Philip J. Rosenthal, MD

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(628) 206-8845

1001 Potrero Ave
San Francisco, CA 94110

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  • Professor, School of Medicine
  • Associate Director, UCSF-Gladstone CFAR

Biography

We have three main areas of interest, all involving malaria, one of the most important infections of humans. First, we study the basic biology of malaria parasites, including the biochemical properties and biological roles of parasite proteases and mechanisms of action of novel antimalarial agents. Second, in collaboration with industry and academic groups, we are pursuing drug discovery, evaluating protease inhibitors, oxaboroles, and other compounds as potential antimalarial drugs. Third, we study malaria in Africa, with translational and laboratory studies at UCSF and in Uganda and Burkina Faso evaluating antimalarial drug efficacy and resistance, the molecular epidemiology of malaria, the roles of host and parasite genetic polymorphisms in treatment outcomes, antimalarial pharmacokinetics and pharmacodynamics, and related areas. Finally, a new area of interest is using genetic tools to characterize causes of febrile illness in African children. In other activities, Dr. Rosenthal is Editor-in-Chief of the American Journal of Tropical Medicine and Hygiene; Chair, Scientific Advisory Committee, WorldWide Antimalarial Resistance Network; Member, Scientific Board, Infectious Diseases Data Observatory; and a member of the World Health Organization Technical Expert Group on Malaria Chemotherapy.

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  1. Arinaitwe E, Mpimbaza A, Nankabirwa JI, Kamya V, Asiimwe A, Kuule JK, Kamya MR, Drakeley C, Dorsey G, Rosenthal PJ, Staedke SG. Malaria Diagnosed in an Urban Setting Strongly Associated with Recent Overnight Travel: A Case-Control Study from Kampala, Uganda. Am J Trop Med Hyg. 2020 Aug 24. View on Pubmed
  2. Rosenthal PJ, Bausch DG, Goraleski KA, Hill DR, Jacobson JA, John CC, Breman JG. Keep Politics out of Funding Decisions for Medical Research and Public Health. Am J Trop Med Hyg. 2020 Jul 22. View on Pubmed
  3. Cuu G, Asua V, Tukwasibwe S, Nsobya S, Mpimbaza A, Rosenthal PJ. Associations between aminoquinoline resistance genotypes and clinical presentations of Plasmodium falciparum infection in Uganda. Antimicrob Agents Chemother. 2020 Jul 13. View on Pubmed
  4. Rodriguez-Baez N, Murray KF, Kleiner DE, Ling SC, Rosenthal P, Carlin K, Cooper K, Schwarz KB, Schwarzenberg SJ, Teckman JH, Ghany MG, Alawad AS. Hepatic Histology in Treatment-naïve Children With Chronic Hepatitis B Infection Living in the United States and Canada. J Pediatr Gastroenterol Nutr. 2020 Jul; 71(1):99-105. View on Pubmed
  5. Tukwasibwe S, Nakimuli A, Traherne J, Chazara O, Jayaraman J, Trowsdale J, Moffett A, Jagannathan P, Rosenthal PJ, Cose S, Colucci F. Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria. Cell Mol Immunol. 2020 Aug; 17(8):799-806. View on Pubmed
  6. Andrus JK, Evans-Gilbert T, Santos JI, Guzman MG, Rosenthal PJ, Toscano C, Valenzuela MT, Siqueira M, Etienne C, Breman JG. Perspectives on Battling COVID-19 in Countries of Latin America and the Caribbean. Am J Trop Med Hyg. 2020 08; 103(2):593-596. View on Pubmed
  7. Kumar S, Saini A, Legac J, Rosenthal PJ, Raj R, Kumar V. Amalgamating Isatin/Indole/Nitroimidazole with 7-chloroquinolines via azide-alkyne cycloaddition: Synthesis, anti-plasmodial, and cytotoxic evaluation. Chem Biol Drug Des. 2020 Jun 08. View on Pubmed
  8. Rosenthal PJ, Breman JG, Djimde AA, John CC, Kamya MR, Leke RGF, Moeti MR, Nkengasong J, Bausch DG. COVID-19: Shining the Light on Africa. Am J Trop Med Hyg. 2020 06; 102(6):1145-1148. View on Pubmed
  9. Mwebaza N, Cheah V, Forsman C, Kajubi R, Marzan F, Wallender E, Dorsey G, Rosenthal PJ, Aweeka F, Huang L. Determination of piperaquine concentration in human plasma and the correlation of capillary versus venous plasma concentrations. PLoS One. 2020; 15(5):e0233893. View on Pubmed
  10. Kancharla P, Dodean RA, Li Y, Pou S, Pybus B, Melendez V, Read L, Bane CE, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, Gaona H, Potter B, Sousa J, Marcsisin S, Caridha D, Xie L, Vuong C, Zeng Q, Zhang J, Zhang P, Lin H, Butler K, Roncal N, Gaynor-Ohnstad L, Leed SE, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Mu J, Bayles BR, Cooper RA, Reynolds KA, Smilkstein MJ, Riscoe MK, Kelly JX. Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials. J Med Chem. 2020 Jun 11; 63(11):6179-6202. View on Pubmed
  11. Rosenthal P, Narkewicz MR, Yao BB, Jolley CD, Lobritto SJ, Wen J, Molleston JP, Hsu EK, Jonas MM, Zha J, Liu L, Leung DH. Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Mini-Tabs Plus Ribavirin for Children Aged 3-11 Years with Hepatitis C Genotype 1a. Adv Ther. 2020 Jul; 37(7):3299-3310. View on Pubmed
  12. Blank BR, Gonciarz RL, Talukder P, Gut J, Legac J, Rosenthal PJ, Renslo AR. Antimalarial Trioxolanes with Superior Drug-Like Properties and In Vivo Efficacy. ACS Infect Dis. 2020 Jul 10; 6(7):1827-1835. View on Pubmed
  13. Kamya MR, Kakuru A, Muhindo M, Arinaitwe E, Nankabirwa JI, Rek J, Bigira V, Kapisi J, Wanzira H, Achan J, Natureeba P, Gasasira A, Havlir D, Jagannathan P, Rosenthal PJ, Rodriguez-Barraquer I, Dorsey G. The Impact of Control Interventions on Malaria Burden in Young Children in a Historically High-Transmission District of Uganda: A Pooled Analysis of Cohort Studies from 2007 to 2018. Am J Trop Med Hyg. 2020 May 18. View on Pubmed
  14. Newton KP, Lavine JE, Wilson L, Behling C, Vos MB, Molleston JP, Rosenthal P, Miloh T, Fishbein MH, Jain AK, Murray KF, Schwimmer JB. Alanine Aminotransferase and Gamma Glutamyl Transpeptidase Predict Histologic Improvement in Pediatric Nonalcoholic Steatohepatitis. Hepatology. 2020 May 16. View on Pubmed
  15. Rosenthal PJ. The Importance of Diagnostic Testing during a Viral Pandemic: Early Lessons from Novel Coronavirus Disease (COVID-19). Am J Trop Med Hyg. 2020 05; 102(5):915-916. View on Pubmed
  16. Verity R, Aydemir O, Brazeau NF, Watson OJ, Hathaway NJ, Mwandagalirwa MK, Marsh PW, Thwai K, Fulton T, Denton M, Morgan AP, Parr JB, Tumwebaze PK, Conrad M, Rosenthal PJ, Ishengoma DS, Ngondi J, Gutman J, Mulenga M, Norris DE, Moss WJ, Mensah BA, Myers-Hansen JL, Ghansah A, Tshefu AK, Ghani AC, Meshnick SR, Bailey JA, Juliano JJ. The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC. Nat Commun. 2020 04 30; 11(1):2107. View on Pubmed
  17. Rosenthal PJ. Are three drugs for malaria better than two? Lancet. 2020 04 25; 395(10233):1316-1317. View on Pubmed
  18. Sindhe KMV, Wu W, Legac J, Zhang YK, Easom EE, Cooper RA, Plattner JJ, Freund YR, DeRisi JL, Rosenthal PJ. Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation. mBio. 2020 01 28; 11(1). View on Pubmed
  19. Kakande E, Greenhouse B, Bajunirwe F, Drakeley C, Nankabirwa JI, Walakira A, Nsobya SL, Katureebe A, Rek J, Arinaitwe E, Rosenthal PJ, Kamya MR, Dorsey G, Rodriguez-Barraquer I. Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study. Malar J. 2020 Jan 15; 19(1):21. View on Pubmed
  20. Rosenthal PJ. Falcipain cysteine proteases of malaria parasites: An update. Biochim Biophys Acta Proteins Proteom. 2020 03; 1868(3):140362. View on Pubmed
  21. Legac J, Adeniyi AA, Kisten P, Rosenthal PJ, Singh P, Kumar V. Functionalized Naphthalimide-4-aminoquinoline Conjugates as Promising Antiplasmodials, with Mechanistic Insights. ACS Med Chem Lett. 2020 Feb 13; 11(2):154-161. View on Pubmed
  22. Aguiar L, Biosca A, Lantero E, Gut J, Vale N, Rosenthal PJ, Nogueira F, Andreu D, Fernàndez-Busquets X, Gomes P. Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates. Molecules. 2019 Dec 12; 24(24). View on Pubmed
  23. Rani A, Kumar S, Legac J, Adeniyi AA, Awolade P, Singh P, Rosenthal PJ, Kumar V. Design, synthesis, heme binding and density functional theory studies of isoindoline-dione-4-aminoquinolines as potential antiplasmodials. Future Med Chem. 2020 02; 12(3):193-205. View on Pubmed
  24. Oldenburg CE, Amza A, Cooley G, Kadri B, Nassirou B, Arnold BF, Rosenthal PJ, O'Brien KS, West SK, Bailey RL, Porco TC, Keenan JD, Lietman TM, Martin DL. Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial. Malar J. 2019 Dec 03; 18(1):389. View on Pubmed
  25. Kortz TB, Nyirenda J, Tembo D, Elfving K, Baltzell K, Bandawe G, Rosenthal PJ, Macfarlane SB, Mandala W, Nyirenda TS. Distinct Biomarker Profiles Distinguish Malawian Children with Malarial and Non-malarial Sepsis. Am J Trop Med Hyg. 2019 12; 101(6):1424-1433. View on Pubmed
  26. Tilley L, Rosenthal PJ. Malaria parasites fine-tune mutations to resist drugs. Nature. 2019 12; 576(7786):217-219. View on Pubmed
  27. Sharma B, Kaur S, Legac J, Rosenthal PJ, Kumar V. Synthesis, anti-plasmodial and cytotoxic evaluation of 1H-1,2,3-triazole/acyl hydrazide integrated tetrahydro-ß-carboline-4-aminoquinoline conjugates. Bioorg Med Chem Lett. 2020 01 15; 30(2):126810. View on Pubmed
  28. Rosenthal PJ. Be Careful What You Eat! Am J Trop Med Hyg. 2019 11; 101(5):955-956. View on Pubmed
  29. de J Parra Y, Andueza L FD, Ferrer M RE, Bruno Colmenarez J, Acosta ME, Charris J, Rosenthal PJ, Gut J. [(7-chloroquinolin-4-yl)amino]acetophenones and their copper(II) derivatives: Synthesis, characterization, computational studies and antimalarial activity. EXCLI J. 2019; 18:962-987. View on Pubmed
  30. Conrad MD, Nsobya SL, Rosenthal PJ. The Diversity of the Plasmodium falciparum K13 Propeller Domain Did Not Increase after Implementation of Artemisinin-Based Combination Therapy in Uganda. Antimicrob Agents Chemother. 2019 10; 63(10). View on Pubmed
  31. Rosenthal PJ. Artemisinin Resistance in Eastern India. Clin Infect Dis. 2019 09 13; 69(7):1153-1155. View on Pubmed
  32. Rosenthal P, Schwarz KB, Gonzalez-Peralta RP, Lin CH, Kelly DA, Nightingale S, Balistreri WF, Bansal S, Jonas MM, Massetto B, Brainard DM, Hsueh CH, Shao J, Parhy B, Davison S, Feiterna-Sperling C, Gillis LA, Indolfi G, Sokal EM, Murray KF, Wirth S. Sofosbuvir and Ribavirin Therapy for Children Aged 3 to <12 Years With Hepatitis C Virus Genotype 2 or 3 Infection. Hepatology. 2020 01; 71(1):31-43. View on Pubmed
  33. Conrad MD, Rosenthal PJ. Antimalarial drug resistance in Africa: the calm before the storm? Lancet Infect Dis. 2019 10; 19(10):e338-e351. View on Pubmed
  34. Whalen ME, Kajubi R, Chamankhah N, Huang L, Orukan F, Wallender E, Kamya MR, Dorsey G, Jagannathan P, Rosenthal PJ, Mwebaza N, Aweeka FT. Reduced Exposure to Piperaquine, Compared to Adults, in Young Children Receiving Dihydroartemisinin-Piperaquine as Malaria Chemoprevention. Clin Pharmacol Ther. 2019 12; 106(6):1310-1318. View on Pubmed
  35. Rosenthal PJ. A shorter course for anti-relapse therapy against vivax malaria. Lancet. 2019 09 14; 394(10202):898-900. View on Pubmed
  36. Guler JL, Rosenthal PJ. Mass Drug Administration to Control and Eliminate Malaria in Africa: How Do We Best Utilize the Tools at Hand? Clin Infect Dis. 2019 07 02; 69(2):287-289. View on Pubmed
  37. Lunde CS, Stebbins EE, Jumani RS, Hasan MM, Miller P, Barlow J, Freund YR, Berry P, Stefanakis R, Gut J, Rosenthal PJ, Love MS, McNamara CW, Easom E, Plattner JJ, Jacobs RT, Huston CD. Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis. Nat Commun. 2019 06 27; 10(1):2816. View on Pubmed
  38. Arzika AM, Maliki R, Boubacar N, Kane S, Cotter SY, Lebas E, Cook C, Bailey RL, West SK, Rosenthal PJ, Porco TC, Lietman TM, Keenan JD. Biannual mass azithromycin distributions and malaria parasitemia in pre-school children in Niger: A cluster-randomized, placebo-controlled trial. PLoS Med. 2019 06; 16(6):e1002835. View on Pubmed
  39. Zhan W, Visone J, Ouellette T, Harris JC, Wang R, Zhang H, Singh PK, Ginn J, Sukenick G, Wong TT, Okoro JI, Scales RM, Tumwebaze PK, Rosenthal PJ, Kafsack BFC, Cooper RA, Meinke PT, Kirkman LA, Lin G. Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors. J Med Chem. 2019 07 11; 62(13):6137-6145. View on Pubmed
  40. Ramesh A, Nakielny S, Hsu J, Kyohere M, Byaruhanga O, de Bourcy C, Egger R, Dimitrov B, Juan YF, Sheu J, Wang J, Kalantar K, Langelier C, Ruel T, Mpimbaza A, Wilson MR, Rosenthal PJ, DeRisi JL. Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda. PLoS One. 2019; 14(6):e0218318. View on Pubmed
  41. Mpimbaza A, Nayiga S, Ndeezi G, Rosenthal PJ, Karamagi C, Katahoire A. Understanding the context of delays in seeking appropriate care for children with symptoms of severe malaria in Uganda. PLoS One. 2019; 14(6):e0217262. View on Pubmed
  42. Rosenthal PJ, Tan KR. Expanded Availability of Intravenous Artesunate for the Treatment of Severe Malaria in the United States. Am J Trop Med Hyg. 2019 06; 100(6):1295-1296. View on Pubmed
  43. Stoye A, Juillard A, Tang AH, Legac J, Gut J, White KL, Charman SA, Rosenthal PJ, Grau GER, Hunt NH, Payne RJ. Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials. J Med Chem. 2019 06 13; 62(11):5562-5578. View on Pubmed
