinical cohorts in San Francisco, CA and in Kampala, Uganda. Currently, I am PI/Co-PI on these main studies: I AM OLD and I AM OLD-DA (renewal): The Inflammation, Aging, Microbes and Obstructive Lung Disease (I AM OLD) Study and The Inflammation, Aging, Microbes, Obstructive Lung Disease, and Diffusion Abnormalities (I AM OLD-DA) Study is a multi-cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to examine potential mechanisms for development of obstructive lung disease and progression of airflow obstruction and diffusion abnormalities in a multi-national cohort of HIV-infected subjects with opportunistic pneumonia. I AM GOLD: The Integrated Analysis of Microbial and Genomic data in Obstructive Lung Disease (I AM GOLD) Study is a multi-cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to examine airway microbial communities (the lung microbiome) and inflammatory gene expression markers at the time of acute infection and during chronic stable disease that are associated with HIV-associated COPD and lung function decline in HIV and to perform integrative analyses of the airway microbiome, microbial and human transcriptome, metabolome and lung radiographic changes in HIV-associated COPD. Recent, former studies: IHOP: The International HIV-associated Opportunistic Pneumonias (IHOP) Study is a multi-national cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to improve our understanding of the epidemiology, etiology, and outcome of pneumonias in persons with HIV infection. IHOP was part of the Lung HIV Study, a collaborative multi-R01 consortium established by the National Heart, Lung, and Blood Institute (NHLBI) to examine a diverse range of infectious and non-infectious pulmonary diseases in HIV-infected persons. Lung MicroCHIP: The Lung Microbiome in Cohorts of HIV-Infected Persons (Lung MicroChip) Study is a multi-cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to examine the composition and function of the lung microbiome in persons with HIV. Lung MicroChip was part of the Lung HIV Microbiome Project, a collaborative multi-U01 consortium established by the NHLBI to study the lung microbiome in HIV infection. I am also involved in training the next generation of clinical and translational researchers at both fellowship and junior faculty levels, including through the following NIH-funded training programs: Multidisciplinary Training Program in Lung Disease (NIH T32 HL007185): This is a continuation of the UCSF Multidisciplinary Training Program in Lung Disease, which provides training in basic and clinical sciences important to the respiratory system. The program draws on the basic and clinical research skills of the broad group of faculty at UCSF addressing questions directly relevant to lung biology and disease. The grant is to accommodate a total of 13 postdoctoral trainees, including both MDs and PhDs. The main program is an actual research experience under the close supervision of a Preceptor and a review committee selected on the basis of the experimental approaches of the trainee. These approaches include disciplines applicable at the molecular, cellular, tissue, organ, whole animal, clinical, or population levels. CHIC (NIH K12 HL143961): The UCSF Career Development Program in Cardiopulmonary, Hematologic, and Immunologic Comorbidities of HIV (CHIC) is a K12 training grant whose goals are: (1) To recruit MD, MD/PhD and PhD scholars dedicated to independent research careers conducting clinical and translational research in HIV-related heart, lung, and blood research; (2) To design, implement, and monitor individualized and tailored research training and career development of these scholars using an interdisciplinary, team-science, and team-mentoring approach that combines didactic training in research methods with supervised research under the mentorship of an experienced faculty mentor and mentoring team; (3) To produce the ‘next generation’ of researchers in HIV-associated heart, lung and blood diseases.
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Displaying 76 - 100 of 226

  1. Gingo MR, Balasubramani GK, Rice TB, Kingsley L, Kleerup EC, Detels R, Seaberg EC, Greenblatt RM, Holman S, Huang L, Sutton SH, Bertolet M, Morris A. Pulmonary symptoms and diagnoses are associated with HIV in the MACS and WIHS cohorts. BMC Pulm Med. 2014 Apr 30; 14:75.
  2. Iwai S, Huang D, Fong S, Jarlsberg LG, Worodria W, Yoo S, Cattamanchi A, Davis JL, Kaswabuli S, Segal M, Huang L, Lynch SV. The lung microbiome of Ugandan HIV-infected pneumonia patients is compositionally and functionally distinct from that of San Franciscan patients. PLoS One. 2014; 9(4):e95726.
