Warner Greene, MD, PhD

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(415) 734-4805

1650 Owens St
San Francisco, CA 94107

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  • Professor, UCSF School of Medicine
  • Co-Director, UCSF-Gladstone CFAR
  • Director, Gladstone Institute of Virology and Immunology
  • Nick and Sue Hellmann Distinguished Professor of Translational Medicine, Professor of Medicine, Microbiology and Immunology, UCSF
  • President, Accordia Global Health Foundation

Biography

Warner C. Greene, MD, PhD is the Director, Senior Investigator, and Nick and Sue Hellmann Distinguished Processor of Translational Medicine at Gladstone Institute of Virology and Immunology. Dr. Greene is also Professor of Medicine, Microbiology and of Immunology at UCSF. Dr. Greene is a member of the Institute of Medicine of the National Academies and a fellow of the American Academy for the Advancement of Science. He also serves as Co-Director of the UCSF-GIVI Center for AIDS Research, and has served as a councilor and president of the Association of American Physicians. Dr. Greene earned a bachelor’s degree at Stanford University and an MD/PhD at Washington University School of Medicine. He took his internship and residency training in Medicine at the Massachusetts General Hospital at Harvard. After serving as a Senior Investigator at the National Cancer Institute and a Professor of Medicine and Howard Hughes Investigator at Duke University Medical Center, Dr. Greene accepted his current position as the Founding Director of the Gladstone Institute of Virology and Immunology in 1991. The ongoing research in Dr. Greene’s laboratory focuses on the molecular mechanisms underlying HIV pathogenesis, latency, and transmission. He is the author of more than 366 scientific papers and has been recognized as one of the 100 Most Cited Scientists in the world. In 2007, Dr. Greene expanded his work to include global health in sub-Saharan Africa in his service as president and executive chairman of the Accordia Global Health Foundation. Accordia established the Infectious Diseases Institute at Makerere University in Uganda, which has trained thousands of African health care workers, is caring for 30,000 HIV-infected patients, and has brought health care to nearly 500,000 people living in remote rural regions of Uganda. In 2016, Accordia merged with Africare.

Awards

Displaying 1 - 344 of 344

  1. Boehm D, Jeng M, Camus G, Gramatica A, Schwarzer R, Johnson JR, Hull PA, Montano M, Sakane N, Pagans S, Godin R, Deeks SG, Krogan NJ, Greene WC, Ott M. SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency. Cell Host Microbe. 2017 May 10; 21(5):569-579.e6. View on Pubmed
  2. Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Muñoz-Arias I, Greene WC. Corrigendum: Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature. 2017 Apr 06; 544(7648):124. View on Pubmed
  3. Neidleman JA, Chen JC, Kohgadai N, Müller JA, Laustsen A, Thavachelvam K, Jang KS, Stürzel CM, Jones JJ, Ochsenbauer C, Chitre A, Somsouk M, Garcia MM, Smith JF, Greenblatt RM, Münch J, Jakobsen MR, Giudice LC, Greene WC, Roan NR. Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells. PLoS Pathog. 2017 Feb; 13(2):e1006163. View on Pubmed
  4. Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E. The mTOR Complex Controls HIV Latency. Cell Host Microbe. 2016 Dec 14; 20(6):785-797. View on Pubmed
  5. Li P, Kaiser P, Lampiris HW, Kim P, Yukl SA, Havlir DV, Greene WC, Wong JK. Stimulating the RIG-I pathway to kill cells in the latent HIV reservoir following viral reactivation. Nat Med. 2016 Jul; 22(7):807-11. View on Pubmed
  6. LoRicco JG, Xu CS, Neidleman J, Bergkvist M, Greene WC, Roan NR, Makhatadze GI. Gallic Acid Is an Antagonist of Semen Amyloid Fibrils That Enhance HIV-1 Infection. J Biol Chem. 2016 Jul 1; 291(27):14045-55. View on Pubmed
  7. Doitsh G, Greene WC. Dissecting How CD4 T Cells Are Lost During HIV Infection. Cell Host Microbe. 2016 Mar 9; 19(3):280-91. View on Pubmed
  8. Muñoz-Arias I, Doitsh G, Yang Z, Sowinski S, Ruelas D, Greene WC. Blood-Derived CD4 T Cells Naturally Resist Pyroptosis during Abortive HIV-1 Infection. Cell Host Microbe. 2015 Oct 14; 18(4):463-70. View on Pubmed
  9. Ruelas DS, Chan JK, Oh E, Heidersbach AJ, Hebbeler AM, Chavez L, Verdin E, Rape M, Greene WC. MicroRNA-155 Reinforces HIV Latency. J Biol Chem. 2015 May 29; 290(22):13736-48. View on Pubmed
  10. Zirafi O, Kim KA, Roan NR, Kluge SF, Müller JA, Jiang S, Mayer B, Greene WC, Kirchhoff F, Münch J. Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides. Sci Transl Med. 2014 Nov 12; 6(262):262ra157. View on Pubmed
  11. Yang Z, Greene WC. A new activity for SAMHD1 in HIV restriction. Nat Med. 2014 Aug; 20(8):808-9. View on Pubmed
  12. Roan NR, Liu H, Usmani SM, Neidleman J, Müller JA, Avila-Herrera A, Gawanbacht A, Zirafi O, Chu S, Dong M, Kumar ST, Smith JF, Pollard KS, Fändrich M, Kirchhoff F, Münch J, Witkowska HE, Greene WC. Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection. J Virol. 2014 Jul; 88(13):7221-34. View on Pubmed
  13. Roan NR, Chu S, Liu H, Neidleman J, Witkowska HE, Greene WC. Interaction of fibronectin with semen amyloids synergistically enhances HIV infection. J Infect Dis. 2014 Oct 1; 210(7):1062-6. View on Pubmed
  14. Usmani SM, Zirafi O, Müller JA, Sandi-Monroy NL, Yadav JK, Meier C, Weil T, Roan NR, Greene WC, Walther P, Nilsson KP, Hammarström P, Wetzel R, Pilcher CD, Gagsteiger F, Fändrich M, Kirchhoff F, Münch J. Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nat Commun. 2014; 5:3508. View on Pubmed
  15. Chen JC, Johnson BA, Erikson DW, Piltonen TT, Barragan F, Chu S, Kohgadai N, Irwin JC, Greene WC, Giudice LC, Roan NR. Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts. Hum Reprod. 2014 Jun; 29(6):1255-70. View on Pubmed
  16. Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Muñoz-Arias I, Greene WC. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature. 2014 Jan 23; 505(7484):509-14. View on Pubmed
  17. Spina CA, Anderson J, Archin NM, Bosque A, Chan J, Famiglietti M, Greene WC, Kashuba A, Lewin SR, Margolis DM, Mau M, Ruelas D, Saleh S, Shirakawa K, Siliciano RF, Singhania A, Soto PC, Terry VH, Verdin E, Woelk C, Wooden S, Xing S, Planelles V. An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients. PLoS Pathog. 2013; 9(12):e1003834. View on Pubmed
  18. Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC. IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science. 2014 Jan 24; 343(6169):428-32. View on Pubmed
  19. Cavrois M, Neidleman J, Santiago ML, Derdeyn CA, Hunter E, Greene WC. Enhanced fusion and virion incorporation for HIV-1 subtype C envelope glycoproteins with compact V1/V2 domains. J Virol. 2014 Feb; 88(4):2083-94. View on Pubmed
  20. Greene WC. Solutions to global health challenges: no more Band-Aids. J Clin Invest. 2013 Nov; 123(11):4967-70. View on Pubmed
  21. Chan JK, Bhattacharyya D, Lassen KG, Ruelas D, Greene WC. Calcium/calcineurin synergizes with prostratin to promote NF-?B dependent activation of latent HIV. PLoS One. 2013; 8(10):e77749. View on Pubmed
  22. Ruelas DS, Greene WC. An integrated overview of HIV-1 latency. Cell. 2013 Oct 24; 155(3):519-29. View on Pubmed
  23. Webster B, Ott M, Greene WC. Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus. J Virol. 2013 Dec; 87(24):13354-69. View on Pubmed
  24. Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M. Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. PLoS Pathog. 2013; 9(4):e1003302. View on Pubmed
  25. Webster B, Wissing S, Herker E, Ott M, Greene WC. Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis. J Virol. 2013 Jan; 87(1):581-96. View on Pubmed
  26. Roan NR, Cavrois M, Greene WC. [Role of semen-derived amyloid fibrils as facilitators of HIV infection]. Med Sci (Paris). 2012 Apr; 28(4):358-60. View on Pubmed
  27. Chan JK, Greene WC. Dynamic roles for NF-?B in HTLV-I and HIV-1 retroviral pathogenesis. Immunol Rev. 2012 Mar; 246(1):286-310. View on Pubmed
  28. Pillai SK, Abdel-Mohsen M, Guatelli J, Skasko M, Monto A, Fujimoto K, Yukl S, Greene WC, Kovari H, Rauch A, Fellay J, Battegay M, Hirschel B, Witteck A, Bernasconi E, Ledergerber B, Günthard HF, Wong JK. Role of retroviral restriction factors in the interferon-a-mediated suppression of HIV-1 in vivo. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3035-40. View on Pubmed
  29. Lassen KG, Hebbeler AM, Bhattacharyya D, Lobritz MA, Greene WC. A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirs. PLoS One. 2012; 7(1):e30176. View on Pubmed
  30. Tugizov SM, Herrera R, Veluppillai P, Greenspan D, Soros V, Greene WC, Levy JA, Palefsky JM. Differential transmission of HIV traversing fetal oral/intestinal epithelia and adult oral epithelia. J Virol. 2012 Mar; 86(5):2556-70. View on Pubmed
  31. Roan NR, Müller JA, Liu H, Chu S, Arnold F, Stürzel CM, Walther P, Dong M, Witkowska HE, Kirchhoff F, Münch J, Greene WC. Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection. Cell Host Microbe. 2011 Dec 15; 10(6):541-50. View on Pubmed
  32. Arnold F, Schnell J, Zirafi O, Stürzel C, Meier C, Weil T, Ständker L, Forssmann WG, Roan NR, Greene WC, Kirchhoff F, Münch J. Naturally occurring fragments from two distinct regions of the prostatic acid phosphatase form amyloidogenic enhancers of HIV infection. J Virol. 2012 Jan; 86(2):1244-9. View on Pubmed
