Eric Verdin
- Professor, School of Medicine
Displaying 1 - 297 of 297
- de Armas LR, Gavegnano C, Pallikkuth S, Rinaldi S, Pan L, Battivelli E, Verdin E, Younis RT, Pahwa R, Williams SL, Schinazi RF, Pahwa S. The Effect of JAK1/2 Inhibitors on HIV Reservoir Using Primary Lymphoid Cell Model of HIV Latency. Front Immunol. 2021; 12:720697. View on Pubmed
- Curran SP, Lithgow GJ, Verdin E, P C. University of Southern California and buck institute nathan shock center: multidimensional models of aging. Geroscience. 2021 Jul 16. View on Pubmed
- Walter M, Perrone R, Verdin E. Targeting Conserved Sequences Circumvents the Evolution of Resistance in a Viral Gene Drive against Human Cytomegalovirus. J Virol. 2021 07 12; 95(15):e0080221. View on Pubmed
- Hu T, Shukla SK, Vernucci E, He C, Wang D, King RJ, Jha K, Siddhanta K, Mullen NJ, Attri KS, Murthy D, Chaika NV, Thakur R, Mulder SE, Pacheco CG, Fu X, High RR, Yu F, Lazenby A, Steegborn C, Lan P, Mehla K, Rotili D, Chaudhary S, Valente S, Tafani M, Mai A, Auwerx J, Verdin E, Tuveson D, Singh PK. Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression. Gastroenterology. 2021 Jul 08. View on Pubmed
- Sierra F, Caspi A, Fortinsky RH, Haynes L, Lithgow GJ, Moffitt TE, Olshansky SJ, Perry D, Verdin E, Kuchel GA. Moving geroscience from the bench to clinical care and health policy. J Am Geriatr Soc. 2021 09; 69(9):2455-2463. View on Pubmed
- Chen O, Blonquist TM, Mah E, Sanoshy K, Beckman D, Nieman KM, Winters BL, Anthony JC, Verdin E, Newman JC, Stubbs BJ. Tolerability and Safety of a Novel Ketogenic Ester, Bis-Hexanoyl (R)-1,3-Butanediol: A Randomized Controlled Trial in Healthy Adults. Nutrients. 2021 Jun 16; 13(6). View on Pubmed
- Desbiez C, Verdin E, Lecoq H. Complete sequence of an isolate of snake melon asteroid mosaic virus confirms that it is a member of a distinct sobemovirus species. Arch Virol. 2021 Aug; 166(8):2311-2313. View on Pubmed
- Tong D, Schiattarella GG, Jiang N, Altamirano F, Szweda PA, Elnwasany A, Lee DI, Yoo H, Kass DA, Szweda LI, Lavandero S, Verdin E, Gillette TG, Hill JA. NAD+ Repletion Reverses Heart Failure With Preserved Ejection Fraction. Circ Res. 2021 May 28; 128(11):1629-1641. View on Pubmed
- Huang Y, Radenkovic D, Perez K, Nadeau K, Verdin E, Furman D. Modeling Predictive Age-Dependent and Age-Independent Symptoms and Comorbidities of Patients Seeking Treatment for COVID-19: Model Development and Validation Study. J Med Internet Res. 2021 03 25; 23(3):e25696. View on Pubmed
- Stubbs BJ, Nikiforov AI, Rihner MO, Weston S, Higley N, Roy S, Dakoulas E, Verdin E, Newman JC. Genetic Toxicity Studies of the Ketogenic Ester Bis Hexanoyl (R)-1,3-Butanediol. Int J Toxicol. 2021 May-Jun; 40(3):242-249. View on Pubmed
- Stubbs BJ, Nikiforov AI, Rihner MO, Weston SL, Higley N, Stump DG, Krane GA, Gadupudi G, Verdin E, Newman JC. Toxicological evaluation of the ketogenic ester bis hexanoyl (R)-1,3-butanediol: Subchronic toxicity in Sprague Dawley rats. Food Chem Toxicol. 2021 Apr; 150:112084. View on Pubmed
- Gramatica A, Schwarzer R, Brantley W, Varco-Merth B, Sperber HS, Hull PA, Montano M, Migueles SA, Rosenthal D, Hogan LE, Johnson JR, Packard TA, Grimmett ZW, Herzig E, Besnard E, Nekorchuk M, Hsiao F, Deeks SG, Snape M, Kiernan B, Roan NR, Lifson JD, Estes JD, Picker LJ, Verdin E, Krogan NJ, Henrich TJ, Connors M, Ott M, Pillai SK, Okoye AA, Greene WC. Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo. J Virol. 2021 Feb 03. View on Pubmed
- Matsui H, Shirakawa K, Konishi Y, Hirabayashi S, Sarca AD, Fukuda H, Nomura R, Stanford E, Horisawa Y, Kazuma Y, Matsumoto T, Yamazaki H, Murakawa Y, Battivelli E, Verdin E, Koyanagi Y, Takaori-Kondo A. CAGE-seq reveals that HIV-1 latent infection does not trigger unique cellular responses in a Jurkat T cell model. J Virol. 2021 Jan 27. View on Pubmed
- Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Author Correction: Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nat Metab. 2021 Jan; 3(1):120-121. View on Pubmed
- Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY). 2020 12 30; 12(24):24484-24503. View on Pubmed
- Yurista SR, Matsuura TR, Silljé HHW, Nijholt KT, McDaid KS, Shewale SV, Leone TC, Newman JC, Verdin E, van Veldhuisen DJ, de Boer RA, Kelly DP, Westenbrink BD. Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure. Circ Heart Fail. 2021 01; 14(1):e007684. View on Pubmed
- Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021 02; 22(2):119-141. View on Pubmed
- Moron-Lopez S, Telwatte S, Sarabia I, Battivelli E, Montano M, Macedo AB, Aran D, Butte AJ, Jones RB, Bosque A, Verdin E, Greene WC, Wong JK, Yukl SA. Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals. PLoS Pathog. 2020 11; 16(11):e1009060. View on Pubmed
- Gut P, Matilainen S, Meyer JG, Pällijeff P, Richard J, Carroll CJ, Euro L, Jackson CB, Isohanni P, Minassian BA, Alkhater RA, Østergaard E, Civiletto G, Parisi A, Thevenet J, Rardin MJ, He W, Nishida Y, Newman JC, Liu X, Christen S, Moco S, Locasale JW, Schilling B, Suomalainen A, Verdin E. SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. Nat Commun. 2020 11 23; 11(1):5927. View on Pubmed
- Stubbs BJ, Blade T, Mills S, Thomas J, Yufei X, Nelson FR, Higley N, Nikiforov AI, Rhiner MO, Verdin E, Newman JC. In vitro stability and in vivo pharmacokinetics of the novel ketogenic ester, bis hexanoyl (R)-1,3-butanediol. Food Chem Toxicol. 2021 Jan; 147:111859. View on Pubmed
- Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nat Metab. 2020 11; 2(11):1265-1283. View on Pubmed
- Verdin E. Paolo Sassone-Corsi (1956-2020). Science. 2020 Oct 30; 370(6516):532. View on Pubmed
- Dzau VJ, Finkelman EM, Balatbat CA, Verdin EM, Pettigrew RI. Achieving healthy human longevity: A global grand challenge. Sci Transl Med. 2020 10 21; 12(566). View on Pubmed
- Walter M, Verdin E. Viral gene drive in herpesviruses. Nat Commun. 2020 09 28; 11(1):4884. View on Pubmed
- Radenkovic D, Reason , Verdin E. Clinical Evidence for Targeting NAD Therapeutically. Pharmaceuticals (Basel). 2020 Sep 15; 13(9). View on Pubmed
- Colomb F, Giron LB, Kuri-Cervantes L, Adeniji OS, Ma T, Dweep H, Battivelli E, Verdin E, Palmer CS, Tateno H, Kossenkov AV, Roan NR, Betts MR, Abdel-Mohsen M. Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy. Cell Rep. 2020 08 04; 32(5):107991. View on Pubmed
- Stubbs BJ, Koutnik AP, Goldberg EL, Upadhyay V, Turnbaugh PJ, Verdin E, Newman JC. Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections. Med (N Y). 2020 Dec 18; 1(1):43-65. View on Pubmed
- Bengone-Abogourin JG, Chelkha N, Verdin E, Colson P. Sequence Similarities between Viroids and Human MicroRNAs. Intervirology. 2019; 62(5-6):227-234. View on Pubmed
- Vallejo-Gracia A, Chen IP, Perrone R, Besnard E, Boehm D, Battivelli E, Tezil T, Krey K, Raymond KA, Hull PA, Walter M, Habrylo I, Cruz A, Deeks S, Pillai S, Verdin E, Ott M. FOXO1 promotes HIV latency by suppressing ER stress in T cells. Nat Microbiol. 2020 09; 5(9):1144-1157. View on Pubmed
- Desbiez C, Wipf-Scheibel C, Millot P, Berthier K, Girardot G, Gognalons P, Hirsch J, Moury B, Nozeran K, Piry S, Schoeny A, Verdin E. Distribution and evolution of the major viruses infecting cucurbitaceous and solanaceous crops in the French Mediterranean area. Virus Res. 2020 09; 286:198042. View on Pubmed
- Ang QY, Alexander M, Newman JC, Tian Y, Cai J, Upadhyay V, Turnbaugh JA, Verdin E, Hall KD, Leibel RL, Ravussin E, Rosenbaum M, Patterson AD, Turnbaugh PJ. Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells. Cell. 2020 06 11; 181(6):1263-1275.e16. View on Pubmed
- Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 07; 583(7816):459-468. View on Pubmed
- Dikalova AE, Pandey A, Xiao L, Arslanbaeva L, Sidorova T, Lopez MG, Billings FT, Verdin E, Auwerx J, Harrison DG, Dikalov SI. Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress. Circ Res. 2020 02 14; 126(4):439-452. View on Pubmed
- Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019 12; 25(12):1822-1832. View on Pubmed
- Sõmera M, Kvarnheden A, Desbiez C, Blystad DR, Sooväli P, Kundu JK, Gantsovski M, Nygren J, Lecoq H, Verdin E, Spetz C, Tamisier L, Truve E, Massart S. Sixty Years After the First Description: Genome Sequence and Biological Characterization of European Wheat Striate Mosaic Virus Infecting Cereal Crops. Phytopathology. 2020 Jan; 110(1):68-79. View on Pubmed
- Read DF, Atindaana E, Pyaram K, Yang F, Emery S, Cheong A, Nakama KR, Burnett C, Larragoite ET, Battivelli E, Verdin E, Planelles V, Chang CH, Telesnitsky A, Kidd JM. Stable integrant-specific differences in bimodal HIV-1 expression patterns revealed by high-throughput analysis. PLoS Pathog. 2019 10; 15(10):e1007903. View on Pubmed
- Tezil T, Chamoli M, Ng CP, Simon RP, Butler VJ, Jung M, Andersen J, Kao AW, Verdin E. Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy. NPJ Aging Mech Dis. 2019; 5:7. View on Pubmed
- Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. From discoveries in ageing research to therapeutics for healthy ageing. Nature. 2019 07; 571(7764):183-192. View on Pubmed
- Scussel S, Candresse T, Marais A, Claverie S, Hoareau M, Azali HA, Verdin E, Tepfer M, Filloux D, Fernandez E, Roumagnac P, Robène I, Lefeuvre P, Jourda C, Roux-Cuvelier M, Lett JM. High-throughput sequencing of complete genomes of ipomoviruses associated with an epidemic of cassava brown streak disease in the Comoros Archipelago. Arch Virol. 2019 Aug; 164(8):2193-2196. View on Pubmed
- Wang G, Meyer JG, Cai W, Softic S, Li ME, Verdin E, Newgard C, Schilling B, Kahn CR. Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation. Mol Cell. 2019 05 16; 74(4):844-857.e7. View on Pubmed
- Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, Popov YV, Verdin E, Johnson H, Stossi F, Sinclair DA, Nakamaru-Ogiso E, Lopez-Berestein G, Chang JT, Neilson JR, Meeker A, Finegold M, Baur JA, Sahin E. Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease. Cell Metab. 2019 06 04; 29(6):1274-1290.e9. View on Pubmed
- Massart S, Chiumenti M, De Jonghe K, Glover R, Haegeman A, Koloniuk I, Komínek P, Kreuze J, Kutnjak D, Lotos L, Maclot F, Maliogka V, Maree HJ, Olivier T, Olmos A, Pooggin MM, Reynard JS, Ruiz-García AB, Safarova D, Schneeberger PHH, Sela N, Turco S, Vainio EJ, Varallyay E, Verdin E, Westenberg M, Brostaux Y, Candresse T. Virus Detection by High-Throughput Sequencing of Small RNAs: Large-Scale Performance Testing of Sequence Analysis Strategies. Phytopathology. 2019 Mar; 109(3):488-497. View on Pubmed
- Schilling B, Meyer JG, Wei L, Ott M, Verdin E. High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets. Methods Mol Biol. 2019; 1983:3-16. View on Pubmed
- Meyer JG, Softic S, Basisty N, Rardin MJ, Verdin E, Gibson BW, Ilkayeva O, Newgard CB, Kahn CR, Schilling B. Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose. PLoS One. 2018; 13(12):e0208973. View on Pubmed
- Sémétey O, Gaudin J, Danet JL, Salar P, Theil S, Fontaine M, Krausz M, Chaisse E, Eveillard S, Verdin E, Foissac X. Lavender Decline in France Is Associated with Chronic Infection by Lavender-Specific Strains of "Candidatus Phytoplasma solani". Appl Environ Microbiol. 2018 12 15; 84(24). View on Pubmed
- Battivelli E, Verdin E. HIVGKO: A Tool to Assess HIV-1 Latency Reversal Agents in Human Primary CD4+ T Cells. Bio Protoc. 2018 Oct 20; 8(20). View on Pubmed
- Lecoq H, Wipf-Scheibel C, Verdin E, Desbiez C. Characterization of the first tenuivirus naturally infecting dicotyledonous plants. Arch Virol. 2019 Jan; 164(1):297-301. View on Pubmed
- Bruning U, Morales-Rodriguez F, Kalucka J, Goveia J, Taverna F, Queiroz KCS, Dubois C, Cantelmo AR, Chen R, Loroch S, Timmerman E, Caixeta V, Bloch K, Conradi LC, Treps L, Staes A, Gevaert K, Tee A, Dewerchin M, Semenkovich CF, Impens F, Schilling B, Verdin E, Swinnen JV, Meier JL, Kulkarni RA, Sickmann A, Ghesquière B, Schoonjans L, Li X, Mazzone M, Carmeliet P. Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation. Cell Metab. 2018 12 04; 28(6):866-880.e15. View on Pubmed
- Verdin E, Marais A, Wipf-Scheibel C, Faure C, Pelletier B, David P, Svanella-Dumas L, Poisblaud C, Lecoq H, Candresse T. Biological and Genetic Characterization of New and Known Necroviruses Causing an Emerging Systemic Necrosis Disease of Corn Salad (Valerianella locusta) in France. Phytopathology. 2018 08; 108(8):1002-1010. View on Pubmed
- Kuo HH, Ahmad R, Lee GQ, Gao C, Chen HR, Ouyang Z, Szucs MJ, Kim D, Tsibris A, Chun TW, Battivelli E, Verdin E, Rosenberg ES, Carr SA, Yu XG, Lichterfeld M. Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4+ T Cells. Immunity. 2018 06 19; 48(6):1183-1194.e5. View on Pubmed
- Battivelli E, Dahabieh MS, Abdel-Mohsen M, Svensson JP, Tojal Da Silva I, Cohn LB, Gramatica A, Deeks S, Greene WC, Pillai SK, Verdin E. Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells. Elife. 2018 05 01; 7. View on Pubmed
- Kasler HG, Lee IS, Lim HW, Verdin E. Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T Cells. Elife. 2018 04 17; 7. View on Pubmed
- Porter LC, Franczyk MP, Pietka T, Yamaguchi S, Lin JB, Sasaki Y, Verdin E, Apte RS, Yoshino J. NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism. Am J Physiol Endocrinol Metab. 2018 10 01; 315(4):E520-E530. View on Pubmed
- Carrico C, Meyer JG, He W, Gibson BW, Verdin E. The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications. Cell Metab. 2018 03 06; 27(3):497-512. View on Pubmed
- Ali I, Conrad RJ, Verdin E, Ott M. Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics. Chem Rev. 2018 02 14; 118(3):1216-1252. View on Pubmed
- Wood JG, Schwer B, Wickremesinghe PC, Hartnett DA, Burhenn L, Garcia M, Li M, Verdin E, Helfand SL. Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):1564-1569. View on Pubmed
- Shrimp JH, Garlick JM, Tezil T, Sorum AW, Worth AJ, Blair IA, Verdin E, Snyder NW, Meier JL. Defining Metabolic and Nonmetabolic Regulation of Histone Acetylation by NSAID Chemotypes. Mol Pharm. 2018 03 05; 15(3):729-736. View on Pubmed
- Jeng MY, Hull PA, Fei M, Kwon HS, Tsou CL, Kasler H, Ng CP, Gordon DE, Johnson J, Krogan N, Verdin E, Ott M. Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. J Exp Med. 2018 01 02; 215(1):51-62. View on Pubmed
- Tognini P, Murakami M, Liu Y, Eckel-Mahan KL, Newman JC, Verdin E, Baldi P, Sassone-Corsi P. Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet. Cell Metab. 2017 Sep 05; 26(3):523-538.e5. View on Pubmed
- Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng CP, Huang Y, Haldar S, Verdin E. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice. Cell Metab. 2017 Sep 05; 26(3):547-557.e8. View on Pubmed
- Ho L, Wang L, Roth TM, Pan Y, Verdin EM, Hsiao EC, Nissenson RA. Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice. Endocrinology. 2017 09 01; 158(9):2741-2753. View on Pubmed
- Newman JC, Verdin E. β-Hydroxybutyrate: A Signaling Metabolite. Annu Rev Nutr. 2017 08 21; 37:51-76. View on Pubmed
- Ramachandran D, Clara R, Fedele S, Hu J, Lackzo E, Huang JY, Verdin E, Langhans W, Mansouri A. Intestinal SIRT3 overexpression in mice improves whole body glucose homeostasis independent of body weight. Mol Metab. 2017 10; 6(10):1264-1273. View on Pubmed