  3. Campo M, Oursler KK, Huang L, Goetz MB, Rimland D, Hoo GS, Brown ST, Rodriguez-Barradas MC, Au D, Akgün KM, Shahrir S, Crothers K. Association of chronic cough and pulmonary function with 6-minute walk test performance in HIV infection. J Acquir Immune Defic Syndr. 2014 Apr 15; 65(5):557-63.
  4. Yoon C, Davis JL, Huang L, Muzoora C, Byakwaga H, Scibetta C, Bangsberg DR, Nahid P, Semitala FC, Hunt PW, Martin JN, Cattamanchi A. Point-of-care C-reactive protein testing to facilitate implementation of isoniazid preventive therapy for people living with HIV. J Acquir Immune Defic Syndr. 2014 Apr 15; 65(5):551-6.
  5. Parobek CM, Jiang LY, Patel JC, Alvarez-Martínez MJ, Miro JM, Worodria W, Andama A, Fong S, Huang L, Meshnick SR, Taylor SM, Juliano JJ. Multilocus microsatellite genotyping array for investigation of genetic epidemiology of Pneumocystis jirovecii. J Clin Microbiol. 2014 May; 52(5):1391-9.
  6. Tokman S, Barnett CF, Jarlsberg LG, Taub PR, den Boon S, Davis JL, Cattamanchi A, Worodria W, Maisel A, Huang L. Procalcitonin predicts mortality in HIV-infected Ugandan adults with lower respiratory tract infections. Respirology. 2014 Apr; 19(3):382-8.
  7. Blount RJ, Djawe K, Daly KR, Jarlsberg LG, Fong S, Balmes J, Miller RF, Walzer PD, Huang L. Ambient air pollution associated with suppressed serologic responses to Pneumocystis jirovecii in a prospective cohort of HIV-infected patients with Pneumocystis pneumonia. PLoS One. 2013; 8(11):e80795.
  8. Fitzpatrick ME, Gingo MR, Kessinger C, Lucht L, Kleerup E, Greenblatt RM, Claman D, Ponath C, Fong S, Huang L, Morris A. HIV infection is associated with diffusing capacity impairment in women. J Acquir Immune Defic Syndr. 2013 Nov 01; 64(3):284-8.
  9. Crothers K, McGinnis K, Kleerup E, Wongtrakool C, Hoo GS, Kim J, Sharafkhaneh A, Huang L, Luo Z, Thompson B, Diaz P, Kirk GD, Rom W, Detels R, Kingsley L, Morris A. HIV infection is associated with reduced pulmonary diffusing capacity. J Acquir Immune Defic Syndr. 2013 Nov 01; 64(3):271-8.
  10. Fong S, Daly KR, Tipirneni R, Jarlsberg LG, Djawe K, Koch JV, Swartzman A, Roth B, Walzer PD, Huang L. Antibody responses against Pneumocystis jirovecii in health care workers over time. Emerg Infect Dis. 2013 Oct; 19(10):1612-9.
  11. Twigg HL, Morris A, Ghedin E, Curtis JL, Huffnagle GB, Crothers K, Campbell TB, Flores SC, Fontenot AP, Beck JM, Huang L, Lynch S, Knox KS, Weinstock G. Use of bronchoalveolar lavage to assess the respiratory microbiome: signal in the noise. Lancet Respir Med. 2013 Jul; 1(5):354-6.
  12. Huang YJ, Charlson ES, Collman RG, Colombini-Hatch S, Martinez FD, Senior RM. The role of the lung microbiome in health and disease. A National Heart, Lung, and Blood Institute workshop report. Am J Respir Crit Care Med. 2013 Jun 15; 187(12):1382-7.
  13. Akgün KM, Tate JP, Pisani M, Fried T, Butt AA, Gibert CL, Huang L, Rodriguez-Barradas MC, Rimland D, Justice AC, Crothers K. Medical ICU admission diagnoses and outcomes in human immunodeficiency virus-infected and virus-uninfected veterans in the combination antiretroviral era. Crit Care Med. 2013 Jun; 41(6):1458-67.