  33. Wissing S, Muñoz-Lopez M, Macia A, Yang Z, Montano M, Collins W, Garcia-Perez JL, Moran JV, Greene WC. Reprogramming somatic cells into iPS cells activates LINE-1 retroelement mobility. Hum Mol Genet. 2012 Jan 1; 21(1):208-18. View on Pubmed
  34. Smith DS, Guo K, Barrett BS, Heilman KJ, Evans LH, Hasenkrug KJ, Greene WC, Santiago ML. Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response. PLoS Pathog. 2011 Oct; 7(10):e1002284. View on Pubmed
  35. Siliciano RF, Greene WC. HIV latency. Cold Spring Harb Perspect Med. 2011 Sep; 1(1):a007096. View on Pubmed
  36. Wissing S, Montano M, Garcia-Perez JL, Moran JV, Greene WC. Endogenous APOBEC3B restricts LINE-1 retrotransposition in transformed cells and human embryonic stem cells. J Biol Chem. 2011 Oct 21; 286(42):36427-37. View on Pubmed
  37. Sakane N, Kwon HS, Pagans S, Kaehlcke K, Mizusawa Y, Kamada M, Lassen KG, Chan J, Greene WC, Schnoelzer M, Ott M. Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). PLoS Pathog. 2011 Aug; 7(8):e1002184. View on Pubmed
  38. Chan JK, Greene WC. NF-?B/Rel: agonist and antagonist roles in HIV-1 latency. Curr Opin HIV AIDS. 2011 Jan; 6(1):12-8. View on Pubmed
  39. Doitsh G, Cavrois M, Lassen KG, Zepeda O, Yang Z, Santiago ML, Hebbeler AM, Greene WC. Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue. Cell. 2010 Nov 24; 143(5):789-801. View on Pubmed
  40. Tugizov SM, Herrera R, Veluppillai P, Greenspan D, Soros V, Greene WC, Levy JA, Palefsky JM. HIV is inactivated after transepithelial migration via adult oral epithelial cells but not fetal epithelial cells. Virology. 2011 Jan 20; 409(2):211-22. View on Pubmed
  41. Santiago ML, Smith DS, Barrett BS, Montano M, Benitez RL, Pelanda R, Hasenkrug KJ, Greene WC. Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor. J Virol. 2011 Jan; 85(1):189-99. View on Pubmed
  42. Lassen KG, Wissing S, Lobritz MA, Santiago M, Greene WC. Identification of two APOBEC3F splice variants displaying HIV-1 antiviral activity and contrasting sensitivity to Vif. J Biol Chem. 2010 Sep 17; 285(38):29326-35. View on Pubmed
  43. Kim KA, Yolamanova M, Zirafi O, Roan NR, Staendker L, Forssmann WG, Burgener A, Dejucq-Rainsford N, Hahn BH, Shaw GM, Greene WC, Kirchhoff F, Münch J. Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI. Retrovirology. 2010; 7:55. View on Pubmed
  44. Santiago ML, Benitez RL, Montano M, Hasenkrug KJ, Greene WC. Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo. J Immunol. 2010 Jul 15; 185(2):1114-23. View on Pubmed
  45. Wissing S, Galloway NL, Greene WC. HIV-1 Vif versus the APOBEC3 cytidine deaminases: an intracellular duel between pathogen and host restriction factors. Mol Aspects Med. 2010 Oct; 31(5):383-97. View on Pubmed
  46. Cavrois M, Neidleman J, Galloway N, Derdeyn CA, Hunter E, Greene WC. Measuring HIV fusion mediated by envelopes from primary viral isolates. Methods. 2011 Jan; 53(1):34-8. View on Pubmed
  47. Roan NR, Sowinski S, Münch J, Kirchhoff F, Greene WC. Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection). J Biol Chem. 2010 Jan 15; 285(3):1861-9. View on Pubmed
  48. Chiu YL, Greene WC. APOBEC3G: an intracellular centurion. Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12; 364(1517):689-703. View on Pubmed
  49. Richman DD, Margolis DM, Delaney M, Greene WC, Hazuda D, Pomerantz RJ. The challenge of finding a cure for HIV infection. Science. 2009 Mar 6; 323(5919):1304-7. View on Pubmed
  50. Michel N, Goffinet C, Ganter K, Allespach I, Kewalramani VN, Saifuddin M, Littman DR, Greene WC, Goldsmith MA, Keppler OT. Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo. Retrovirology. 2009; 6:2. View on Pubmed
  51. Abbadessa G, Accolla R, Aiuti F, Albini A, Aldovini A, Alfano M, Antonelli G, Bartholomew C, Bentwich Z, Bertazzoni U, Berzofsky JA, Biberfeld P, Boeri E, Buonaguro L, Buonaguro FM, Bukrinsky M, Burny A, Caruso A, Cassol S, Chandra P, Ceccherini-Nelli L, Chieco-Bianchi L, Clerici M, Colombini-Hatch S, de Giuli Morghen C, de Maria A, de Rossi A, Dierich M, Della-Favera R, Dolei A, Douek D, Erfle V, Felber B, Fiorentini S, Franchini G, Gershoni JM, Gotch F, Green P, Greene WC, Hall W, Haseltine W, Jacobson S, Kallings LO, Kalyanaraman VS, Katinger H, Khalili K, Klein G, Klein E, Klotman M, Klotman P, Kotler M, Kurth R, Lafeuillade A, La Placa M, Lewis J, Lillo F, Lisziewicz J, Lomonico A, Lopalco L, Lori F, Lusso P, Macchi B, Malim M, Margolis L, Markham PD, McClure M, Miller N, Mingari MC, Moretta L, Noonan D, O'Brien S, Okamoto T, Pal R, Palese P, Panet A, Pantaleo G, Pavlakis G, Pistello M, Plotkin S, Poli G, Pomerantz R, Radaelli A, Robertguroff M, Roederer M, Sarngadharan MG, Schols D, Secchiero P, Shearer G, Siccardi A, Stevenson M, Svoboda J, Tartaglia J, Torelli G, Tornesello ML, Tschachler E, Vaccarezza M, Vallbracht A, van Lunzen J, Varnier O, Vicenzi E, von Melchner H, Witz I, Zagury D, Zagury JF, Zauli G, Zipeto D. Unsung hero Robert C. Gallo. Science. 2009 Jan 9; 323(5911):206-7. View on Pubmed
  52. LaRue RS, Andrésdóttir V, Blanchard Y, Conticello SG, Derse D, Emerman M, Greene WC, Jónsson SR, Landau NR, Löchelt M, Malik HS, Malim MH, Münk C, O'Brien SJ, Pathak VK, Strebel K, Wain-Hobson S, Yu XF, Yuhki N, Harris RS. Guidelines for naming nonprimate APOBEC3 genes and proteins. J Virol. 2009 Jan; 83(2):494-7. View on Pubmed
  53. Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F, Greene WC. The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection. J Virol. 2009 Jan; 83(1):73-80. View on Pubmed
  54. Greene WC, Debyser Z, Ikeda Y, Freed EO, Stephens E, Yonemoto W, Buckheit RW, Esté JA, Cihlar T. Novel targets for HIV therapy. Antiviral Res. 2008 Dec; 80(3):251-65. View on Pubmed
  55. Santiago ML, Montano M, Benitez R, Messer RJ, Yonemoto W, Chesebro B, Hasenkrug KJ, Greene WC. Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science. 2008 Sep 5; 321(5894):1343-6. View on Pubmed
  56. Fauci AS, Johnston MI, Dieffenbach CW, Burton DR, Hammer SM, Hoxie JA, Martin M, Overbaugh J, Watkins DI, Mahmoud A, Greene WC. HIV vaccine research: the way forward. Science. 2008 Jul 25; 321(5888):530-2. View on Pubmed
  57. Cavrois M, Neidleman J, Greene WC. The achilles heel of the trojan horse model of HIV-1 trans-infection. PLoS Pathog. 2008 Jun; 4(6):e1000051. View on Pubmed
  58. Kwon HS, Brent MM, Getachew R, Jayakumar P, Chen LF, Schnolzer M, McBurney MW, Marmorstein R, Greene WC, Ott M. Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe. 2008 Mar 13; 3(3):158-67. View on Pubmed
  59. Chiu YL, Greene WC. The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements. Annu Rev Immunol. 2008; 26:317-53. View on Pubmed
  60. Roan NR, Greene WC. A seminal finding for understanding HIV transmission. Cell. 2007 Dec 14; 131(6):1044-6. View on Pubmed
  61. Greene WC. A history of AIDS: looking back to see ahead. Eur J Immunol. 2007 Nov; 37 Suppl 1:S94-102. View on Pubmed
  62. Goffinet C, Michel N, Allespach I, Tervo HM, Hermann V, Kräusslich HG, Greene WC, Keppler OT. Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression. Retrovirology. 2007; 4:53. View on Pubmed
  63. Williams SA, Greene WC. Regulation of HIV-1 latency by T-cell activation. Cytokine. 2007 Jul; 39(1):63-74. View on Pubmed
  64. Ellery PJ, Tippett E, Chiu YL, Paukovics G, Cameron PU, Solomon A, Lewin SR, Gorry PR, Jaworowski A, Greene WC, Sonza S, Crowe SM. The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo. J Immunol. 2007 May 15; 178(10):6581-9. View on Pubmed
  65. Williams SA, Kwon H, Chen LF, Greene WC. Sustained induction of NF-kappa B is required for efficient expression of latent human immunodeficiency virus type 1. J Virol. 2007 Jun; 81(11):6043-56. View on Pubmed
  66. Soros VB, Greene WC. APOBEC3G and HIV-1: strike and counterstrike. Curr HIV/AIDS Rep. 2007 Feb; 4(1):3-9. View on Pubmed
  67. Soros VB, Yonemoto W, Greene WC. Newly synthesized APOBEC3G is incorporated into HIV virions, inhibited by HIV RNA, and subsequently activated by RNase H. PLoS Pathog. 2007 Feb; 3(2):e15. View on Pubmed
  68. Cavrois M, Neidleman J, Kreisberg JF, Greene WC. In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions. PLoS Pathog. 2007 Jan; 3(1):e4. View on Pubmed
  69. Stopak KS, Chiu YL, Kropp J, Grant RM, Greene WC. Distinct patterns of cytokine regulation of APOBEC3G expression and activity in primary lymphocytes, macrophages, and dendritic cells. J Biol Chem. 2007 Feb 9; 282(6):3539-46. View on Pubmed
  70. Ahuja SK, Aiuti F, Berkhout B, Biberfeld P, Burton DR, Colizzi V, Deeks SG, Desrosiers RC, Dierich MP, Doms RW, Emerman M, Gallo RC, Girard M, Greene WC, Hoxie JA, Hunter E, Klein G, Korber B, Kuritzkes DR, Lederman MM, Malim MH, Marx PA, McCune JM, McMichael A, Miller C, Miller V, Montagnier L, Montefiori DC, Moore JP, Nixon DF, Overbaugh J, Pauza CD, Richman DD, Saag MS, Sattentau Q, Schooley RT, Shattock R, Shaw GM, Stevenson M, Trkola A, Wainberg MA, Weiss RA, Wolinsky S, Zack JA. A plea for justice for jailed medical workers. Science. 2006 Nov 10; 314(5801):924-5. View on Pubmed
  71. Chiu YL, Witkowska HE, Hall SC, Santiago M, Soros VB, Esnault C, Heidmann T, Greene WC. High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15588-93. View on Pubmed
