Nevan Krogan, PhD

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Nevan Krogan, PhD

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Member, CFAR Scientific Council
Professor, School of Medicine
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Biography

Dr. Krogan was born and raised in Regina, Saskatchewan, Canada, obtained his undergraduate degree from the University of Regina and his PhD from the University of Toronto. Dr. Krogan’s lab at UCSF focuses on developing and applying quantitative, systematic proteomic and genetic approaches to study complex biological and biomedical problems. At present time, the Krogan group is focused on studying cancer, infectious disease and psychiatric disorders.
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  1. Roguev A, Wiren M, Weissman JS, Krogan NJ. High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe. Nat Methods. 2007 Oct; 4(10):861-6.
    http://www.ncbi.nlm.nih.gov/pubmed/17660412
  2. Suter B, Pogoutse O, Guo X, Krogan N, Lewis P, Greenblatt JF, Rine J, Emili A. Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p. BMC Biol. 2007 Sep 19; 5:38.
    http://www.ncbi.nlm.nih.gov/pubmed/17643376
  3. Morrison AJ, Kim JA, Person MD, Highland J, Xiao J, Wehr TS, Hensley S, Bao Y, Shen J, Collins SR, Weissman JS, Delrow J, Krogan NJ, Haber JE, Shen X. Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses. Cell. 2007 Aug 10; 130(3):499-511.
    http://www.ncbi.nlm.nih.gov/pubmed/17551511
  4. Zaharik ML, Lamb SS, Baker KE, Krogan NJ, Neuhard J, Kelln RA. Mutations in yhiT enable utilization of exogenous pyrimidine intermediates in Salmonella enterica serovar Typhimurium. Microbiology (Reading). 2007 Aug; 153(Pt 8):2472-2482.
    http://www.ncbi.nlm.nih.gov/pubmed/17473877
  5. Wyce A, Xiao T, Whelan KA, Kosman C, Walter W, Eick D, Hughes TR, Krogan NJ, Strahl BD, Berger SL. H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex. Mol Cell. 2007 Jul 20; 27(2):275-88.
    http://www.ncbi.nlm.nih.gov/pubmed/17389874
  6. Gupta R, Kus B, Fladd C, Wasmuth J, Tonikian R, Sidhu S, Krogan NJ, Parkinson J, Rotin D. Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast. Mol Syst Biol. 2007; 3:116.
    http://www.ncbi.nlm.nih.gov/pubmed/17389396
  7. Roguev A, Krogan NJ. SIN-fully silent: HDAC complexes in fission yeast. Nat Struct Mol Biol. 2007 May; 14(5):358-9.
    http://www.ncbi.nlm.nih.gov/pubmed/17314980
  8. Ihmels J, Collins SR, Schuldiner M, Krogan NJ, Weissman JS. Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss. Mol Syst Biol. 2007; 3:86.
    http://www.ncbi.nlm.nih.gov/pubmed/16983699
  9. Laribee RN, Shibata Y, Mersman DP, Collins SR, Kemmeren P, Roguev A, Weissman JS, Briggs SD, Krogan NJ, Strahl BD. CCR4/NOT complex associates with the proteasome and regulates histone methylation. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):5836-41.
    http://www.ncbi.nlm.nih.gov/pubmed/17200106
  10. Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A, Allis CD, Toczyski DP, Weissman JS, Greenblatt JF, Krogan NJ. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature. 2007 Apr 12; 446(7137):806-10.
    http://www.ncbi.nlm.nih.gov/pubmed/17101447
  11. Butland G, Krogan NJ, Xu J, Yang WH, Aoki H, Li JS, Krogan N, Menendez J, Cagney G, Kiani GC, Jessulat MG, Datta N, Ivanov I, Abouhaidar MG, Emili A, Greenblatt J, Ganoza MC, Golshani A. Investigating the in vivo activity of the DeaD protein using protein-protein interactions and the translational activity of structured chloramphenicol acetyltransferase mRNAs. J Cell Biochem. 2007 Feb 15; 100(3):642-52.
    http://www.ncbi.nlm.nih.gov/pubmed/17088384
  12. Collins SR, Kemmeren P, Zhao XC, Greenblatt JF, Spencer F, Holstege FC, Weissman JS, Krogan NJ. Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae. Mol Cell Proteomics. 2007 Mar; 6(3):439-50.