- Desbiez C, Wipf-Scheibel C, Millot P, Verdin E, Dafalla G, Lecoq H. New species in the papaya ringspot virus cluster: Insights into the evolution of the PRSV lineage. Virus Res. 2017 09 15; 241:88-94. View on Pubmed
- Fernández-Del-Río L, Nag A, Gutiérrez Casado E, Ariza J, Awad AM, Joseph AI, Kwon O, Verdin E, de Cabo R, Schneider C, Torres JZ, Burón MI, Clarke CF, Villalba JM. Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor. Free Radic Biol Med. 2017 09; 110:176-187. View on Pubmed
- Verdin E, Wipf-Scheibel C, Gognalons P, Aller F, Jacquemond M, Tepfer M. Sequencing viral siRNAs to identify previously undescribed viruses and viroids in a panel of ornamental plant samples structured as a matrix of pools. Virus Res. 2017 09 15; 241:19-28. View on Pubmed
- Myers DR, Lau T, Markegard E, Lim HW, Kasler H, Zhu M, Barczak A, Huizar JP, Zikherman J, Erle DJ, Zhang W, Verdin E, Roose JP. Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells. Cell Rep. 2017 05 23; 19(8):1558-1571. View on Pubmed
- Tomiyama AJ, Milush JM, Lin J, Flynn JM, Kapahi P, Verdin E, Sinclair E, Melov S, Epel ES. Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study. Nutr Healthy Aging. 2017 Mar 31; 4(2):147-156. View on Pubmed
- Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E. The mTOR Complex Controls HIV Latency. . 2016 Dec 14; 20(6):785-797. View on Pubmed
- Bindu S, Pillai VB, Kanwal A, Samant S, Mutlu GM, Verdin E, Dulin N, Gupta MP. SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage. . 2017 01 01; 312(1):L68-L78. View on Pubmed
- Fu Y, Kinter M, Hudson J, Humphries KM, Lane RS, White JR, Hakim M, Pan Y, Verdin E, Griffin TM. Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis. Arthritis Rheumatol. 2016 08; 68(8):1887-98. View on Pubmed
- Desbiez C, Verdin E, Tepfer M, Wipf-Scheibel C, Millot P, Dafalla G, Lecoq H. Characterization of a new cucurbit-infecting ipomovirus from Sudan. Arch Virol. 2016 Oct; 161(10):2913-5. View on Pubmed
- Shirakawa K, Wang L, Man N, Maksimoska J, Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E. Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife. 2016 05 31; 5. View on Pubmed
- Vranckx LS, Demeulemeester J, Saleh S, Boll A, Vansant G, Schrijvers R, Weydert C, Battivelli E, Verdin E, Cereseto A, Christ F, Gijsbers R, Debyser Z. LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV. EBioMedicine. 2016 Jun; 8:248-264. View on Pubmed
- Tepfer M, Girardot G, Fénéant L, Ben Tamarzizt H, Verdin E, Moury B, Jacquemond M. A genetically novel, narrow-host-range isolate of cucumber mosaic virus (CMV) from rosemary. Arch Virol. 2016 Jul; 161(7):2013-7. View on Pubmed
- Lecoq H, Verdin E, Tepfer M, Wipf-Scheibel C, Millot P, Dafalla G, Desbiez C. Characterization and occurrence of squash chlorotic leaf spot virus, a tentative new torradovirus infecting cucurbits in Sudan. Arch Virol. 2016 Jun; 161(6):1651-5. View on Pubmed
- Alhazzazi TY, Kamarajan P, Xu Y, Ai T, Chen L, Verdin E, Kapila YL. A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells. Anticancer Res. 2016 Jan; 36(1):49-60. View on Pubmed
- Sundaresan NR, Bindu S, Pillai VB, Samant S, Pan Y, Huang JY, Gupta M, Nagalingam RS, Wolfgeher D, Verdin E, Gupta MP. SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β. Mol Cell Biol. 2015 Dec 14; 36(5):678-92. View on Pubmed
- Wiley CD, Velarde MC, Lecot P, Liu S, Sarnoski EA, Freund A, Shirakawa K, Lim HW, Davis SS, Ramanathan A, Gerencser AA, Verdin E, Campisi J. Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype. Cell Metab. 2016 Feb 09; 23(2):303-14. View on Pubmed
- Verdin E. NAD⁺ in aging, metabolism, and neurodegeneration. Science. 2015 Dec 04; 350(6265):1208-13. View on Pubmed
- Rafati H, Parra M, Hakre S, Moshkin Y, Verdin E, Mahmoudi T. Correction: Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency. PLoS Biol. 2015 Nov; 13(11):e1002302. View on Pubmed
- Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nat Med. 2015 Oct; 21(10):1154-62. View on Pubmed
- Chavez L, Calvanese V, Verdin E. HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells. PLoS Pathog. 2015 Jun; 11(6):e1004955. View on Pubmed
- Nishida Y, Rardin MJ, Carrico C, He W, Sahu AK, Gut P, Najjar R, Fitch M, Hellerstein M, Gibson BW, Verdin E. SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target. Mol Cell. 2015 Jul 16; 59(2):321-32. View on Pubmed
- Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. SIRT1 deacetylates RORγt and enhances Th17 cell generation. J Exp Med. 2015 Jun 01; 212(6):973. View on Pubmed
- Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. SIRT1 deacetylates RORγt and enhances Th17 cell generation. J Exp Med. 2015 May 04; 212(5):607-17. View on Pubmed
- Ruelas DS, Chan JK, Oh E, Heidersbach AJ, Hebbeler AM, Chavez L, Verdin E, Rape M, Greene WC. MicroRNA-155 Reinforces HIV Latency. J Biol Chem. 2015 May 29; 290(22):13736-48. View on Pubmed
- Zhang Y, Bharathi SS, Rardin MJ, Uppala R, Verdin E, Gibson BW, Goetzman ES. SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase. PLoS One. 2015; 10(3):e0122297. View on Pubmed
- Dahabieh MS, Battivelli E, Verdin E. Understanding HIV latency: the road to an HIV cure. Annu Rev Med. 2015; 66:407-21. View on Pubmed
- Verdin E, Ott M. 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond. Nat Rev Mol Cell Biol. 2015 04; 16(4):258-64. View on Pubmed
- Brown KD, Maqsood S, Huang JY, Pan Y, Harkcom W, Li W, Sauve A, Verdin E, Jaffrey SR. Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss. Cell Metab. 2014 Dec 02; 20(6):1059-68. View on Pubmed
- Tang Q, Kang SM. Interpretation of transplant biopsies and immune responses following Treg cell therapy. Curr Opin Organ Transplant. 2014 Dec; 19(6):616-20. View on Pubmed
- Newman JC, Verdin E. β-hydroxybutyrate: much more than a metabolite. Diabetes Res Clin Pract. 2014 Nov; 106(2):173-81. View on Pubmed
- Choudhary C, Weinert BT, Nishida Y, Verdin E, Mann M. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug; 15(8):536-50. View on Pubmed
- Svanella-Dumas L, Verdin E, Faure C, German-Retana S, Gognalons P, Danet JL, Marais A, Candresse T. Adaptation of lettuce mosaic virus to Catharanthus roseus involves mutations in the central domain of the VPg. Mol Plant Microbe Interact. 2014 May; 27(5):491-7. View on Pubmed
- Manson McManamy ME, Hakre S, Verdin EM, Margolis DM. Therapy for latent HIV-1 infection: the role of histone deacetylase inhibitors. Antivir Chem Chemother. 2014 Jan 29; 23(4):145-9. View on Pubmed
- Colin L, Verdin E, Van Lint C. HIV-1 chromatin, transcription, and the regulatory protein Tat. Methods Mol Biol. 2014; 1087:85-101. View on Pubmed
- Verdin E. The many faces of sirtuins: Coupling of NAD metabolism, sirtuins and lifespan. Nat Med. 2014 Jan; 20(1):25-7. View on Pubmed
- Spina CA, Anderson J, Archin NM, Bosque A, Chan J, Famiglietti M, Greene WC, Kashuba A, Lewin SR, Margolis DM, Mau M, Ruelas D, Saleh S, Shirakawa K, Siliciano RF, Singhania A, Soto PC, Terry VH, Verdin E, Woelk C, Wooden S, Xing S, Planelles V. An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients. PLoS Pathog. 2013; 9(12):e1003834. View on Pubmed
- Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, Mulhern D, Stevens RD, Ilkayeva OR, Newgard CB, Jacobson MP, Hellerstein M, Goetzman ES, Gibson BW, Verdin E. SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab. 2013 Dec 03; 18(6):920-33. View on Pubmed
- Ho L, Titus AS, Banerjee KK, George S, Lin W, Deota S, Saha AK, Nakamura K, Gut P, Verdin E, Kolthur-Seetharam U. SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY). 2013 Nov; 5(11):835-49. View on Pubmed
