Adithya Cattamanchi, MD, MAS
Biography
My research is focused on two thematic areas: 1) Development and evaluation of tuberculosis (TB) diagnostics and 2) Implementation and dissemination of evidence-based preventative, diagnostic, and treatment interventions for TB. I have considerable experience with the evaluation of TB diagnostics in low-income countries, including studying the impact of new diagnostics on patient- and public health-important outcomes. I have served on several World Health Organization (WHO) Expert Group panels to develop new policies related to TB diagnostics and serve as a faculty member for the Advanced Tuberculosis Diagnostics Research workshop sponsored by the WHO Stop TB Partnership. I have initiated a number of collaborations with engineers in industry and academia to develop and evaluate new diagnostic platforms for TB including: 1) mobile phone-based microscopy; 2) mobile phone-based molecular diagnostic platforms; and 3) single-particle aerosol mass spectrometry. We are currently evaluating the mobile phone-based microscopy platform and health centers in Hanoi, Vietnam in a demonstration project funded by the TB REACH initiative.
In addition to research on TB diagnostics, I have developed an active research agenda related to implementation science. I helped establish a platform for monitoring the quality of TB care at 6 rural health centers in Uganda (Uganda Tuberculosis Surveillance Project). My current work, supported through an NIH/NIAID R21 in Implementation and Dissemination Science, is focused on improving the quality of TB suspect evaluation at these health centers.
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- Pai M, Denkinger CM, Kik SV, Rangaka MX, Zwerling A, Oxlade O, Metcalfe JZ, Cattamanchi A, Dowdy DW, Dheda K, Banaei N. Gamma interferon release assays for detection of Mycobacterium tuberculosis infection. Clin Microbiol Rev. 2014 Jan; 27(1):3-20.
- Yoon C, Davis JL, Cattamanchi A. C-reactive protein and tuberculosis screening: a new trick for an old dog? Int J Tuberc Lung Dis. 2013 Dec; 17(12):1656.
- Millman AJ, Dowdy DW, Miller CR, Brownell R, Metcalfe JZ, Cattamanchi A, Davis JL. Rapid molecular testing for TB to guide respiratory isolation in the U.S.: a cost-benefit analysis. PLoS One. 2013; 8(11):e79669.
- Cattamanchi A, Walter ND, Metcalfe JZ, Davis JL. A transcriptional signature for active TB: have we found the needle in the haystack? PLoS Med. 2013 Oct; 10(10):e1001539.
- Dowdy DW, Davis JL, den Boon S, Walter ND, Katamba A, Cattamanchi A. Population-level impact of same-day microscopy and Xpert MTB/RIF for tuberculosis diagnosis in Africa. PLoS One. 2013; 8(8):e70485.
- Andama AO, den Boon S, Meya D, Cattamanchi A, Worodria W, Davis JL, Walter ND, Yoo SD, Kalema N, Haller B, Huang L. Prevalence and outcomes of cryptococcal antigenemia in HIV-seropositive patients hospitalized for suspected tuberculosis in Uganda. J Acquir Immune Defic Syndr. 2013 Jun 01; 63(2):189-94.
- Tapley A, Switz N, Reber C, Davis JL, Miller C, Matovu JB, Worodria W, Huang L, Fletcher DA, Cattamanchi A. Mobile digital fluorescence microscopy for diagnosis of tuberculosis. J Clin Microbiol. 2013 Jun; 51(6):1774-8.
- Yoon C, Davis JL, Cattamanchi A. C-reactive protein and tuberculosis screening: a new trick for an old dog? Int J Tuberc Lung Dis. 2013 Dec; 17(12):1656.
- Blount RJ, Jarlsberg LG, Daly KR, Worodria W, Davis JL, Cattamanchi A, Djawe K, Andama A, Koch J, Walzer PD, Huang L. Serologic responses to recombinant Pneumocystis jirovecii major surface glycoprotein among Ugandan patients with respiratory symptoms. PLoS One. 2012; 7(12):e51545.
- Taylor SM, Meshnick SR, Worodria W, Andama A, Cattamanchi A, Davis JL, Yoo SD, Byanyima P, Kaswabuli S, Goodman CD, Huang L. Low prevalence of Pneumocystis pneumonia (PCP) but high prevalence of pneumocystis dihydropteroate synthase (dhps) gene mutations in HIV-infected persons in Uganda. PLoS One. 2012; 7(11):e49991.