  72. O'Mahony A, Raber J, Montano M, Foehr E, Han V, Lu SM, Kwon H, LeFevour A, Chakraborty-Sett S, Greene WC. NF-kappaB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticity. Mol Cell Biol. 2006 Oct; 26(19):7283-98. View on Pubmed
  73. Zimmerman ES, Sherman MP, Blackett JL, Neidleman JA, Kreis C, Mundt P, Williams SA, Warmerdam M, Kahn J, Hecht FM, Grant RM, de Noronha CM, Weyrich AS, Greene WC, Planelles V. Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo. J Virol. 2006 Nov; 80(21):10407-18. View on Pubmed
  74. Soros VB, Greene WC. APOBEC3G and HIV-1: strike and counterstrike. Curr Infect Dis Rep. 2006 Jun; 8(4):317-23. View on Pubmed
  75. Chiu YL, Greene WC. Multifaceted antiviral actions of APOBEC3 cytidine deaminases. Trends Immunol. 2006 Jun; 27(6):291-7. View on Pubmed
  76. Kreisberg JF, Yonemoto W, Greene WC. Endogenous factors enhance HIV infection of tissue naive CD4 T cells by stimulating high molecular mass APOBEC3G complex formation. J Exp Med. 2006 Apr 17; 203(4):865-70. View on Pubmed
  77. Chandrasekar B, Mummidi S, Mahimainathan L, Patel DN, Bailey SR, Imam SZ, Greene WC, Valente AJ. Interleukin-18-induced human coronary artery smooth muscle cell migration is dependent on NF-kappaB- and AP-1-mediated matrix metalloproteinase-9 expression and is inhibited by atorvastatin. J Biol Chem. 2006 Jun 2; 281(22):15099-109. View on Pubmed
  78. Cavrois M, Neidleman J, Kreisberg JF, Fenard D, Callebaut C, Greene WC. Human immunodeficiency virus fusion to dendritic cells declines as cells mature. J Virol. 2006 Feb; 80(4):1992-9. View on Pubmed
  79. Chiu YL, Greene WC. APOBEC3 cytidine deaminases: distinct antiviral actions along the retroviral life cycle. J Biol Chem. 2006 Mar 31; 281(13):8309-12. View on Pubmed
  80. Williams SA, Chen LF, Kwon H, Ruiz-Jarabo CM, Verdin E, Greene WC. NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J. 2006 Jan 11; 25(1):139-49. View on Pubmed
  81. Fenard D, Yonemoto W, de Noronha C, Cavrois M, Williams SA, Greene WC. Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement. J Immunol. 2005 Nov 1; 175(9):6050-7. View on Pubmed
  82. Chen LF, Williams SA, Mu Y, Nakano H, Duerr JM, Buckbinder L, Greene WC. NF-kappaB RelA phosphorylation regulates RelA acetylation. Mol Cell Biol. 2005 Sep; 25(18):7966-75. View on Pubmed
  83. Kwon H, Ogle L, Benitez B, Bohuslav J, Montano M, Felsher DW, Greene WC. Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax. J Biol Chem. 2005 Oct 21; 280(42):35713-22. View on Pubmed
  84. Chen LF, Greene WC. Assessing acetylation of NF-kappaB. Methods. 2005 Aug; 36(4):368-75. View on Pubmed
  85. Williams SA, Greene WC. Host factors regulating post-integration latency of HIV. Trends Microbiol. 2005 Apr; 13(4):137-9. View on Pubmed
  86. Stopak K, Greene WC. Protecting APOBEC3G: a potential new target for HIV drug discovery. Curr Opin Investig Drugs. 2005 Feb; 6(2):141-7. View on Pubmed
  87. Keppler OT, Allespach I, Schüller L, Fenard D, Greene WC, Fackler OT. Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef. J Virol. 2005 Feb; 79(3):1655-65. View on Pubmed
  88. Yonezawa A, Cavrois M, Greene WC. Studies of ebola virus glycoprotein-mediated entry and fusion by using pseudotyped human immunodeficiency virus type 1 virions: involvement of cytoskeletal proteins and enhancement by tumor necrosis factor alpha. J Virol. 2005 Jan; 79(2):918-26. View on Pubmed
  89. Cavrois M, Neidleman J, Yonemoto W, Fenard D, Greene WC. HIV-1 virion fusion assay: uncoating not required and no effect of Nef on fusion. Virology. 2004 Oct 10; 328(1):36-44. View on Pubmed
  90. Greene WC. The brightening future of HIV therapeutics. Nat Immunol. 2004 Sep; 5(9):867-71. View on Pubmed
  91. Greene WC. Redistricting the retroviral restriction factors. Nat Med. 2004 Aug; 10(8):778-80. View on Pubmed
  92. Williams SA, Chen LF, Kwon H, Fenard D, Bisgrove D, Verdin E, Greene WC. Prostratin antagonizes HIV latency by activating NF-kappaB. J Biol Chem. 2004 Oct 1; 279(40):42008-17. View on Pubmed
  93. Chen LF, Greene WC. Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol. 2004 May; 5(5):392-401. View on Pubmed
  94. Bohuslav J, Chen LF, Kwon H, Mu Y, Greene WC. p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1. J Biol Chem. 2004 Jun 18; 279(25):26115-25. View on Pubmed
  95. O'Mahony AM, Montano M, Van Beneden K, Chen LF, Greene WC. Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65. J Biol Chem. 2004 Apr 30; 279(18):18137-45. View on Pubmed
  96. Schaeffer E, Soros VB, Greene WC. Compensatory link between fusion and endocytosis of human immunodeficiency virus type 1 in human CD4 T lymphocytes. J Virol. 2004 Feb; 78(3):1375-83. View on Pubmed
  97. Cavrois M, Neidleman J, Bigos M, Greene WC. Fluorescence resonance energy transfer-based HIV-1 virion fusion assay. Methods Mol Biol. 2004; 263:333-44. View on Pubmed
  98. Greene WC. How resting T cells deMURR HIV infection. Nat Immunol. 2004 Jan; 5(1):18-9. View on Pubmed
  99. Greene WC, Chen LF. Regulation of NF-kappaB action by reversible acetylation. Novartis Found Symp. 2004; 259:208-17; discussion 218-25. View on Pubmed
  100. Stopak K, de Noronha C, Yonemoto W, Greene WC. HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. Mol Cell. 2003 Sep; 12(3):591-601. View on Pubmed
  101. Chen LF, Greene WC. Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation. J Mol Med (Berl). 2003 Sep; 81(9):549-57. View on Pubmed
  102. Zander K, Sherman MP, Tessmer U, Bruns K, Wray V, Prechtel AT, Schubert E, Henklein P, Luban J, Neidleman J, Greene WC, Schubert U. Cyclophilin A interacts with HIV-1 Vpr and is required for its functional expression. J Biol Chem. 2003 Oct 31; 278(44):43202-13. View on Pubmed
  103. Sherman MP, de Noronha CM, Eckstein LA, Hataye J, Mundt P, Williams SA, Neidleman JA, Goldsmith MA, Greene WC. Nuclear export of Vpr is required for efficient replication of human immunodeficiency virus type 1 in tissue macrophages. J Virol. 2003 Jul; 77(13):7582-9. View on Pubmed
  104. Stoddart CA, Geleziunas R, Ferrell S, Linquist-Stepps V, Moreno ME, Bare C, Xu W, Yonemoto W, Bresnahan PA, McCune JM, Greene WC. Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis. J Virol. 2003 Feb; 77(3):2124-33. View on Pubmed
  105. Chen LF, Mu Y, Greene WC. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J. 2002 Dec 2; 21(23):6539-48. View on Pubmed
  106. Sherman MP, Schubert U, Williams SA, de Noronha CM, Kreisberg JF, Henklein P, Greene WC. HIV-1 Vpr displays natural protein-transducing properties: implications for viral pathogenesis. Virology. 2002 Oct 10; 302(1):95-105. View on Pubmed
  107. Cavrois M, De Noronha C, Greene WC. A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes. Nat Biotechnol. 2002 Nov; 20(11):1151-4. View on Pubmed
  108. Sherman MP, De Noronha CM, Williams SA, Greene WC. Insights into the biology of HIV-1 viral protein R. DNA Cell Biol. 2002 Sep; 21(9):679-88. View on Pubmed
  109. Greene WC, Peterlin BM. Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy. Nat Med. 2002 Jul; 8(7):673-80. View on Pubmed
  110. Sherman MP, Greene WC. Slipping through the door: HIV entry into the nucleus. Microbes Infect. 2002 Jan; 4(1):67-73. View on Pubmed
  111. Eckstein DA, Sherman MP, Penn ML, Chin PS, De Noronha CM, Greene WC, Goldsmith MA. HIV-1 Vpr enhances viral burden by facilitating infection of tissue macrophages but not nondividing CD4+ T cells. J Exp Med. 2001 Nov 19; 194(10):1407-19. View on Pubmed
  112. de Noronha CM, Sherman MP, Lin HW, Cavrois MV, Moir RD, Goldman RD, Greene WC. Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science. 2001 Nov 2; 294(5544):1105-8. View on Pubmed
  113. Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science. 2001 Aug 31; 293(5535):1653-7. View on Pubmed
  114. Geleziunas R, Xu W, Takeda K, Ichijo H, Greene WC. HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell. Nature. 2001 Apr 12; 410(6830):834-8. View on Pubmed
  115. Schaeffer E, Geleziunas R, Greene WC. Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions. J Virol. 2001 Mar; 75(6):2993-3000. View on Pubmed
  116. Sherman MP, de Noronha CM, Heusch MI, Greene S, Greene WC. Nucleocytoplasmic shuttling by human immunodeficiency virus type 1 Vpr. J Virol. 2001 Feb; 75(3):1522-32. View on Pubmed
  117. Foehr ED, Bohuslav J, Chen LF, DeNoronha C, Geleziunas R, Lin X, O'Mahony A, Greene WC. The NF-kappa B-inducing kinase induces PC12 cell differentiation and prevents apoptosis. J Biol Chem. 2000 Nov 3; 275(44):34021-4. View on Pubmed
  118. Foehr ED, Lin X, O'Mahony A, Geleziunas R, Bradshaw RA, Greene WC. NF-kappa B signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells. J Neurosci. 2000 Oct 15; 20(20):7556-63. View on Pubmed
  119. Henklein P, Bruns K, Sherman MP, Tessmer U, Licha K, Kopp J, de Noronha CM, Greene WC, Wray V, Schubert U. Functional and structural characterization of synthetic HIV-1 Vpr that transduces cells, localizes to the nucleus, and induces G2 cell cycle arrest. J Biol Chem. 2000 Oct 13; 275(41):32016-26. View on Pubmed
  120. Lin L, DeMartino GN, Greene WC. Cotranslational dimerization of the Rel homology domain of NF-kappaB1 generates p50-p105 heterodimers and is required for effective p50 production. EMBO J. 2000 Sep 1; 19(17):4712-22. View on Pubmed
