CFAR Summary of CROI 2026 Abstracts
ORAL PRESENTATIONS SUNDAY – FEBRUARY 22, 2026
Workshop-04 | Clinical Trial Design and Analysis Workshop
2:00 PM - 4:00 PM • Four Seasons Ballroom 1
2:00PM: Clinical Trials in the Post-Lenacapavir Era
David V. Glidden, PhD MS
Monday – February 23, 2026
Oral Abstract Session-01 | Interaction of HIV With Cells and People
10:00 AM - 12:00 PM • Mile High Ballroom 4
11:13AM: 105 Systematic Discovery of Pro- and Anti-HIV Host Factors in Primary Human CD4+ T Cells
Eli Dugan, Ujjwal Rathore, Hunter Thornton, Vigneshwari Kumar, Rama Dajani, Ryan C. Burdick, Reanna Lao, Krista A. Delviks-Frankenberry, Ishaan Dureja, Maya M. Arce, Vinay K. Pathak, Harmit S. Malik, Nevan J. Krogan, Alexander Marson
Oral Abstract Session-02 | Frontiers in Neuropathogenesis and Tissue Biology: Decoded Through Cellular Dynamics, Metabolics, and Imaging
10:00 AM - 12:00 PM • Four Seasons Ballroom 1
11:13AM: 113 Multimodal PET Imaging Reveals Focal HIV Activity and Immune Activation During ATI Prior to Rebound
Oral Abstract Session-03 | Beyond the Virus: The Expanding Landscape of HIV-Associated Conditions
10:00 AM - 12:00 PM • Four Seasons Ballroom 2-3
10:29AM: 119 Population-Level Obesity Trends by HIV Status in Pre-/Post-DTG Era in Rural East Africa SEARCH Study
Elijah R. Kakande, James Ayieko, Laura B. Balzer, Jane Kabami, Colette I. Aoko, Asiphas Owaraganise, George Agengo, Helen Sunday, Erick Wafula, Marilyn Nyabuti, Gabriel Chamie, Maya Petersen, Moses R. Kamya, Diane V. Havlir, Matt Hickey, for the SEARCH Collaboration
Themed Discussion-01 | Mechanisms and Modifiers: Treatable Causes of Cognitive Impairment and Depression 1:30 PM - 2:30 PM • Four Seasons Ballroom 2-3
1:42PM: 448 - Modifiable Factors Could Mitigate Greater Burden of Brain Small Vessel Injury in Female Individuals
Felicia C. Chow, Yifei Ma, Yannan Yu, Mackenzie Vogan, Jennifer Sullivano, Anastasia Polos, Stephen Gange, Catalina Ramirez, Claudiu Schirda, Weili Lin, Michelle Floris-Moore, Phyllis Tien, Bernard J. C. Macatangay, Jared Narvid, Elana Farrell
POSTER SESSIONS BY DAY MONDAY, FEBRUARY 23, 2026 2:30 PM - 4:00 PM
Poster Session-A1 | The Ins and Outs of Viral Replication
203 - Galectin-9 Enables HIV Infection of Resting CD4+ T Cells and Promotes Latent Reservoir Expansion
Li Du, Thomas Premeaux, Mohamed Bouzidi, Prerna Dabral, Rebecca Hoh, Toshiro Niki, Lishomwa C. Ndhlovu, Steven Deeks, Satish K. Pillai
Poster Session-B1 | Immunopathogenesis
228 - Immune and Metabolic Programs Shape Biphasic HIV Reservoir Decay During Acute ART Initiation
Namratha Shivani Chalasani, Alaa Abdellatif, Alton Barbehenn, Caroline Sheikhzadeh, Sonia Savur, Erik Lundgren, Rebecca Hoh, Jessica Tsui, Saba Shaikh, Lenka Maliskova, Gabriela Fragiadakis, Alexis Combes, Steven Deeks, Walter Eckalbar, Sulggi A. Lee
Poster Session-B2 | Immune Activations and Inflammation
231 - Inflammatory Monocyte and T-Cell Signatures Linked to IL-1β, a Marker of Vascular Risk in HIV
Namratha Shivani Chalasani, Ana C. Santana, Giuliana Xavier de Medeiros, Felipe ten Caten, Alton Barbehenn, Caroline Sheikhzadeh, Sonia Savur, Xiuping Chu, Daniel Winder, Colin T. Maguire, Jeffrey Tomalka, Rafick P. Sekaly, Brian K. Agan, Susan P. Ribeiro, Sulggi A. Lee
Poster Session-D01 | HIV Reservoir Dynamics
332 - The Plasma Cell–Free DNA Methylome Predicts Intact HIV Reservoir Decay During Antiretroviral Therapy
