Liusheng Huang, PhD
Co-Director, CFAR Pharmacology of Cure and Pathogenesis Subcore
Co-Dir, Drug Research Unit, School of Pharmacy
Email: liusheng.huang@ucsf.edu
Biography
As associate director of the Drug Research Unit (DRU), Dr. Huang brings nearly 20 years experience in analytical development and focus on development of novel methods for some of the most critical but understudied drugs in the world, such as drugs for malaria. His research interest is in optimizing these methods so we can quantitate drugs as close to the site of pharmacological action as is possible with the overarching goal of treating patients with the best drug regimens. Administratively, he oversees analytical work at the DRU and core activities that support our UCSF collaborators for a variety of research projects and facilitate identifying new collaborations.
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- Huang L, Ortiz de Montellano PR. Heme-protein covalent bonds in peroxidases and resistance to heme modification during halide oxidation. Arch Biochem Biophys. 2006 Feb 01; 446(1):77-83.
- Huang L, Kerns RJ. Diversity-oriented chemical modification of heparin: Identification of charge-reduced N-acyl heparin derivatives having increased selectivity for heparin-binding proteins. Bioorg Med Chem. 2006 Apr 01; 14(7):2300-13.
- Wojciechowski G, Huang L, Ortiz de Montellano PR. Autocatalytic modification of the prosthetic heme of horseradish but not lactoperoxidase by thiocyanate oxidation products. A role for heme-protein covalent cross-linking. J Am Chem Soc. 2005 Nov 16; 127(45):15871-9.
- Huang L, Wojciechowski G, Ortiz de Montellano PR. Prosthetic heme modification during halide ion oxidation. Demonstration of chloride oxidation by horseradish peroxidase. J Am Chem Soc. 2005 Apr 20; 127(15):5345-53.
- Huang L, Colas C, Ortiz de Montellano PR. Oxidation of carboxylic acids by horseradish peroxidase results in prosthetic heme modification and inactivation. J Am Chem Soc. 2004 Oct 13; 126(40):12865-73.
- Wang J, Niemevz F, Lad L, Huang L, Alvarez DE, Buldain G, Poulos TL, de Montellano PR. Human heme oxygenase oxidation of 5- and 15-phenylhemes. J Biol Chem. 2004 Oct 08; 279(41):42593-604.
- Huang L, Tao G, Li L, Chi H.. Computer-aided molecular design of HIV-1 protease dissociative inhibitors. Acta Pharmaceutica Sinica (YaoXueXueBao). 1999; (5):353-357.
- Huang L, Yang H.. Method for determination of total mercury in foods by atomic fluorescence spectrometry. J. Chinese Food Hygiene. 1997; (1):3-5.
- Yang H, Zou Z, Jin C, Yi F, Liang C, Xu X, Wang X, Huang, L. Monitoring of lead content in foodstuff in China. J. Chinese Preventive Medicine. 1995; 29:96-98.
- Yang H, Huang L, Xie B.. Study on the tolerance limit for nitrite in Chinese foods. Hygiene Research. 1995; 24:176-178.
- Yang H, Zou Z, Jin C, Gu W, Liang C, Yi F, Xie B, Huang, L.. A study on cadmium content in foods of six provinces and cities. J. Chinese Prenentive Medicine. 1994; 28:6-8.
- Yang H, Han Y, Huang L.. Survey of mercury contamination of food in some areas of China. J. Hygiene Research. 1994; 23:95-96.