  121. Sherman MP, de Noronha CM, Pearce D, Greene WC. Human immunodeficiency virus type 1 Vpr contains two leucine-rich helices that mediate glucocorticoid receptor coactivation independently of its effects on G(2) cell cycle arrest. J Virol. 2000 Sep; 74(17):8159-65. View on Pubmed
  122. Lin X, O'Mahony A, Mu Y, Geleziunas R, Greene WC. Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta. Mol Cell Biol. 2000 Apr; 20(8):2933-40. View on Pubmed
  123. O'Mahony A, Lin X, Geleziunas R, Greene WC. Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions. Mol Cell Biol. 2000 Feb; 20(4):1170-8. View on Pubmed
  124. Heusch M, Lin L, Geleziunas R, Greene WC. The generation of nfkb2 p52: mechanism and efficiency. Oncogene. 1999 Nov 4; 18(46):6201-8. View on Pubmed
  125. Bresnahan PA, Yonemoto W, Greene WC. Cutting edge: SIV Nef protein utilizes both leucine- and tyrosine-based protein sorting pathways for down-regulation of CD4. J Immunol. 1999 Sep 15; 163(6):2977-81. View on Pubmed
  126. Lin X, Cunningham ET, Mu Y, Geleziunas R, Greene WC. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases. Immunity. 1999 Feb; 10(2):271-80. View on Pubmed
  127. Jenkins Y, McEntee M, Weis K, Greene WC. Characterization of HIV-1 vpr nuclear import: analysis of signals and pathways. J Cell Biol. 1998 Nov 16; 143(4):875-85. View on Pubmed
  128. Bresnahan PA, Yonemoto W, Ferrell S, Williams-Herman D, Geleziunas R, Greene WC. A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor. Curr Biol. 1998 Nov 5; 8(22):1235-8. View on Pubmed
  129. Lin X, Mu Y, Cunningham ET, Marcu KB, Geleziunas R, Greene WC. Molecular determinants of NF-kappaB-inducing kinase action. Mol Cell Biol. 1998 Oct; 18(10):5899-907. View on Pubmed
  130. Liegler TJ, Yonemoto W, Elbeik T, Vittinghoff E, Buchbinder SP, Greene WC. Diminished spontaneous apoptosis in lymphocytes from human immunodeficiency virus-infected long-term nonprogressors. J Infect Dis. 1998 Sep; 178(3):669-79. View on Pubmed
  131. Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC. Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases. Mol Cell Biol. 1998 Sep; 18(9):5157-65. View on Pubmed
  132. Lin L, DeMartino GN, Greene WC. Cotranslational biogenesis of NF-kappaB p50 by the 26S proteasome. Cell. 1998 Mar 20; 92(6):819-28. View on Pubmed
  133. Liu KD, Gaffen SL, Goldsmith MA, Greene WC. Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation. Curr Biol. 1997 Nov 1; 7(11):817-26. View on Pubmed
  134. Ghoda L, Lin X, Greene WC. The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro. J Biol Chem. 1997 Aug 22; 272(34):21281-8. View on Pubmed
  135. Miller MD, Warmerdam MT, Ferrell SS, Benitez R, Greene WC. Intravirion generation of the C-terminal core domain of HIV-1 Nef by the HIV-1 protease is insufficient to enhance viral infectivity. Virology. 1997 Aug 4; 234(2):215-25. View on Pubmed
  136. Powell DM, Amaral MC, Wu JY, Maniatis T, Greene WC. HIV Rev-dependent binding of SF2/ASF to the Rev response element: possible role in Rev-mediated inhibition of HIV RNA splicing. Proc Natl Acad Sci U S A. 1997 Feb 4; 94(3):973-8. View on Pubmed
  137. Tie F, Adya N, Greene WC, Giam CZ. Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat. J Virol. 1996 Dec; 70(12):8368-74. View on Pubmed
  138. Geleziunas R, Miller MD, Greene WC. Unraveling the function of HIV type 1 Nef. AIDS Res Hum Retroviruses. 1996 Nov 20; 12(17):1579-82. View on Pubmed
  139. Shapiro VS, Mollenauer MN, Greene WC, Weiss A. c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1. J Exp Med. 1996 Nov 1; 184(5):1663-9. View on Pubmed
  140. Gaffen SL, Lai SY, Ha M, Liu X, Hennighausen L, Greene WC, Goldsmith MA. Distinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversity. J Biol Chem. 1996 Aug 30; 271(35):21381-90. View on Pubmed
  141. Kim JH, McLinden RJ, Mosca JD, Vahey MT, Greene WC, Redfield RR. Inhibition of HIV replication by sense and antisense rev response elements in HIV-based retroviral vectors. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1; 12(4):343-51. View on Pubmed
  142. Liu KD, Greene WC, Goldsmith MA. The alpha chain of the IL-2 receptor determines the species specificity of high-affinity IL-2 binding. Cytokine. 1996 Aug; 8(8):613-21. View on Pubmed
  143. Greene WC. Denying HIV safe haven. N Engl J Med. 1996 May 9; 334(19):1264-5. View on Pubmed
  144. Miller MD, Greene WC. Is the Nef protein of HIV-1 required for pathogenesis? Trends Microbiol. 1996 May; 4(5):171-2; discussion 173. View on Pubmed
  145. Hsu DK, Hammes SR, Kuwabara I, Greene WC, Liu FT. Human T lymphotropic virus-I infection of human T lymphocytes induces expression of the beta-galactoside-binding lectin, galectin-3. Am J Pathol. 1996 May; 148(5):1661-70. View on Pubmed
  146. Sun S, Elwood J, Greene WC. Both amino- and carboxyl-terminal sequences within I kappa B alpha regulate its inducible degradation. Mol Cell Biol. 1996 Mar; 16(3):1058-65. View on Pubmed
  147. Lai SY, Xu W, Gaffen SL, Liu KD, Longmore GD, Greene WC, Goldsmith MA. The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes. Proc Natl Acad Sci U S A. 1996 Jan 9; 93(1):231-5. View on Pubmed
  148. Béraud C, Greene WC. Interaction of HTLV-I Tax with the human proteasome: implications for NF-kappa B induction. J Acquir Immune Defic Syndr Hum Retrovirol. 1996; 13 Suppl 1:S76-84. View on Pubmed
  149. Evans GA, Goldsmith MA, Johnston JA, Xu W, Weiler SR, Erwin R, Howard OM, Abraham RT, O'Shea JJ, Greene WC. Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association. J Biol Chem. 1995 Dec 1; 270(48):28858-63. View on Pubmed
  150. Greene WC. Predicting progression to AIDS. Ann Intern Med. 1995 Nov 1; 123(9):726-7. View on Pubmed
  151. Liu KD, Lai SY, Goldsmith MA, Greene WC. Identification of a variable region within the cytoplasmic tail of the IL-2 receptor beta chain that is required for growth signal transduction. J Biol Chem. 1995 Sep 22; 270(38):22176-81. View on Pubmed
  152. Goldsmith MA, Lai SY, Xu W, Amaral MC, Kuczek ES, Parent LJ, Mills GB, Tarr KL, Longmore GD, Greene WC. Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain. J Biol Chem. 1995 Sep 15; 270(37):21729-37. View on Pubmed
  153. Gaffen SL, Lai SY, Xu W, Gouilleux F, Groner B, Goldsmith MA, Greene WC. Signaling through the interleukin 2 receptor beta chain activates a STAT-5-like DNA-binding activity. Proc Natl Acad Sci U S A. 1995 Aug 1; 92(16):7192-6. View on Pubmed
  154. Goldsmith MA, Warmerdam MT, Atchison RE, Miller MD, Greene WC. Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef. J Virol. 1995 Jul; 69(7):4112-21. View on Pubmed
  155. Goldsmith MA, Amaral MC, Greene WC. Ligand binding by the IL-2 receptor is modulated by intracellular determinants of the IL-2 receptor beta-chain. J Immunol. 1995 Mar 1; 154(5):2033-40. View on Pubmed
  156. Miller MD, Warmerdam MT, Page KA, Feinberg MB, Greene WC. Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry. J Virol. 1995 Jan; 69(1):579-84. View on Pubmed
  157. Sun SC, Elwood J, Béraud C, Greene WC. Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene. Mol Cell Biol. 1994 Nov; 14(11):7377-84. View on Pubmed
  158. Miller MD, Feinberg MB, Greene WC. The HIV-1 nef gene acts as a positive viral infectivity factor. Trends Microbiol. 1994 Aug; 2(8):294-8. View on Pubmed
  159. Goldsmith MA, Xu W, Amaral MC, Kuczek ES, Greene WC. The cytoplasmic domain of the interleukin-2 receptor beta chain contains both unique and functionally redundant signal transduction elements. J Biol Chem. 1994 May 20; 269(20):14698-704. View on Pubmed
  160. Williamson P, Merida I, Greene WC, Gaulton G. The membrane proximal segment of the IL-2 receptor beta-chain acidic region is essential for IL2-dependent protein tyrosine kinase activation. Leukemia. 1994 Apr; 8 Suppl 1:S186-9. View on Pubmed
  161. Sun SC, Ganchi PA, Béraud C, Ballard DW, Greene WC. Autoregulation of the NF-kappa B transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs. Proc Natl Acad Sci U S A. 1994 Feb 15; 91(4):1346-50. View on Pubmed
  162. Béraud C, Sun SC, Ganchi P, Ballard DW, Greene WC. Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency. Mol Cell Biol. 1994 Feb; 14(2):1374-82. View on Pubmed
  163. Miller MD, Warmerdam MT, Gaston I, Greene WC, Feinberg MB. The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J Exp Med. 1994 Jan 1; 179(1):101-13. View on Pubmed
  164. Ganchi PA, Sun SC, Greene WC, Ballard DW. A novel NF-kappa B complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerization. Mol Cell Biol. 1993 Dec; 13(12):7826-35. View on Pubmed
  165. Stein B, Baldwin AS, Ballard DW, Greene WC, Angel P, Herrlich P. Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J. 1993 Oct; 12(10):3879-91. View on Pubmed
  166. Greene WC. AIDS and the immune system. Sci Am. 1993 Sep; 269(3):98-105. View on Pubmed
  167. Bogerd H, Greene WC. Dominant negative mutants of human T-cell leukemia virus type I Rex and human immunodeficiency virus type 1 Rev fail to multimerize in vivo. J Virol. 1993 May; 67(5):2496-502. View on Pubmed
  168. Kuziel WA, Ju G, Grdina TA, Greene WC. Unexpected effects of the IL-2 receptor alpha subunit on high affinity IL-2 receptor assembly and function detected with a mutant IL-2 analog. J Immunol. 1993 Apr 15; 150(8 Pt 1):3357-65. View on Pubmed
