Virologic and immunologic correlates of SARS-CoV-2 infection in people living with HIV

Award amount: 40,000.00

Little is known about the short- and long-term impact of SARS-CoV-2 infection in people living with HIV. In Aim 1, we will characterize a clinical cohort of PLWH with PCR-confirmed SARS-CoV-2 through a collaboration with colleagues in New York City. In Aim 2, we will characterize the SARS-CoV-2-specific T cell responses in HIVpositive and -negative individuals in the UCSF SCOPE-COVID and LIINC cohorts to determine how these differ in PLWH. In Aim 3, we will measure the effects of COVID-19 on HIV reservoir dynamics. Taken together, these studies will contribute significantly to our knowledge of this novel co-infection in PLWH.
 
Co-Investigators for this project include: 
Steven Deeks, MD, Timothy Henrich, MD; Lillian Cohn, PhD and Hsi-en Ho, MD