Manukumar Honnayakanahalli Marichannegowda, Xutao Deng, Sergio SerranoVillar, Rebecca Hoh, Thomas Dalhuisen, Steven Deeks, Michael J. Peluso, Satish K. Pillai
Poster Session-D04 | Transcription in the HIV Reservoir
354 - HIV DNA and RNA Levels Before and After ART in Natural Controllers and Comparison to Noncontrollers
Sun Jin Kim, Julie Janssens, Cordelia Isbell, Adam Wedrychowski, Alton Barbehenn, Rebecca Hoh, Michael J. Peluso, Sulggi A. Lee, Satish K. Pillai, Timothy J. Henrich, Nadia R. Roan, Steven Deeks, Steven A. Yukl, for the ReACTOR Study Group
357 - Immune Clearance Proteomic Signatures and Efavirenz Linked to Lower Completed HIV Transcript Levels
Peter W. Hunt, Antonia de Andraca Serrano, Julian Kim, Steven Deeks, Noah Aquino, Ahmed Abdelhak, Yoshinori Fukazawa, Steven A. Yukl
Poster Session-F1 | The Real World of Pharmacokinetics: New Methods, Diverse Populations, and Fresh Insights
483 - Sex Differences in Cabotegravir Pharmacokinetics in the SEARCH Study in Kenya and Uganda
Catherine A. Koss, Moses R. Kamya, Marilyn Nyabuti, Hideaki Okochi, Jane Kabami, David V. Glidden, Elijah R. Kakande, Moses Akuno, Hellen N. Atuhaire, Alex R. Rinehart, Elizabeth A. Bukusi, Maya Petersen, Diane V. Havlir, Monica Gandhi, James Ayieko, for the SEARCH Collaboration
484 - Lower Cabotegravir Levels Predict Elevated Viral Load on Long-Acting ART in a Real-World Setting
Matthew Spinelli, Megan J. Heise, David V. Glidden, Shivani Mahuvakar, Kevin Sassaman, Karen Kuncze, Alexander Louie, Janet Grochowski, Jon Oskarsson, Jeffrey Whitman, Hideaki Okochi, Monica Gandhi
ORAL PRESENTATIONS Tuesday – February 24, 2026
Oral Abstract Session-08 | We Thought You'd Never Ask: Improving HIV Testing, Treatment, and Prevention
10:00 AM - 12:00 PM • Mile High Ballroom 4
11:13AM: 163 - The Impact of SEARCH Community Precision Health on HIV Incidence in Rural Kenya and Uganda
Gabriel Chamie, Maya Petersen, Laura B. Balzer, James Ayieko, Jane Kabami, Elijah R. Kakande, Matt Hickey, Catherine A. Koss, Andrew Phillips, Carol Camlin, Theodore Ruel, Moses R. Ka
Oral Abstract Session-06 | Three Battles - One Stage: TB, Hepatitis, and Hepatocellular Cancer 10:00 AM - 12:00 PM • Four Seasons Ballroom 2-3
10:13AM: 142 - Hepatitis B Reactivation/Infection in People With HIV on Tenofovir- Sparing Antiretroviral Therapy
Grace Haser, Nadra Lisha, H. Nina Kim, Greer Burkholder, Edward Cachay, Heidi M. Crane, Oluwaseun Falade-Nwulia, Julia Fleming, Mari Kitahata, April Pettit, Sarah Rutstein, George Yendewa, Katerina Christopoulos, Anne F. Luetkemeyer, for the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) Cohort
Themed Discussion-08 | Machines, Models, and Messages
1:30 PM - 2:30 PM • Four Seasons Ballroom 1
1:46PM: 1078 - Measuring Provider Quality of Care in Tanzania Using Large Language Models
Alaa Abdellatif, Calvin Chiu, Sutina Chou, Lila Sheira, Laurel Packel, Jenny Liu, Agatha Mnyippembe, Werner Maokola, Emma Anderson
POSTER SESSIONS BY DAY TUESDAY, FEBRUARY 24, 2026 2:30 PM - 4:00 PM
Poster Session-A3 | Regulation of HIV Integration and Gene Expression
213 - Targeting Proliferating Cell Nuclear Antigen (PCNA) to Cure HIV Infection
Prerna Dabral, Li Du, Mohamed Bouzidi, Long Gu, Caroline Li, Pouya Haratipour, Robert Hickey, Linda Malkas, Satish K. Pillai
Poster Session-C1 | Unique Aspects of Immunity to HIV Infection