  44. Di Bisceglie AM, King WC, Lisker-Melman M, Khalili M, Belle SH, Feld JJ, Ghany MG, Janssen HLA, Lau D, Lee WM, Ling SC, Cooper S, Rosenthal P, Schwarz KB, Sterling RK, Teckman JH, Terrault N. Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B. J Viral Hepat. 2019 07; 26(7):856-865. View on Pubmed
  45. Rani A, Legac J, Rosenthal PJ, Kumar V. Substituted 1,3-dioxoisoindoline-4-aminoquinolines coupled via amide linkers: Synthesis, antiplasmodial and cytotoxic evaluation. Bioorg Chem. 2019 07; 88:102912. View on Pubmed
  46. Yeka A, Wallender E, Mulebeke R, Kibuuka A, Kigozi R, Bosco A, Kyambadde P, Opigo J, Kalyesubula S, Senzoga J, Vinden J, Conrad M, Rosenthal PJ. Comparative Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Malaria in Ugandan Children. J Infect Dis. 2019 03 15; 219(7):1112-1120. View on Pubmed
  47. Nankabirwa JI, Briggs J, Rek J, Arinaitwe E, Nayebare P, Katrak S, Staedke SG, Rosenthal PJ, Rodriguez-Barraquer I, Kamya MR, Dorsey G, Greenhouse B. Persistent Parasitemia Despite Dramatic Reduction in Malaria Incidence After 3 Rounds of Indoor Residual Spraying in Tororo, Uganda. J Infect Dis. 2019 03 15; 219(7):1104-1111. View on Pubmed
  48. Asua V, Vinden J, Conrad MD, Legac J, Kigozi SP, Kamya MR, Dorsey G, Nsobya SL, Rosenthal PJ. Changing Molecular Markers of Antimalarial Drug Sensitivity across Uganda. Antimicrob Agents Chemother. 2019 03; 63(3). View on Pubmed
  49. Rosenthal PJ, John CC, Rabinovich NR. Malaria: How Are We Doing and How Can We Do Better? Am J Trop Med Hyg. 2019 02; 100(2):239-241. View on Pubmed
  50. Wallender E, Zhang N, Conrad M, Kakuru A, Muhindo M, Tumwebaze P, Kajubi R, Mota D, Legac J, Jagannathan P, Havlir D, Kamya M, Dorsey G, Aweeka F, Rosenthal PJ, Savic RM. Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda. Antimicrob Agents Chemother. 2019 02; 63(2). View on Pubmed
  51. Chotsiri P, Zongo I, Milligan P, Compaore YD, Somé AF, Chandramohan D, Hanpithakpong W, Nosten F, Greenwood B, Rosenthal PJ, White NJ, Ouédraogo JB, Tarning J. Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children. Nat Commun. 2019 01 29; 10(1):480. View on Pubmed
  52. Arinaitwe E, Dorsey G, Nankabirwa JI, Kigozi SP, Katureebe A, Kakande E, Rek J, Rosenthal PJ, Drakeley C, Kamya MR, Staedke SG. Association Between Recent Overnight Travel and Risk of Malaria: A Prospective Cohort Study at 3 Sites in Uganda. Clin Infect Dis. 2019 01 07; 68(2):313-320. View on Pubmed
  53. Rosenthal PJ, Vinetz JM, Siegel C, Kazura JW. Volume 100 of the American Journal of Tropical Medicine and Hygiene. Am J Trop Med Hyg. 2019 01; 100(1):3-4. View on Pubmed
  54. Mpimbaza A, Katahoire A, Rosenthal PJ, Karamagi C, Ndeezi G. Caregiver responses and association with delayed care-seeking in children with uncomplicated and severe malaria. Malar J. 2018 Dec 18; 17(1):476. View on Pubmed
  55. Rosenthal PJ. Artemisinin Resistance Outside of Southeast Asia. Am J Trop Med Hyg. 2018 12; 99(6):1357-1359. View on Pubmed
  56. Nsanzabana C, Ariey F, Beck HP, Ding XC, Kamau E, Krishna S, Legrand E, Lucchi N, Miotto O, Nag S, Noedl H, Roper C, Rosenthal PJ, Schallig HDFH, Taylor SM, Volkman SK, Gonzalez IJ. Molecular assays for antimalarial drug resistance surveillance: A target product profile. PLoS One. 2018; 13(9):e0204347. View on Pubmed
  57. Mpimbaza A, Walakira A, Ndeezi G, Katahoire A, Karamagi C, Nsobya SL, Tukwasibwe S, Asua V, Rosenthal PJ. Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study. PLoS One. 2018; 13(9):e0203229. View on Pubmed
  58. Savic RM, Jagannathan P, Kajubi R, Huang L, Zhang N, Were M, Kakuru A, Muhindo MK, Mwebaza N, Wallender E, Clark TD, Opira B, Kamya M, Havlir DV, Rosenthal PJ, Dorsey G, Aweeka FT. Intermittent Preventive Treatment for Malaria in Pregnancy: Optimization of Target Concentrations of Dihydroartemisinin-Piperaquine. Clin Infect Dis. 2018 09 14; 67(7):1079-1088. View on Pubmed
  59. Siqueira-Neto JL, Debnath A, McCall LI, Bernatchez JA, Ndao M, Reed SL, Rosenthal PJ. Cysteine proteases in protozoan parasites. PLoS Negl Trop Dis. 2018 08; 12(8):e0006512. View on Pubmed
  60. Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M, Imaeda T, Okamoto R, Sato K, Michino M, Alvaro EF, Guiang LF, Sanz L, Mota DJ, Govindasamy K, Wang R, Ling Y, Tumwebaze PK, Sukenick G, Shi L, Vendome J, Bhanot P, Rosenthal PJ, Aso K, Foley MA, Cooper RA, Kafsack B, Doggett JS, Nathan CF, Lin G. Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance. Proc Natl Acad Sci U S A. 2018 07 17; 115(29):E6863-E6870. View on Pubmed
  61. Siddiqui FA, Cabrera M, Wang M, Brashear A, Kemirembe K, Wang Z, Miao J, Chookajorn T, Yang Z, Cao Y, Dong G, Rosenthal PJ, Cui L. Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association With Artemisinin Resistance. J Infect Dis. 2018 07 02; 218(3):434-442. View on Pubmed
  62. Wallender E, Vucicevic K, Jagannathan P, Huang L, Natureeba P, Kakuru A, Muhindo M, Nakalembe M, Havlir D, Kamya M, Aweeka F, Dorsey G, Rosenthal PJ, Savic RM. Predicting Optimal Dihydroartemisinin-Piperaquine Regimens to Prevent Malaria During Pregnancy for Human Immunodeficiency Virus-Infected Women Receiving Efavirenz. J Infect Dis. 2018 03 05; 217(6):964-972. View on Pubmed
  63. Capela R, Magalhães J, Miranda D, Machado M, Sanches-Vaz M, Albuquerque IS, Sharma M, Gut J, Rosenthal PJ, Frade R, Perry MJ, Moreira R, Prudêncio M, Lopes F. Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability. Eur J Med Chem. 2018 Apr 10; 149:69-78. View on Pubmed
  64. Katrak S, Nayebare P, Rek J, Arinaitwe E, Nankabirwa JI, Kamya M, Dorsey G, Rosenthal PJ, Greenhouse B. Clinical consequences of submicroscopic malaria parasitaemia in Uganda. Malar J. 2018 Feb 05; 17(1):67. View on Pubmed
  65. Dunavan CP, Rosenthal PJ. "The Way We Were" Ken Warren's Legacy and Modern Investments in Global Health. Am J Trop Med Hyg. 2017 12; 97(6):1955-1957. View on Pubmed
  66. Rasmussen SA, Ceja FG, Conrad MD, Tumwebaze PK, Byaruhanga O, Katairo T, Nsobya SL, Rosenthal PJ, Cooper RA. Changing Antimalarial Drug Sensitivities in Uganda. Antimicrob Agents Chemother. 2017 12; 61(12). View on Pubmed
  67. Rani A, Singh A, Gut J, Rosenthal PJ, Kumar V. Microwave-promoted facile access to 4-aminoquinoline-phthalimides: Synthesis and anti-plasmodial evaluation. Eur J Med Chem. 2018 Jan 01; 143:150-156. View on Pubmed
  68. Conrad MD, Mota D, Foster M, Tukwasibwe S, Legac J, Tumwebaze P, Whalen M, Kakuru A, Nayebare P, Wallender E, Havlir DV, Jagannathan P, Huang L, Aweeka F, Kamya MR, Dorsey G, Rosenthal PJ. Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Uganda. J Infect Dis. 2017 11 15; 216(8):1008-1017. View on Pubmed
  69. Conrad MD, Mota D, Musiime A, Kilama M, Rek J, Kamya M, Dorsey G, Rosenthal PJ. Comparative Prevalence of Plasmodium falciparum Resistance-Associated Genetic Polymorphisms in Parasites Infecting Humans and Mosquitoes in Uganda. Am J Trop Med Hyg. 2017 Nov; 97(5):1576-1580. View on Pubmed
  70. Mpimbaza A, Ndeezi G, Katahoire A, Rosenthal PJ, Karamagi C. Demographic, Socioeconomic, and Geographic Factors Leading to Severe Malaria and Delayed Care Seeking in Ugandan Children: A Case-Control Study. Am J Trop Med Hyg. 2017 Nov; 97(5):1513-1523. View on Pubmed
  71. Katrak S, Murphy M, Nayebare P, Rek J, Smith M, Arinaitwe E, Nankabirwa JI, Kamya M, Dorsey G, Rosenthal PJ, Greenhouse B. Performance of Loop-Mediated Isothermal Amplification for the Identification of Submicroscopic Plasmodium falciparum Infection in Uganda. Am J Trop Med Hyg. 2017 12; 97(6):1777-1781. View on Pubmed
  72. Walakira A, Tukwasibwe S, Kiggundu M, Verra F, Kakeeto P, Ruhamyankaka E, Drakeley C, Dorsey G, Kamya MR, Nsobya SL, Rosenthal PJ. Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda. Infect Genet Evol. 2017 11; 55:281-287. View on Pubmed
  73. Rosenthal PJ, Goraleski KA, Rabinovich NR, Walker PF. Let's Eliminate Diseases, Not Institutes: The Case for the Fogarty International Center. Am J Trop Med Hyg. 2017 09; 97(3):629-630. View on Pubmed
  74. Asua V, Tukwasibwe S, Conrad M, Walakira A, Nankabirwa JI, Mugenyi L, Kamya MR, Nsobya SL, Rosenthal PJ. Plasmodium Species Infecting Children Presenting with Malaria in Uganda. Am J Trop Med Hyg. 2017 Sep; 97(3):753-757. View on Pubmed
  75. Previti S, Ettari R, Cosconati S, Amendola G, Chouchene K, Wagner A, Hellmich UA, Ulrich K, Krauth-Siegel RL, Wich PR, Schmid I, Schirmeister T, Gut J, Rosenthal PJ, Grasso S, Zappalà M. Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs). J Med Chem. 2017 08 24; 60(16):6911-6923. View on Pubmed
  76. Ippolito MM, Johnson J, Mullin C, Mallow C, Morgan N, Wallender E, Li T, Rosenthal PJ. The Relative Effects of Artemether-lumefantrine and Non-artemisinin Antimalarials on Gametocyte Carriage and Transmission of Plasmodium falciparum: A Systematic Review and Meta-analysis. Clin Infect Dis. 2017 Aug 01; 65(3):486-494. View on Pubmed
  77. Kumar S, Saini A, Gut J, Rosenthal PJ, Raj R, Kumar V. 4-Aminoquinoline-chalcone/-N-acetylpyrazoline conjugates: Synthesis and antiplasmodial evaluation. Eur J Med Chem. 2017 Sep 29; 138:993-1001. View on Pubmed
  78. O'Brien KS, Cotter SY, Amza A, Kadri B, Nassirou B, Stoller NE, Zhou Z, Cotter C, West SK, Bailey RL, Rosenthal PJ, Gaynor BD, Porco TC, Lietman TM. Mass Azithromycin and Malaria Parasitemia in Niger: Results from a Community-Randomized Trial. Am J Trop Med Hyg. 2017 Sep; 97(3):696-701. View on Pubmed
  79. Blank BR, Gut J, Rosenthal PJ, Renslo AR. Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane. J Med Chem. 2017 07 27; 60(14):6400-6407. View on Pubmed
  80. Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Freund YR, Berry P, Ciaravino V, Erve JCL, Rosenthal PJ, Campo B, Gamo FJ, Sanz LM, Cao J. Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate. J Med Chem. 2017 07 13; 60(13):5889-5908. View on Pubmed
  81. Singh A, Rani A, Gut J, Rosenthal PJ, Kumar V. Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation. Chem Biol Drug Des. 2017 Oct; 90(4):590-595. View on Pubmed
  82. Tukwasibwe S, Tumwebaze P, Conrad M, Arinaitwe E, Kamya MR, Dorsey G, Nsobya SL, Greenhouse B, Rosenthal PJ. Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. Malar J. 2017 03 21; 16(1):125. View on Pubmed
  83. Sonoiki E, Ng CL, Lee MC, Guo D, Zhang YK, Zhou Y, Alley MR, Ahyong V, Sanz LM, Lafuente-Monasterio MJ, Dong C, Schupp PG, Gut J, Legac J, Cooper RA, Gamo FJ, DeRisi J, Freund YR, Fidock DA, Rosenthal PJ. A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue. Nat Commun. 2017 03 06; 8:14574. View on Pubmed
  84. Palencia A, Bougdour A, Brenier-Pinchart MP, Touquet B, Bertini RL, Sensi C, Gay G, Vollaire J, Josserand V, Easom E, Freund YR, Pelloux H, Rosenthal PJ, Cusack S, Hakimi MA. Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis. EMBO Mol Med. 2017 03; 9(3):385-394. View on Pubmed
  85. Tumwebaze P, Tukwasibwe S, Taylor A, Conrad M, Ruhamyankaka E, Asua V, Walakira A, Nankabirwa J, Yeka A, Staedke SG, Greenhouse B, Nsobya SL, Kamya MR, Dorsey G, Rosenthal PJ. Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda. J Infect Dis. 2017 02 15; 215(4):631-635. View on Pubmed
  86. Ssewanyana I, Arinaitwe E, Nankabirwa JI, Yeka A, Sullivan R, Kamya MR, Rosenthal PJ, Dorsey G, Mayanja-Kizza H, Drakeley C, Greenhouse B, Tetteh KK. Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda. Malar J. 2017 02 10; 16(1):67. View on Pubmed
  87. Rosenthal PJ, Bausch DG, Higgs S, Rabinovich NR, Hill DR, Plowe CV, Goraleski KA, Walker PF. Evidence-Based Policies on Migration and Global Health are Essential to Maintain the Health of Those Inside and Outside the United States. Am J Trop Med Hyg. 2017 Jan 11; 96(1):5-6. View on Pubmed
  88. Sonoiki E, Nsanzabana C, Legac J, Sindhe KM, DeRisi J, Rosenthal PJ. Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1. Antimicrob Agents Chemother. 2017 01; 61(1). View on Pubmed
  89. Katureebe A, Zinszer K, Arinaitwe E, Rek J, Kakande E, Charland K, Kigozi R, Kilama M, Nankabirwa J, Yeka A, Mawejje H, Mpimbaza A, Katamba H, Donnelly MJ, Rosenthal PJ, Drakeley C, Lindsay SW, Staedke SG, Smith DL, Greenhouse B, Kamya MR, Dorsey G. Measures of Malaria Burden after Long-Lasting Insecticidal Net Distribution and Indoor Residual Spraying at Three Sites in Uganda: A Prospective Observational Study. PLoS Med. 2016 Nov; 13(11):e1002167. View on Pubmed
  90. Rosenthal PJ, Hill DR, Bausch DG, Goraleski KA, Higgs S, Walker PF, Plowe CV. The (International) American Society of Tropical Medicine and Hygiene. Am J Trop Med Hyg. 2016 Nov 02; 95(5):980-982. View on Pubmed
  91. Taylor AR, Flegg JA, Holmes CC, Guérin PJ, Sibley CH, Conrad MD, Dorsey G, Rosenthal PJ. Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Plasmodium Falciparum Drug Sensitivity-Associated Haplotypes in Uganda. Open Forum Infect Dis. 2017; 4(1):ofw229. View on Pubmed
  92. Rosenthal PJ. Communicable Diseases: A Global Perspective. Am J Trop Med Hyg. 2016 Oct 05; 95(4):974-975. View on Pubmed
  93. Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S. Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase. Antimicrob Agents Chemother. 2016 10; 60(10):5817-27. View on Pubmed
