Note: Beginning with Fall 2016, The Basic Science program has been combined into the Mentored Scientist Award mechanism - which now has three scientific priority areas for funding: Basic Science, Clinical/ Translational/ Epidemiological/ Behavioral, and Implementation Science.
Below are the awards made under the Basic Science program from 1994 to 2016.
58 Awards
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Investigation of the Effects of IL-2 on the Frequency of FcRL3+ Tregs and T cell Activation in HIV-infected Patients
Investigation of the Effects of IL-2 on the Frequency of FcRL3+ Tregs and T cell Activation in HIV-infected Patients
Abstract
Regulatory T cells (Tregs), defined by expression of FoxP3 and the IL-2 receptor CD25, play a critical role in self-tolerance and suppressing immune responses elicited against infectious agents such as HIV. As it is now recognized that some of the immunopathology wrought by HIV infection may be due to aberrant immune activation, much focus is centered on the role of Tregs and how they may decrease immune activation and slow disease progression.
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Characterization of the Epstein Barr Virus BMRF-2 Gene and its Role in the Pathogenesis of Hairy Leukoplakia
Characterization of the Epstein Barr Virus BMRF-2 Gene and its Role in the Pathogenesis of Hairy Leukoplakia
Abstract
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Identification of Novel HIV Co-Receptors and Characterization of Their Role in Viral Transmission
Identification of Novel HIV Co-Receptors and Characterization of Their Role in Viral Transmission
Abstract
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SAHA Induced Mechanism of HIV Reactivation from Latency
SAHA Induced Mechanism of HIV Reactivation from Latency
Abstract
Despite heroic efforts and better highly active antiretroviral therapy (HAART), HIV remains a lifelong infection that interferes with productivity, decreases lifespan, and is ultimately fatal. Wide-ranging vaccine trials have failed. Thus, this is an opportune time to turn to the persistent infection, and develop new therapies to purge the reservoir of HIV from the infected host.
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Molecular Biology of HIV Macrophage Infection
Molecular Biology of HIV Macrophage Infection
Abstract
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High CD8+ T cell Activation Associates with HIV Disease Outcome
High CD8+ T cell Activation Associates with HIV Disease Outcome
Abstract
Publications:
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Activation of the SIRT1 Deacetylase as a Therapeutic Concept in HIV-induced T Cell Hyperactivation
Activation of the SIRT1 Deacetylase as a Therapeutic Concept in HIV-induced T Cell Hyperactivation
Abstract
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Genetic Diversity of HIV-1 in vivo During Very Early Primary Infection
Genetic Diversity of HIV-1 in vivo During Very Early Primary Infection
Abstract
Publications:
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BRD4 Overexpression Increases the Propensity for Proviral Latency and Determine how this Relates to HIV Latency in vivo.
BRD4 Overexpression Increases the Propensity for Proviral Latency and Determine how this Relates to HIV Latency in vivo.
Abstract
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Optimization of Cytokine Flow Cytometry (CFC) for Trans-Shipped Specimens
Optimization of Cytokine Flow Cytometry (CFC) for Trans-Shipped Specimens
Abstract