  14. Andama AO, den Boon S, Meya D, Cattamanchi A, Worodria W, Davis JL, Walter ND, Yoo SD, Kalema N, Haller B, Huang L. Prevalence and outcomes of cryptococcal antigenemia in HIV-seropositive patients hospitalized for suspected tuberculosis in Uganda. J Acquir Immune Defic Syndr. 2013 Jun 01; 63(2):189-94.
  15. Crothers K, Huang L, Morris A. Recent global estimates indicate that approximately 34 million people are living with HIV infection. Introduction. Clin Chest Med. 2013 Jun; 34(2):xiii-xiv.
  16. Morris A, Beck JM, Schloss PD, Campbell TB, Crothers K, Curtis JL, Flores SC, Fontenot AP, Ghedin E, Huang L, Jablonski K, Kleerup E, Lynch SV, Sodergren E, Twigg H, Young VB, Bassis CM, Venkataraman A, Schmidt TM, Weinstock GM. Comparison of the respiratory microbiome in healthy nonsmokers and smokers. Am J Respir Crit Care Med. 2013 May 15; 187(10):1067-75.
  17. Lozupone C, Cota-Gomez A, Palmer BE, Linderman DJ, Charlson ES, Sodergren E, Mitreva M, Abubucker S, Martin J, Yao G, Campbell TB, Flores SC, Ackerman G, Stombaugh J, Ursell L, Beck JM, Curtis JL, Young VB, Lynch SV, Huang L, Weinstock GM, Knox KS, Twigg H, Morris A, Ghedin E, Bushman FD, Collman RG, Knight R, Fontenot AP. Widespread colonization of the lung by Tropheryma whipplei in HIV infection. Am J Respir Crit Care Med. 2013 May 15; 187(10):1110-7.
  18. Everett CK, Subramanian A, Jarisberg LG, Fei M, Huang L. Characteristics of Drug-Susceptible and Drug-Resistant Staphylococcus aureus Pneumonia in Patients with HIV. Epidemiology (Sunnyvale). 2013 May 06; 3(1).
  19. Tokman S, Huang L. Evaluation of respiratory disease. Clin Chest Med. 2013 Jun; 34(2):191-204.
  20. Miller RF, Huang L, Walzer PD. Pneumocystis pneumonia associated with human immunodeficiency virus. Clin Chest Med. 2013 Jun; 34(2):229-41.
  21. Tapley A, Switz N, Reber C, Davis JL, Miller C, Matovu JB, Worodria W, Huang L, Fletcher DA, Cattamanchi A. Mobile digital fluorescence microscopy for diagnosis of tuberculosis. J Clin Microbiol. 2013 Jun; 51(6):1774-8.
  22. Gingo MR, Balasubramani GK, Kingsley L, Rinaldo CR, Alden CB, Detels R, Greenblatt RM, Hessol NA, Holman S, Huang L, Kleerup EC, Phair J, Sutton SH, Seaberg EC, Margolick JB, Wisniewski SR, Morris A. The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts. PLoS One. 2013; 8(3):e58812.
  23. Yoon C, Subramanian A, Chi A, Crothers K, Meshnick SR, Taylor SM, Beard CB, Jarlsberg LG, Lawrence GG, Avery M, Swartzman A, Fong S, Roth B, Huang L. Dihydropteroate synthase mutations in Pneumocystis pneumonia: impact of applying different definitions of prophylaxis, mortality endpoints and mutant in a single cohort. Med Mycol. 2013 Aug; 51(6):568-75.
  24. Baxi S, Platts-Mills J, Dhruva S, Huang L, Hanks D, Dhaliwal G. A double-edged sword. J Hosp Med. 2013 Jan; 8(1):47-51.
  25. Akgün KM, Gordon K, Pisani M, Fried T, McGinnis KA, Tate JP, Butt AA, Gibert CL, Huang L, Rodriguez-Barradas MC, Rimland D, Justice AC, Crothers K. Risk factors for hospitalization and medical intensive care unit (MICU) admission among HIV-infected Veterans. J Acquir Immune Defic Syndr. 2013 Jan 01; 62(1):52-9.