  94. Nankabirwa JI, Conrad MD, Legac J, Tukwasibwe S, Tumwebaze P, Wandera B, Brooker SJ, Staedke SG, Kamya MR, Nsobya SL, Dorsey G, Rosenthal PJ. Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine in Ugandan Schoolchildren Selects for Plasmodium falciparum Transporter Polymorphisms That Modify Drug Sensitivity. Antimicrob Agents Chemother. 2016 10; 60(10):5649-54. View on Pubmed
  95. Singh A, Gut J, Rosenthal PJ, Kumar V. 4-Aminoquinoline-ferrocenyl-chalcone conjugates: Synthesis and anti-plasmodial evaluation. Eur J Med Chem. 2017 Jan 05; 125:269-277. View on Pubmed
  96. Rek J, Katrak S, Obasi H, Nayebare P, Katureebe A, Kakande E, Arinaitwe E, Nankabirwa JI, Jagannathan P, Drakeley C, Staedke SG, Smith DL, Bousema T, Kamya M, Rosenthal PJ, Dorsey G, Greenhouse B. Characterizing microscopic and submicroscopic malaria parasitaemia at three sites with varied transmission intensity in Uganda. Malar J. 2016 09 15; 15:470. View on Pubmed
  97. Carrasco MP, Machado M, Gonçalves L, Sharma M, Gut J, Lukens AK, Wirth DF, André V, Duarte MT, Guedes RC, Dos Santos DJ, Rosenthal PJ, Mazitschek R, Prudêncio M, Moreira R. Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites. ChemMedChem. 2016 10 06; 11(19):2194-2204. View on Pubmed
  98. Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, Hernandez VS, Zhang YK, Choi W, Gut J, Legac J, Cooper R, Alley MR, Freund YR, DeRisi J, Cusack S, Rosenthal PJ. Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase. Antimicrob Agents Chemother. 2016 08; 60(8):4886-95. View on Pubmed
  99. Rosenthal PJ. Azithromycin for Malaria? Am J Trop Med Hyg. 2016 07 06; 95(1):2-4. View on Pubmed
  100. Ribeiro CJ, Espadinha M, Machado M, Gut J, Gonçalves LM, Rosenthal PJ, Prudêncio M, Moreira R, Santos MM. Novel squaramides with in vitro liver stage antiplasmodial activity. Bioorg Med Chem. 2016 Apr 15; 24(8):1786-92. View on Pubmed
  101. Nankabirwa JI, Yeka A, Arinaitwe E, Kigozi R, Drakeley C, Kamya MR, Greenhouse B, Rosenthal PJ, Dorsey G, Staedke SG. Estimating malaria parasite prevalence from community surveys in Uganda: a comparison of microscopy, rapid diagnostic tests and polymerase chain reaction. Malar J. 2015 Dec 30; 14:528. View on Pubmed
  102. Yeka A, Kigozi R, Conrad MD, Lugemwa M, Okui P, Katureebe C, Belay K, Kapella BK, Chang MA, Kamya MR, Staedke SG, Dorsey G, Rosenthal PJ. Artesunate/Amodiaquine Versus Artemether/Lumefantrine for the Treatment of Uncomplicated Malaria in Uganda: A Randomized Trial. J Infect Dis. 2016 Apr 01; 213(7):1134-42. View on Pubmed
  103. Pereira NA, Monteiro Â, Machado M, Gut J, Molins E, Perry MJ, Dourado J, Moreira R, Rosenthal PJ, Prudêncio M, Santos MM. Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites. ChemMedChem. 2015 Dec; 10(12):2080-9. View on Pubmed
  104. Rosenthal PJ. Artefenomel: a promising new antimalarial drug. Lancet Infect Dis. 2016 Jan; 16(1):6-8. View on Pubmed
  105. Lauterwasser EM, Fontaine SD, Li H, Gut J, Katneni K, Charman SA, Rosenthal PJ, Bogyo M, Renslo AR. Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria. ACS Med Chem Lett. 2015 Nov 12; 6(11):1145-9. View on Pubmed
  106. Rosenthal PJ. The RTS,S/AS01 vaccine continues to show modest protection against malaria in African infants and children. Evid Based Med. 2015 Oct; 20(5):179. View on Pubmed
  107. Cui L, Mharakurwa S, Ndiaye D, Rathod PK, Rosenthal PJ. Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network. Am J Trop Med Hyg. 2015 Sep; 93(3 Suppl):57-68. View on Pubmed
  108. Helb DA, Tetteh KK, Felgner PL, Skinner J, Hubbard A, Arinaitwe E, Mayanja-Kizza H, Ssewanyana I, Kamya MR, Beeson JG, Tappero J, Smith DL, Crompton PD, Rosenthal PJ, Dorsey G, Drakeley CJ, Greenhouse B. Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):E4438-47. View on Pubmed
  109. Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Sanders V, Freund YR, Campo B, Rosenthal PJ, Bu W, Gamo FJ, Sanz LM, Ge M, Li L, Ding J, Yang Y. Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles. J Med Chem. 2015 Jul 09; 58(13):5344-54. View on Pubmed
  110. Kibuuka A, Byakika-Kibwika P, Achan J, Yeka A, Nalyazi JN, Mpimbaza A, Rosenthal PJ, Kamya MR. Bacteremia Among Febrile Ugandan Children Treated with Antimalarials Despite a Negative Malaria Test. Am J Trop Med Hyg. 2015 Aug; 93(2):276-280. View on Pubmed
  111. Cooper RA, Conrad MD, Watson QD, Huezo SJ, Ninsiima H, Tumwebaze P, Nsobya SL, Rosenthal PJ. Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays. Antimicrob Agents Chemother. 2015 Aug; 59(8):5061-4. View on Pubmed
  112. Zongo I, Milligan P, Compaore YD, Some AF, Greenwood B, Tarning J, Rosenthal PJ, Sutherland C, Nosten F, Ouedraogo JB. Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso. Antimicrob Agents Chemother. 2015 Aug; 59(8):4387-96. View on Pubmed
  113. Adjuik MA, Allan R, Anvikar AR, Ashley EA, Ba MS, Barennes H, Barnes KI, Bassat Q, Baudin E, Björkman A, Bompart F, Bonnet M, Borrmann S, Brasseur P, Bukirwa H, Checchi F, Cot M, Dahal P, D'Alessandro U, Deloron P, Desai M, Diap G, Djimde AA, Dorsey G, Doumbo OK, Espié E, Etard JF, Fanello CI, Faucher JF, Faye B, Flegg JA, Gaye O, Gething PW, González R, Grandesso F, Guerin PJ, Guthmann JP, Hamour S, Hasugian AR, Hay SI, Humphreys GS, Jullien V, Juma E, Kamya MR, Karema C, Kiechel JR, Kremsner PG, Krishna S, Lameyre V, Ibrahim LM, Lee SJ, Lell B, Mårtensson A, Massougbodji A, Menan H, Ménard D, Menéndez C, Meremikwu M, Moreira C, Nabasumba C, Nambozi M, Ndiaye JL, Nikiema F, Nsanzabana C, Ntoumi F, Ogutu BR, Olliaro P, Osorio L, Ouédraogo JB, Penali LK, Pene M, Pinoges L, Piola P, Price RN, Roper C, Rosenthal PJ, Rwagacondo CE, Same-Ekobo A, Schramm B, Seck A, Sharma B, Sibley CH, Sinou V, Sirima SB, Smith JJ, Smithuis F, Somé FA, Sow D, Staedke SG, Stepniewska K, Swarthout TD, Sylla K, Talisuna AO, Tarning J, Taylor WR, Temu EA, Thwing JI, Tjitra E, Tine RC, Tinto H, Vaillant MT, Valecha N, Van den Broek I, White NJ, Yeka A, Zongo I. The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data. BMC Med. 2015 Mar 31; 13:66. View on Pubmed
  114. Raj R, Saini A, Gut J, Rosenthal PJ, Kumar V. Synthesis and in vitro antiplasmodial evaluation of 7-chloroquinoline-chalcone and 7-chloroquinoline-ferrocenylchalcone conjugates. Eur J Med Chem. 2015 May 05; 95:230-9. View on Pubmed
  115. Rodrigues CA, Frade RF, Albuquerque IS, Perry MJ, Gut J, Machado M, Rosenthal PJ, Prudêncio M, Afonso CA, Moreira R. Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids. ChemMedChem. 2015 May; 10(5):883-90. View on Pubmed
  116. Marques AF, Gomes PS, Oliveira PL, Rosenthal PJ, Pascutti PG, Lima LM. Allosteric regulation of the Plasmodium falciparum cysteine protease falcipain-2 by heme. Arch Biochem Biophys. 2015 May 01; 573:92-9. View on Pubmed
  117. Kamya MR, Arinaitwe E, Wanzira H, Katureebe A, Barusya C, Kigozi SP, Kilama M, Tatem AJ, Rosenthal PJ, Drakeley C, Lindsay SW, Staedke SG, Smith DL, Greenhouse B, Dorsey G. Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control. Am J Trop Med Hyg. 2015 May; 92(5):903-12. View on Pubmed
  118. Tumwebaze P, Conrad MD, Walakira A, LeClair N, Byaruhanga O, Nakazibwe C, Kozak B, Bloome J, Okiring J, Kakuru A, Bigira V, Kapisi J, Legac J, Gut J, Cooper RA, Kamya MR, Havlir DV, Dorsey G, Greenhouse B, Nsobya SL, Rosenthal PJ. Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children. Antimicrob Agents Chemother. 2015; 59(6):3018-30. View on Pubmed
  119. Schwartz A, Baidjoe A, Rosenthal PJ, Dorsey G, Bousema T, Greenhouse B. The Effect of Storage and Extraction Methods on Amplification of Plasmodium falciparum DNA from Dried Blood Spots. Am J Trop Med Hyg. 2015 May; 92(5):922-5. View on Pubmed
  120. Figueiras M, Coelho L, Wicht KJ, Santos SA, Lavrado J, Gut J, Rosenthal PJ, Nogueira F, Egan TJ, Moreira R, Paulo A. N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity. Bioorg Med Chem. 2015 Apr 01; 23(7):1530-9. View on Pubmed
  121. Rosenthal PJ, Bausch DG. Perspectives on Ebola. Am J Trop Med Hyg. 2015 Feb; 92(2):219-220. View on Pubmed
  122. Hsiang MS, Greenhouse B, Rosenthal PJ. Reply to Goyal et al. J Infect Dis. 2015 May 15; 211(10):1687. View on Pubmed
  123. Conroy T, Guo JT, Elias N, Cergol KM, Gut J, Legac J, Khatoon L, Liu Y, McGowan S, Rosenthal PJ, Hunt NH, Payne RJ. Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. J Med Chem. 2014 Dec 26; 57(24):10557-63. View on Pubmed
  124. Sharma RK, Younis Y, Mugumbate G, Njoroge M, Gut J, Rosenthal PJ, Chibale K. Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2. Eur J Med Chem. 2015 Jan 27; 90:507-18. View on Pubmed
  125. Kamya MR, Kapisi J, Bigira V, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Kakuru A, Aweeka FT, Huang L, Jagannathan P, Achan J, Havlir DV, Rosenthal PJ, Dorsey G. Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial. AIDS. 2014 Nov 28; 28(18):2701-9. View on Pubmed
  126. Fontaine SD, Spangler B, Gut J, Lauterwasser EM, Rosenthal PJ, Renslo AR. Drug delivery to the malaria parasite using an arterolane-like scaffold. ChemMedChem. 2015 Jan; 10(1):47-51. View on Pubmed
  127. Taylor SM, Parobek CM, DeConti DK, Kayentao K, Coulibaly SO, Greenwood BM, Tagbor H, Williams J, Bojang K, Njie F, Desai M, Kariuki S, Gutman J, Mathanga DP, Mårtensson A, Ngasala B, Conrad MD, Rosenthal PJ, Tshefu AK, Moormann AM, Vulule JM, Doumbo OK, Ter Kuile FO, Meshnick SR, Bailey JA, Juliano JJ. Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study. J Infect Dis. 2015 Mar 01; 211(5):680-8. View on Pubmed
  128. Conrad MD, Bigira V, Kapisi J, Muhindo M, Kamya MR, Havlir DV, Dorsey G, Rosenthal PJ. Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children. PLoS One. 2014; 9(8):e105690. View on Pubmed
  129. Zongo I, Somé FA, Somda SA, Parikh S, Rouamba N, Rosenthal PJ, Tarning J, Lindegardh N, Nosten F, Ouédraogo JB. Efficacy and day 7 plasma piperaquine concentrations in African children treated for uncomplicated malaria with dihydroartemisinin-piperaquine. PLoS One. 2014; 9(8):e103200. View on Pubmed
  130. Bigira V, Kapisi J, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Osterbauer B, Aweeka FT, Huang L, Achan J, Havlir DV, Rosenthal PJ, Kamya MR, Dorsey G. Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial. PLoS Med. 2014 Aug; 11(8):e1001689. View on Pubmed
  131. Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C, Moriera C, Price RN, Mårtensson A, Rosenthal PJ, Dorsey G, Sutherland CJ, Guérin P, Davis TME, Ménard D, Adam I, Ademowo G, Arze C, Baliraine FN, Berens-Riha N, Björkman A, Borrmann S, Checchi F, Desai M, Dhorda M, Djimdé AA, El-Sayed BB, Eshetu T, Eyase F, Falade C, Faucher JF, Fröberg G, Grivoyannis A, Hamour S, Houzé S, Johnson J, Kamugisha E, Kariuki S, Kiechel JR, Kironde F, Kofoed PE, LeBras J, Malmberg M, Mwai L, Ngasala B, Nosten F, Nsobya SL, Nzila A, Oguike M, Otienoburu SD, Ogutu B, Ouédraogo JB, Piola P, Rombo L, Schramm B, Somé AF, Thwing J, Ursing J, Wong RPM, Zeynudin A, Zongo I, Plowe CV, Sibley CH. Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. Am J Trop Med Hyg. 2014 Oct; 91(4):833-843. View on Pubmed
  132. Gut J, Rosenthal PJ, Kumar V. ß-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: synthesis and antimalarial evaluation. Eur J Med Chem. 2014 Sep 12; 84:566-73. View on Pubmed
  133. Raj R, Mehra V, Gut J, Rosenthal PJ, Wicht KJ, Egan TJ, Hopper M, Wrischnik LA, Land KM, Kumar V. Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity. Eur J Med Chem. 2014 Sep 12; 84:425-32. View on Pubmed
  134. Bertoldo JB, Chiaradia-Delatorre LD, Mascarello A, Leal PC, Cordeiro MN, Nunes RJ, Sarduy ES, Rosenthal PJ, Terenzi H. Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum. J Enzyme Inhib Med Chem. 2015 Apr; 30(2):299-307. View on Pubmed
  135. Oliveira R, Guedes RC, Meireles P, Albuquerque IS, Gonçalves LM, Pires E, Bronze MR, Gut J, Rosenthal PJ, Prudêncio M, Moreira R, O'Neill PM, Lopes F. Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials. J Med Chem. 2014 Jun 12; 57(11):4916-23. View on Pubmed
  136. Wanzira H, Kakuru A, Arinaitwe E, Bigira V, Muhindo MK, Conrad M, Rosenthal PJ, Kamya MR, Tappero JW, Dorsey G. Longitudinal outcomes in a cohort of Ugandan children randomized to artemether-lumefantrine versus dihydroartemisinin-piperaquine for the treatment of malaria. Clin Infect Dis. 2014 Aug 15; 59(4):509-16. View on Pubmed
  137. Mbogo GW, Nankoberanyi S, Tukwasibwe S, Baliraine FN, Nsobya SL, Conrad MD, Arinaitwe E, Kamya M, Tappero J, Staedke SG, Dorsey G, Greenhouse B, Rosenthal PJ. Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda. Am J Trop Med Hyg. 2014 Jul; 91(1):54-61. View on Pubmed
  138. Hsiang MS, Greenhouse B, Rosenthal PJ. Point of care testing for malaria using LAMP, loop mediated isothermal amplification. J Infect Dis. 2014 Oct 15; 210(8):1167-9. View on Pubmed
  139. Carrasco MP, Newton AS, Gonçalves L, Góis A, Machado M, Gut J, Nogueira F, Hänscheid T, Guedes RC, dos Santos DJ, Rosenthal PJ, Moreira R. Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity. Eur J Med Chem. 2014 Jun 10; 80:523-34. View on Pubmed
  140. Kakuru A, Achan J, Muhindo MK, Ikilezi G, Arinaitwe E, Mwangwa F, Ruel T, Clark TD, Charlebois E, Rosenthal PJ, Havlir D, Kamya MR, Tappero JW, Dorsey G. Artemisinin-based combination therapies are efficacious and safe for treatment of uncomplicated malaria in HIV-infected Ugandan children. Clin Infect Dis. 2014 Aug 01; 59(3):446-53. View on Pubmed