- Novis CL, Archin NM, Buzon MJ, Verdin E, Round JL, Lichterfeld M, Margolis DM, Planelles V, Bosque A. Reactivation of latent HIV-1 in central memory CD4⁺ T cells through TLR-1/2 stimulation. Retrovirology. 2013 Oct 24; 10:119. View on Pubmed
- Gut P, Verdin E. The nexus of chromatin regulation and intermediary metabolism. Nature. 2013 Oct 24; 502(7472):489-98. View on Pubmed
- Newman JC, Verdin E. Ketone bodies as signaling metabolites. Trends Endocrinol Metab. 2014 Jan; 25(1):42-52. View on Pubmed
- Bharathi SS, Zhang Y, Mohsen AW, Uppala R, Balasubramani M, Schreiber E, Uechi G, Beck ME, Rardin MJ, Vockley J, Verdin E, Gibson BW, Hirschey MD, Goetzman ES. Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. J Biol Chem. 2013 Nov 22; 288(47):33837-33847. View on Pubmed
- Calvanese V, Chavez L, Laurent T, Ding S, Verdin E. Dual-color HIV reporters trace a population of latently infected cells and enable their purification. Virology. 2013 Nov; 446(1-2):283-92. View on Pubmed
- Verdin E, Ott M. Acetylphosphate: a novel link between lysine acetylation and intermediary metabolism in bacteria. Mol Cell. 2013 Jul 25; 51(2):132-4. View on Pubmed
- Jing E, O'Neill BT, Rardin MJ, Kleinridders A, Ilkeyeva OR, Ussar S, Bain JR, Lee KY, Verdin EM, Newgard CB, Gibson BW, Kahn CR. Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes. 2013 Oct; 62(10):3404-17. View on Pubmed
- Kang SG, Liu WH, Lu P, Jin HY, Lim HW, Shepherd J, Fremgen D, Verdin E, Oldstone MB, Qi H, Teijaro JR, Xiao C. MicroRNAs of the miR-17∼92 family are critical regulators of T(FH) differentiation. Nat Immunol. 2013 Aug; 14(8):849-57. View on Pubmed
- Ott M, Verdin E. Three rules for HIV latency: location, location, and location. . 2013 Jun 12; 13(6):625-6. View on Pubmed
- Gut P, Verdin E. Rejuvenating SIRT1 activators. Cell Metab. 2013 May 07; 17(5):635-7. View on Pubmed
- Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW. Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6601-6. View on Pubmed
- Shirakawa K, Chavez L, Hakre S, Calvanese V, Verdin E. Reactivation of latent HIV by histone deacetylase inhibitors. Trends Microbiol. 2013 Jun; 21(6):277-85. View on Pubmed
- Alhazzazi TY, Kamarajan P, Verdin E, Kapila YL. Sirtuin-3 (SIRT3) and the Hallmarks of Cancer. Genes Cancer. 2013 Mar; 4(3-4):164-71. View on Pubmed
- Merksamer PI, Liu Y, He W, Hirschey MD, Chen D, Verdin E. The sirtuins, oxidative stress and aging: an emerging link. Aging (Albany NY). 2013 Mar; 5(3):144-50. View on Pubmed
- Wirth M, Karaca S, Wenzel D, Ho L, Tishkoff D, Lombard DB, Verdin E, Urlaub H, Jedrusik-Bode M, Fischle W. Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. Mitochondrion. 2013 Nov; 13(6):705-20. View on Pubmed
- Sinclair D, Verdin E. The longevity of sirtuins. Cell Rep. 2012 Dec 27; 2(6):1473-4. View on Pubmed
- Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, Verdin E. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013 Jan 11; 339(6116):211-4. View on Pubmed
- Gut P, Baeza-Raja B, Andersson O, Hasenkamp L, Hsiao J, Hesselson D, Akassoglou K, Verdin E, Hirschey MD, Stainier DY. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol. 2013 Feb; 9(2):97-104. View on Pubmed
- Weir HJ, Murray TK, Kehoe PG, Love S, Verdin EM, O'Neill MJ, Lane JD, Balthasar N. CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease. PLoS One. 2012; 7(11):e48225. View on Pubmed
- Newman JC, He W, Verdin E. Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J Biol Chem. 2012 Dec 14; 287(51):42436-43. View on Pubmed
- Maurer B, Rumpf T, Scharfe M, Stolfa DA, Schmitt ML, He W, Verdin E, Sippl W, Jung M. Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5. ACS Med Chem Lett. 2012 Dec 13; 3(12):1050-3. View on Pubmed
- Bonezzi K, Belotti D, North BJ, Ghilardi C, Borsotti P, Resovi A, Ubezio P, Riva A, Giavazzi R, Verdin E, Taraboletti G. Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies. Neoplasia. 2012 Sep; 14(9):846-54. View on Pubmed
- Pan Y, Nishida Y, Wang M, Verdin E. Metabolic regulation, mitochondria and the life-prolonging effect of rapamycin: a mini-review. Gerontology. 2012; 58(6):524-30. View on Pubmed
- He W, Newman JC, Wang MZ, Ho L, Verdin E. Mitochondrial sirtuins: regulators of protein acylation and metabolism. Trends Endocrinol Metab. 2012 Sep; 23(9):467-76. View on Pubmed
- Jang YC, Liu Y, Hayworth CR, Bhattacharya A, Lustgarten MS, Muller FL, Chaudhuri A, Qi W, Li Y, Huang JY, Verdin E, Richardson A, Van Remmen H. Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD. Aging Cell. 2012 Oct; 11(5):770-82. View on Pubmed
- International AIDS Society Scientific Working Group on HIV Cure , Deeks SG, Autran B, Berkhout B, Benkirane M, Cairns S, Chomont N, Chun TW, Churchill M, Di Mascio M, Katlama C, Lafeuillade A, Landay A, Lederman M, Lewin SR, Maldarelli F, Margolis D, Markowitz M, Martinez-Picado J, Mullins JI, Mellors J, Moreno S, O'Doherty U, Palmer S, Penicaud MC, Peterlin M, Poli G, Routy JP, Rouzioux C, Silvestri G, Stevenson M, Telenti A, Van Lint C, Verdin E, Woolfrey A, Zaia J, Barré-Sinoussi F. Towards an HIV cure: a global scientific strategy. Nat Rev Immunol. 2012 07 20; 12(8):607-14. View on Pubmed
- Kamarajan P, Alhazzazi TY, Danciu T, D'silva NJ, Verdin E, Kapila YL. Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis. Cancer. 2012 Dec 01; 118(23):5800-10. View on Pubmed
- Deeks SG, Verdin E, McCune JM. Immunosenescence and HIV. Curr Opin Immunol. 2012 Aug; 24(4):501-6. View on Pubmed
- Ismail H, Mofarrahi M, Echavarria R, Harel S, Verdin E, Lim HW, Jin ZG, Sun J, Zeng H, Hussain SN. Angiopoietin-1 and vascular endothelial growth factor regulation of leukocyte adhesion to endothelial cells: role of nuclear receptor-77. Arterioscler Thromb Vasc Biol. 2012 Jul; 32(7):1707-16. View on Pubmed
- Hakre S, Chavez L, Shirakawa K, Verdin E. HIV latency: experimental systems and molecular models. FEMS Microbiol Rev. 2012 May; 36(3):706-16. View on Pubmed
- Schilling B, Rardin MJ, MacLean BX, Zawadzka AM, Frewen BE, Cusack MP, Sorensen DJ, Bereman MS, Jing E, Wu CC, Verdin E, Kahn CR, Maccoss MJ, Gibson BW. Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation. Mol Cell Proteomics. 2012 May; 11(5):202-14. View on Pubmed
- Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR. Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. J Proteome Res. 2012 Mar 02; 11(3):1633-43. View on Pubmed
- Kwon HS, Lim HW, Wu J, Schnölzer M, Verdin E, Ott M. Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol. 2012 Mar 15; 188(6):2712-21. View on Pubmed
- Peixoto P, Castronovo V, Matheus N, Polese C, Peulen O, Gonzalez A, Boxus M, Verdin E, Thiry M, Dequiedt F, Mottet D. HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells. Cell Death Differ. 2012 Jul; 19(7):1239-52. View on Pubmed
- Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li PC, Planelles V, Bradner JE, Zhou MM, Siliciano RF, Weinberger L, Verdin E, Ott M. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. . 2013 Feb 01; 12(3):452-62. View on Pubmed
- Gallastegui E, Marshall B, Vidal D, Sanchez-Duffhues G, Collado JA, Alvarez-Fernández C, Luque N, Terme JM, Gatell JM, Sánchez-Palomino S, Muñoz E, Mestres J, Verdin E, Jordan A. Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1. J Virol. 2012 Apr; 86(7):3795-808. View on Pubmed
- Streeper RS, Grueter CA, Salomonis N, Cases S, Levin MC, Koliwad SK, Zhou P, Hirschey MD, Verdin E, Farese RV. Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging (Albany NY). 2012 Jan; 4(1):13-27. View on Pubmed