271 - Timing of ART Affects Frequencies and Phenotypes of HIV-Specific CD8+ T Cells
Alicer K. Andrew, Xiaoyu Luo, Jason Neidleman, Michael J. Peluso, Rebecca Hoh, Steven Deeks, Sulggi A. Lee, Steven A. Yukl, Nadia R. Roan
279 - Sex Differences in Immunologic Response to Letermovir-Mediated CMV Suppression in People With HIV
Rebecca Abelman, Adam Olshen, Kristine M. Erlandson, Douglas Kitch, Shirley Qiu, Yoshinori Fukazawa, Noah Aquino, Scott L. Letendre, Lawrence Fox, John Koethe, Priscilla Hsue, Davey Smith, Michael L. Freeman, Sara Gianella, Peter W. Hunt, for the ACTG 5383 Study
Poster Session-D05 | In Vivo Immune Interventions for an HIV Cure
376 - bNAbs Detected in Tissue Up to 46 Weeks Postadministration
Chao Wang, Brian Lafranchi, Emmanuel Velazquez, Lilian Grimbert, Meghann Williams, Monika Deswal, Rebecca Hoh, Sandeep Narpala, Leonid Serebryannyy, Ma Somsouk, Rachel L. Rutishauser, Steven Deeks, Michael J. Peluso, Timothy J. Henrich, Amelia N. Deitchman
368 - Safety and Antiviral Activity of CD4 Mimetic Treatment in SHIV-Infected Rhesus Macaques Leonardo Sorrentino, Jonathan Richard, Cesar Ariel Trifone, Kevin Nguyen, James Auger, Hannah Rei Flores, Li Zhu, Laurence Raymond Marchand, Derek Yang, Donna Huryn, Priti Kumar, Nicolas Chomont, Joseph Sodroski, Andrés Finzi, Mirko Paiardini
Poster Session-D06 | Cellular HIV Reservoirs
380 - HIV Reservoir Cells From ART‑Suppressed PWH Exhibit Distinct but Heterogeneous Glycomic Signatures
Ifeanyi Ezeonwumelu, Tongcui Ma, Xiaoyu Luo, Jason Neidleman, Ashley F. George, Leila B. Giron, Rebecca Hoh, Steven Deeks, Mohamed AbdelMohsen, Nadia R. Roan
Poster Session-N5 | Tuberculosis Treatment Outcomes: Monitoring, Inflammation, and ART
777 - Time to Stable Sputum Culture Positivity as a Surrogate Endpoint in Phase II/III Tuberculosis Trials
Tae Kyu Chung, Pieter Van Brantegem, Bélen P. Solans, Marjorie Z. Imperial, Vincent K. Chang, Gustavo E. Velásquez, Rada Savic
Poster Session-S2 | Getting Close to Zero: Challenges and Opportunities
990 - PrEP Digital Diary and Delivery (PrEP-3D): An RCT of Online Pharmacy-Delivered PrEP in California
Susan Buchbinder, Juwann Moss, David V. Glidden, Sam Gassen, Geovanny Munoz Acosta, Cat-Dancing Alleyne, Tracy Nguyen, Susan Sun, Jennifer Velloza, Robert Pitts, Mellesia Jeetoo, Hyman Scott, Albert Y. Liu
Poster Session-T4 | The Realities of Doxy-PEP
1038 - Differential Risk Reduction of Gonorrhea and Chlamydia Among DoxyPEP Users Reporting High Adherence
Michael P. Barry, Jason Bena, Jorge Roman, Diana M. Tordoff, Hyman Scott
1042 - Doxy-PEP Associated With Clearance of Mycoplasma genitalium Urogenital Infection
Emma D. Bainbridge, Katherine Thomas, Cole Grabow, Olusegun O. Soge, Stephanie E. Cohen, Julie Dombrowski, Chase A. Cannon, Hyman Scott, Clare E. Brown, Lisa Manhart, Connie L. Celum, Anne F. Luetkemeyer, for the DoxyPEP Study Team
Poster Session-U03 | Novel Interventions
1070 - Preferences for Biomedical HIV Prevention Services of Alcohol-Venue Patrons/Workers in East Africa
Nicholas DesLauriers, Brian Beesiga, Janice Litunya, Kara Marson, Erick Wafula, Carol Camlin, Starley Shade, Judith Hahn, Jane Kabami, Maya Petersen, Diane V. Havlir, Laura B. Balzer, Moses R. Kamya, James Ayieko, Gabriel Chamie, for the OPAL-East Africa Study
1073 - School-Based HIV Prevention for Adolescent Mothers: Population Data From 8 African Countries