  141. Paulo A, Figueiras M, Machado M, Charneira C, Lavrado J, Santos SA, Lopes D, Gut J, Rosenthal PJ, Nogueira F, Moreira R. Bis-alkylamine Indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities. J Med Chem. 2014 Apr 24; 57(8):3295-313. View on Pubmed
  142. Ruel TD, Kakuru A, Ikilezi G, Mwangwa F, Dorsey G, Rosenthal PJ, Charlebois E, Havlir D, Kamya M, Achan J. Virologic and immunologic outcomes of HIV-infected Ugandan children randomized to lopinavir/ritonavir or nonnucleoside reverse transcriptase inhibitor therapy. J Acquir Immune Defic Syndr. 2014 Apr 15; 65(5):535-41. View on Pubmed
  143. Somé AF, Zongo I, Compaoré YD, Sakandé S, Nosten F, Ouédraogo JB, Rosenthal PJ. Selection of drug resistance-mediating Plasmodium falciparum genetic polymorphisms by seasonal malaria chemoprevention in Burkina Faso. Antimicrob Agents Chemother. 2014 Jul; 58(7):3660-5. View on Pubmed
  144. Sundararaj S, Saxena AK, Sharma R, Vashisht K, Sharma S, Anvikar A, Dixit R, Rosenthal PJ, Pandey KC. Cross-talk between malarial cysteine proteases and falstatin: the BC loop as a hot-spot target. PLoS One. 2014; 9(4):e93008. View on Pubmed
  145. Taylor AR, Flegg JA, Nsobya SL, Yeka A, Kamya MR, Rosenthal PJ, Dorsey G, Sibley CH, Guerin PJ, Holmes CC. Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections. Malar J. 2014 Mar 17; 13:102. View on Pubmed
  146. Raj R, Biot C, Carrère-Kremer S, Kremer L, Guérardel Y, Gut J, Rosenthal PJ, Forge D, Kumar V. 7-chloroquinoline-isatin conjugates: antimalarial, antitubercular, and cytotoxic evaluation. Chem Biol Drug Des. 2014 May; 83(5):622-9. View on Pubmed
  147. Nankoberanyi S, Mbogo GW, LeClair NP, Conrad MD, Tumwebaze P, Tukwasibwe S, Kamya MR, Tappero J, Nsobya SL, Rosenthal PJ. Validation of the ligase detection reaction fluorescent microsphere assay for the detection of Plasmodium falciparum resistance mediating polymorphisms in Uganda. Malar J. 2014 Mar 14; 13:95. View on Pubmed
  148. Nankabirwa JI, Wandera B, Amuge P, Kiwanuka N, Dorsey G, Rosenthal PJ, Brooker SJ, Staedke SG, Kamya MR. Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: a randomized, placebo-controlled trial. Clin Infect Dis. 2014 May; 58(10):1404-12. View on Pubmed
  149. Gaynor BD, Amza A, Kadri B, Nassirou B, Lawan O, Maman L, Stoller NE, Yu SN, Chin SA, West SK, Bailey RL, Rosenthal PJ, Keenan JD, Porco TC, Lietman TM. Impact of mass azithromycin distribution on malaria parasitemia during the low-transmission season in Niger: a cluster-randomized trial. Am J Trop Med Hyg. 2014 May; 90(5):846-51. View on Pubmed
  150. Conrad MD, LeClair N, Arinaitwe E, Wanzira H, Kakuru A, Bigira V, Muhindo M, Kamya MR, Tappero JW, Greenhouse B, Dorsey G, Rosenthal PJ. Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children. J Infect Dis. 2014 Aug 01; 210(3):344-53. View on Pubmed
  151. Weldon DJ, Shah F, Chittiboyina AG, Sheri A, Chada RR, Gut J, Rosenthal PJ, Shivakumar D, Sherman W, Desai P, Jung JC, Avery MA. Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of a-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum. Bioorg Med Chem Lett. 2014 Mar 01; 24(5):1274-9. View on Pubmed
  152. Tukwasibwe S, Mugenyi L, Mbogo GW, Nankoberanyi S, Maiteki-Sebuguzi C, Joloba ML, Nsobya SL, Staedke SG, Rosenthal PJ. Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda. J Infect Dis. 2014 Jul 01; 210(1):154-7. View on Pubmed
  153. Raj R, Gut J, Rosenthal PJ, Kumar V. 1H-1,2,3-Triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates: synthesis and antimalarial evaluation. Bioorg Med Chem Lett. 2014 Feb 01; 24(3):756-9. View on Pubmed
  154. Rosenthal PJ. Changes at our journal. Am J Trop Med Hyg. 2014 Jan; 90(1):1-2. View on Pubmed
  155. Kjellin LL, Dorsey G, Rosenthal PJ, Aweeka F, Huang L. Determination of the antimalarial drug piperaquine in small volume pediatric plasma samples by LC-MS/MS. Bioanalysis. 2014; 6(23):3081-9. View on Pubmed
  156. Miranda D, Capela R, Albuquerque IS, Meireles P, Paiva I, Nogueira F, Amewu R, Gut J, Rosenthal PJ, Oliveira R, Mota MM, Moreira R, Marti F, Prudêncio M, O'Neill PM, Lopes F. Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities. ACS Med Chem Lett. 2014 Feb 13; 5(2):108-12. View on Pubmed
  157. Singh P, Raj R, Singh P, Gut J, Rosenthal PJ, Kumar V. Urea/oxalamide tethered ß-lactam-7-chloroquinoline conjugates: synthesis and in vitro antimalarial evaluation. Eur J Med Chem. 2014 Jan; 71:128-34. View on Pubmed
  158. Raj R, Biot C, Carrère-Kremer S, Kremer L, Guérardel Y, Gut J, Rosenthal PJ, Kumar V. 4-Aminoquinoline-ß-lactam conjugates: synthesis, antimalarial, and antitubercular evaluation. Chem Biol Drug Des. 2014 Feb; 83(2):191-7. View on Pubmed
  159. Mugumbate G, Newton AS, Rosenthal PJ, Gut J, Moreira R, Chibale K, Guedes RC. Novel anti-plasmodial hits identified by virtual screening of the ZINC database. J Comput Aided Mol Des. 2013 Oct; 27(10):859-71. View on Pubmed
  160. Tukulula M, Njoroge M, Abay ET, Mugumbate GC, Wiesner L, Taylor D, Gibhard L, Norman J, Swart KJ, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Kameni-Tcheudji J, Chibale K. Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds. ACS Med Chem Lett. 2013 Dec 12; 4(12):1198-202. View on Pubmed
  161. Ressurreição AS, Gonçalves D, Sitoe AR, Albuquerque IS, Gut J, Góis A, Gonçalves LM, Bronze MR, Hanscheid T, Biagini GA, Rosenthal PJ, Prudêncio M, O'Neill P, Mota MM, Lopes F, Moreira R. Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability. J Med Chem. 2013 Oct 10; 56(19):7679-90. View on Pubmed
  162. Rodrigues T, Ressurreição AS, da Cruz FP, Albuquerque IS, Gut J, Carrasco MP, Gonçalves D, Guedes RC, dos Santos DJ, Mota MM, Rosenthal PJ, Moreira R, Prudêncio M, Lopes F. Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds. Eur J Med Chem. 2013 Nov; 69:872-80. View on Pubmed
  163. Ribeiro CJ, Kumar SP, Gut J, Gonçalves LM, Rosenthal PJ, Moreira R, Santos MM. Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents. Eur J Med Chem. 2013 Nov; 69:365-72. View on Pubmed
  164. Gong L, Parikh S, Rosenthal PJ, Greenhouse B. Biochemical and immunological mechanisms by which sickle cell trait protects against malaria. Malar J. 2013 Sep 11; 12:317. View on Pubmed
  165. Prasad R, Kolla VK, Legac J, Singhal N, Navale R, Rosenthal PJ, Sijwali PS. Blocking Plasmodium falciparum development via dual inhibition of hemoglobin degradation and the ubiquitin proteasome system by MG132. PLoS One. 2013; 8(9):e73530. View on Pubmed
  166. Rosenthal PJ. The interplay between drug resistance and fitness in malaria parasites. Mol Microbiol. 2013 Sep; 89(6):1025-38. View on Pubmed
  167. Mba'ning BM, Lenta BN, Noungoué DT, Antheaume C, Fongang YF, Ngouela SA, Boyom FF, Rosenthal PJ, Tsamo E, Sewald N, Laatsch H. Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry. 2013 Dec; 96:347-52. View on Pubmed
  168. Oliveira R, Newton AS, Guedes RC, Miranda D, Amewu RK, Srivastava A, Gut J, Rosenthal PJ, O'Neill PM, Ward SA, Lopes F, Moreira R. An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites. ChemMedChem. 2013 Sep; 8(9):1528-36. View on Pubmed
  169. Tukulula M, Njoroge M, Mugumbate GC, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Heudi O, Kameni-Tcheudji J, Chibale K. Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents. Bioorg Med Chem. 2013 Sep 01; 21(17):4904-13. View on Pubmed
  170. Schuck DC, Ferreira SB, Cruz LN, da Rocha DR, Moraes MS, Nakabashi M, Rosenthal PJ, Ferreira VF, Garcia CR. Biological evaluation of hydroxynaphthoquinones as anti-malarials. Malar J. 2013 Jul 10; 12:234. View on Pubmed
  171. Gantt S, Huang ML, Magaret A, Bunts L, Selke S, Wald A, Rosenthal PJ, Dorsey G, Casper C. An artesunate-containing antimalarial treatment regimen did not suppress cytomegalovirus viremia. J Clin Virol. 2013 Sep; 58(1):276-8. View on Pubmed
  172. Ochong E, Tumwebaze PK, Byaruhanga O, Greenhouse B, Rosenthal PJ. Fitness Consequences of Plasmodium falciparum pfmdr1 Polymorphisms Inferred from Ex Vivo Culture of Ugandan Parasites. Antimicrob Agents Chemother. 2013 Sep; 57(9):4245-4251. View on Pubmed
  173. Carrasco MP, Gut J, Rodrigues T, Ribeiro MH, Lopes F, Rosenthal PJ, Moreira R, Dos Santos DJ. Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits. Mol Inform. 2013 Jul; 32(7):659-70. View on Pubmed
  174. LeClair NP, Conrad MD, Baliraine FN, Nsanzabana C, Nsobya SL, Rosenthal PJ. Optimization of a ligase detection reaction-fluorescent microsphere assay for characterization of resistance-mediating polymorphisms in African samples of Plasmodium falciparum. J Clin Microbiol. 2013 Aug; 51(8):2564-70. View on Pubmed
  175. Rodrigues T, da Cruz FP, Lafuente-Monasterio MJ, Gonçalves D, Ressurreição AS, Sitoe AR, Bronze MR, Gut J, Schneider G, Mota MM, Rosenthal PJ, Prudêncio M, Gamo FJ, Lopes F, Moreira R. Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria. J Med Chem. 2013 Jun 13; 56(11):4811-5. View on Pubmed
  176. Njogu PM, Gut J, Rosenthal PJ, Chibale K. Design, Synthesis, and Antiplasmodial Activity of Hybrid Compounds Based on (2R,3S)-N-Benzoyl-3-phenylisoserine. ACS Med Chem Lett. 2013 Jul 11; 4(7):637-41. View on Pubmed
  177. Andayi WA, Egan TJ, Gut J, Rosenthal PJ, Chibale K. Synthesis, Antiplasmodial Activity, and ß-Hematin Inhibition of Hydroxypyridone-Chloroquine Hybrids. ACS Med Chem Lett. 2013 Jul 11; 4(7):642-6. View on Pubmed
  178. Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML. In vitro and in vivo antimalarial efficacies of optimized tetracyclines. Antimicrob Agents Chemother. 2013 Jul; 57(7):3131-6. View on Pubmed
  179. Marques AF, Esser D, Rosenthal PJ, Kassack MU, Lima LM. Falcipain-2 inhibition by suramin and suramin analogues. Bioorg Med Chem. 2013 Jul 01; 21(13):3667-73. View on Pubmed
  180. Raj R, Singh P, Singh P, Gut J, Rosenthal PJ, Kumar V. Azide-alkyne cycloaddition en route to 1H-1,2,3-triazole-tethered 7-chloroquinoline-isatin chimeras: synthesis and antimalarial evaluation. Eur J Med Chem. 2013 Apr; 62:590-6. View on Pubmed
  181. Ikilezi G, Achan J, Kakuru A, Ruel T, Charlebois E, Clark TD, Rosenthal PJ, Havlir D, Kamya MR, Dorsey G. Prevalence of asymptomatic parasitemia and gametocytemia among HIV-infected Ugandan children randomized to receive different antiretroviral therapies. Am J Trop Med Hyg. 2013 Apr; 88(4):744-6. View on Pubmed
  182. Cotrin SS, Gouvêa IE, Melo PM, Bagnaresi P, Assis DM, Araújo MS, Juliano MA, Gazarini ML, Rosenthal PJ, Juliano L, Carmona AK. Substrate specificity studies of the cysteine peptidases falcipain-2 and falcipain-3 from Plasmodium falciparum and demonstration of their kininogenase activity. Mol Biochem Parasitol. 2013 Feb; 187(2):111-6. View on Pubmed
  183. Pérez BC, Teixeira C, Albuquerque IS, Gut J, Rosenthal PJ, Gomes JR, Prudêncio M, Gomes P. N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads. J Med Chem. 2013 Jan 24; 56(2):556-67. View on Pubmed
  184. Jagannathan P, Muhindo MK, Kakuru A, Arinaitwe E, Greenhouse B, Tappero J, Rosenthal PJ, Kaharuza F, Kamya MR, Dorsey G. Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda. Malar J. 2012 Dec 28; 11:435. View on Pubmed
  185. Pérez B, Teixeira C, Gomes AS, Albuquerque IS, Gut J, Rosenthal PJ, Prudêncio M, Gomes P. In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites. Bioorg Med Chem Lett. 2013 Feb 01; 23(3):610-3. View on Pubmed
  186. Keh CE, Jha AR, Nzarubara B, Lanar DE, Dutta S, Theisen M, Rosenthal PJ, Dorsey G, Nixon DF, Greenhouse B. Associations between antibodies to a panel of Plasmodium falciparum specific antigens and response to sub-optimal antimalarial therapy in Kampala, Uganda. PLoS One. 2012; 7(12):e52571. View on Pubmed
  187. Baltzell KA, Shakely D, Hsiang M, Kemere J, Ali AS, Björkman A, Mårtensson A, Omar R, Elfving K, Msellem M, Aydin-Schmidt B, Rosenthal PJ, Greenhouse B. Prevalence of PCR detectable malaria infection among febrile patients with a negative Plasmodium falciparum specific rapid diagnostic test in Zanzibar. Am J Trop Med Hyg. 2013 Feb; 88(2):289-91. View on Pubmed
  188. Mahajan SS, Gut J, Rosenthal PJ, Renslo AR. Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite. Future Med Chem. 2012 Dec; 4(18):2241-9. View on Pubmed
  189. Achan J, Kakuru A, Ikilezi G, Ruel T, Clark TD, Nsanzabana C, Charlebois E, Aweeka F, Dorsey G, Rosenthal PJ, Havlir D, Kamya MR. Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children. N Engl J Med. 2012 Nov 29; 367(22):2110-8. View on Pubmed
  190. Kamkumo RG, Ngoutane AM, Tchokouaha LR, Fokou PV, Madiesse EA, Legac J, Kezetas JJ, Lenta BN, Boyom FF, Dimo T, Mbacham WF, Gut J, Rosenthal PJ. Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo. Malar J. 2012 Nov 21; 11:382. View on Pubmed
  191. Huang L, Parikh S, Rosenthal PJ, Lizak P, Marzan F, Dorsey G, Havlir D, Aweeka FT. Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers. J Acquir Immune Defic Syndr. 2012 Nov 01; 61(3):310-6. View on Pubmed