- Moury B, Verdin E. Viruses of pepper crops in the Mediterranean basin: a remarkable stasis. Adv Virus Res. 2012; 84:127-62. View on Pubmed
- Rafati H, Parra M, Hakre S, Moshkin Y, Verdin E, Mahmoudi T. Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency. PLoS Biol. 2011 Nov; 9(11):e1001206. View on Pubmed
- Hirschey MD, Shimazu T, Huang JY, Schwer B, Verdin E. SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism. Cold Spring Harb Symp Quant Biol. 2011; 76:267-77. View on Pubmed
- Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M. Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem. 2012 Jan 06; 287(2):1090-9. View on Pubmed
- Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stancáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV, Kahn CR, Verdin E. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell. 2011 Oct 21; 44(2):177-90. View on Pubmed
- Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M, Luo H, Zhang Y, He W, Yang K, Zwaans BM, Tishkoff D, Ho L, Lombard D, He TC, Dai J, Verdin E, Ye Y, Zhao Y. The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics. 2011 Dec; 10(12):M111.012658. View on Pubmed
- Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D, Verdin EM, Kahn CR. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14608-13. View on Pubmed
- Hirschey MD, Shimazu T, Capra JA, Pollard KS, Verdin E. SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2. Aging (Albany NY). 2011 Jun; 3(6):635-42. View on Pubmed
- Alhazzazi TY, Kamarajan P, Verdin E, Kapila YL. SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta. 2011 Aug; 1816(1):80-8. View on Pubmed
- Kasler HG, Young BD, Mottet D, Lim HW, Collins AM, Olson EN, Verdin E. Histone deacetylase 7 regulates cell survival and TCR signaling in CD4/CD8 double-positive thymocytes. J Immunol. 2011 Apr 15; 186(8):4782-93. View on Pubmed
- Hakre S, Chavez L, Shirakawa K, Verdin E. Epigenetic regulation of HIV latency. Curr Opin HIV AIDS. 2011 Jan; 6(1):19-24. View on Pubmed
- Tentchev D, Verdin E, Marchal C, Jacquet M, Aguilar JM, Moury B. Evolution and structure of Tomato spotted wilt virus populations: evidence of extensive reassortment and insights into emergence processes. J Gen Virol. 2011 Apr; 92(Pt 4):961-73. View on Pubmed
- Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab. 2010 Dec 01; 12(6):662-7. View on Pubmed
- Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab. 2010 Dec 01; 12(6):654-61. View on Pubmed
- Alhazzazi TY, Kamarajan P, Joo N, Huang JY, Verdin E, D'Silva NJ, Kapila YL. Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer. 2011 Apr 15; 117(8):1670-8. View on Pubmed
- Verdin E, Hirschey MD, Finley LW, Haigis MC. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci. 2010 Dec; 35(12):669-75. View on Pubmed
- Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E. Dietary restriction: standing up for sirtuins. Science. 2010 Aug 27; 329(5995):1012-3; author reply 1013-4. View on Pubmed
- Yan W, Si Y, Slaymaker S, Li J, Zheng H, Young DL, Aslanian A, Saunders L, Verdin E, Charo IF. Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility. J Biol Chem. 2010 Oct 08; 285(41):31418-26. View on Pubmed
- Trono D, Van Lint C, Rouzioux C, Verdin E, Barré-Sinoussi F, Chun TW, Chomont N. HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals. Science. 2010 Jul 09; 329(5988):174-80. View on Pubmed
- Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, Willenbring H, Verdin E. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY). 2010 Jul; 2(7):415-31. View on Pubmed
- Chávez L, Kauder S, Verdin E. In vivo, in vitro, and in silico analysis of methylation of the HIV-1 provirus. Methods. 2011 Jan; 53(1):47-53. View on Pubmed
- Ott M, Verdin E. HAT trick: p300, small molecule, inhibitor. Chem Biol. 2010 May 28; 17(5):417-8. View on Pubmed
- Shimazu T, Hirschey MD, Huang JY, Ho LT, Verdin E. Acetate metabolism and aging: An emerging connection. Mech Ageing Dev. 2010 Jul-Aug; 131(7-8):511-6. View on Pubmed
- Parra M, Verdin E. Regulatory signal transduction pathways for class IIa histone deacetylases. Curr Opin Pharmacol. 2010 Aug; 10(4):454-60. View on Pubmed
- Carle P, Saillard C, Carrère N, Carrère S, Duret S, Eveillard S, Gaurivaud P, Gourgues G, Gouzy J, Salar P, Verdin E, Breton M, Blanchard A, Laigret F, Bové JM, Renaudin J, Foissac X. Partial chromosome sequence of Spiroplasma citri reveals extensive viral invasion and important gene decay. Appl Environ Microbiol. 2010 Jun; 76(11):3420-6. View on Pubmed
- Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J. Impact papers on aging in 2009. Aging (Albany NY). 2010 Mar; 2(3):111-21. View on Pubmed
- Pagans S, Kauder SE, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel RC, Verdin E, Schnolzer M, Ott M. The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. . 2010 Mar 18; 7(3):234-44. View on Pubmed
- Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Alt FW, Kahn CR, Verdin E. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010 Mar 04; 464(7285):121-5. View on Pubmed
- Huang JY, Hirschey MD, Shimazu T, Ho L, Verdin E. Mitochondrial sirtuins. Biochim Biophys Acta. 2010 Aug; 1804(8):1645-51. View on Pubmed
- Verdin E, Gognalons P, Wipf-Scheibel C, Bornard I, Ridray G, Schoen L, Lecoq H. First Report of Tomato torrado virus in Tomato Crops in France. Plant Dis. 2009 Dec; 93(12):1352. View on Pubmed
- Malik S, Jiang S, Garee JP, Verdin E, Lee AV, O'Malley BW, Zhang M, Belaguli NS, Oesterreich S. Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM. Mol Cell Biol. 2010 Jan; 30(2):399-412. View on Pubmed
- Blazkova J, Trejbalova K, Gondois-Rey F, Halfon P, Philibert P, Guiguen A, Verdin E, Olive D, Van Lint C, Hejnar J, Hirsch I. CpG methylation controls reactivation of HIV from latency. PLoS Pathog. 2009 Aug; 5(8):e1000554. View on Pubmed
- Kauder SE, Bosque A, Lindqvist A, Planelles V, Verdin E. Epigenetic regulation of HIV-1 latency by cytosine methylation. PLoS Pathog. 2009 Jun; 5(6):e1000495. View on Pubmed
- Cooper HM, Huang JY, Verdin E, Spelbrink JN. A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein. PLoS One. 2009; 4(3):e4986. View on Pubmed
- Saunders LR, Verdin E. Cell biology. Stress response and aging. Science. 2009 Feb 20; 323(5917):1021-2. View on Pubmed
- Pintchovski SA, Peebles CL, Kim HJ, Verdin E, Finkbeiner S. The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons. J Neurosci. 2009 Feb 04; 29(5):1525-37. View on Pubmed
- Schäfer S, Saunders L, Schlimme S, Valkov V, Wagner JM, Kratz F, Sippl W, Verdin E, Jung M. Pyridylalanine-containing hydroxamic acids as selective HDAC6 inhibitors. ChemMedChem. 2009 Feb; 4(2):283-90. View on Pubmed
- Hirschey MD, Shimazu T, Huang JY, Verdin E. Acetylation of mitochondrial proteins. Methods Enzymol. 2009; 457:137-47. View on Pubmed
- Uciechowska U, Schemies J, Neugebauer RC, Huda EM, Schmitt ML, Meier R, Verdin E, Jung M, Sippl W. Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing. ChemMedChem. 2008 Dec; 3(12):1965-76. View on Pubmed
- Mottet D, Pirotte S, Lamour V, Hagedorn M, Javerzat S, Bikfalvi A, Bellahcène A, Verdin E, Castronovo V. HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism. Oncogene. 2009 Jan 15; 28(2):243-56. View on Pubmed
- Scott GK, Marx C, Berger CE, Saunders LR, Verdin E, Schäfer S, Jung M, Benz CC. Destabilization of ERBB2 transcripts by targeting 3' untranslated region messenger RNA associated HuR and histone deacetylase-6. Mol Cancer Res. 2008 Jul; 6(7):1250-8. View on Pubmed
- Wang S, Li X, Parra M, Verdin E, Bassel-Duby R, Olson EN. Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7738-43. View on Pubmed