    http://www.ncbi.nlm.nih.gov/pubmed/16936829
  13. Jiahao Huang, Nevan Krogan, Maya Schuldiner. Genetic Interaction mapping of essential genes in Saccharomyces cerevisiae. The FASEB Journal. 2007 Jan 1; 21(6):a1004-a1004.
    http://www.ncbi.nlm.nih.gov/pubmed/16872538
  14. Schuldiner M, Collins SR, Weissman JS, Krogan NJ. Quantitative genetic analysis in Saccharomyces cerevisiae using epistatic miniarray profiles (E-MAPs) and its application to chromatin functions. Methods. 2006 Dec; 40(4):344-52.
    http://www.ncbi.nlm.nih.gov/pubmed/16677414
  15. Xiao T, Shibata Y, Rao B, Laribee RN, O'Rourke R, Buck MJ, Greenblatt JF, Krogan NJ, Lieb JD, Strahl BD. The RNA polymerase II kinase Ctk1 regulates positioning of a 5' histone methylation boundary along genes. Mol Cell Biol. 2007 Jan; 27(2):721-31.
    http://www.ncbi.nlm.nih.gov/pubmed/16564010
  16. Fillingham J, Keogh MC, Krogan NJ. GammaH2AX and its role in DNA double-strand break repair. Biochem Cell Biol. 2006 Aug; 84(4):568-77.
    http://www.ncbi.nlm.nih.gov/pubmed/16554755
  17. Pitre S, Dehne F, Chan A, Cheetham J, Duong A, Emili A, Gebbia M, Greenblatt J, Jessulat M, Krogan N, Luo X, Golshani A. PIPE: a protein-protein interaction prediction engine based on the re-occurring short polypeptide sequences between known interacting protein pairs. BMC Bioinformatics. 2006 Jul 27; 7:365.
    http://www.ncbi.nlm.nih.gov/pubmed/16543219
  18. Krogan NJ, Hughes TR. Signals and systems. Genome Biol. 2006; 7(4):313.
    http://www.ncbi.nlm.nih.gov/pubmed/16738550
  19. Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D. A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell. 2006 Mar 24; 124(6):1155-68.
    http://www.ncbi.nlm.nih.gov/pubmed/16859555
  20. Krogan NJ, Cagney G, Yu H, Zhong G, Guo X, Ignatchenko A, Li J, Pu S, Datta N, Tikuisis AP, Punna T, Peregrín-Alvarez JM, Shales M, Zhang X, Davey M, Robinson MD, Paccanaro A, Bray JE, Sheung A, Beattie B, Richards DP, Canadien V, Lalev A, Mena F, Wong P, Starostine A, Canete MM, Vlasblom J, Wu S, Orsi C, Collins SR, Chandran S, Haw R, Rilstone JJ, Gandi K, Thompson NJ, Musso G, St Onge P, Ghanny S, Lam MH, Butland G, Altaf-Ul AM, Kanaya S, Shilatifard A, O'Shea E, Weissman JS, Ingles CJ, Hughes TR, Parkinson J, Gerstein M, Wodak SJ, Emili A, Greenblatt JF. Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30; 440(7084):637-43.
    http://www.ncbi.nlm.nih.gov/pubmed/16959047
  21. Keogh MC, Mennella TA, Sawa C, Berthelet S, Krogan NJ, Wolek A, Podolny V, Carpenter LR, Greenblatt JF, Baetz K, Buratowski S. The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4. Genes Dev. 2006 Mar 15; 20(6):660-5.
    http://www.ncbi.nlm.nih.gov/pubmed/16299494
  22. Brian D Strahl, R. Nicholas Laribee, Tiaojiang Xiao, Nevan J Krogan, Yoichiro Shibata, Timothy R Hughes, Jack F Greenblatt. Transcription-linked kinases that regulate histone lysine methylation states. The FASEB Journal. 2006 Mar 1; 20(5):a850-a850.
    http://www.ncbi.nlm.nih.gov/pubmed/16286008
  23. Maciag K, Altschuler SJ, Slack MD, Krogan NJ, Emili A, Greenblatt JF, Maniatis T, Wu LF. Systems-level analyses identify extensive coupling among gene expression machines. Mol Syst Biol. 2006; 2:2006.0003.
    http://www.ncbi.nlm.nih.gov/pubmed/16269340
  24. Collins SR, Schuldiner M, Krogan NJ, Weissman JS. A strategy for extracting and analyzing large-scale quantitative epistatic interaction data. Genome Biol. 2006; 7(7):R63.
    http://www.ncbi.nlm.nih.gov/pubmed/16260625
  25. Cagney G, Alvaro D, Reid RJ, Thorpe PH, Rothstein R, Krogan NJ. Functional genomics of the yeast DNA-damage response. Genome Biol. 2006; 7(9):233.
    http://www.ncbi.nlm.nih.gov/pubmed/16040246