Mentored Scientist Award

I. DESCRIPTION
The CFAR Mentored Scientist Award is a mentoring and training grant targeted toward early stage (either at a senior stage of clinical or postdoctoral training or junior faculty) investigators at UCSF or affiliated partner institutes in the conduct of a research project. These awards are typically used to acquire preliminary data and research skills leading toward a future grant effort. Applicants for this award must indicate a faculty research mentor(s) who will commit to guiding the applicant throughout the duration of the proposed project.

Funding for this program is $50,000 in direct costs (may include personnel salary and benefits). The funding period is one year. Any carry forward of funding is not guaranteed and must be justified. If awarded, indirect costs at appropriate rates will be added to the total direct costs.

Of high interest to CFAR are investigations ranging from basic pathogenesis to clinical outcomes in the research areas of HIV/aging and inflammation, latency, cure, vaccines, co-infections, HIV in women, and research related to health disparities in HIV-infected and HIV-impacted Bay Area populations. Our CFAR Science Cores and Working Group are available to assist you in your research, see VII below.
NOTE: Projects must be within NIH’s HIV/AIDS research high or medium priority areas.

Applicants for this award must indicate a faculty research mentor(s) who will commit to guiding the applicant throughout the duration of the proposed project (see III below)

Applications must be submitted via the RAP website by September 18, 2:00 PM PT. Any questions about proposal submission and review process contact rap.ucsf.edu.  

Program Contact - Should you have any questions regarding submission or reporting procedures, please contact Brenda Sanchez, CFAR Developmental Core Manager. If you are considering a study involving any clinical or behavioral intervention, please contact (brenda.sanchez@ucsf,edu) or lauren.sterling@ucsf.edu) with a brief description of your study to determine whether your proposed project would be eligible for funding through CFAR. The complete guidelines for this RFA can be found here: http://cfar.ucsf.edu/sites/cfar.ucsf.edu/files/Mentored-Science-Program-2017-CFAR-Guidelines.pdf

II. ELIGIBILITY - 
Eligibility requirements need to be met as of date of submission; no waivers are allowed.
Investigators must be at UCSF or affiliated partner institutes (Gladstone Institutes, Blood Systems Research Institute, San Francisco Department of Public Health, and San Francisco Veterans Affairs Medical Center/NCIRE.) Investigators with backgrounds in clinical, basic, behavioral-epidemiological, implementation, and/or health disparities HIV research are all welcome to apply.

(http://cfar.ucsf.edu/about/partners).

Who is eligible:

  • Postdoctoral or clinical fellows in training
  • Current faculty at the assistant professor or clinical instructor level (including acting positions) who have not yet received an R01-equivalent award in HIV/AIDS
  • Non-faculty series - Professional Research Series including Specialist Series. Investigators in these series must make a strong case for their plan for becoming independent researchers

Who is Not eligible:  Associate and full professors; staff

Special Considerations for Current NIH T32 and K Awardees:

  • Current T32 awardees can apply for CFAR funds provided NO salary/stipends are taken from the CFAR award
  • CFAR allows current K awardees to provide complementary effort on their CFAR award with salary within their remaining 25% effort, if they also maintain the 75% required on the K-award as long as the specific aims differ from those on the “K” award. Please see the guide notice for details: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-17-094.html.

III. DESIGNATION OF MENTOR
All Mentored award applications require a faculty research mentor from UCSF or a UCSF-affiliate. (http://cfar.ucsf.edu/about/partners) at the time of submission. CFAR requires your research mentor’s support to advise and guide the research portion of your application before submitting it to RAP.  The mentor should be recognized as an accomplished investigator in AIDS research, and should be able to demonstrate past success in training/mentoring independent investigators. The mentor’s role is to provide oversight on the planning, direction, and execution of the proposed research. In addition, the mentor must commit to mentoring the applicant’s throughout the duration of the research project.

NOTE: Mentor cannot have supervisory authority over the applicant(s) under any circumstance part-time or full-time during the project period. If the applicant works in your lab and you are his/her supervisor, you are required to find another person to act as a Research Mentor for the applicant’s project. If questions arise, please contact Lauren Sterling, at Lauren.Sterling@ucsf.edu, CFAR Managing Director.

