Mahley Auditorium, Gladstone Institutes

Welcome: Paul A. Volberding, MD and Warner Greene, MD, PhD

Opening Address

• Haile T. Debas, MD
  Dean, School of Medicine, University of California San Francisco

Morning Session

Moderator: Charles S. Craik, PhD

Keynote Address

• Possibilities for Eradicating HIV Infection
  David D. Ho, MD

Transmission

• Determinants of HIV Vertical Transmission
  Yvonne J. Bryson, MD
• Role of Dendritic Cells in Lentivirus-Mucosal Infection
  Melissa Pope, PhD

Vaccines

• HIV Vaccines
  Margaret I. Johnston, PhD
• DNA Vaccines

The 2002 symposium focused on new developments in basic biological research in HIV.

This year's symposium focused on new developments in basic biological research regarding the immunology of HIV infection.

This day-long seminar provided HIV investigators with information regarding reproductive biology, with special attention to under-recognized aspects relevant to HIV research. The seminar also fostered and facilitated novel, multidisciplinary research collaborations.

This two-day symposium examined antiretroviral therapy (ART) from the research clinician's perspective, including novel applications of ART in patient settings, new data on early infection and transmission of resistance, and chemokine receptor biology in the context of patient therapy. The symposium also sought to foster and facilitate novel, multidisciplinary research collaborations between basic science investigators and clinicians.

Presentations

Welcome: Paul A. Volberding, MD and Diane Havlir, MD

This two-day symposium focused on current and planned research being conducted by the next generation of HIV investigators with the University of California, San Francisco, the Gladstone Institute of Virology and Immunology, the Blood Systems Research Institute, SF Department of Public Health (HIV Research Section), and other partner institutes. Research presentations spanned basic, clinical, epidemiologic, prevention, and translational science.

Agenda

The Intersection of HIV and Aging

• Development and Reversion of Immunosenescence in HIV-1 Infection
  Victor Appay, PhD
• The Role of HIV-Associated Inflammation in Aging
  Russell P. Tracy, PhD
• Polarized Immune Responses Regulate Cancer Development
  Lisa Coussens, PhD
• How Might HIV Infection and Therapy Drive Aging and Age-Related Disease?
  Judith Campisi, PhD
• The HIV Tat Protein Regulates Immune Activation via SIRT1

For the first time in the global response to HIV/AIDS, consensus is emerging that turning the tide against the global pandemic is possible. Treatment of HIV infection has evolved from toxic, complex and relatively brittle to well tolerated, simple and potent. HIV-infection persons, especially if treated early in the course of disease, can expect normal lifespans.