  169. Sun SC, Ganchi PA, Ballard DW, Greene WC. NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science. 1993 Mar 26; 259(5103):1912-5. View on Pubmed
  170. Merida I, Williamson P, Kuziel WA, Greene WC, Gaulton GN. The serine-rich cytoplasmic domain of the interleukin-2 receptor beta chain is essential for interleukin-2-dependent tyrosine protein kinase and phosphatidylinositol-3-kinase activation. J Biol Chem. 1993 Mar 25; 268(9):6765-70. View on Pubmed
  171. Hammes SR, Greene WC. Multiple arginine residues within the basic domain of HTLV-I Rex are required for specific RNA binding and function. Virology. 1993 Mar; 193(1):41-9. View on Pubmed
  172. Doerre S, Sista P, Sun SC, Ballard DW, Greene WC. The c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus. Proc Natl Acad Sci U S A. 1993 Feb 1; 90(3):1023-7. View on Pubmed
  173. Ganchi PA, Sun SC, Greene WC, Ballard DW. I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding. Mol Biol Cell. 1992 Dec; 3(12):1339-52. View on Pubmed
  174. Mills GB, Arima N, May C, Hill M, Schmandt R, Li J, Miyamoto NG, Greene WC. Neither the LCK nor the FYN kinases are obligatory for IL-2-mediated signal transduction in HTLV-I-infected human T cells. Int Immunol. 1992 Nov; 4(11):1233-43. View on Pubmed
  175. Feinberg MB, Greene WC. Molecular insights into human immunodeficiency virus type 1 pathogenesis. Curr Opin Immunol. 1992 Aug; 4(4):466-74. View on Pubmed
  176. Walker WH, Stein B, Ganchi PA, Hoffman JA, Kaufman PA, Ballard DW, Hannink M, Greene WC. The v-rel oncogene: insights into the mechanism of transcriptional activation, repression, and transformation. J Virol. 1992 Aug; 66(8):5018-29. View on Pubmed
  177. Kaufman PA, Weinberg JB, Greene WC. Nuclear expression of the 50- and 65-kD Rel-related subunits of nuclear factor-kappa B is differentially regulated in human monocytic cells. J Clin Invest. 1992 Jul; 90(1):121-9. View on Pubmed
  178. Arima N, Kuziel WA, Grdina TA, Greene WC. IL-2-induced signal transduction involves the activation of nuclear NF-kappa B expression. J Immunol. 1992 Jul 1; 149(1):83-91. View on Pubmed
  179. Weichselbraun I, Berger J, Dobrovnik M, Bogerd H, Grassmann R, Greene WC, Hauber J, Böhnlein E. Dominant-negative mutants are clustered in a domain of the human T-cell leukemia virus type I Rex protein: implications for trans dominance. J Virol. 1992 Jul; 66(7):4540-5. View on Pubmed
  180. Smith MR, Greene WC. Characterization of a novel nuclear localization signal in the HTLV-I tax transactivator protein. Virology. 1992 Mar; 187(1):316-20. View on Pubmed
  181. Ballard DW, Dixon EP, Peffer NJ, Bogerd H, Doerre S, Stein B, Greene WC. The 65-kDa subunit of human NF-kappa B functions as a potent transcriptional activator and a target for v-Rel-mediated repression. Proc Natl Acad Sci U S A. 1992 Mar 1; 89(5):1875-9. View on Pubmed
  182. Arima N, Molitor JA, Smith MR, Kim JH, Daitoku Y, Greene WC. Human T-cell leukemia virus type I Tax induces expression of the Rel-related family of kappa B enhancer-binding proteins: evidence for a pretranslational component of regulation. J Virol. 1991 Dec; 65(12):6892-9. View on Pubmed
  183. Molitor JA, Ballard DW, Greene WC. Kappa B-specific DNA binding proteins are differentially inhibited by enhancer mutations and biological oxidation. New Biol. 1991 Oct; 3(10):987-96. View on Pubmed
  184. Smith MR, Greene WC. Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway. J Clin Invest. 1991 Sep; 88(3):1038-42. View on Pubmed
  185. Bogerd HP, Huckaby GL, Ahmed YF, Hanly SM, Greene WC. The type I human T-cell leukemia virus (HTLV-I) Rex trans-activator binds directly to the HTLV-I Rex and the type 1 human immunodeficiency virus Rev RNA response elements. Proc Natl Acad Sci U S A. 1991 Jul 1; 88(13):5704-8. View on Pubmed
  186. Hémar A, Cereghini S, Cornet V, Blank V, Israël A, Greene WC, Dautry-Varsat A. Kappa B binding proteins are constitutively expressed in an IL-2 autocrine human T cell line. J Immunol. 1991 Apr 1; 146(7):2409-16. View on Pubmed
  187. Lee JH, Li YC, Doerre S, Sista P, Ballard DW, Greene WC, Franza BR. A member of the set of kappa B binding proteins, HIVEN86A, is a product of the human c-rel proto-oncogene. Oncogene. 1991 Apr; 6(4):665-7. View on Pubmed
  188. Smith MR, Greene WC. Molecular biology of the type I human T-cell leukemia virus (HTLV-I) and adult T-cell leukemia. J Clin Invest. 1991 Mar; 87(3):761-6. View on Pubmed
  189. Ahmed YF, Gilmartin GM, Hanly SM, Nevins JR, Greene WC. The HTLV-I Rex response element mediates a novel form of mRNA polyadenylation. Cell. 1991 Feb 22; 64(4):727-37. View on Pubmed
  190. Greene WC. The molecular biology of human immunodeficiency virus type 1 infection. N Engl J Med. 1991 Jan 31; 324(5):308-17. View on Pubmed
  191. Smith MR, Greene WC. Functional analyses of the type I human T-cell leukemia virus tax gene product. Trans Assoc Am Physicians. 1991; 104:78-91. View on Pubmed
  192. Kim JH, Kaufman PA, Hanly SM, Rimsky LT, Greene WC. Rex transregulation of human T-cell leukemia virus type II gene expression. J Virol. 1991 Jan; 65(1):405-14. View on Pubmed
  193. Molitor JA, Walker WH, Doerre S, Ballard DW, Greene WC. NF-kappa B: a family of inducible and differentially expressed enhancer-binding proteins in human T cells. Proc Natl Acad Sci U S A. 1990 Dec; 87(24):10028-32. View on Pubmed
  194. Ballard DW, Walker WH, Doerre S, Sista P, Molitor JA, Dixon EP, Peffer NJ, Hannink M, Greene WC. The v-rel oncogene encodes a kappa B enhancer binding protein that inhibits NF-kappa B function. Cell. 1990 Nov 16; 63(4):803-14. View on Pubmed
  195. Smith MR, Greene WC. Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes. Genes Dev. 1990 Nov; 4(11):1875-85. View on Pubmed
  196. Cullen BR, Greene WC. Functions of the auxiliary gene products of the human immunodeficiency virus type 1. Virology. 1990 Sep; 178(1):1-5. View on Pubmed
  197. Rubin LA, Galli F, Greene WC, Nelson DL, Jay G. The molecular basis for the generation of the human soluble interleukin 2 receptor. Cytokine. 1990 Sep; 2(5):330-6. View on Pubmed
  198. Kuziel WA, Greene WC. Interleukin-2 and the IL-2 receptor: new insights into structure and function. J Invest Dermatol. 1990 Jun; 94(6 Suppl):27S-32S. View on Pubmed
  199. Ahmed YF, Hanly SM, Malim MH, Cullen BR, Greene WC. Structure-function analyses of the HTLV-I Rex and HIV-1 Rev RNA response elements: insights into the mechanism of Rex and Rev action. Genes Dev. 1990 Jun; 4(6):1014-22. View on Pubmed
  200. Fung MR, Greene WC. The human interleukin-2 receptor: insights into subunit structure and growth signal transduction. Semin Immunol. 1990 Mar; 2(2):119-28. View on Pubmed
  201. Mills GB, May C, McGill M, Fung M, Baker M, Sutherland R, Greene WC. Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated. J Biol Chem. 1990 Feb 25; 265(6):3561-7. View on Pubmed
  202. Greene WC. Regulation of HIV-1 gene expression. Annu Rev Immunol. 1990; 8:453-75. View on Pubmed
  203. Pomerantz JL, Mauxion F, Yoshida M, Greene WC, Sen R. A second sequence element located 3' to the NF-kappa B-binding site regulates IL-2 receptor-alpha gene induction. J Immunol. 1989 Dec 15; 143(12):4275-81. View on Pubmed
  204. Hammes SR, Dixon EP, Malim MH, Cullen BR, Greene WC. Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9549-53. View on Pubmed
  205. Smith MR, Greene WC. The same 50-kDa cellular protein binds to the negative regulatory elements of the interleukin 2 receptor alpha-chain gene and the human immunodeficiency virus type 1 long terminal repeat. Proc Natl Acad Sci U S A. 1989 Nov; 86(21):8526-30. View on Pubmed
  206. Rimsky L, Dodon MD, Dixon EP, Greene WC. Trans-dominant inactivation of HTLV-I and HIV-1 gene expression by mutation of the HTLV-I Rex transactivator. Nature. 1989 Oct 5; 341(6241):453-6. View on Pubmed
  207. Ballard DW, Böhnlein E, Hoffman JA, Bogerd HP, Dixon EP, Franza BR, Greene WC. Activation of the interleukin-2 receptor alpha gene: regulatory role for DNA-protein interactions flanking the kappa B enhancer. New Biol. 1989 Oct; 1(1):83-92. View on Pubmed
  208. Hanly SM, Rimsky LT, Malim MH, Kim JH, Hauber J, Duc Dodon M, Le SY, Maizel JV, Cullen BR, Greene WC. Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements. Genes Dev. 1989 Oct; 3(10):1534-44. View on Pubmed
  209. Cullen BR, Greene WC. Regulatory pathways governing HIV-1 replication. Cell. 1989 Aug 11; 58(3):423-6. View on Pubmed
  210. Greene WC, Böhnlein E, Ballard DW. HIV-1, HTLV-1 and normal T-cell growth: transcriptional strategies and surprises. Immunol Today. 1989 Aug; 10(8):272-8. View on Pubmed
  211. Böhnlein E, Ballard DW, Bogerd H, Peffer NJ, Lowenthal JW, Greene WC. Induction of interleukin-2 receptor-alpha gene expression is regulated by post-translational activation of kappa B specific DNA binding proteins. J Biol Chem. 1989 May 25; 264(15):8475-8. View on Pubmed
  212. Lowenthal JW, Ballard DW, Bogerd H, Böhnlein E, Greene WC. Tumor necrosis factor-alpha activation of the IL-2 receptor-alpha gene involves the induction of kappa B-specific DNA binding proteins. J Immunol. 1989 May 1; 142(9):3121-8. View on Pubmed
  213. Hoyos B, Ballard DW, Böhnlein E, Siekevitz M, Greene WC. Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression. Science. 1989 Apr 28; 244(4903):457-60. View on Pubmed