- Neugebauer RC, Uchiechowska U, Meier R, Hruby H, Valkov V, Verdin E, Sippl W, Jung M. Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. J Med Chem. 2008 Mar 13; 51(5):1203-13. View on Pubmed
- Schwer B, Verdin E. Conserved metabolic regulatory functions of sirtuins. Cell Metab. 2008 Feb; 7(2):104-12. View on Pubmed
- Verdin E. Regulation of human immunodeficiency virus-1 latency and its reactivation. Bull Mem Acad R Med Belg. 2008; 163(6):355-64; discussion 364-5. View on Pubmed
- Verdin E. AROuSing SIRT1: identification of a novel endogenous SIRT1 activator. Mol Cell. 2007 Nov 09; 28(3):354-6. View on Pubmed
- Schäfer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M. Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). Bioorg Med Chem. 2008 Feb 15; 16(4):2011-33. View on Pubmed
- Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec; 27(24):8807-14. View on Pubmed
- North BJ, Verdin E. Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS One. 2007 Aug 29; 2(8):e784. View on Pubmed
- Ahuja N, Schwer B, Carobbio S, Waltregny D, North BJ, Castronovo V, Maechler P, Verdin E. Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem. 2007 Nov 16; 282(46):33583-33592. View on Pubmed
- Saunders LR, Verdin E. Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene. 2007 Aug 13; 26(37):5489-504. View on Pubmed
- Bisgrove DA, Mahmoudi T, Henklein P, Verdin E. Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. Proc Natl Acad Sci U S A. 2007 Aug 21; 104(34):13690-5. View on Pubmed
- Barrett A, Santangelo S, Tan K, Catchpole S, Roberts K, Spencer-Dene B, Hall D, Scibetta A, Burchell J, Verdin E, Freemont P, Taylor-Papadimitriou J. Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. Int J Cancer. 2007 Jul 15; 121(2):265-75. View on Pubmed
- North BJ, Verdin E. Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. J Biol Chem. 2007 Jul 06; 282(27):19546-55. View on Pubmed
- Kasler HG, Verdin E. Histone deacetylase 7 functions as a key regulator of genes involved in both positive and negative selection of thymocytes. Mol Cell Biol. 2007 Jul; 27(14):5184-200. View on Pubmed
- Pagan JK, Arnold J, Hanchard KJ, Kumar R, Bruno T, Jones MJ, Richard DJ, Forrest A, Spurdle A, Verdin E, Crossley M, Fanciulli M, Chenevix-Trench G, Young DB, Khanna KK. A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. J Biol Chem. 2007 May 18; 282(20):15248-57. View on Pubmed
- Parra M, Mahmoudi T, Verdin E. Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes. Genes Dev. 2007 Mar 15; 21(6):638-43. View on Pubmed
- Candresse T, Marais A, Ollivier F, Verdin E, Blancard D. First Report of the Presence of Tomato apical stunt viroid on Tomato in Sénégal. Plant Dis. 2007 Mar; 91(3):330. View on Pubmed
- Krennhrubec K, Marshall BL, Hedglin M, Verdin E, Ulrich SM. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15; 17(10):2874-8. View on Pubmed
- Ohnuma-Ishikawa K, Morio T, Yamada T, Sugawara Y, Ono M, Nagasawa M, Yasuda A, Morimoto C, Ohnuma K, Dang NH, Hosoi H, Verdin E, Mizutani S. Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells. Cancer Res. 2007 Feb 01; 67(3):1019-29. View on Pubmed
- Trapp J, Jochum A, Meier R, Saunders L, Marshall B, Kunick C, Verdin E, Goekjian P, Sippl W, Jung M. Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. J Med Chem. 2006 Dec 14; 49(25):7307-16. View on Pubmed
- Saunders LR, Verdin E. Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors. . 2006 Nov; 5(11):2777-85. View on Pubmed
- Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10224-10229. View on Pubmed
- Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M, Verdin E. The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. J Biol Chem. 2006 Jul 21; 281(29):19960-8. View on Pubmed
- Parrella G, Verdin E, Gognalons P, Marchoux G. Detection and characterization of tobacco mild green mosaic virus (TMGMV) large type isolate from trailing petunia in France. Commun Agric Appl Biol Sci. 2006; 71(3 Pt B):1237-44. View on Pubmed
- Olaharski AJ, Rine J, Marshall BL, Babiarz J, Zhang L, Verdin E, Smith MT. The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. PLoS Genet. 2005 Dec; 1(6):e77. View on Pubmed
- Williams SA, Chen LF, Kwon H, Ruiz-Jarabo CM, Verdin E, Greene WC. NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J. 2006 Jan 11; 25(1):139-49. View on Pubmed
- Bisgrove D, Lewinski M, Bushman F, Verdin E. Molecular mechanisms of HIV-1 proviral latency. Expert Rev Anti Infect Ther. 2005 Oct; 3(5):805-14. View on Pubmed
- North BJ, Schwer B, Ahuja N, Marshall B, Verdin E. Preparation of enzymatically active recombinant class III protein deacetylases. Methods. 2005 Aug; 36(4):338-45. View on Pubmed
- Wittich S, Scherf H, Xie C, Heltweg B, Dequiedt F, Verdin E, Gerhäuser C, Jung M. Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines. Anticancer Drugs. 2005 Jul; 16(6):635-43. View on Pubmed
- Lewinski MK, Bisgrove D, Shinn P, Chen H, Hoffmann C, Hannenhalli S, Verdin E, Berry CC, Ecker JR, Bushman FD. Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription. J Virol. 2005 Jun; 79(11):6610-9. View on Pubmed
- Jayakumar P, Berger I, Autschbach F, Weinstein M, Funke B, Verdin E, Goldsmith MA, Keppler OT. Tissue-resident macrophages are productively infected ex vivo by primary X4 isolates of human immunodeficiency virus type 1. J Virol. 2005 Apr; 79(8):5220-6. View on Pubmed
- Waltregny D, Glénisson W, Tran SL, North BJ, Verdin E, Colige A, Castronovo V. Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility. FASEB J. 2005 Jun; 19(8):966-8. View on Pubmed
- Pagans S, Pedal A, North BJ, Kaehlcke K, Marshall BL, Dorr A, Hetzer-Egger C, Henklein P, Frye R, McBurney MW, Hruby H, Jung M, Verdin E, Ott M. SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol. 2005 Feb; 3(2):e41. View on Pubmed
- Parra M, Kasler H, McKinsey TA, Olson EN, Verdin E. Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation. J Biol Chem. 2005 Apr 08; 280(14):13762-70. View on Pubmed
- Heltweg B, Dequiedt F, Marshall BL, Brauch C, Yoshida M, Nishino N, Verdin E, Jung M. Subtype selective substrates for histone deacetylases. J Med Chem. 2004 Oct 07; 47(21):5235-43. View on Pubmed
- Waltregny D, De Leval L, Glénisson W, Ly Tran S, North BJ, Bellahcène A, Weidle U, Verdin E, Castronovo V. Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues. Am J Pathol. 2004 Aug; 165(2):553-64. View on Pubmed
- Williams SA, Chen LF, Kwon H, Fenard D, Bisgrove D, Verdin E, Greene WC. Prostratin antagonizes HIV latency by activating NF-kappaB. J Biol Chem. 2004 Oct 01; 279(40):42008-17. View on Pubmed
- Waltregny D, North B, Van Mellaert F, de Leval J, Verdin E, Castronovo V. Screening of histone deacetylases (HDAC) expression in human prostate cancer reveals distinct class I HDAC profiles between epithelial and stromal cells. Eur J Histochem. 2004 Jul-Sep; 48(3):273-90. View on Pubmed
- North BJ, Verdin E. Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol. 2004; 5(5):224. View on Pubmed
- Verdin E, Dequiedt F, Kasler H. HDAC7 regulates apoptosis in developing thymocytes. Novartis Found Symp. 2004; 259:115-29; discussion 129-31, 163-9. View on Pubmed
- Verdin E, Dequiedt F, Fischle W, Frye R, Marshall B, North B. Measurement of mammalian histone deacetylase activity. Methods Enzymol. 2004; 377:180-96. View on Pubmed
- Ott M, Dorr A, Hetzer-Egger C, Kaehlcke K, Schnolzer M, Henklein P, Cole P, Zhou MM, Verdin E. Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation. Novartis Found Symp. 2004; 259:182-93; discussion 193-6, 223-5. View on Pubmed