  192. Lu X, Altharawi A, Gut J, Rosenthal PJ, Long TE. 1,4-naphthoquinone cations as antiplasmodial agents: hydroxy-, acyloxy-, and alkoxy-substituted analogues. ACS Med Chem Lett. 2012 Dec 13; 3(12):1029-33. View on Pubmed
  193. Pérez B, Teixeira C, Gut J, Rosenthal PJ, Gomes JR, Gomes P. Cinnamic acid/chloroquinoline conjugates as potent agents against chloroquine-resistant Plasmodium falciparum. ChemMedChem. 2012 Sep; 7(9):1537-40. View on Pubmed
  194. Ongarora DS, Gut J, Rosenthal PJ, Masimirembwa CM, Chibale K. Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation. Bioorg Med Chem Lett. 2012 Aug 01; 22(15):5046-50. View on Pubmed
  195. Pérez BC, Teixeira C, Figueiras M, Gut J, Rosenthal PJ, Gomes JR, Gomes P. Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials. Eur J Med Chem. 2012 Aug; 54:887-99. View on Pubmed
  196. Bagnaresi P, Barros NM, Assis DM, Melo PM, Fonseca RG, Juliano MA, Pesquero JB, Juliano L, Rosenthal PJ, Carmona AK, Gazarini ML. Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins. Malar J. 2012 May 07; 11:156. View on Pubmed
  197. Shah F, Gut J, Legac J, Shivakumar D, Sherman W, Rosenthal PJ, Avery MA. Computer-aided drug design of falcipain inhibitors: virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis. J Chem Inf Model. 2012 Mar 26; 52(3):696-710. View on Pubmed
  198. Long TE, Lu X, Galizzi M, Docampo R, Gut J, Rosenthal PJ. Phosphonium lipocations as antiparasitic agents. Bioorg Med Chem Lett. 2012 Apr 15; 22(8):2976-9. View on Pubmed
  199. Gong L, Maiteki-Sebuguzi C, Rosenthal PJ, Hubbard AE, Drakeley CJ, Dorsey G, Greenhouse B. Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait. Blood. 2012 Apr 19; 119(16):3808-14. View on Pubmed
  200. Ruel TD, Boivin MJ, Boal HE, Bangirana P, Charlebois E, Havlir DV, Rosenthal PJ, Dorsey G, Achan J, Akello C, Kamya MR, Wong JK. Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts. Clin Infect Dis. 2012 Apr; 54(7):1001-9. View on Pubmed
  201. Rosenthal PJ. How do we best diagnose malaria in Africa? Am J Trop Med Hyg. 2012 Feb; 86(2):192-193. View on Pubmed
  202. Kamya MR, Byakika-Kibwika P, Gasasira AF, Havlir D, Rosenthal PJ, Dorsey G, Achan J. The effect of HIV on malaria in the context of the current standard of care for HIV-infected populations in Africa. Future Virol. 2012; 7(7):699-708. View on Pubmed
  203. Matos J, da Cruz FP, Cabrita É, Gut J, Nogueira F, do Rosário VE, Moreira R, Rosenthal PJ, Prudêncio M, Gomes P. Novel potent metallocenes against liver stage malaria. Antimicrob Agents Chemother. 2012 Mar; 56(3):1564-70. View on Pubmed
  204. Singh P, Singh P, Kumar M, Gut J, Rosenthal PJ, Kumar K, Kumar V, Mahajan MP, Bisetty K. Synthesis, docking and in vitro antimalarial evaluation of bifunctional hybrids derived from ß-lactams and 7-chloroquinoline using click chemistry. Bioorg Med Chem Lett. 2012 Jan 01; 22(1):57-61. View on Pubmed
  205. Makanga M, Bassat Q, Falade CO, Premji ZG, Krudsood S, Hunt P, Walter V, Beck HP, Marrast AC, Cousin M, Rosenthal PJ. Efficacy and safety of artemether-lumefantrine in the treatment of acute, uncomplicated Plasmodium falciparum malaria: a pooled analysis. Am J Trop Med Hyg. 2011 Nov; 85(5):793-804. View on Pubmed
  206. Gupta V, Perez-Perez GI, Dorsey G, Rosenthal PJ, Blaser MJ. The seroprevalence of Helicobacter pylori and its relationship to malaria in Ugandan children. Trans R Soc Trop Med Hyg. 2012 Jan; 106(1):35-42. View on Pubmed
  207. Glória PM, Gut J, Gonçalves LM, Rosenthal PJ, Moreira R, Santos MM. Aza vinyl sulfones: synthesis and evaluation as antiplasmodial agents. Bioorg Med Chem. 2011 Dec 15; 19(24):7635-42. View on Pubmed
  208. Baliraine FN, Rosenthal PJ. Prolonged selection of pfmdr1 polymorphisms after treatment of falciparum malaria with artemether-lumefantrine in Uganda. J Infect Dis. 2011 Oct 01; 204(7):1120-4. View on Pubmed
  209. Rodrigues T, Moreira R, Gut J, Rosenthal PJ, O Neill PM, Biagini GA, Lopes F, dos Santos DJ, Guedes RC. Identification of new antimalarial leads by use of virtual screening against cytochrome bc1. Bioorg Med Chem. 2011 Nov 01; 19(21):6302-8. View on Pubmed
  210. Nsanzabana C, Rosenthal PJ. In vitro activity of antiretroviral drugs against Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Nov; 55(11):5073-7. View on Pubmed
  211. Gama BE, Pereira-Carvalho GA, Lutucuta Kosi FJ, Almeida de Oliveira NK, Fortes F, Rosenthal PJ, do Rosário VE, Daniel-Ribeiro CT, de Fátima Ferreira-da-Cruz M. Molecular markers of antifolate resistance in Plasmodium falciparum isolates from Luanda, Angola. Malar J. 2011 Aug 24; 10:248. View on Pubmed
  212. Capela R, Cabal GG, Rosenthal PJ, Gut J, Mota MM, Moreira R, Lopes F, Prudêncio M. Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy. Antimicrob Agents Chemother. 2011 Oct; 55(10):4698-706. View on Pubmed
  213. Kemgne EA, Mbacham WF, Boyom FF, Zollo PH, Tsamo E, Rosenthal PJ. In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants. Parasitol Res. 2012 Jan; 110(1):109-17. View on Pubmed
  214. Talisuna A, Adibaku S, Dorsey G, Kamya MR, Rosenthal PJ. Malaria in Uganda: challenges to control on the long road to elimination. II. The path forward. Acta Trop. 2012 Mar; 121(3):196-201. View on Pubmed
  215. Greenhouse B, Ho B, Hubbard A, Njama-Meya D, Narum DL, Lanar DE, Dutta S, Rosenthal PJ, Dorsey G, John CC. Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic. J Infect Dis. 2011 Jul 01; 204(1):19-26. View on Pubmed
  216. Rosenthal PJ. Lessons from sickle cell disease in the treatment and control of malaria. N Engl J Med. 2011 Jun 30; 364(26):2549-51. View on Pubmed
  217. Klonis N, Crespo-Ortiz MP, Bottova I, Abu-Bakar N, Kenny S, Rosenthal PJ, Tilley L. Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11405-10. View on Pubmed
  218. Langolf S, Machon U, Ehlers M, Sicking W, Schirmeister T, Büchhold C, Gelhaus C, Rosenthal PJ, Schmuck C. Development of antitrypanosomal and antiplasmodial nonpeptidic cysteine protease inhibitors based on N-protected-guanidino-furan and -pyrrole building blocks. ChemMedChem. 2011 Sep 05; 6(9):1581-6. View on Pubmed
  219. Achan J, Talisuna AO, Erhart A, Yeka A, Tibenderana JK, Baliraine FN, Rosenthal PJ, D'Alessandro U. Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria. Malar J. 2011 May 24; 10:144. View on Pubmed
  220. Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Bhampidipati R, Kopinathan A, Smith PJ, Chibale K. Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies. J Med Chem. 2011 May 26; 54(10):3637-49. View on Pubmed
  221. Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Mining a cathepsin inhibitor library for new antiparasitic drug leads. PLoS Negl Trop Dis. 2011 May 03; 5(5):e1023. View on Pubmed
  222. Shah F, Mukherjee P, Gut J, Legac J, Rosenthal PJ, Tekwani BL, Avery MA. Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library. J Chem Inf Model. 2011 Apr 25; 51(4):852-64. View on Pubmed
  223. Yeka A, Gasasira A, Mpimbaza A, Achan J, Nankabirwa J, Nsobya S, Staedke SG, Donnelly MJ, Wabwire-Mangen F, Talisuna A, Dorsey G, Kamya MR, Rosenthal PJ. Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts. Acta Trop. 2012 Mar; 121(3):184-95. View on Pubmed
  224. Hans RH, Wiid IJ, van Helden PD, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents. Bioorg Med Chem Lett. 2011 Apr 01; 21(7):2055-8. View on Pubmed
  225. Gut J, Ang KK, Legac J, Arkin MR, Rosenthal PJ, McKerrow JH. An image-based assay for high throughput screening of Giardia lamblia. J Microbiol Methods. 2011 Mar; 84(3):398-405. View on Pubmed
  226. Boyom FF, Fokou PV, Yamthe LR, Mfopa AN, Kemgne EM, Mbacham WF, Tsamo E, Zollo PH, Gut J, Rosenthal PJ. Potent antiplasmodial extracts from Cameroonian Annonaceae. J Ethnopharmacol. 2011 Apr 12; 134(3):717-24. View on Pubmed
  227. Praveen Kumar S, Gut J, Guedes RC, Rosenthal PJ, Santos MM, Moreira R. Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. Eur J Med Chem. 2011 Mar; 46(3):927-33. View on Pubmed
  228. Lavrado J, Cabal GG, Prudêncio M, Mota MM, Gut J, Rosenthal PJ, Díaz C, Guedes RC, dos Santos DJ, Bichenkova E, Douglas KT, Moreira R, Paulo A. Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies. J Med Chem. 2011 Feb 10; 54(3):734-50. View on Pubmed
  229. Büchold C, Hemberger Y, Heindl C, Welker A, Degel B, Pfeuffer T, Staib P, Schneider S, Rosenthal PJ, Gut J, Morschhäuser J, Bringmann G, Schirmeister T. New cis-configured aziridine-2-carboxylates as aspartic acid protease inhibitors. ChemMedChem. 2011 Jan 03; 6(1):141-52. View on Pubmed
  230. Ruel TD, Kamya MR, Li P, Pasutti W, Charlebois ED, Liegler T, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK, Achan J. Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan children. J Acquir Immune Defic Syndr. 2011 Jan 01; 56(1):44-50. View on Pubmed
  231. Rosenthal PJ. Falcipains and other cysteine proteases of malaria parasites. Adv Exp Med Biol. 2011; 712:30-48. View on Pubmed
  232. Cruz LN, Alves E, Leal MT, Juliano MA, Rosenthal PJ, Juliano L, Garcia CR. FRET peptides reveal differential proteolytic activation in intraerythrocytic stages of the malaria parasites Plasmodium berghei and Plasmodium yoelii. Int J Parasitol. 2011 Mar; 41(3-4):363-72. View on Pubmed
  233. Zhang YK, Plattner JJ, Freund YR, Easom EE, Zhou Y, Gut J, Rosenthal PJ, Waterson D, Gamo FJ, Angulo-Barturen I, Ge M, Li Z, Li L, Jian Y, Cui H, Wang H, Yang J. Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents. Bioorg Med Chem Lett. 2011 Jan 15; 21(2):644-51. View on Pubmed
  234. Gama BE, de Oliveira NK, de Souza JM, Santos F, de Carvalho LJ, Melo YF, Rosenthal PJ, Daniel-Ribeiro CT, Ferreira-da-Cruz Mde F. Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy. Malar J. 2010 Dec 08; 9:355. View on Pubmed
  235. Boyom FF, Ngouana V, Kemgne EA, Zollo PH, Menut C, Bessiere JM, Gut J, Rosenthal PJ. Antiplasmodial volatile extracts from Cleistopholis patens Engler & Diels and Uvariastrum pierreanum Engl. (Engl. & Diels) (Annonaceae) growing in Cameroon. Parasitol Res. 2011 May; 108(5):1211-7. View on Pubmed
  236. Baliraine FN, Nsobya SL, Achan J, Tibenderana JK, Talisuna AO, Greenhouse B, Rosenthal PJ. Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda. Antimicrob Agents Chemother. 2011 Feb; 55(2):615-22. View on Pubmed
  237. Sun L, Shah F, Helal MA, Wu Y, Pedduri Y, Chittiboyina AG, Gut J, Rosenthal PJ, Avery MA. Design, synthesis, and development of novel guaianolide-endoperoxides as potential antimalarial agents. J Med Chem. 2010 Nov 11; 53(21):7864-8. View on Pubmed
  238. Charlebois ED, Ruel TD, Gasasira AF, Achan J, Kateera F, Akello C, Cao H, Dorsey G, Rosenthal PJ, Ssewanyana I, Kamya MR, Havlir DV. Short-term risk of HIV disease progression and death in Ugandan children not eligible for antiretroviral therapy. J Acquir Immune Defic Syndr. 2010 Nov; 55(3):330-5. View on Pubmed
  239. Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Smith PJ, Chibale K. Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds. Bioorg Med Chem. 2010 Dec 01; 18(23):8243-56. View on Pubmed
  240. Gibbons P, Verissimo E, Araujo NC, Barton V, Nixon GL, Amewu RK, Chadwick J, Stocks PA, Biagini GA, Srivastava A, Rosenthal PJ, Gut J, Guedes RC, Moreira R, Sharma R, Berry N, Cristiano ML, Shone AE, Ward SA, O'Neill PM. Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity. J Med Chem. 2010 Nov 25; 53(22):8202-6. View on Pubmed
  241. Nankabirwa J, Cundill B, Clarke S, Kabatereine N, Rosenthal PJ, Dorsey G, Brooker S, Staedke SG. Efficacy, safety, and tolerability of three regimens for prevention of malaria: a randomized, placebo-controlled trial in Ugandan schoolchildren. PLoS One. 2010 Oct 19; 5(10):e13438. View on Pubmed
  242. Na BK, Bae YA, Zo YG, Choe Y, Kim SH, Desai PV, Avery MA, Craik CS, Kim TS, Rosenthal PJ, Kong Y. Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4. PLoS Negl Trop Dis. 2010 Oct 12; 4(10):e849. View on Pubmed
  243. Li P, Ruel T, Fujimoto K, Hatano H, Yukl S, Eller LA, Liegler T, Kamya M, Gassasira A, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK. Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypes. J Virol Methods. 2010 Dec; 170(1-2):115-20. View on Pubmed
  244. Coterón JM, Catterick D, Castro J, Chaparro MJ, Díaz B, Fernández E, Ferrer S, Gamo FJ, Gordo M, Gut J, de las Heras L, Legac J, Marco M, Miguel J, Muñoz V, Porras E, de la Rosa JC, Ruiz JR, Sandoval E, Ventosa P, Rosenthal PJ, Fiandor JM. Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series. J Med Chem. 2010 Aug 26; 53(16):6129-52. View on Pubmed
  245. Lavrado J, Gani K, Nobre PA, Santos SA, Figueiredo P, Lopes D, Rosário Vd, Gut J, Rosenthal PJ, Moreira R, Paulo A. Bis-alkylamine quindolone derivatives as new antimalarial leads. Bioorg Med Chem Lett. 2010 Oct 01; 20(19):5634-7. View on Pubmed
  246. Bebell LM, Pilcher CD, Dorsey G, Havlir D, Kamya MR, Busch MP, Dunn Williams J, Nugent CT, Bentsen C, Rosenthal PJ, Charlebois ED. Acute HIV-1 infection is highly prevalent in Ugandan adults with suspected malaria. AIDS. 2010 Jul 31; 24(12):1945-52. View on Pubmed
  247. Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Greenhouse B, Staedke SG, Kamya MR, Dorsey G, Rosenthal PJ. Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children. PLoS One. 2010 Jul 30; 5(7):e11759. View on Pubmed