  214. Böhnlein E, Siekevitz M, Ballard DW, Lowenthal JW, Rimsky L, Bogérd H, Hoffman J, Wano Y, Franza BR, Greene WC. Stimulation of the human immunodeficiency virus type 1 enhancer by the human T-cell leukemia virus type I tax gene product involves the action of inducible cellular proteins. J Virol. 1989 Apr; 63(4):1578-86. View on Pubmed
  215. Lowenthal JW, Ballard DW, Böhnlein E, Greene WC. Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes. Proc Natl Acad Sci U S A. 1989 Apr; 86(7):2331-5. View on Pubmed
  216. Böhnlein E, Lowenthal JW, Wano Y, Franza BR, Ballard DW, Greene WC. HIV-1, HTLV-I and the interleukin-2 receptor: insights into transcriptional control. Haematol Blood Transfus. 1989; 32:393-401. View on Pubmed
  217. Wano Y, Feinberg M, Hosking JB, Bogerd H, Greene WC. Stable expression of the tax gene of type I human T-cell leukemia virus in human T cells activates specific cellular genes involved in growth. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9733-7. View on Pubmed
  218. Fung MR, Ju G, Greene WC. Co-internalization of the p55 and p70 subunits of the high-affinity human interleukin 2 receptor. Evidence for a stable ternary receptor complex. J Exp Med. 1988 Nov 1; 168(5):1923-8. View on Pubmed
  219. Rimsky L, Hauber J, Dukovich M, Malim MH, Langlois A, Cullen BR, Greene WC. Functional replacement of the HIV-1 rev protein by the HTLV-1 rex protein. Nature. 1988 Oct 20; 335(6192):738-40. View on Pubmed
  220. Collins L, Tsien WH, Seals C, Hakimi J, Weber D, Bailon P, Hoskings J, Greene WC, Toome V, Ju G. Identification of specific residues of human interleukin 2 that affect binding to the 70-kDa subunit (p70) of the interleukin 2 receptor. Proc Natl Acad Sci U S A. 1988 Oct; 85(20):7709-13. View on Pubmed
  221. Ballard DW, Böhnlein E, Lowenthal JW, Wano Y, Franza BR, Greene WC. HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene. Science. 1988 Sep 23; 241(4873):1652-5. View on Pubmed
  222. Froussard P, Chastagner P, Sommé G, Abadie A, Greene W, Thèze J, Longacre S. p55 IL-2 receptor mRNA precursors in murine T lymphocyte nuclei. J Immunol. 1988 Aug 15; 141(4):1358-64. View on Pubmed
  223. Böhnlein E, Lowenthal JW, Siekevitz M, Ballard DW, Franza BR, Greene WC. The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV. Cell. 1988 Jun 3; 53(5):827-36. View on Pubmed
  224. Lowenthal JW, Böhnlein E, Ballard DW, Greene WC. Regulation of interleukin 2 receptor alpha subunit (Tac or CD25 antigen) gene expression: binding of inducible nuclear proteins to discrete promoter sequences correlates with transcriptional activation. Proc Natl Acad Sci U S A. 1988 Jun; 85(12):4468-72. View on Pubmed
  225. Cullen BR, Podlaski FJ, Peffer NJ, Hosking JB, Greene WC. Sequence requirements for ligand binding and cell surface expression of the Tac antigen, a human interleukin-2 receptor. J Biol Chem. 1988 Apr 5; 263(10):4900-6. View on Pubmed
  226. Greene WC. Sarcoidosis and interleukin-2 receptors. Am Rev Respir Dis. 1988 Apr; 137(4):757-8. View on Pubmed
  227. Zeitz M, Greene WC, Peffer NJ, James SP. Lymphocytes isolated from the intestinal lamina propria of normal nonhuman primates have increased expression of genes associated with T-cell activation. Gastroenterology. 1988 Mar; 94(3):647-55. View on Pubmed
  228. Greene WC. In: Gallin J, Goldstein I, Snyderman R (Eds.), Inflammation: Basic principles and clinical correlations. IL-2, IL-2 receptors, and the growth of human T cells. 1988; 209-288. View on Pubmed
  229. Greene WC, Böhnlein E, Siekevitz M, Franza BR, Lowenthal J. The human interleukin-2 receptor. Recent studies of structure and regulation. Ann N Y Acad Sci. 1988; 546:116-21. View on Pubmed
  230. Wano Y, Dukovich M, Kehrl JH, Greene WC. In: Smith KA (Ed.), Interleukin 2. New perspectives on the structure of the human high affinity i nterleukin-2 receptor. 1988; 99-112. View on Pubmed
  231. Greene WC, Wano YJ, Dukovich M. New insights into the structure of high-affinity interleukin-2 receptors. Recent Prog Horm Res. 1988; 44:141-55. View on Pubmed
  232. Kehrl JH, Dukovich M, Whalen G, Katz P, Fauci AS, Greene WC. Novel interleukin 2 (IL-2) receptor appears to mediate IL-2-induced activation of natural killer cells. J Clin Invest. 1988 Jan; 81(1):200-5. View on Pubmed
  233. Siekevitz M, Josephs SF, Dukovich M, Peffer N, Wong-Staal F, Greene WC. Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I. Science. 1987 Dec 11; 238(4833):1575-8. View on Pubmed
  234. Rubin LA, Hoekzema GS, Nelson DL, Greene WC, Jay G. Reconstitution of a functional interleukin 2 receptor in a nonlymphoid cell. J Immunol. 1987 Oct 1; 139(7):2355-60. View on Pubmed
  235. Lowenthal JW, Greene WC. Contrasting interleukin 2 binding properties of the alpha (p55) and beta (p70) protein subunits of the human high-affinity interleukin 2 receptor. J Exp Med. 1987 Oct 1; 166(4):1156-61. View on Pubmed
  236. Greene WC. The human interleukin-2 receptor: a molecular and biochemical analysis of structure and function. Clin Res. 1987 Sep; 35(5):439-50. View on Pubmed
  237. Bich-Thuy LT, Dukovich M, Peffer NJ, Fauci AS, Kehrl JH, Greene WC. Direct activation of human resting T cells by IL 2: the role of an IL 2 receptor distinct from the Tac protein. J Immunol. 1987 Sep 1; 139(5):1550-6. View on Pubmed
  238. Wano Y, Hattori T, Matsuoka M, Takatsuki K, Chua AO, Gubler U, Greene WC. Interleukin 1 gene expression in adult T cell leukemia. J Clin Invest. 1987 Sep; 80(3):911-6. View on Pubmed
  239. Siekevitz M, Feinberg MB, Holbrook N, Wong-Staal F, Greene WC. Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I. Proc Natl Acad Sci U S A. 1987 Aug; 84(15):5389-93. View on Pubmed
  240. Dukovich M, Wano Y. A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors. Nature. 1987 Jun 11-17; 327(6122):518-22. View on Pubmed
  241. Holter W, Goldman CK, Casabo L, Nelson DL, Greene WC, Waldmann TA. Expression of functional IL 2 receptors by lipopolysaccharide and interferon-gamma stimulated human monocytes. J Immunol. 1987 May 1; 138(9):2917-22. View on Pubmed
  242. Wano Y, Cullen BR, Svetlik PA, Peffer NJ, Greene WC. Reconstitution of high affinity IL-2 receptor expression in a human T-cell line using a retroviral cDNA expression vector. Mol Biol Med. 1987 Apr; 4(2):95-109.
  243. Bernard O, Fazekas de St Groth B, Ullrich A, Green W, Schlessinger J. High-affinity interleukin 2 binding by an oncogenic hybrid interleukin 2-epidermal growth factor receptor molecule. Proc Natl Acad Sci U S A. 1987 Apr; 84(8):2125-9.
  244. Robb RJ, Rusk CM, Yodoi J, Greene WC. Interleukin 2 binding molecule distinct from the Tac protein: analysis of its role in formation of high-affinity receptors. Proc Natl Acad Sci U S A. 1987 Apr; 84(7):2002-6. View on Pubmed
  245. Robb RJ, Greene WC. Internalization of interleukin 2 is mediated by the beta chain of the high-affinity interleukin 2 receptor. J Exp Med. 1987 Apr 1; 165(4):1201-6. View on Pubmed
  246. Greene WC, Leonard WJ, Wano Y, Svetlik PB, Peffer NJ, Sodroski JG, Rosen CA, Goh WC, Haseltine WA. Trans-activator gene of HTLV-II: interpretation. Science. 1987 Feb 27; 235(4792):1073. View on Pubmed
  247. Greene WC. Int. J. Immunother. III. Expression of interleukin-2 receptors in normal and neoplastic T cells. 1987; 3:171-175. View on Pubmed
  248. Greene WC, Leonard WJ. Human interleukin 2 receptor (Tac antigen). Methods Enzymol. 1987; 150:682-700. View on Pubmed
  249. Greene WC. Proceedings of the AACR 1987. IL-2, IL-2 receptors and human retroviruses. 1987; 469-470. View on Pubmed
  250. Greene WC, Dukovich M, Wano Y, Kehrl JH, Robb RJ. In: Webb DR, Pierce CW, Cohen S (Eds.), Proceedings of the Fifth International Lymphokine Workshop. The human high affinity for interleukin-2 receptor. 1987; 171-179. View on Pubmed
  251. Greene WC, Leonard WJ, Wano Y, Sodroski JG, Rosen CA, Haseltine WA. In: Pruzanki W, Seligmann M (Eds.), Clinical Immunology. The transactivator (tat) gene of HTLV-II induces the expression of cellular genes involved in T cell growth. 1987; 213-216. View on Pubmed
  252. Greene WC. An overview of the human interleukin-2 receptor: molecular, biochemical, and functional properties. Cancer Invest. 1987; 5(4):369-76. View on Pubmed
  253. Chanda PK, Chen GF, Baine Y, Leonard WJ, Greene WC, Chang TW, Chang NT. Expression of human interleukin-2 receptor cDNA in E. coli. Biochem Biophys Res Commun. 1986 Dec 15; 141(2):804-11. View on Pubmed
  254. Neckers LM, Bauer S, McGlennen RC, Trepel JB, Rao K, Greene WC. Diltiazem inhibits transferrin receptor expression and causes G1 arrest in normal and neoplastic T cells. Mol Cell Biol. 1986 Dec; 6(12):4244-50. View on Pubmed
  255. Greene WC. Characterization of the human interleukin 2 receptor at the DNA, RNA, and protein level. Immunobiology. 1986 Sep; 172(3-5):357-64. View on Pubmed
  256. Greene WC, Depper JM, Krönke M, Leonard WJ. The human interleukin-2 receptor: analysis of structure and function. Immunol Rev. 1986 Aug; 92:29-48. View on Pubmed
  257. Krönke M, Schlick E, Waldmann TA, Vitetta ES, Greene WC. Selective killing of human T-lymphotropic virus-I infected leukemic T-cells by monoclonal anti-interleukin 2 receptor antibody-ricin A chain conjugates: potentiation by ammonium chloride and monensin. Cancer Res. 1986 Jul; 46(7):3295-8.
