Ya-Chi Ho is an Associate Professor in Department of Microbial Pathogenesis with a secondary appointment in Department of Medicine (Infectious Diseases) at Yale University School of Medicine. She works on mechanisms of HIV persistence and the clonal expansion dynamics of HIV reservoir. She received her MD (phi tau phi) and practiced as and ID attending physician in Taiwan and her PhD (phi beta kappa) at Johns Hopkins University School of Medicine. She discovered how immune selection pressure shapes HIV proviral landscape (Cell 2013, CHM 2017), pioneered single-cell profiling of HIV reservoir (STM 2020, Immunity 2022, Immunity 2023), identified HIV silencing factors and drugs (JVI 2023, JCI 2022), and identified HIV-host interactions in the 3D chromatin context (Genome Research 2023). She was elected to the American Society for Clinical Investigation (ASCI) and the Interurban Clinical Club (established by William Osler in 1905). She a Yale Top Scholar, Alan Kaplan Prize awardee, Gilead HIV Scholar, Keynote Speaker in IAS 2023, and the Director of Graduate Studies for the Yale Microbiology PhD Program.