- Heltweg B, Dequiedt F, Verdin E, Jung M. Nonisotopic substrate for assaying both human zinc and NAD+-dependent histone deacetylases. Anal Biochem. 2003 Aug 01; 319(1):42-8. View on Pubmed
- Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V, Henklein P, Schnoelzer M, Loret E, Cole PA, Verdin E, Ott M. Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Mol Cell. 2003 Jul; 12(1):167-76. View on Pubmed
- Danet JL, Foissac X, Zreik L, Salar P, Verdin E, Nourrisseau JG, Garnier M. "Candidatus Phlomobacter fragariae" Is the Prevalent Agent of Marginal Chlorosis of Strawberry in French Production Fields and Is Transmitted by the Planthopper Cixius wagneri (China). Phytopathology. 2003 Jun; 93(6):644-9. View on Pubmed
- Verdin E, Salar P, Danet JL, Choueiri E, Jreijiri F, El Zammar S, Gélie B, Bové JM, Garnier M. 'Candidatus phytoplasma phoenicium' sp. nov., a novel phytoplasma associated with an emerging lethal disease of almond trees in Lebanon and Iran. Int J Syst Evol Microbiol. 2003 May; 53(Pt 3):833-838. View on Pubmed
- Verdin E, Dequiedt F, Kasler HG. Class II histone deacetylases: versatile regulators. Trends Genet. 2003 May; 19(5):286-93. View on Pubmed
- Dequiedt F, Kasler H, Fischle W, Kiermer V, Weinstein M, Herndier BG, Verdin E. HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity. 2003 May; 18(5):687-98. View on Pubmed
- Jordan A, Bisgrove D, Verdin E. HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J. 2003 Apr 15; 22(8):1868-77. View on Pubmed
- Pion M, Jordan A, Biancotto A, Dequiedt F, Gondois-Rey F, Rondeau S, Vigne R, Hejnar J, Verdin E, Hirsch I. Transcriptional suppression of in vitro-integrated human immunodeficiency virus type 1 does not correlate with proviral DNA methylation. J Virol. 2003 Apr; 77(7):4025-32. View on Pubmed
- North BJ, Marshall BL, Borra MT, Denu JM, Verdin E. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell. 2003 Feb; 11(2):437-44. View on Pubmed
- Schwer B, North BJ, Frye RA, Ott M, Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol. 2002 Aug 19; 158(4):647-57. View on Pubmed
- Dorr A, Kiermer V, Pedal A, Rackwitz HR, Henklein P, Schubert U, Zhou MM, Verdin E, Ott M. Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J. 2002 Jun 03; 21(11):2715-23. View on Pubmed
- Choueiri E, Jreijiri F, El Zammar S, Verdin E, Salar P, Danet JL, Bové J, Garnier M. First Report of Grapevine "Bois Noir" Disease and a New Phytoplasma Infecting Solanaceous Plants in Lebanon. Plant Dis. 2002 Jun; 86(6):697. View on Pubmed
- Murphy JC, Fischle W, Verdin E, Sinclair JH. Control of cytomegalovirus lytic gene expression by histone acetylation. EMBO J. 2002 Mar 01; 21(5):1112-20. View on Pubmed
- Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, Ott M, Verdin E, Zhou MM. Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell. 2002 Mar; 9(3):575-86. View on Pubmed
- Borra MT, O'Neill FJ, Jackson MD, Marshall B, Verdin E, Foltz KR, Denu JM. Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases. J Biol Chem. 2002 Apr 12; 277(15):12632-41. View on Pubmed
- Deroanne CF, Bonjean K, Servotte S, Devy L, Colige A, Clausse N, Blacher S, Verdin E, Foidart JM, Nusgens BV, Castronovo V. Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene. 2002 Jan 17; 21(3):427-36. View on Pubmed
- Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell. 2002 Jan; 9(1):45-57. View on Pubmed
- Chen Lf , Fischle W, Verdin E, Greene WC. Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science. 2001 Aug 31; 293(5535):1653-7. View on Pubmed
- Kruhlak MJ, Hendzel MJ, Fischle W, Bertos NR, Hameed S, Yang XJ, Verdin E, Bazett-Jones DP. Regulation of global acetylation in mitosis through loss of histone acetyltransferases and deacetylases from chromatin. J Biol Chem. 2001 Oct 12; 276(41):38307-19. View on Pubmed
- Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E. Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. J Biol Chem. 2001 Sep 21; 276(38):35826-35. View on Pubmed
- Choueiri E, Jreijiri F, Issa S, Verdin E, Bové J, Garnier M. First Report of a Phytoplasma Disease of Almond (Prunus amygdalus) in Lebanon. Plant Dis. 2001 Jul; 85(7):802. View on Pubmed
- Jordan A, Defechereux P, Verdin E. The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation. EMBO J. 2001 Apr 02; 20(7):1726-38. View on Pubmed
- Geenen V, Verdin E. [Egg-cell complex, molecular embryology, human genome, then, human proteome]. Rev Med Liege. 2001 Mar; 56(3):170. View on Pubmed
- Fischle W, Kiermer V, Dequiedt F, Verdin E. The emerging role of class II histone deacetylases. Biochem Cell Biol. 2001; 79(3):337-48. View on Pubmed
- Verdin E, Kobisch M, Bové JM, Garnier M, Saillard C. Use of an internal control in a nested-PCR assay for Mycoplasma hyopneumoniae detection and quantification in tracheobronchiolar washings from pigs. Mol Cell Probes. 2000 Dec; 14(6):365-72. View on Pubmed
- Verdin E, Saillard C, Labbé A, Bové JM, Kobisch M. A nested PCR assay for the detection of Mycoplasma hyopneumoniae in tracheobronchiolar washings from pigs. Vet Microbiol. 2000 Sep 15; 76(1):31-40. View on Pubmed
- Gaurivaud P, Laigret F, Verdin E, Garnier M, Bové JM. Fructose operon mutants of Spiroplasma citri. Microbiology (Reading). 2000 Sep; 146 ( Pt 9):2229-2236. View on Pubmed
- Huynh KD, Fischle W, Verdin E, Bardwell VJ. BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev. 2000 Jul 15; 14(14):1810-23. View on Pubmed
- Kruhlak MJ, Lever MA, Fischle W, Verdin E, Bazett-Jones DP, Hendzel MJ. Reduced mobility of the alternate splicing factor (ASF) through the nucleoplasm and steady state speckle compartments. J Cell Biol. 2000 Jul 10; 150(1):41-51. View on Pubmed
- Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes Dev. 2000 May 01; 14(9):1048-57. View on Pubmed
- Wang JK, Kiyokawa E, Verdin E, Trono D. The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc Natl Acad Sci U S A. 2000 Jan 04; 97(1):394-9. View on Pubmed
- Ott M, Schnölzer M, Garnica J, Fischle W, Emiliani S, Rackwitz HR, Verdin E. Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity. Curr Biol. 1999 Dec 16-30; 9(24):1489-92. View on Pubmed
- Mahlknecht U, Hoelzer D, Bucala R, Verdin E. Cloning and characterization of the murine histone deacetylase (HDAC3). Biochem Biophys Res Commun. 1999 Sep 24; 263(2):482-90. View on Pubmed
- Critchfield JW, Ho O, Roberts BD, Van Lint C, Verdin E, Butera ST. Isoquinolinesulphonamide derivatives inhibit transcriptional elongation of human immunodeficiency virus type 1 RNA in a promyelocytic model of latency. Antivir Chem Chemother. 1999 Sep; 10(5):275-84. View on Pubmed
- Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E. A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p. J Biol Chem. 1999 Apr 23; 274(17):11713-20. View on Pubmed
- Mahlknecht U, Emiliani S, Najfeld V, Young S, Verdin E. Genomic organization and chromosomal localization of the human histone deacetylase 3 gene. Genomics. 1999 Mar 01; 56(2):197-202. View on Pubmed
- Mahlknecht U, Bucala R, Verdin E. Assignment of the histone deacetylase gene (Hdac3) to mouse chromosome 18B3 by in situ hybridization. Cytogenet Cell Genet. 1999; 84(3-4):192-3. View on Pubmed
- Mahlknecht U, Bucala R, Hoelzer D, Verdin E. High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region. Cytogenet Cell Genet. 1999; 86(3-4):237-9. View on Pubmed
- Herbein G, Mahlknecht U, Batliwalla F, Gregersen P, Pappas T, Butler J, O'Brien WA, Verdin E. Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4. Nature. 1998 Sep 10; 395(6698):189-94. View on Pubmed