  258. Treiger BF, Leonard WJ, Svetlik P, Rubin LA, Nelson DL, Greene WC. A secreted form of the human interleukin 2 receptor encoded by an "anchor minus" cDNA. J Immunol. 1986 Jun 1; 136(11):4099-105. View on Pubmed
  259. Greene WC, Leonard WJ, Wano Y, Svetlik PB, Peffer NJ, Sodroski JG, Rosen CA, Goh WC, Haseltine WA. Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression. Science. 1986 May 16; 232(4752):877-80. View on Pubmed
  260. Weissman AM, Harford JB, Svetlik PB, Leonard WL, Depper JM, Waldmann TA, Greene WC, Klausner RD. Only high-affinity receptors for interleukin 2 mediate internalization of ligand. Proc Natl Acad Sci U S A. 1986 Mar; 83(5):1463-6. View on Pubmed
  261. Greene WC, Leonard WJ. The human interleukin-2 receptor. Annu Rev Immunol. 1986; 4:69-95. View on Pubmed
  262. Greene WC, Leonard WJ, Depper JM. Growth of human T lymphocytes: an analysis of interleukin 2 and its cellular receptor. Prog Hematol. 1986; 14:283-301. View on Pubmed
  263. Greene WC, Depper JM, Krönke M, Leonard WJ. The human interleukin-2 receptor: role in normal T-cell growth and association with HTLV-I-induced T-cell leukemia. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 2:731-7. View on Pubmed
  264. In: Greene WC, moderator. The human interleukin-2 receptor: normal and abnormal expression in T cells and in leukemias induced by the human T lymphotropic retroviruses. Ann. Int. Med. Deregulated interleukin-2 receptor expression in Adult T-cell Leukemia. 1986; 105:566-569. View on Pubmed
  265. Greene WC, Leonard WJ, Wano Y, Sodroski JG, Rosen CA, Haseltine WA. In: Marget M, Lang W, Gabler-Sandberger E (Eds.), Proceedings of the IXth International Congress of Infectious and Parasitic Diseases. The transactivator (tat) gene of HTLV-II activates IL-2 receptor, IL-2, and class II major histocompatibility complex cellular gene expression. 1986; 1:67-69. View on Pubmed
  266. Waldmann TA, Korsmeyer SJ, Greene WC. The arrangement of immunoglobulin, T cell antigen receptor, and interleukin 2 receptor genes in human lymphoid neoplasms. Symp Fundam Cancer Res. 1986; 38:63-78. View on Pubmed
  267. Depper JM, Leonard WJ, Greene WC. In: Pincus S, Pisetsky D, Rosenwasser L (Eds.), Biologically based immunomodulators in the therapy of rheumatic diseases. The human receptor for interleukin-2: characterization, controversies, and expression in rheumatic diseases. 1986; 297-306. View on Pubmed
  268. Leonard WJ, Depper JM, Kanehisa M, Krönke M, Peffer NJ, Svetlik PB, Sullivan M, Greene WC. Structure of the human interleukin-2 receptor gene. Science. 1985 Nov 8; 230(4726):633-9. View on Pubmed
  269. Reed JC, Greene WC, Hoover RG, Nowell PC. Monoclonal antibody OKT11A inhibits and recombinant interleukin 2 (IL 2) augments expression of IL 2 receptors at a pretranslational level. J Immunol. 1985 Oct; 135(4):2478-82. View on Pubmed
  270. Waldmann TA, Longo DL, Leonard WJ, Depper JM, Thompson CB, Krönke M, Goldman CK, Sharrow S, Bongiovanni K, Greene WC. Interleukin 2 receptor (Tac antigen) expression in HTLV-I-associated adult T-cell leukemia. Cancer Res. 1985 Sep; 45(9 Suppl):4559s-4562s. View on Pubmed
  271. Greene WC, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Krönke M, Svetlik P, Peffer NJ, Waldmann TA. Isolation and expression of complementary DNAs encoding the human interleukin 2 receptor. Cancer Res. 1985 Sep; 45(9 Suppl):4563s-4567s. View on Pubmed
  272. Leonard WJ, Krönke M, Peffer NJ, Depper JM, Greene WC. Interleukin 2 receptor gene expression in normal human T lymphocytes. Proc Natl Acad Sci U S A. 1985 Sep; 82(18):6281-5. View on Pubmed
  273. Lane HC, Depper JM, Greene WC, Whalen G, Waldmann TA, Fauci AS. Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognition. N Engl J Med. 1985 Jul 11; 313(2):79-84. View on Pubmed
  274. Greene WC, Robb RJ, Svetlik PB, Rusk CM, Depper JM, Leonard WJ. Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells. J Exp Med. 1985 Jul 1; 162(1):363-8. View on Pubmed
  275. Leonard WJ, Donlon TA, Lebo RV, Greene WC. Localization of the gene encoding the human interleukin-2 receptor on chromosome 10. Science. 1985 Jun 28; 228(4707):1547-9.
  276. Krönke M, Leonard WJ, Depper JM, Greene WC. Deregulation of interleukin-2 receptor gene expression in HTLV-I-induced adult T-cell leukemia. Science. 1985 Jun 7; 228(4704):1215-7. View on Pubmed
  277. Depper JM, Leonard WJ, Drogula C, Krönke M, Waldmann TA, Greene WC. Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene. Proc Natl Acad Sci U S A. 1985 Jun; 82(12):4230-4. View on Pubmed
  278. Krönke M, Leonard WJ, Depper JM, Greene WC. Sequential expression of genes involved in human T lymphocyte growth and differentiation. J Exp Med. 1985 Jun 1; 161(6):1593-8. View on Pubmed
  279. Miller J, Malek TR, Leonard WJ, Greene WC, Shevach EM, Germain RN. Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA. J Immunol. 1985 Jun; 134(6):4212-7. View on Pubmed
  280. Krönke M, Depper JM, Leonard WJ, Vitetta ES, Waldmann TA, Greene WC. Adult T cell leukemia: a potential target for ricin A chain immunotoxins. Blood. 1985 Jun; 65(6):1416-21. View on Pubmed
  281. Leonard WJ, Depper JM, Krönke M, Robb RJ, Waldmann TA, Greene WC. The human receptor for T-cell growth factor. Evidence for variable post-translational processing, phosphorylation, sulfation, and the ability of precursor forms of the receptor to bind T-cell growth factor. J Biol Chem. 1985 Feb 10; 260(3):1872-80. View on Pubmed
  282. Leonard WJ, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Kronke M, Svetlik P, Peffer NJ, Waldmann TA, Greene WC. In: Sorg C, Schimple A (Eds.), Cellular and molecular biology of lymphokines. Cloning of cDNAs for the human interleukin-2 receptor and determination of its complete protein sequence. 1985; 623-633. View on Pubmed
  283. Depper JM, Leonard WJ, Kronke M, Waldmann TA, Greene WC. In: Sorg P, Schimple A (Eds.), Cellular and molecular biology of lymphokines. The role of protein kinase C, and effects of 5-azacytidine on regulation on interleukin-2 receptor expression. 1985; 151-156.
  284. Greene WC, Robb RJ. Receptors for T-cell growth factor: structure, function and expression on normal and neoplastic cells. Contemp Top Mol Immunol. 1985; 10:1-34.
  285. Leonard WJ, Depper JM, Crabtee GM, Rudikoff S, Pumphrey J, Robb RJ, Kronke M, Svetlik P, Peffer NJ, Waldmann TA, Greene WC. In: Feldmann M, Mitchison NA (Eds.), Immune Regulation. Molecular cloning and expression of cDNAs encoding the human interleukin-2 receptor. 1985; 185-195. View on Pubmed
  286. Greene WC, Depper JM, Krönke M, Leonard WJ. The human interleukin-2 receptor. J Cell Sci Suppl. 1985; 3:97-106. View on Pubmed
  287. Greene WC, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Kronke M, Svetlik P, Peffer NJ, Waldmann TA, Leonard WJ. In: Pattengale PK, Lukes RJ, Taylor CR (Eds.), Lymphoproliferative Diseases: Pathogenesis, Diagnosis, and Therapy. Molecular analysis of the human interleukin-2 receptor. 1985; 8-20. View on Pubmed
  288. Reed JC, Robb RJ, Greene WC, Nowell PC. Effect of wheat germ agglutinin on the interleukin pathway of human T lymphocyte activation. J Immunol. 1985 Jan; 134(1):314-23. View on Pubmed
  289. Greene WC, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Krönke M, Svetlik P, Peffer NJ, Waldmann TA. Molecular cloning of cDNA for the human interleukin-2 receptor. Haematol Blood Transfus. 1985; 29:388-95. View on Pubmed
  290. Waldmann TA, Leonard WJ, Depper JM, Kronke M, Kozak R, Greene WC. In: Cancer Cells 3: Growth factors and transformation. Structure, function, and expression of the receptor for interleukin-2 on normal and malignant lymphocytes. 1985; 221-226. View on Pubmed
  291. Waldmann TA, Leonard WJ, Depper JM, Kronke M, Goldman CK, Bongiovani KF, Greene WC.. In: Feldman M (Ed.), Human T cell clones: An approach to immune regulation. Interleukin-2 receptors. 1985; 285-300. View on Pubmed
  292. Waldmann TA, Leonard WJ, Depper JM, Kronke M, Goldman CK, Sharrow S, Greene WC. In: Pinchera A, Doria G, Dammacco F, Bargellesi A (Eds.), Monoclonal Antibodies 1984: Biological and Clinical Applications. Interleukin-2 receptors on lymphocytes. 1985; 329-338. View on Pubmed
  293. Depper JM, Leonard WJ, Drogula CL, Krönke M, Waldmann TA, Greene WC. Activators of protein kinase C and 5-azacytidine induce IL-2 receptor expression on human T lymphocytes. J Cell Biochem. 1985; 27(3):267-76. View on Pubmed
  294. Kronke M, Depper JM, Leonard WJ, Wong-Staal F, Gallo RC, Waldmann TA, Greene WC. In: Sorg C, Schimple A (Eds.), Cellular and molecular biology of lymphokines. Cyclosporin A inhibits expression of select T-cell activation genes. 1985; 647-652. View on Pubmed
  295. Depper JM, Leonard WJ, Krönke M, Noguchi PD, Cunningham RE, Waldmann TA, Greene WC. Regulation of interleukin 2 receptor expression: effects of phorbol diester, phospholipase C, and reexposure to lectin or antigen. J Immunol. 1984 Dec; 133(6):3054-61. View on Pubmed
  296. Korsmeyer SJ, Greene WC, Waldmann TA. Cellular origin of hairy cell leukemia: malignant B cells that express receptors for T cell growth factor. Semin Oncol. 1984 Dec; 11(4):394-400. View on Pubmed
  297. Waldmann TA, Goldman CK, Robb RJ, Depper JM, Leonard WJ, Sharrow SO, Bongiovanni KF, Korsmeyer SJ, Greene WC. Expression of interleukin 2 receptors on activated human B cells. J Exp Med. 1984 Nov 1; 160(5):1450-66. View on Pubmed
  298. Depper JM, Leonard WJ, Krönke M, Waldmann TA, Greene WC. Augmented T cell growth factor receptor expression in HTLV-1-infected human leukemic T cells. J Immunol. 1984 Oct; 133(4):1691-5. View on Pubmed
  299. Leonard WJ, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Krönke M, Svetlik PB, Peffer NJ, Waldmann TA. Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature. 1984 Oct 18-24; 311(5987):626-31. View on Pubmed