  248. Khanye SD, Smith GS, Lategan C, Smith PJ, Gut J, Rosenthal PJ, Chibale K. Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity. J Inorg Biochem. 2010 Oct; 104(10):1079-83. View on Pubmed
  249. Gasasira AF, Kamya MR, Ochong EO, Vora N, Achan J, Charlebois E, Ruel T, Kateera F, Meya DN, Havlir D, Rosenthal PJ, Dorsey G. Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance. Malar J. 2010 Jun 23; 9:177. View on Pubmed
  250. Gama BE, Pereira-Carvalho GA, Lutucuta Kosi FJ, Almeida de Oliveira NK, Fortes F, Rosenthal PJ, Daniel-Ribeiro CT, de Fátima Ferreira-da-Cruz M. Plasmodium falciparum isolates from Angola show the StctVMNT haplotype in the pfcrt gene. Malar J. 2010 Jun 18; 9:174. View on Pubmed
  251. Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal PJ, Derisi JL, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK. Chemical genetics of Plasmodium falciparum. Nature. 2010 May 20; 465(7296):311-5. View on Pubmed
  252. Sijwali PS, Rosenthal PJ. Functional evaluation of Plasmodium export signals in Plasmodium berghei suggests multiple modes of protein export. PLoS One. 2010 Apr 19; 5(4):e10227. View on Pubmed
  253. Somé AF, Séré YY, Dokomajilar C, Zongo I, Rouamba N, Greenhouse B, Ouédraogo JB, Rosenthal PJ. Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina Faso. Antimicrob Agents Chemother. 2010 May; 54(5):1949-54. View on Pubmed
  254. Breuning A, Degel B, Schulz F, Büchold C, Stempka M, Machon U, Heppner S, Gelhaus C, Leippe M, Leyh M, Kisker C, Rath J, Stich A, Gut J, Rosenthal PJ, Schmuck C, Schirmeister T. Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids. J Med Chem. 2010 Mar 11; 53(5):1951-63. View on Pubmed
  255. Hans RH, Gut J, Rosenthal PJ, Chibale K. Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids. Bioorg Med Chem Lett. 2010 Apr 01; 20(7):2234-7. View on Pubmed
  256. Gupta V, Dorsey G, Hubbard AE, Rosenthal PJ, Greenhouse B. Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda. Malar J. 2010 Jan 15; 9:19. View on Pubmed
  257. Nsobya SL, Kiggundu M, Nanyunja S, Joloba M, Greenhouse B, Rosenthal PJ. In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda. Antimicrob Agents Chemother. 2010 Mar; 54(3):1200-6. View on Pubmed
  258. Hans RH, Guantai EM, Lategan C, Smith PJ, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. Synthesis, antimalarial and antitubercular activity of acetylenic chalcones. Bioorg Med Chem Lett. 2010 Feb 01; 20(3):942-4. View on Pubmed
  259. Vale N, Prudêncio M, Marques CA, Collins MS, Gut J, Nogueira F, Matos J, Rosenthal PJ, Cushion MT, do Rosário VE, Mota MM, Moreira R, Gomes P. Imidazoquines as antimalarial and antipneumocystis agents. J Med Chem. 2009 Dec 10; 52(23):7800-7. View on Pubmed
  260. Arinaitwe E, Sandison TG, Wanzira H, Kakuru A, Homsy J, Kalamya J, Kamya MR, Vora N, Greenhouse B, Rosenthal PJ, Tappero J, Dorsey G. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children. Clin Infect Dis. 2009 Dec 01; 49(11):1629-37. View on Pubmed
  261. Nawaz F, Nsobya SL, Kiggundu M, Joloba M, Rosenthal PJ. Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda. J Infect Dis. 2009 Dec 01; 200(11):1650-7. View on Pubmed
  262. Newman PM, Wanzira H, Tumwine G, Arinaitwe E, Waldman S, Achan J, Havlir D, Rosenthal PJ, Dorsey G, Clark TD, Cohan D. Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda. Malar J. 2009 Nov 14; 8:254. View on Pubmed
  263. Löser R, Gut J, Rosenthal PJ, Frizler M, Gütschow M, Andrews KT. Antimalarial activity of azadipeptide nitriles. Bioorg Med Chem Lett. 2010 Jan 01; 20(1):252-5. View on Pubmed
  264. Mwesigwa J, Parikh S, McGee B, German P, Drysdale T, Kalyango JN, Clark TD, Dorsey G, Lindegardh N, Annerberg A, Rosenthal PJ, Kamya MR, Aweeka F. Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda. Antimicrob Agents Chemother. 2010 Jan; 54(1):52-9. View on Pubmed
  265. Johnson MK, Clark TD, Njama-Meya D, Rosenthal PJ, Parikh S. Impact of the method of G6PD deficiency assessment on genetic association studies of malaria susceptibility. PLoS One. 2009 Sep 30; 4(9):e7246. View on Pubmed
  266. Machon U, Büchold C, Stempka M, Schirmeister T, Gelhaus C, Leippe M, Gut J, Rosenthal PJ, Kisker C, Leyh M, Schmuck C. On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences. J Med Chem. 2009 Sep 24; 52(18):5662-72. View on Pubmed
  267. Lavine JE, Schwimmer JB, Molleston JP, Scheimann AO, Murray KF, Abrams SH, Rosenthal P, Sanyal AJ, Robuck PR, Brunt EM, Unalp A, Tonascia J. Treatment of nonalcoholic fatty liver disease in children: TONIC trial design. Contemp Clin Trials. 2010 Jan; 31(1):62-70. View on Pubmed
  268. Jensen TP, Bukirwa H, Njama-Meya D, Francis D, Kamya MR, Rosenthal PJ, Dorsey G. Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children. Malar J. 2009 Sep 15; 8:213. View on Pubmed
  269. Butler LM, Dorsey G, Hladik W, Rosenthal PJ, Brander C, Neilands TB, Mbisa G, Whitby D, Kiepiela P, Mosam A, Mzolo S, Dollard SC, Martin JN. Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission. J Infect Dis. 2009 Aug 01; 200(3):430-8. View on Pubmed
  270. German P, Parikh S, Lawrence J, Dorsey G, Rosenthal PJ, Havlir D, Charlebois E, Hanpithakpong W, Lindegardh N, Aweeka FT. Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers. J Acquir Immune Defic Syndr. 2009 Aug 01; 51(4):424-9. View on Pubmed
  271. Achan J, Tibenderana JK, Kyabayinze D, Wabwire Mangen F, Kamya MR, Dorsey G, D'Alessandro U, Rosenthal PJ, Talisuna AO. Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial. BMJ. 2009 Jul 21; 339:b2763. View on Pubmed
  272. Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem. 2009 Sep 18; 284(38):25697-703. View on Pubmed
  273. Arico-Muendel C, Centrella PA, Contonio BD, Morgan BA, O'Donovan G, Paradise CL, Skinner SR, Sluboski B, Svendsen JL, White KF, Debnath A, Gut J, Wilson N, McKerrow JH, DeRisi JL, Rosenthal PJ, Chiang PK. Antiparasitic activities of novel, orally available fumagillin analogs. Bioorg Med Chem Lett. 2009 Sep 01; 19(17):5128-31. View on Pubmed
  274. Mpimbaza A, Staedke SG, Ndeezi G, Byarugaba J, Rosenthal PJ. Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda. Malar J. 2009 Jun 29; 8:145. View on Pubmed
  275. Pandey KC, Barkan DT, Sali A, Rosenthal PJ. Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum. PLoS One. 2009 May 27; 4(5):e5694. View on Pubmed
  276. Rodrigues T, Guedes RC, dos Santos DJ, Carrasco M, Gut J, Rosenthal PJ, Moreira R, Lopes F. Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials. Bioorg Med Chem Lett. 2009 Jul 01; 19(13):3476-80. View on Pubmed
  277. Capela R, Oliveira R, Gonçalves LM, Domingos A, Gut J, Rosenthal PJ, Lopes F, Moreira R. Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition. Bioorg Med Chem Lett. 2009 Jun 15; 19(12):3229-32. View on Pubmed
  278. Subramanian S, Hardt M, Choe Y, Niles RK, Johansen EB, Legac J, Gut J, Kerr ID, Craik CS, Rosenthal PJ. Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3. PLoS One. 2009; 4(4):e5156. View on Pubmed
  279. Staedke SG, Mwebaza N, Kamya MR, Clark TD, Dorsey G, Rosenthal PJ, Whitty CJ. Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial. Lancet. 2009 May 09; 373(9675):1623-31. View on Pubmed
  280. Mobula L, Lilley B, Tshefu AK, Rosenthal PJ. Resistance-mediating polymorphisms in Plasmodium falciparum infections in Kinshasa, Democratic Republic of the Congo. Am J Trop Med Hyg. 2009 Apr; 80(4):555-8. View on Pubmed
  281. Boyom FF, Kemgne EM, Tepongning R, Ngouana V, Mbacham WF, Tsamo E, Zollo PH, Gut J, Rosenthal PJ. Antiplasmodial activity of extracts from seven medicinal plants used in malaria treatment in Cameroon. J Ethnopharmacol. 2009 Jun 25; 123(3):483-8. View on Pubmed
  282. Noungoue DT, Chaabi M, Ngouela S, Antheaume C, Boyom FF, Gut J, Rosenthal PJ, Lobstein A, Tsamo E. Antimalarial compounds from the stem bark of Vismia laurentii. Z Naturforsch C J Biosci. 2009 Mar-Apr; 64(3-4):210-4. View on Pubmed
  283. Greenhouse B, Slater M, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Clark TD, Staedke SG, Kamya MR, Hubbard A, Rosenthal PJ, Dorsey G. Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistance. J Infect Dis. 2009 Mar 01; 199(5):758-65. View on Pubmed
  284. Kerr ID, Lee JH, Pandey KC, Harrison A, Sajid M, Rosenthal PJ, Brinen LS. Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. J Med Chem. 2009 Feb 12; 52(3):852-7. View on Pubmed
  285. Ssewanyana I, Baker CA, Ruel T, Bousheri S, Kamya M, Dorsey G, Rosenthal PJ, Charlebois E, Havlir D, Cao H. The Distribution and Immune Profile of T Cell Subsets in HIV-Infected Children from Uganda. AIDS Res Hum Retroviruses. 2009 Jan; 25(1):65-71. View on Pubmed
  286. Dude MA, Kaeppler U, Herb M, Schiller M, Schulz F, Vedder B, Heppner S, Pradel G, Gut J, Rosenthal PJ, Schirmeister T, Leippe M, Gelhaus C. Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid. Molecules. 2008 Dec 23; 14(1):19-35. View on Pubmed
  287. McKerrow JH, Rosenthal PJ, Swenerton R, Doyle P. Development of protease inhibitors for protozoan infections. Curr Opin Infect Dis. 2008 Dec; 21(6):668-72. View on Pubmed
  288. Nsobya SL, Kiggundu M, Joloba M, Dorsey G, Rosenthal PJ. Complexity of Plasmodium falciparum clinical samples from Uganda during short-term culture. J Infect Dis. 2008 Nov 15; 198(10):1554-7. View on Pubmed
  289. Parikh S, Rosenthal PJ. Human genetics and malaria: relevance for the design of clinical trials. J Infect Dis. 2008 Nov 01; 198(9):1255-7. View on Pubmed
  290. Dominguez JN, Leon C, Rodrigues J, Gamboa de Dominguez N, Gut J, Rosenthal PJ. Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities. Eur J Med Chem. 2009 Apr; 44(4):1457-62. View on Pubmed
  291. Kim CC, Parikh S, Sun JC, Myrick A, Lanier LL, Rosenthal PJ, DeRisi JL. Experimental malaria infection triggers early expansion of natural killer cells. Infect Immun. 2008 Dec; 76(12):5873-82. View on Pubmed
  292. Clark TD, Greenhouse B, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Staedke SG, Seto E, Kamya MR, Rosenthal PJ, Dorsey G. Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda. J Infect Dis. 2008 Aug 01; 198(3):393-400. View on Pubmed
  293. Yeka A, Dorsey G, Kamya MR, Talisuna A, Lugemwa M, Rwakimari JB, Staedke SG, Rosenthal PJ, Wabwire-Mangen F, Bukirwa H. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda. PLoS One. 2008 Jun 11; 3(6):e2390. View on Pubmed
  294. Staedke SG, Jagannathan P, Yeka A, Bukirwa H, Banek K, Maiteki-Sebuguzi C, Clark TD, Nzarubara B, Njama-Meya D, Mpimbaza A, Rosenthal PJ, Kamya MR, Wabwire-Mangen F, Dorsey G, Talisuna AO. Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda. Malar J. 2008 Jun 11; 7:107. View on Pubmed
  295. Maiteki-Sebuguzi C, Jagannathan P, Yau VM, Clark TD, Njama-Meya D, Nzarubara B, Talisuna AO, Kamya MR, Rosenthal PJ, Dorsey G, Staedke SG. Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children. Malar J. 2008 Jun 11; 7:106. View on Pubmed
  296. Ruel TD, Achan J, Gasasira AF, Charlebois ED, Mehbratu T, Rosenthal PJ, Dorsey G, Kamya MR, Kekitiinwa A, Wong J, Havlir DV. HIV RNA suppression among HIV-infected Ugandan children with measles. J Acquir Immune Defic Syndr. 2008 Jun 01; 48(2):225-7. View on Pubmed
  297. Vale N, Matos J, Gut J, Nogueira F, do Rosário V, Rosenthal PJ, Moreira R, Gomes P. Imidazolidin-4-one peptidomimetic derivatives of primaquine: synthesis and antimalarial activity. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):4150-3. View on Pubmed
  298. Angulo-Barturen I, Jiménez-Díaz MB, Mulet T, Rullas J, Herreros E, Ferrer S, Jiménez E, Mendoza A, Regadera J, Rosenthal PJ, Bathurst I, Pompliano DL, Gómez de las Heras F, Gargallo-Viola D. A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes. PLoS One. 2008 May 21; 3(5):e2252. View on Pubmed
  299. Verissimo E, Berry N, Gibbons P, Cristiano ML, Rosenthal PJ, Gut J, Ward SA, O'Neill PM. Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):4210-4. View on Pubmed
  300. Dahl EL, Rosenthal PJ. Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics. Trends Parasitol. 2008 Jun; 24(6):279-84. View on Pubmed
  301. Rosenthal PJ. Artesunate for the treatment of severe falciparum malaria. N Engl J Med. 2008 Apr 24; 358(17):1829-36. View on Pubmed
  302. Mehlotra RK, Mattera G, Bockarie MJ, Maguire JD, Baird JK, Sharma YD, Alifrangis M, Dorsey G, Rosenthal PJ, Fryauff DJ, Kazura JW, Stoneking M, Zimmerman PA. Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother. 2008 Jun; 52(6):2212-22. View on Pubmed
  303. Gasasira AF, Kamya MR, Achan J, Mebrahtu T, Kalyango JN, Ruel T, Charlebois E, Staedke SG, Kekitiinwa A, Rosenthal PJ, Havlir D, Dorsey G. High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. Clin Infect Dis. 2008 Apr 01; 46(7):985-91. View on Pubmed
  304. Ngouamegne ET, Fongang RS, Ngouela S, Boyom FF, Rohmer M, Tsamo E, Gut J, Rosenthal PJ. Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides. Chem Pharm Bull (Tokyo). 2008 Mar; 56(3):374-7. View on Pubmed