- Kiermer V, Van Lint C, Briclet D, Vanhulle C, Kettmann R, Verdin E, Burny A, Droogmans L. An interferon regulatory factor binding site in the U5 region of the bovine leukemia virus long terminal repeat stimulates Tax-independent gene expression. J Virol. 1998 Jul; 72(7):5526-34. View on Pubmed
- Richon VM, Emiliani S, Verdin E, Webb Y, Breslow R, Rifkind RA, Marks PA. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):3003-7. View on Pubmed
- Emiliani S, Fischle W, Van Lint C, Al-Abed Y, Verdin E. Characterization of a human RPD3 ortholog, HDAC3. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):2795-800. View on Pubmed
- Ott M, Lovett JL, Mueller L, Verdin E. Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-kappaB factors. J Immunol. 1998 Mar 15; 160(6):2872-80. View on Pubmed
- Emiliani S, Fischle W, Ott M, Van Lint C, Amella CA, Verdin E. Mutations in the tat gene are responsible for human immunodeficiency virus type 1 postintegration latency in the U1 cell line. J Virol. 1998 Feb; 72(2):1666-70. View on Pubmed
- Herbein G, Van Lint C, Lovett JL, Verdin E. Distinct mechanisms trigger apoptosis in human immunodeficiency virus type 1-infected and in uninfected bystander T lymphocytes. J Virol. 1998 Jan; 72(1):660-70. View on Pubmed
- Sheridan PL, Mayall TP, Verdin E, Jones KA. Histone acetyltransferases regulate HIV-1 enhancer activity in vitro. Genes Dev. 1997 Dec 15; 11(24):3327-40. View on Pubmed
- Van Lint C, Amella CA, Emiliani S, John M, Jie T, Verdin E. Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity. J Virol. 1997 Aug; 71(8):6113-27. View on Pubmed
- Ott M, Emiliani S, Van Lint C, Herbein G, Lovett J, Chirmule N, McCloskey T, Pahwa S, Verdin E. Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway. Science. 1997 Mar 07; 275(5305):1481-5. View on Pubmed
- McCloskey TW, Ott M, Tribble E, Khan SA, Teichberg S, Paul MO, Pahwa S, Verdin E, Chirmule N. Dual role of HIV Tat in regulation of apoptosis in T cells. J Immunol. 1997 Jan 15; 158(2):1014-9. View on Pubmed
- Emiliani S, Van Lint C, Fischle W, Paras P, Ott M, Brady J, Verdin E. A point mutation in the HIV-1 Tat responsive element is associated with postintegration latency. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6377-81. View on Pubmed
- Van Lint C, Emiliani S, Ott M, Verdin E. Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. EMBO J. 1996 Mar 01; 15(5):1112-20. View on Pubmed
- Van Lint C, Emiliani S, Verdin E. The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation. Gene Expr. 1996; 5(4-5):245-53. View on Pubmed
- Renaudin J, Marais A, Verdin E, Duret S, Foissac X, Laigret F, Bové JM. Integrative and free Spiroplasma citri oriC plasmids: expression of the Spiroplasma phoeniceum spiralin in Spiroplasma citri. J Bacteriol. 1995 May; 177(10):2870-7. View on Pubmed
- Verdin E, Van Lint C. Internal transcriptional regulatory elements in HIV-1 and other retroviruses. Cell Mol Biol (Noisy-le-grand). 1995 May; 41(3):365-9. View on Pubmed
- el Kharroubi A, Verdin E. Protein-DNA interactions within DNase I-hypersensitive sites located downstream of the HIV-1 promoter. J Biol Chem. 1994 Aug 05; 269(31):19916-24. View on Pubmed
- Van Lint C, Ghysdael J, Paras P, Burny A, Verdin E. A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of human immunodeficiency virus type 1. J Virol. 1994 Apr; 68(4):2632-48. View on Pubmed
- Verdin E, Paras P, Van Lint C. Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation. EMBO J. 1993 Aug; 12(8):3249-59. View on Pubmed
- Sharpless N, Gilbert D, Vandercam B, Zhou JM, Verdin E, Ronnett G, Friedman E, Dubois-Dalcq M. The restricted nature of HIV-1 tropism for cultured neural cells. Virology. 1992 Dec; 191(2):813-25. View on Pubmed
- Sharpless NE, O'Brien WA, Verdin E, Kufta CV, Chen IS, Dubois-Dalcq M. Human immunodeficiency virus type 1 tropism for brain microglial cells is determined by a region of the env glycoprotein that also controls macrophage tropism. J Virol. 1992 Apr; 66(4):2588-93. View on Pubmed
- Verdin E. DNase I-hypersensitive sites are associated with both long terminal repeats and with the intragenic enhancer of integrated human immunodeficiency virus type 1. J Virol. 1991 Dec; 65(12):6790-9. View on Pubmed
- Montgomery LB, Kao CY, Verdin E, Cahill C, Maratos-Flier E. Infection of a polarized epithelial cell line with wild-type reovirus leads to virus persistence and altered cellular function. J Gen Virol. 1991 Dec; 72 ( Pt 12):2939-46. View on Pubmed
- Van Lint C, Burny A, Verdin E. The intragenic enhancer of human immunodeficiency virus type 1 contains functional AP-1 binding sites. J Virol. 1991 Dec; 65(12):7066-72. View on Pubmed
- Verdin E, Deveaux E, Deveaux B. [Forced eruption, a clinical procedure: apropos of 2 clinical cases]. Inf Dent. 1990 Sep 13; 72(31):2711-20. View on Pubmed
- Verdin E, Becker N, Bex F, Droogmans L, Burny A. Identification and characterization of an enhancer in the coding region of the genome of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A. 1990 Jun; 87(12):4874-8. View on Pubmed
- Delchambre M, Gheysen D, Thines D, Thiriart C, Jacobs E, Verdin E, Horth M, Burny A, Bex F. The GAG precursor of simian immunodeficiency virus assembles into virus-like particles. EMBO J. 1989 Sep; 8(9):2653-60. View on Pubmed
- Verdin EM, King GL, Maratos-Flier E. Characterization of a common high-affinity receptor for reovirus serotypes 1 and 3 on endothelial cells. J Virol. 1989 Mar; 63(3):1318-25. View on Pubmed
- Verdin EM, Lynn SP, Fields BN, Maratos-Flier E. Uptake of reovirus serotype 1 by the lungs from the bloodstream is mediated by the viral hemagglutinin. J Virol. 1988 Feb; 62(2):545-51. View on Pubmed
- Burny A, Bex F, Brasseur R, Khim MC, Delchambre M, Horth M, Verdin E. Human immunodeficiency virus cell entry: new insights into the fusion mechanism. J Acquir Immune Defic Syndr (1988). 1988; 1(6):579-82. View on Pubmed
- Maratos-Flier E, Kao CY, Verdin EM, King GL. Receptor-mediated vectorial transcytosis of epidermal growth factor by Madin-Darby canine kidney cells. J Cell Biol. 1987 Oct; 105(4):1595-601. View on Pubmed
- Verdin EM, Maratos-Flier E, Kahn CR, Sodoyez JC, Sodoyez-Goffaux F, De Vos CJ, Lynn SP, Fields BN. Visualization of viral clearance in the living animal. Science. 1987 Apr 24; 236(4800):439-42. View on Pubmed
- Verdin EM, Maratos-Flier E, Carpentier JL, Kahn CR. Persistent infection with a nontransforming RNA virus leads to impaired growth factor receptors and response. J Cell Physiol. 1986 Sep; 128(3):457-65. View on Pubmed
- Paolisso G, Scheen AJ, Verdin EM, Luyckx AS, Lefebvre PJ. Insulin oscillations per se do not affect glucose turnover parameters in normal man. J Clin Endocrinol Metab. 1986 Aug; 63(2):520-5. View on Pubmed
- Verdin E, Smitz S, Thibaut A, Born J, Legros JJ, Luyckx A. Adipsic hypernatremia in a patient with pseudotumor cerebri and the primary empty sella syndrome. J Endocrinol Invest. 1985 Aug; 8(4):369-72. View on Pubmed
- Verdin E, Castillo M, Luyckx AS, Lefebvre PJ. Similar metabolic effects of pulsatile versus continuous human insulin delivery during euglycemic, hyperinsulinemic glucose clamp in normal man. Diabetes. 1984 Dec; 33(12):1169-74. View on Pubmed
- Verdin EM, Green FW. VIP and the pancreatic cholera syndrome. N Engl J Med. 1984 May 31; 310(22):1465-6. View on Pubmed
- Castillo M, Nemery A, Verdin E, Lefebvre PJ, Luyckx AS. Circadian profiles of blood glucose and plasma free insulin during treatment with semisynthetic and biosynthetic human insulin, and comparison with conventional monocomponent preparations. Eur J Clin Pharmacol. 1983; 25(6):767-71. View on Pubmed