  300. Robb RJ, Greene WC, Rusk CM. Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen. J Exp Med. 1984 Oct 1; 160(4):1126-46. View on Pubmed
  301. Krönke M, Leonard WJ, Depper JM, Arya SK, Wong-Staal F, Gallo RC, Waldmann TA, Greene WC. Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc Natl Acad Sci U S A. 1984 Aug; 81(16):5214-8. View on Pubmed
  302. Greene WC, Robb RJ, Depper JM, Leonard WJ, Drogula C, Svetlik PB, Wong-Staal F, Gallo RC, Waldmann TA. Phorbol diester induces expression of Tac antigen on human acute T lymphocytic leukemic cells. J Immunol. 1984 Aug; 133(2):1042-7. View on Pubmed
  303. Waldmann TA, Greene WC, Sarin PS, Saxinger C, Blayney DW, Blattner WA, Goldman CK, Bongiovanni K, Sharrow S, Depper JM. Functional and phenotypic comparison of human T cell leukemia/lymphoma virus positive adult T cell leukemia with human T cell leukemia/lymphoma virus negative Sézary leukemia, and their distinction using anti-Tac. Monoclonal antibody identifying the human receptor for T cell growth factor. J Clin Invest. 1984 Jun; 73(6):1711-8. View on Pubmed
  304. Waldmann TA, Broder S, Greene WC. In: Sasazuki T (Ed.), Immunogenetics: Its application to clinical medicine. Cell-cell interactions in the human immune response: Analysis of leukemic T calls with immunoregulatory functions. 1984; 137-142. View on Pubmed
  305. Waldmann TA, Goldman CK, Leonard WJ, Depper JM, Robb RJ, Korsmeyer SJ, Greene WC. Interleukin-2 receptors on activated malignant and normal B-cells. Curr Top Microbiol Immunol. 1984; 113:96-101. View on Pubmed
  306. Leonard WJ, Depper JM, Waldmann TA, Greene WC. In: Greaves M (Ed.), Receptors and Recognition. A monoclonal antibody to the human receptor for T cell growth factor. 1984; 17:45-66. View on Pubmed
  307. Waldmann TA, Leonard WJ, Depper JM, Krönke M, Goldman CK, Oh T, Greene WC. Interleukin-2 receptor expression in retrovirus associated adult T-cell leukemia. Princess Takamatsu Symp. 1984; 15:259-68. View on Pubmed
  308. Depper JM, Leonard WJ, Waldmann TA, Greene WC. In: Pick E (Ed.), Lymphokines. A monoclonal antibody which recognizes the human receptor for T cell growth factor: Functional effects and use as a probe to investigate receptor regulation. 1984; 9:127-152. View on Pubmed
  309. Lipkowitz S, Greene WC, Rubin AL, Novogrodsky A, Stenzel KH. Expression of receptors for interleukin 2: Role in the commitment of T lymphocytes to proliferate. J Immunol. 1984 Jan; 132(1):31-7. View on Pubmed
  310. Littman BH, Muchmore AV, Steinberg AD, Greene WC. Monoclonal lupus autoantibody secretion by human-human hybridomas. Selection of hybrids by conventional and novel techniques. J Clin Invest. 1983 Dec; 72(6):1987-94. View on Pubmed
  311. Leonard WJ, Depper JM, Robb RJ, Waldmann TA, Greene WC. Characterization of the human receptor for T-cell growth factor. Proc Natl Acad Sci U S A. 1983 Nov; 80(22):6957-61. View on Pubmed
  312. Robb RJ, Greene WC. Direct demonstration of the identity of T cell growth factor binding protein and the Tac antigen. J Exp Med. 1983 Oct 1; 158(4):1332-7. View on Pubmed
  313. Lando Z, Sarin P, Megson M, Greene WC, Waldman TA, Gallo RC, Broder S. Association of human T-cell leukaemia/lymphoma virus with the Tac antigen marker for the human T-cell growth factor receptor. Nature. 1983 Oct 20-26; 305(5936):733-6. View on Pubmed
  314. Depper JM, Leonard WJ, Robb RJ, Waldmann TA, Greene WC. Blockade of the interleukin-2 receptor by anti-Tac antibody: inhibition of human lymphocyte activation. J Immunol. 1983 Aug; 131(2):690-6. View on Pubmed
  315. Korsmeyer SJ, Greene WC, Cossman J, Hsu SM, Jensen JP, Neckers LM, Marshall SL, Bakhshi A, Depper JM, Leonard WJ, Jaffe ES, Waldmann TA. Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia. Proc Natl Acad Sci U S A. 1983 Jul; 80(14):4522-6. View on Pubmed
  316. Koretzky GA, Daniele RP, Greene WC, Nowell PC. Evidence for an interleukin-independent pathway for human lymphocyte activation. Proc Natl Acad Sci U S A. 1983 Jun; 80(11):3444-7. View on Pubmed
  317. Cossman J, Neckers LM, Leonard WJ, Greene WC. Polymorphonuclear neutrophils express the common acute lymphoblastic leukemia antigen. J Exp Med. 1983 Mar 1; 157(3):1064-9. View on Pubmed
  318. Greene WC, Cossman J, Leonard WJ, Bakshi A, Waldmann TA, Korsmeyer SJ. In: Golde DW, Marks PA (Eds.), Normal and Neoplastic Hematopoiesis, UCLA Symposia on Molecular and Cellular Biology. Hairy cell leukemia: A malignant expansion of B cells that express Tac antigen. 1983; 9:491-500. View on Pubmed
  319. Blaese RM, Tosato G, Greene WC, Fleisher TA, Muchmore AV. The role of cell surface lectin--carbohydrate interactions in cellular recognition, cooperation, and regulation. Am J Pediatr Hematol Oncol. 1983; 5(2):199-206. View on Pubmed
  320. Greene WC, Depper JM, Leonard WJ, Fleisher TA, Waldmann TA. Construction of human suppressor T cell hybridomas. Lymphokine Res. 1983; 2(2):53-60. View on Pubmed
  321. Leonard WJ, Depper JM, Uchiyama T, Smith KA, Waldmann TA, Greene WC. A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor. Nature. 1982 Nov 18; 300(5889):267-9. View on Pubmed
  322. Greene WC, Fleisher TA, Nelson DL, Waldmann TA. Production of human suppressor T cell hybridomas. J Immunol. 1982 Nov; 129(5):1986-92. View on Pubmed
  323. Fleisher TA, Attallah AM, Tosato G, Blaese RM, Greene WC. Interferon-mediated inhibition of human polyclonal immunoglobulin synthesis. J Immunol. 1982 Sep; 129(3):1099-103. View on Pubmed
  324. Greene WC, Fleisher TA, Depper JM, Leonard WJ, Stanton GJ, Waldmann TA. Characterization of a soluble suppressor of human B cell function produced by a continuous human suppressor T cell line. II. Evidence for suppression through a direct action of CTC-SISS-B on human B cells. J Immunol. 1982 Sep; 129(3):1120-3. View on Pubmed
  325. Depper JM, Leonard WJ, Smith KA, Waldmann TA, Greene WC. In: Oppenheim JJ, Cohen S (Eds.), Interleukins, lymphokines, and cytokines. Monoclonal anti-Tac blocks the action of human interleukin-2. 1982; 19-24. View on Pubmed
  326. Greene WC, Goldman CK, Marshall ST, Fleisher TA, Waldmann TA. Stimulation of immunoglobulin biosynthesis in human B cells by wheat germ agglutinin. I. Evidence that WGA can produce both a positive and negative signal for activation of human lymphocytes. J Immunol. 1981 Aug; 127(2):799-804. View on Pubmed
  327. Fleisher TA, Greene WC, Uchiyama T, Goldman CK, Nelson DL, Blaese RM, Waldmann TA. Characterization of a soluble suppressor of human B cell immunoglobulin biosynthesis produced by a continuous human suppressor T cell line. J Exp Med. 1981 Jul 1; 154(1):156-67. View on Pubmed
  328. Greene WC, Fleisher TA, Waldmann TA. Soluble suppressor supernatants elaborated by concanavalin A-activated human mononuclear cells. I. Characterization of a soluble suppressor T cell proliferation. J Immunol. 1981 Mar; 126(3):1185-91. View on Pubmed
  329. Fleisher TA, Greene WC, Blaese RM, Waldmann TA. Soluble suppressor supernatants elaborated by concanavalin A-activated human mononuclear cells. II. Characterization of a soluble suppressor of B cell immunoglobulin production. J Immunol. 1981 Mar; 126(3):1192-7. View on Pubmed
  330. Greene WC, Fleisher TA, Waldmann TA. Suppression of human T and B lymphocyte activation by Agaricus bisporus lectin. I. Suggestive evidence for a surface "suppressor" receptor in human lymphocytes. J Immunol. 1981 Feb; 126(2):580-6. View on Pubmed
  331. Greene WC, Waldmann TA. Inhibition of human lymphocyte proliferation by the nonmitogenic lectin wheat germ agglutinin. J Immunol. 1980 Jun; 124(6):2979-87. View on Pubmed
  332. Parker CW, Greene WC. In: Cramer H, Schultz J (Eds.), Mechanism of Action. Cyclic nucleotides in the immune response. 1977; 161-187. View on Pubmed
  333. Greene WC, Parker CM, Parker CW. Cytochalasin sensitive structures and lymphocyte activation. Exp Cell Res. 1976 Nov; 103(1):109-17. View on Pubmed
  334. Parker CW, Greene WC, MacDonald HH. Cytochalasin binding in lymphocytes and polymorphonuclear leukocytes. Exp Cell Res. 1976 Nov; 103(1):99-108. View on Pubmed
  335. Greene WC, Parker CM, Parker CW. Colchicine-sensitive structures and lymphocyte activation. J Immunol. 1976 Sep; 117(3):1015-22. View on Pubmed
  336. Greene WC, Parker CM, Parker CW. Opposing effects of mitogenic and nonmitogenic lectins on lymphocyte activation. Evidence that wheat germ agglutinin produces a negative signal. J Biol Chem. 1976 Jul 10; 251(13):4017-25. View on Pubmed
  337. Greene WC, Parker CM, Parker CW. Calcium and lymphocyte activation. Cell Immunol. 1976 Jul; 25(1):74-89.
  338. Atkinson JP, Greene WC, McNearney TA, Parker CW. Studies on the stimulation of cAMP metabolism in human lymphocytes by latex polymers. Exp Cell Res. 1976 May; 99(2):395-407.
  339. Greene WC, Wedner HJ, Parker CW. In: Eijsvoogel W, Roos D, Zeijlemaker WP (Eds.), Leukocyte membrane determinants regulating immune reactivity. Calcium ionophore A23187 and lymphocyte activation. 1976; 10:129.
  340. Parker CW, Dankner RE, Falkenhein SF, Greene WC. Suggestive evidence for both stimulatory and inhibitory domains on human lymphocytes, as indicated by phospholipid turnover studies with wheat germ agglutinin and other lectins. Immunol Commun. 1976; 5(1-2):13-25.
  341. Greene WC, Parker CW. A role for cytochalasin-sensitive proteins in the regulation of calcium transport in activated human lymphocytes. Biochem Biophys Res Commun. 1975 Jul 22; 65(2):456-63.
  342. Sullivan TJ, Greene WC, Parker CW. Concanavalin A-induced histamine release from normal rat mast cells. J Immunol. 1975 Jul; 115(1):278-82.
  343. Peterson DT, Greene WC, Reaven GM. Effect of experimental diabetes mellitus on kidney ribosomal protein synthesis. Diabetes. 1971 Oct; 20(10):649-54.
  344. Peterson DT, Greene WC, Reaven GM. Effect of experimental diabetes mellitus on kidney ribosomal protein synthesis. Diabetes. 1971 Oct; 20(10):649-54.