- Yoon C, Cattamanchi A, Davis JL, Worodria W, den Boon S, Kalema N, Katagira W, Kaswabuli S, Miller C, Andama A, Albert H, Nabeta P, Gray C, Ayakaka I, Huang L. Impact of Xpert MTB/RIF testing on tuberculosis management and outcomes in hospitalized patients in Uganda. PLoS One. 2012; 7(11):e48599.
- Van Deun A, Cattamanchi A, Davis JL, Ridderhof J. In reply to 'Can LED fluorescence microscopy replace Ziehl-Neelsen microscopy in tuberculosis detection?'. Int J Tuberc Lung Dis. 2012 Nov; 16(11):1558-9.
- Metcalfe JZ, Cattamanchi A, McCulloch CE, Lew JD, Ha NP, Graviss EA. Test variability of the QuantiFERON-TB gold in-tube assay in clinical practice. Am J Respir Crit Care Med. 2013 Jan 15; 187(2):206-11.
- Davis JL, Cattamanchi A, Cuevas LE, Hopewell PC, Steingart KR. Diagnostic accuracy of same-day microscopy versus standard microscopy for pulmonary tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis. 2013 Feb; 13(2):147-54.
- Davis JL, Dowdy DW, den Boon S, Walter ND, Katamba A, Cattamanchi A. Test and treat: a new standard for smear-positive tuberculosis. J Acquir Immune Defic Syndr. 2012 Sep 01; 61(1):e6-8.
- Kalema N, Boon SD, Cattamanchi A, Davis JL, Andama A, Katagira W, Everett C, Walter N, Byanyima P, Kaswabuli S, Worodria W, Huang L. Oral antimicrobial rinse to reduce mycobacterial culture contamination among tuberculosis suspects in Uganda: a prospective study. PLoS One. 2012; 7(7):e38888.
- Cattamanchi A, Ssewenyana I, Nabatanzi R, Miller CR, Den Boon S, Davis JL, Andama A, Worodria W, Yoo SD, Cao H, Huang L. Bronchoalveolar lavage enzyme-linked immunospot for diagnosis of smear-negative tuberculosis in HIV-infected patients. PLoS One. 2012; 7(6):e39838.
- Dantes R, Metcalfe J, Kim E, Kato-Maeda M, Hopewell PC, Kawamura M, Nahid P, Cattamanchi A. Impact of isoniazid resistance-conferring mutations on the clinical presentation of isoniazid monoresistant tuberculosis. PLoS One. 2012; 7(5):e37956.
- Chang J, Arbeláez P, Switz N, Reber C, Tapley A, Davis JL, Cattamanchi A, Fletcher D, Malik J. Automated tuberculosis diagnosis using fluorescence images from a mobile microscope. Med Image Comput Comput Assist Interv. 2012; 15(Pt 3):345-52.
- Taylor SM, Meshnick SR, Worodria W, Andama A, Davis JL, Cattamanchi A, den Boon S, Yoo SD, Goodman CD, Huang L. Low prevalence of Pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia. Diagn Microbiol Infect Dis. 2012 Feb; 72(2):139-43.
- Metcalfe JZ, Everett CK, Steingart KR, Cattamanchi A, Huang L, Hopewell PC, Pai M. Interferon-? release assays for active pulmonary tuberculosis diagnosis in adults in low- and middle-income countries: systematic review and meta-analysis. J Infect Dis. 2011 Nov 15; 204 Suppl 4:S1120-9.
- Worodria W, Anderson J, Cattamanchi A, Davis JL, den Boon S, Andama A, Yoo SD, Joloba M, Huang L, Kato-Maeda M. The role of speciation in positive Lowenstein-Jensen culture isolates from a high tuberculosis burden country. PLoS One. 2011; 6(11):e27017.
- Kisembo HN, Boon SD, Davis JL, Okello R, Worodria W, Cattamanchi A, Huang L, Kawooya MG. Chest radiographic findings of pulmonary tuberculosis in severely immunocompromised patients with the human immunodeficiency virus. Br J Radiol. 2012 Jun; 85(1014):e130-9.
- Dowdy DW, Cattamanchi A, Steingart KR, Pai M. Is scale-up worth it? Challenges in economic analysis of diagnostic tests for tuberculosis. PLoS Med. 2011 Jul; 8(7):e1001063.
- Yoo SD, Cattamanchi A, Den Boon S, Worodria W, Kisembo H, Huang L, Davis JL. Clinical significance of normal chest radiographs among HIV-seropositive patients with suspected tuberculosis in Uganda. Respirology. 2011 Jul; 16(5):836-41.