  305. Drew ME, Banerjee R, Uffman EW, Gilbertson S, Rosenthal PJ, Goldberg DE. Plasmodium food vacuole plasmepsins are activated by falcipains. J Biol Chem. 2008 May 09; 283(19):12870-6. View on Pubmed
  306. Hopkins H, Bebell L, Kambale W, Dokomajilar C, Rosenthal PJ, Dorsey G. Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda. J Infect Dis. 2008 Feb 15; 197(4):510-8. View on Pubmed
  307. Ndjakou Lenta B, Devkota KP, Ngouela S, Fekam Boyom F, Naz Q, Choudhary MI, Tsamo E, Rosenthal PJ, Sewald N. Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum. Chem Pharm Bull (Tokyo). 2008 Feb; 56(2):222-6. View on Pubmed
  308. Lavrado J, Paulo A, Gut J, Rosenthal PJ, Moreira R. Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity. Bioorg Med Chem Lett. 2008 Feb 15; 18(4):1378-81. View on Pubmed
  309. Mpimbaza A, Ndeezi G, Staedke S, Rosenthal PJ, Byarugaba J. Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial. Pediatrics. 2008 Jan; 121(1):e58-64. View on Pubmed
  310. Bebell LM, Gasasira A, Kiggundu M, Dokomajilar C, Kamya MR, Charlebois ED, Havlir D, Rosenthal PJ, Dorsey G. HIV-1 infection in patients referred for malaria blood smears at government health clinics in Uganda. J Acquir Immune Defic Syndr. 2007 Dec 15; 46(5):624-30. View on Pubmed
  311. Vale N, Collins MS, Gut J, Ferraz R, Rosenthal PJ, Cushion MT, Moreira R, Gomes P. Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. Bioorg Med Chem Lett. 2008 Jan 15; 18(2):485-8. View on Pubmed
  312. Ssewanyana I, Pietras C, Baker CA, Nghania F, Jones NG, Rosenthal PJ, Dorsey G, Cao H. Pattern of malaria-specific T-cell responses in a cohort of Ugandan children. J Trop Pediatr. 2008 Feb; 54(1):6-13. View on Pubmed
  313. Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Séré Y, Rosenthal PJ, Ouédraogo JB. Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso. Clin Infect Dis. 2007 Dec 01; 45(11):1453-61. View on Pubmed
  314. Biot C, Pradines B, Sergeant MH, Gut J, Rosenthal PJ, Chibale K. Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues. Bioorg Med Chem Lett. 2007 Dec 01; 17(23):6434-8. View on Pubmed
  315. Kamya MR, Gasasira AF, Achan J, Mebrahtu T, Ruel T, Kekitiinwa A, Charlebois ED, Rosenthal PJ, Havlir D, Dorsey G. Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children. AIDS. 2007 Oct 01; 21(15):2059-66. View on Pubmed
  316. Plowe CV, Roper C, Barnwell JW, Happi CT, Joshi HH, Mbacham W, Meshnick SR, Mugittu K, Naidoo I, Price RN, Shafer RW, Sibley CH, Sutherland CJ, Zimmerman PA, Rosenthal PJ. World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria. Malar J. 2007 Sep 06; 6:121. View on Pubmed
  317. Dahl EL, Rosenthal PJ. Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. Antimicrob Agents Chemother. 2007 Oct; 51(10):3485-90. View on Pubmed
  318. Schulz F, Gelhaus C, Degel B, Vicik R, Heppner S, Breuning A, Leippe M, Gut J, Rosenthal PJ, Schirmeister T. Screening of protease inhibitors as antiplasmodial agents. Part I: Aziridines and epoxides. ChemMedChem. 2007 Aug; 2(8):1214-24. View on Pubmed
  319. Greenhouse B, Dokomajilar C, Hubbard A, Rosenthal PJ, Dorsey G. Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials. Antimicrob Agents Chemother. 2007 Sep; 51(9):3096-103. View on Pubmed
  320. Subramanian S, Sijwali PS, Rosenthal PJ. Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole. J Biol Chem. 2007 Aug 24; 282(34):24961-9. View on Pubmed
  321. Nsobya SL, Dokomajilar C, Joloba M, Dorsey G, Rosenthal PJ. Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Antimicrob Agents Chemother. 2007 Aug; 51(8):3023-5. View on Pubmed
  322. Hopkins H, Kambale W, Kamya MR, Staedke SG, Dorsey G, Rosenthal PJ. Comparison of HRP2- and pLDH-based rapid diagnostic tests for malaria with longitudinal follow-up in Kampala, Uganda. Am J Trop Med Hyg. 2007 Jun; 76(6):1092-7. View on Pubmed
  323. Dorsey G, Staedke S, Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Dokomajilar C, Kamya MR, Rosenthal PJ. Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial. JAMA. 2007 May 23; 297(20):2210-9. View on Pubmed
  324. Kamya MR, Yeka A, Bukirwa H, Lugemwa M, Rwakimari JB, Staedke SG, Talisuna AO, Greenhouse B, Nosten F, Rosenthal PJ, Wabwire-Mangen F, Dorsey G. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. PLoS Clin Trials. 2007 May 18; 2(5):e20. View on Pubmed
  325. Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure. 2007 May; 15(5):535-43. View on Pubmed
  326. Singh A, Walker KJ, Sijwali PS, Lau AL, Rosenthal PJ. A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2. Protein Eng Des Sel. 2007 Apr; 20(4):171-7. View on Pubmed
  327. German P, Greenhouse B, Coates C, Dorsey G, Rosenthal PJ, Charlebois E, Lindegardh N, Havlir D, Aweeka FT. Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz. Clin Infect Dis. 2007 Mar 15; 44(6):889-91. View on Pubmed
  328. Parikh S, Ouedraogo JB, Goldstein JA, Rosenthal PJ, Kroetz DL. Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa. Clin Pharmacol Ther. 2007 Aug; 82(2):197-203. View on Pubmed
  329. Ndjakou Lenta B, Ngouela S, Fekam Boyom F, Tantangmo F, Feuya Tchouya GR, Tsamo E, Gut J, Rosenthal PJ, Donald Connolly J. Anti-plasmodial activity of some constituents of the root bark of Harungana madagascariensis LAM. (Hypericaceae). Chem Pharm Bull (Tokyo). 2007 Mar; 55(3):464-7. View on Pubmed
  330. Zongo I, Dorsey G, Rouamba N, Tinto H, Dokomajilar C, Guiguemde RT, Rosenthal PJ, Ouedraogo JB. Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial. Lancet. 2007 Feb 10; 369(9560):491-8. View on Pubmed
  331. León C, Rodrigues J, Gamboa de Domínguez N, Charris J, Gut J, Rosenthal PJ, Domínguez JN. Synthesis and evaluation of sulfonylurea derivatives as novel antimalarials. Eur J Med Chem. 2007 Jun; 42(6):735-42. View on Pubmed
  332. Collins WJ, Greenhouse B, Rosenthal PJ, Dorsey G. The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005. Malar J. 2006 Dec 14; 5:122. View on Pubmed
  333. Pandey KC, Singh N, Arastu-Kapur S, Bogyo M, Rosenthal PJ. Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion. PLoS Pathog. 2006 Nov; 2(11):e117. View on Pubmed
  334. Greenhouse B, Myrick A, Dokomajilar C, Woo JM, Carlson EJ, Rosenthal PJ, Dorsey G. Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infections. Am J Trop Med Hyg. 2006 Nov; 75(5):836-42. View on Pubmed
  335. Chipeleme A, Gut J, Rosenthal PJ, Chibale K. Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum. Bioorg Med Chem. 2007 Jan 01; 15(1):273-82. View on Pubmed
  336. Malamba SS, Mermin J, Reingold A, Lule JR, Downing R, Ransom R, Kigozi A, Hunt BM, Hubbard A, Rosenthal PJ, Dorsey G. Effect of cotrimoxazole prophylaxis taken by human immunodeficiency virus (HIV)-infected persons on the selection of sulfadoxine-pyrimethamine-resistant malaria parasites among HIV-uninfected household members. Am J Trop Med Hyg. 2006 Sep; 75(3):375-80. View on Pubmed
  337. Dahl EL, Shock JL, Shenai BR, Gut J, DeRisi JL, Rosenthal PJ. Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother. 2006 Sep; 50(9):3124-31. View on Pubmed
  338. Gasasira AF, Dorsey G, Kamya MR, Havlir D, Kiggundu M, Rosenthal PJ, Charlebois ED. False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria. J Clin Microbiol. 2006 Aug; 44(8):3021-4. View on Pubmed
  339. Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11503-8. View on Pubmed
  340. Sijwali PS, Koo J, Singh N, Rosenthal PJ. Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum. Mol Biochem Parasitol. 2006 Nov; 150(1):96-106. View on Pubmed
  341. Dokomajilar C, Lankoande ZM, Dorsey G, Zongo I, Ouedraogo JB, Rosenthal PJ. Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso. Am J Trop Med Hyg. 2006 Jul; 75(1):162-5. View on Pubmed
  342. Parikh S, Liu J, Sijwali P, Gut J, Goldberg DE, Rosenthal PJ. Antimalarial effects of human immunodeficiency virus type 1 protease inhibitors differ from those of the aspartic protease inhibitor pepstatin. Antimicrob Agents Chemother. 2006 Jun; 50(6):2207-9. View on Pubmed
  343. Hwang J, Bitarakwate E, Pai M, Reingold A, Rosenthal PJ, Dorsey G. Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic review. Trop Med Int Health. 2006 Jun; 11(6):789-99. View on Pubmed
  344. Bukirwa H, Yeka A, Kamya MR, Talisuna A, Banek K, Bakyaita N, Rwakimari JB, Rosenthal PJ, Wabwire-Mangen F, Dorsey G, Staedke SG. Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. PLoS Clin Trials. 2006 May; 1(1):e7. View on Pubmed
  345. Valente C, Guedes RC, Moreira R, Iley J, Gut J, Rosenthal PJ. Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum. Bioorg Med Chem Lett. 2006 Aug 01; 16(15):4115-9. View on Pubmed
  346. Musonda CC, Gut J, Rosenthal PJ, Yardley V, Carvalho de Souza RC, Chibale K. Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol. Bioorg Med Chem. 2006 Aug 15; 14(16):5605-15. View on Pubmed
  347. Dokomajilar C, Nsobya SL, Greenhouse B, Rosenthal PJ, Dorsey G. Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic. Antimicrob Agents Chemother. 2006 May; 50(5):1893-5. View on Pubmed
  348. Myrick A, Leemann E, Dokomajilar C, Hopkins H, Dorsey G, Kamya MR, Rosenthal PJ. Short report: Dynamics of Plasmodium falciparum malaria after sub-optimal therapy in Uganda. Am J Trop Med Hyg. 2006 May; 74(5):758-61. View on Pubmed
  349. Lee SA, Yeka A, Nsobya SL, Dokomajilar C, Rosenthal PJ, Talisuna A, Dorsey G. Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda. J Infect Dis. 2006 Apr 15; 193(8):1160-3. View on Pubmed
  350. Desai PV, Patny A, Gut J, Rosenthal PJ, Tekwani B, Srivastava A, Avery M. Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory. J Med Chem. 2006 Mar 09; 49(5):1576-84. View on Pubmed
  351. Francis D, Nsobya SL, Talisuna A, Yeka A, Kamya MR, Machekano R, Dokomajilar C, Rosenthal PJ, Dorsey G. Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance. J Infect Dis. 2006 Apr 01; 193(7):978-86. View on Pubmed
  352. Eggena MP, Hopkins H, Barugahare B, Okello M, Ssali F, Mugyenyi P, Rosenthal PJ, Cao H, Dorsey G. CD4 T cell activation as a predictor for treatment failure in Ugandans with Plasmodium falciparum malaria. Am J Trop Med Hyg. 2006 Jan; 74(1):41-3. View on Pubmed
  353. Ngouela S, Lenta BN, Noungoue DT, Ngoupayo J, Boyom FF, Tsamo E, Gut J, Rosenthal PJ, Connolly JD. Anti-plasmodial and antioxidant activities of constituents of the seed shells of Symphonia globulifera Linn f. Phytochemistry. 2006 Feb; 67(3):302-6. View on Pubmed
  354. Singh N, Sijwali PS, Pandey KC, Rosenthal PJ. Plasmodium falciparum: biochemical characterization of the cysteine protease falcipain-2'. Exp Parasitol. 2006 Mar; 112(3):187-92. View on Pubmed
  355. Kamya MR, Gasasira AF, Yeka A, Bakyaita N, Nsobya SL, Francis D, Rosenthal PJ, Dorsey G, Havlir D. Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study. J Infect Dis. 2006 Jan 01; 193(1):9-15. View on Pubmed
  356. Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Lankoande M, Ouedraogo JB, Rosenthal PJ. Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso. Am J Trop Med Hyg. 2005 Nov; 73(5):826-32. View on Pubmed
  357. Slater M, Kiggundu M, Dokomajilar C, Kamya MR, Bakyaita N, Talisuna A, Rosenthal PJ, Dorsey G. Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacy. Am J Trop Med Hyg. 2005 Aug; 73(2):256-62. View on Pubmed
  358. Yeka A, Banek K, Bakyaita N, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya SL, Kilian A, Slater M, Reingold A, Rosenthal PJ, Wabwire-Mangen F, Dorsey G. Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. PLoS Med. 2005 Jul; 2(7):e190. View on Pubmed
  359. Parikh S, Gut J, Istvan E, Goldberg DE, Havlir DV, Rosenthal PJ. Antimalarial activity of human immunodeficiency virus type 1 protease inhibitors. Antimicrob Agents Chemother. 2005 Jul; 49(7):2983-5. View on Pubmed
  360. Pandey KC, Wang SX, Sijwali PS, Lau AL, McKerrow JH, Rosenthal PJ. The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9138-43. View on Pubmed
  361. Domínguez JN, León C, Rodrigues J, Gamboa de Domínguez N, Gut J, Rosenthal PJ. Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives. J Med Chem. 2005 May 19; 48(10):3654-8. View on Pubmed
  362. Chiyanzu I, Clarkson C, Smith PJ, Lehman J, Gut J, Rosenthal PJ, Chibale K. Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives. Bioorg Med Chem. 2005 May 02; 13(9):3249-61. View on Pubmed
  363. Bakyaita N, Dorsey G, Yeka A, Banek K, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya S, Kilian A, Reingold A, Rosenthal PJ, Wabwire-Mangen F. Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda. Am J Trop Med Hyg. 2005 May; 72(5):573-80. View on Pubmed
  364. Domínguez JN, León C, Rodrigues J, Gamboa de Domínguez N, Gut J, Rosenthal PJ. Synthesis and antimalarial activity of sulfonamide chalcone derivatives. Farmaco. 2005 Apr; 60(4):307-11. View on Pubmed
  365. Dahl EL, Rosenthal PJ. Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum. Mol Biochem Parasitol. 2005 Feb; 139(2):205-12. View on Pubmed
  366. Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Bioorg Med Chem Lett. 2005 Jan 03; 15(1):121-3. View on Pubmed
  367. Rosenthal PJ. Cysteine proteases of malaria parasites. Int J Parasitol. 2004 Dec; 34(13-14):1489-99. View on Pubmed