Noah Mancuso, Alinda M. Nyamaizi, Patrick Smith, Marie Stoner, Kirsten Stoebenau, Opeyemi Babajide, Bukiwe Sihlongonyane, Jessica Justman, Alex Ezeh, Allison Groves
Poster Session-U04 | Machine Learning and AI
1078 - Measuring Provider Quality of Care in Tanzania Using Large Language Models
Alaa Abdellatif, Calvin Chiu, Sutina Chou, Lila Sheira, Laurel Packel, Jenny Liu, Agatha Mnyippembe, Werner Maokola, Emma Anderson
ORAL PRESENTATIONS Wednesday – February 25, 2026
Themed Discussion-09 | Harnessing B-Cells and Antibodies for HIV Control
1:30 PM - 2:30 PM • Mile High Ballroom 4
1:46PM: 297 - Evidence of Immune Activation During bNAb-Mediated HIV Suppression Following ATI
Julia A. Wagner, Ravi K. Patel, Michela Traglia, Demi A. Sandel, Reuben Thomas, Pamela Milani, Clara Di Germanio, Michael P. Busch, Peter W. Hunt, Amelia N. Deitchman, Michael J. Peluso, Steven Deeks, Rachel L. Rutishauser
POSTER SESSIONS BY DAY WEDNESDAY, FEBRUAY 25, 2026 2:30 PM - 4:00 PM
Poster Session-G4 | Cabotegravir and Rilpivirine in the "Real World"
529 - Virologic Outcomes After LA ART Initiation With and Without Viremia in 2 Large US Clinic Cohort
Matthew Spinelli, Megan J. Heise, David V. Glidden, Janet Grochowski, Jon Oskarsson, Larisa NilesCarnes, Eudiah Ochieng, Meredith Lora, Amalia Aldredge, Nathanael L. Gistand, Chesa Cox, Jonathan Colasanti, Monica Gandhi, Lauren F. Collins
Poster Session-H6 | Resistance to Other Antiviral Drugs
582 - Initiating Long-Acting Lenacapavir in a Cohort of PWH With High Baseline Resistance: A Case Series
Nathanael L. Gistand, Ishaan C. Mishra, Megan J. Heise, Chesa Cox, Janet Grochowski, Francis Mayorga-Munoz, Jon Oskarsson, Mary Shiels, Matthew Spinelli
Poster Session-Q11 | Mental Health, Substance Use, and Behavioral Health
Psychosocial Stressors and HIV Nonsuppression in SEARCH Adult Patient-Centered Care in East Africa
Nicholas DesLauriers, Helen Sunday, Colette I. Aoko, John Schrom, Elijah R. Kakande, James Ayieko, Jane Kabami, Laura B. Balzer, Florence Mwangwa, Theodore Ruel, Maya Petersen, Moses R. Kamya, Matt Hickey, Diane V. Havlir, Gabriel Chamie, for the SEARCH Collaboration
Poster Session-U07 | Testing and Linkage
1093 - At-Home Urine Tenofovir Testing is Feasible and Correlates With Adherence in Dried Blood Spots
Renata Buccheri, Matthew Spinelli, Parya Saberi, Torsten Neilands, Stefany Coxe, Monica Gandhi, Judy Y. Tan False-Positi
1095 - Hair and Point-of-Care Tenofovir Urine SelfCollection Feasible With Urine TFV Predicting Viral Load
Kevin Sassaman, Megan J. Heise, Shivani Mahuvakar, David V. Glidden, Torsten Neilands, Dustin T. Duncan, Keith J. Horvath, Sabina Hirshfield, Renessa Williams, Mallory O. Johnson, Christian Grov, Adam W. Carrico, Monica Gandhi, Matthew Spinelli
Poster Session-U10 | Integration
1125 - Tracking Equitable Rollout of Doxy-PEP and CAB-LA for STI & HIV Prevention in San Francisco Clinics
Susan Buchbinder, Courtney Liebi, Thiago S. Torres, Stephanie E. Cohen, Monica Gandhi, Hyman Scott, Madeline Sankaran, Jason Bena, Janet Q. Nguyen, Anne F. Luetkemeyer, Diane V. Havlir
Poster Session-U11 | Substance Use and Mental Health
1128 - High Long-Acting PrEP Retention in a Low-Barrier, Status-Neutral Clinic for People Who Use Drugs
Ayesha Appa, Christy Camp, Matthew Spinelli, Negin Zahedikia, Janet Grochowski, Jon Oskarsson, Mary Shiels, Monica Gandhi, Albert Y. Liu
