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This two-day symposium examined antiretroviral therapy (ART) from the research clinician's perspective, including novel applications of ART in patient settings, new data on early infection and transmission of resistance, and chemokine receptor biology in the context of patient therapy. The symposium also sought to foster and facilitate novel, multidisciplinary research collaborations between basic science investigators and clinicians.
Presentations
Welcome: Paul A. Volberding, MD and Diane Havlir, MD
Day 1 Morning Session: The Research Frontier of Antiretroviral Therapy
Session Moderators: Drs. Harry Lampiris and Laura Napolitano
- HIV Adaptation: Genetic Hurdle, Selective Advantage and Replicative Cost
Simon Mallal, MD, Professor and Executive Director Center for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital - The Central Challenges of Viral Eradication
Joseph K. Wong, MD, Assistant Adjunct Professor of Medicine, UCSD/VAMC - Immune Activation, Viral Fitness and Disease Progression
Steven G. Deeks, MD, Associate Clinical Professor of Medicine, UCSF - Combating Susceptibility to Drug Resistance: Lessons from HIV-1 Protease
Celia Schiffer, PhD, Professor, Biochemistry and Molecular Pharmacology, University of Massachusetts
Medical School - Moderated Panel Discussion
Day 1 Afternoon Session: Chemokine Receptors and Implications for Therapy
Session Moderators: Drs. Ruth Greenblatt and Warner C. Greene
- Epidemiology and Pathogenesis of HIV-1 Co-receptor Tropism
Eric Daar, MD, Professor of Medicine, David Geffen School of Medicine, UCLA - Development of Chemokine Receptor Inhibitors and Potential Challenges in Application
Howard Mayer, MD, Senior Researcher, Global Research and Development, Pfizer, Inc. - Assays for HIV-1 Co-receptor Utilization and Inhibitor Resistance: Potential Clinical Applications
Chris Petropoulos, PhD, Vice President, Virologic, Inc. - Moderated Panel Discussion
Day 2 Morning Session: Biology of Early Infection and Transmission of Resistance
Session Moderators: Drs. Jay Levy and Rick Hecht
- Evolution of Transmitted Resistance
Walid Heneine, PhD, Chief of the Molecular Epidemiology and Zoonoses Section, HIV and Retroviral Branch - Centers for Disease Control and Prevention - HIV-1 Genetic Variation and Drug Resistance: Implications for Developing Countries
Robert Shafer, MD, Assistant Professor of Medicine, Stanford University - Recombination and Superinfection
Lisa Demeter, MD, Associate Professor, University of Rochester Medical Center - Epidemiology of Transmitted Resistance
Robert M. Grant, MD, MPH, Senior Investigator, Gladstone Institute of Virology and Immunology - How Does HIV Infection Cause Immune Deficiency?
Michael Lederman, MD, Professor of Medicine, Case Western Reserve University - Moderated Panel Discussion