  368. Parikh S, Dorsey G, Rosenthal PJ. Host polymorphisms and the incidence of malaria in Ugandan children. Am J Trop Med Hyg. 2004 Dec; 71(6):750-3. View on Pubmed
  369. Dorsey G, Dokomajilar C, Kiggundu M, Staedke SG, Kamya MR, Rosenthal PJ. Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda. Am J Trop Med Hyg. 2004 Dec; 71(6):758-63. View on Pubmed
  370. Staedke SG, Mpimbaza A, Kamya MR, Nzarubara BK, Dorsey G, Rosenthal PJ. Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial. Lancet. 2004 Nov 27-Dec 3; 364(9449):1950-7. View on Pubmed
  371. Na BK, Kim TS, Rosenthal PJ, Lee JK, Kong Y. Evaluation of cysteine proteases of Plasmodium vivax as antimalarial drug targets: sequence analysis and sensitivity to cysteine protease inhibitors. Parasitol Res. 2004 Oct; 94(4):312-7. View on Pubmed
  372. Go ML, Liu M, Wilairat P, Rosenthal PJ, Saliba KJ, Kirk K. Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes. Antimicrob Agents Chemother. 2004 Sep; 48(9):3241-5. View on Pubmed
  373. Musonda CC, Taylor D, Lehman J, Gut J, Rosenthal PJ, Chibale K. Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts. Bioorg Med Chem Lett. 2004 Aug 02; 14(15):3901-5. View on Pubmed
  374. Singh A, Rosenthal PJ. Selection of cysteine protease inhibitor-resistant malaria parasites is accompanied by amplification of falcipain genes and alteration in inhibitor transport. J Biol Chem. 2004 Aug 20; 279(34):35236-41. View on Pubmed
  375. Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem. 2004 Jun 03; 47(12):3212-9. View on Pubmed
  376. Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S. Antimalarial drug discovery: efficacy models for compound screening. Nat Rev Drug Discov. 2004 Jun; 3(6):509-20. View on Pubmed
  377. Sijwali PS, Kato K, Seydel KB, Gut J, Lehman J, Klemba M, Goldberg DE, Miller LH, Rosenthal PJ. Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8721-6. View on Pubmed
  378. Nsobya SL, Parikh S, Kironde F, Lubega G, Kamya MR, Rosenthal PJ, Dorsey G. Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children. J Infect Dis. 2004 Jun 15; 189(12):2220-6. View on Pubmed
  379. Staedke SG, Sendagire H, Lamola S, Kamya MR, Dorsey G, Rosenthal PJ. Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, Uganda. Trop Med Int Health. 2004 May; 9(5):624-9. View on Pubmed
  380. Sijwali PS, Rosenthal PJ. Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4384-9. View on Pubmed
  381. Na BK, Shenai BR, Sijwali PS, Choe Y, Pandey KC, Singh A, Craik CS, Rosenthal PJ. Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax. Biochem J. 2004 Mar 01; 378(Pt 2):529-38. View on Pubmed
  382. Locher CP, Ruben PC, Gut J, Rosenthal PJ. 5HT1A serotonin receptor agonists inhibit Plasmodium falciparum by blocking a membrane channel. Antimicrob Agents Chemother. 2003 Dec; 47(12):3806-9. View on Pubmed
  383. Lee BJ, Singh A, Chiang P, Kemp SJ, Goldman EA, Weinhouse MI, Vlasuk GP, Rosenthal PJ. Antimalarial activities of novel synthetic cysteine protease inhibitors. Antimicrob Agents Chemother. 2003 Dec; 47(12):3810-4. View on Pubmed
  384. Boyom FF, Ngouana V, Zollo PH, Menut C, Bessiere JM, Gut J, Rosenthal PJ. Composition and anti-plasmodial activities of essential oils from some Cameroonian medicinal plants. Phytochemistry. 2003 Dec; 64(7):1269-75. View on Pubmed
  385. Pandey KC, Sijwali PS, Singh A, Na BK, Rosenthal PJ. Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2. J Biol Chem. 2004 Jan 30; 279(5):3484-91. View on Pubmed
  386. Rosenthal PJ. Antimalarial drug discovery: old and new approaches. J Exp Biol. 2003 Nov; 206(Pt 21):3735-44. View on Pubmed
  387. Chiyanzu I, Hansell E, Gut J, Rosenthal PJ, McKerrow JH, Chibale K. Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20; 13(20):3527-30. View on Pubmed
  388. Dorsey G, Vlahos J, Kamya MR, Staedke SG, Rosenthal PJ. Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malaria. J Infect Dis. 2003 Oct 15; 188(8):1231-8. View on Pubmed
  389. Staedke SG, Nottingham EW, Cox J, Kamya MR, Rosenthal PJ, Dorsey G. Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children. Am J Trop Med Hyg. 2003 Sep; 69(3):244-6. View on Pubmed
  390. Kyabayinze D, Cattamanchi A, Kamya MR, Rosenthal PJ, Dorsey G. Validation of a simplified method for using molecular markers to predict sulfadoxine-pyrimethamine treatment failure in African children with falciparum malaria. Am J Trop Med Hyg. 2003 Sep; 69(3):247-52. View on Pubmed
  391. Batra S, Sabnis YA, Rosenthal PJ, Avery MA. Structure-based approach to falcipain-2 inhibitors: synthesis and biological evaluation of 1,6,7-trisubstituted dihydroisoquinolines and isoquinolines. Bioorg Med Chem. 2003 May 15; 11(10):2293-9. View on Pubmed
  392. Sabnis YA, Desai PV, Rosenthal PJ, Avery MA. Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies. Protein Sci. 2003 Mar; 12(3):501-9. View on Pubmed
  393. Gasasira AF, Dorsey G, Nzarubara B, Staedke SG, Nassali A, Rosenthal PJ, Kamya MR. Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. Am J Trop Med Hyg. 2003 Feb; 68(2):127-32. View on Pubmed
  394. Cattamanchi A, Kyabayinze D, Hubbard A, Rosenthal PJ, Dorsey G. Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp. Am J Trop Med Hyg. 2003 Feb; 68(2):133-9. View on Pubmed
  395. Shenai BR, Lee BJ, Alvarez-Hernandez A, Chong PY, Emal CD, Neitz RJ, Roush WR, Rosenthal PJ. Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones. Antimicrob Agents Chemother. 2003 Jan; 47(1):154-60. View on Pubmed
  396. Dorsey G, Njama D, Kamya MR, Cattamanchi A, Kyabayinze D, Staedke SG, Gasasira A, Rosenthal PJ. Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial. Lancet. 2002 Dec 21-28; 360(9350):2031-8. View on Pubmed
  397. Singh A, Shenai BR, Choe Y, Gut J, Sijwali PS, Craik CS, Rosenthal PJ. Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites. Biochem J. 2002 Nov 15; 368(Pt 1):273-81. View on Pubmed
  398. Shenai BR, Rosenthal PJ. Reducing requirements for hemoglobin hydrolysis by Plasmodium falciparum cysteine proteases. Mol Biochem Parasitol. 2002 Jun; 122(1):99-104. View on Pubmed
  399. Park BS, Kim DY, Rosenthal PJ, Huh SC, Lee BJ, Park E-, Kim SM, Kim JE, Kim MH, Huh TL, Choi YJ, Suh KH, Choi WS, Lee SE. Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana Moens ex Trimen. Bioorg Med Chem Lett. 2002 May 20; 12(10):1351-5. View on Pubmed
  400. Shenai BR, Semenov AV, Rosenthal PJ. Stage-specific antimalarial activity of cysteine protease inhibitors. Biol Chem. 2002 May; 383(5):843-7. View on Pubmed
  401. Sabnis Y, Rosenthal PJ, Desai P, Avery MA. Homology modeling of falcipain-2: validation, de novo ligand design and synthesis of novel inhibitors. J Biomol Struct Dyn. 2002 Apr; 19(5):765-74. View on Pubmed
  402. Rosenthal PJ. Hydrolysis of erythrocyte proteins by proteases of malaria parasites. Curr Opin Hematol. 2002 Mar; 9(2):140-5. View on Pubmed
  403. Sijwali PS, Shenai BR, Rosenthal PJ. Folding of the Plasmodium falciparum cysteine protease falcipain-2 is mediated by a chaperone-like peptide and not the prodomain. J Biol Chem. 2002 Apr 26; 277(17):14910-5. View on Pubmed
  404. Rosenthal PJ, Sijwali PS, Singh A, Shenai BR. Cysteine proteases of malaria parasites: targets for chemotherapy. Curr Pharm Des. 2002; 8(18):1659-72. View on Pubmed
  405. Sijwali PS, Shenai BR, Gut J, Singh A, Rosenthal PJ. Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3. Biochem J. 2001 Dec 01; 360(Pt 2):481-9. View on Pubmed
  406. Joachimiak MP, Chang C, Rosenthal PJ, Cohen FE. The impact of whole genome sequence data on drug discovery--a malaria case study. Mol Med. 2001 Oct; 7(10):698-710. View on Pubmed
  407. Staedke SG, Kamya MR, Dorsey G, Gasasira A, Ndeezi G, Charlebois ED, Rosenthal PJ. Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial. Lancet. 2001 Aug 04; 358(9279):368-74. View on Pubmed
  408. Sijwali PS, Brinen LS, Rosenthal PJ. Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2. Protein Expr Purif. 2001 Jun; 22(1):128-34. View on Pubmed
  409. Dorsey G, Kamya MR, Singh A, Rosenthal PJ. Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda. J Infect Dis. 2001 May 01; 183(9):1417-20. View on Pubmed
  410. Singh A, Rosenthal PJ. Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparum. Antimicrob Agents Chemother. 2001 Mar; 45(3):949-51. View on Pubmed
  411. Kamya MR, Dorsey G, Gasasira A, Ndeezi G, Babirye JN, Staedke SG, Rosenthal PJ. The comparative efficacy of chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. Trans R Soc Trop Med Hyg. 2001 Jan-Feb; 95(1):50-5. View on Pubmed
  412. Shenai BR, Sijwali PS, Singh A, Rosenthal PJ. Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum. J Biol Chem. 2000 Sep 15; 275(37):29000-10. View on Pubmed
  413. Dorsey G, Gandhi M, Oyugi JH, Rosenthal PJ. Difficulties in the prevention, diagnosis, and treatment of imported malaria. Arch Intern Med. 2000 Sep 11; 160(16):2505-10. View on Pubmed
  414. Dorsey G, Kamya MR, Ndeezi G, Babirye JN, Phares CR, Olson JE, Katabira ET, Rosenthal PJ. Predictors of chloroquine treatment failure in children and adults with falciparum malaria in Kampala, Uganda. Am J Trop Med Hyg. 2000 Jun; 62(6):686-92. View on Pubmed
  415. Olson JE, Lee GK, Semenov A, Rosenthal PJ. Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors. Bioorg Med Chem. 1999 Apr; 7(4):633-8. View on Pubmed
  416. Rosenthal PJ. Proteases of protozoan parasites. Adv Parasitol. 1999; 43:105-59. View on Pubmed
  417. Rosenthal PJ, Semenov A, Ploplis VA, Plow EF. Plasminogen activators are not required in the erythrocytic life cycle of malaria parasites. Mol Biochem Parasitol. 1998 Nov 30; 97(1-2):253-7. View on Pubmed
  418. Semenov A, Olson JE, Rosenthal PJ. Antimalarial synergy of cysteine and aspartic protease inhibitors. Antimicrob Agents Chemother. 1998 Sep; 42(9):2254-8. View on Pubmed
  419. Gor DO, Li AC, Wiser MF, Rosenthal PJ. Plasmodial serine repeat antigen homologues with properties of schizont cysteine proteases. Mol Biochem Parasitol. 1998 Sep 01; 95(1):153-8. View on Pubmed
  420. Gor DO, Rosenthal PJ. Humoral immune responses of Africans to cysteine protease-related antigens of Plasmodium falciparum. J Infect Dis. 1998 Jul; 178(1):285-8. View on Pubmed
  421. Gor DO, Li AC, Rosenthal PJ. Protective immune responses against protease-like antigens of the murine malaria parasite Plasmodium vinckei. Vaccine. 1998 Jul; 16(11-12):1193-202. View on Pubmed
  422. Rosenthal PJ. Proteases of malaria parasites: new targets for chemotherapy. Emerg Infect Dis. 1998 Jan-Mar; 4(1):49-57. View on Pubmed
  423. Rosenthal PJ, Meshnick SR. Hemoglobin catabolism and iron utilization by malaria parasites. Mol Biochem Parasitol. 1996 Dec 20; 83(2):131-9. View on Pubmed
  424. Rosenthal PJ, Olson JE, Lee GK, Palmer JT, Klaus JL, Rasnick D. Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors. Antimicrob Agents Chemother. 1996 Jul; 40(7):1600-3. View on Pubmed
  425. Gamboa de Domínguez ND, Rosenthal PJ. Cysteine proteinase inhibitors block early steps in hemoglobin degradation by cultured malaria parasites. Blood. 1996 May 15; 87(10):4448-54. View on Pubmed
  426. Rosenthal PJ. Conservation of key amino acids among the cysteine proteinases of multiple malarial species. Mol Biochem Parasitol. 1996 Jan; 75(2):255-60. View on Pubmed
  427. Salas F, Fichmann J, Lee GK, Scott MD, Rosenthal PJ. Functional expression of falcipain, a Plasmodium falciparum cysteine proteinase, supports its role as a malarial hemoglobinase. Infect Immun. 1995 Jun; 63(6):2120-5. View on Pubmed
  428. Rosenthal PJ. Plasmodium falciparum: effects of proteinase inhibitors on globin hydrolysis by cultured malaria parasites. Exp Parasitol. 1995 Mar; 80(2):272-81. View on Pubmed
  429. Li Z, Chen X, Davidson E, Zwang O, Mendis C, Ring CS, Roush WR, Fegley G, Li R, Rosenthal PJ. Anti-malarial drug development using models of enzyme structure. Chem Biol. 1994 Sep; 1(1):31-7. View on Pubmed
  430. Rosenthal PJ, Ring CS, Chen X, Cohen FE. Characterization of a Plasmodium vivax cysteine proteinase gene identifies uniquely conserved amino acids that may mediate the substrate specificity of malarial hemoglobinases. J Mol Biol. 1994 Aug 12; 241(2):312-6. View on Pubmed
  431. Rosenthal PJ. A Plasmodium vinckei cysteine proteinase shares unique features with its Plasmodium falciparum analogue. Biochim Biophys Acta. 1993 Apr 29; 1173(1):91-3. View on Pubmed
  432. Rosenthal PJ, Lee GK, Smith RE. Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria. J Clin Invest. 1993 Mar; 91(3):1052-6. View on Pubmed
  433. Rosenthal PJ, Nelson RG. Isolation and characterization of a cysteine proteinase gene of Plasmodium falciparum. Mol Biochem Parasitol. 1992 Mar; 51(1):143-52. View on Pubmed
  434. Rosenthal PJ, Wollish WS, Palmer JT, Rasnick D. Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase. J Clin Invest. 1991 Nov; 88(5):1467-72. View on Pubmed
  435. Rosenthal PJ, McKerrow JH, Rasnick D, Leech JH. Plasmodium falciparum: inhibitors of lysosomal cysteine proteinases inhibit a trophozoite proteinase and block parasite development. Mol Biochem Parasitol. 1989 Jun 15; 35(2):177-83. View on Pubmed
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