IV. AWARD RESTRICTIONS

  • Clinical Trials: NIH does not allow CFAR to fund clinical trials. If you are considering a study involving a clinical or behavioral intervention, please contact Brenda Sanchez with a brief description of your study (brenda.sanchez@ucsf.edu, cc: lauren.sterling@ucsf.edu) to determine whether your proposed project would be eligible for funding through CFAR. If it is not, we will provide advice on alternative funding options.
  • Studies with Foreign Components: If the study has an international component requiring expenditure of funds (excluding travel) or a subcontract to a foreign institution, additional NIH approval and review is required. IRB approvals (both local and foreign), institutional FWA numbers, and human subjects training certifications (for local and foreign investigators) will be required before the release of any funding. [See NIH checklist form: https://www.niaid.nih.gov/sites/default/files/internationalstudieschecklist.doc.] Once all paperwork has been filed with the NIH, approval takes approximately 8–12 weeks.
  • Studies Above Minimal Risk: The NIH requires additional review (clinical checklist) for all studies above minimal risk or in vulnerable populations. https://www.niaid.nih.gov/sites/default/files/cfarguideclinresstud.doc.
  • Human Subjects: New investigators should visit the UCSF CHR website for details on when and how to apply for CHR approval at http://irb.ucsf.edu. Information on training, including online training resources, can be found on the CHR website at http://irb.ucsf.edu/citi-human-subjects-training.
  • Resubmissions: Same research topic with an amended application or research plan rather than a new research topic and new research plan. Requirements: Please use up to one extra page to introduce your revised proposal, addressing the issues raised in the review, and any additional changes to your proposal. A new letter from the Chair is not required if the resubmission is within 2 cycles (one skipped cycle max). You will include the old letter and state your resubmission is within 2 cycles and new letter is not required. Make sure the new changes are highlighted in bold or italic font so the reviewers can easily see where and how the proposal has changed. Do NOT use track changes.​

V. CRITERIA FOR REVIEW / EVALUATION OF APPLICANTS
Completed applications which meet eligibility requirements will be evaluated for scientific and technical merit by an appropriate review committee convened by the UCSF Resource Allocation Program in accordance with NIH review criteria: 1. Significance, 2. Approach, 3. Innovation, 4. Investigator, 5. Environment. Each of these criteria will be addressed and considered in assigning the overall application score.

VI. SELECTION OF AWARDEES
CFAR makes funding decisions based on several factors – scientific review score, alignment of proposal to CFAR/OAR strategic goals, proposal research area of focus, potential for the PI to become an independent investigator, and alignment with other requirements set forth in the RFA.

VII.  OTHER RESOURCES: CFAR Sciences Cores - Awardees are encouraged to use one or more support services from our CFAR research resources:

  • Implementation Science Scientific Working Group: Applicants proposing a study in the field of implementation science are required to have an expert from the new Implementation Science Working Group consult with them regarding their study. Send an email with a brief study description to Elvin Geng, SWG Director (elvin.geng@ucsf.edu).
  • Clinical and Population Sciences Core: Steven Deeks, MD & Jeff Martin, MD, MPH, Directors; (SDeeks@php.ucsf.edu; martin@psg.ucsf.edu).
  • Immunology Core: Jeffrey Milush, PhD, Director (Jeffrey.Milush@ucsf.edu)
  • Virology Core: Joseph Wong, MD, Director; (joseph.wong2@va.gov).
  • Specimen Bank Core: Richard Jordan, DDS, PhD & Yvonne DeSouza, MS, Directors (richard.jordan@ucsf.edu,Yvonne.DeSouza@ucsf.edu).
  • Pharmacology Core: Francesca Aweeka, Director (FAweeka@sfghsom.ucsf.edu)
  • Health Disparities Core: Applicants proposing to conduct research with human subjects, especially local and/or underserved communities, are encouraged to consult with the Health Disparities Core. Send an email with a brief study description to Lauren Sterling, Managing Director (lauren.sterling@ucsf.edu) to receive this consultation.

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