Sharof Tugizov, PhD

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Sharof Tugizov, PhD

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Professor, School of Medicine
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Biography

A goal of my laboratory is to understand the molecular mechanisms of the interactions of human viruses, including human immunodeficiency virus and herpes viruses with oropharyngeal and anogenital mucosal epithelia. Specifically, we investigate the molecular mechanisms of transepithelial transmission of these viruses through the mucosal epithelium. Understanding viral transmission via the mucosal epithelium is important for preventing the initial steps of viral infection.
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  1. Walston JJ, Hayman IR, Gore M, Ferguson M, Temple RM, Liao J, Alam S, Meyers C, Tugizov SM, Hutt-Fletcher L, Sample CE. The Epstein-Barr Virus Glycoprotein BDLF2 Is Essential for Efficient Viral Spread in Stratified Epithelium. J Virol. 2023 Jan 23; e0152822.
  2. Lien K, Mayer W, Herrera R, Padilla NT, Cai X, Lin V, Pholcharoenchit R, Palefsky J, Tugizov SM. HIV-1 Proteins gp120 and Tat Promote Epithelial-Mesenchymal Transition and Invasiveness of HPV-Positive and HPV-Negative Neoplastic Genital and Oral Epithelial Cells. Microbiol Spectr. 2022 12 21; 10(6):e0362222.
  3. Herrera R, Rosbe K, Tugizov SM. Inactivation of HIV-1 in Polarized Infant Tonsil Epithelial Cells by Human Beta-Defensins 2 and 3 Tagged with the Protein Transduction Domain of HIV-1 Tat. Viruses. 2021 10 11; 13(10).
  4. Sufiawati I, Herrera R, Mayer W, Cai X, Borkakoti J, Lin V, Rosbe K, Tugizov SM. Human Immunodeficiency Virus (HIV) and Human Cytomegalovirus (HCMV) Coinfection of Infant Tonsil Epithelium May Synergistically Promote both HIV-1 and HCMV Spread and Infection. J Virol. 2021 Aug 25; 95(18):e0092121.
  5. Tugizov S. Virus-associated disruption of mucosal epithelial tight junctions and its role in viral transmission and spread. Tissue Barriers. 2021 Jul 09; 1943274.
  6. Tugizov SM. Human immunodeficiency virus interaction with oral and genital mucosal epithelia may lead to epithelial-mesenchymal transition and sequestration of virions in the endosomal compartments. Oral Dis. 2020 Sep; 26 Suppl 1:40-46.
  7. Weinberg A, Tugizov S, Pandiyan P, Jin G, Rakshit S, Vyakarnam A, Naglik JR. Innate immune mechanisms to oral pathogens in oral mucosa of HIV-infected individuals. Oral Dis. 2020 Sep; 26 Suppl 1:69-79.
  8. Lien K, Mayer W, Herrera R, Rosbe K, Tugizov SM. HIV-1 proteins gp120 and tat induce the epithelial-mesenchymal transition in oral and genital mucosal epithelial cells. PLoS One. 2019; 14(12):e0226343.
  9. Walhart T, Isaacson-Wechsler E, Ang KH, Arkin M, Tugizov S, Palefsky JM. A Cell-Based Renilla Luminescence Reporter Plasmid Assay for High-Throughput Screening to Identify Novel FDA-Approved Drug Inhibitors of HPV-16 Infection. SLAS Discov. 2020 01; 25(1):79-86.
  10. Wechsler EI, Tugizov S, Herrera R, Costa MD, Palefsky JM. Erratum: E5 can be expressed in anal cancer and leads to epidermal growth factor receptor-induced invasion in a human papillomavirus 16-transformed anal epithelial cell line. J Gen Virol. 2018 07; 99(7):948.
  11. Sufiawati I, Tugizov SM. HIV-induced matrix metalloproteinase-9 activation through mitogen-activated protein kinase signalling promotes HSV-1 cell-to-cell spread in oral epithelial cells. J Gen Virol. 2018 07; 99(7):937-947.
  12. Wechsler EI, Tugizov S, Herrera R, Da Costa M, Palefsky JM. E5 can be expressed in anal cancer and leads to epidermal growth factor receptor-induced invasion in a human papillomavirus 16-transformed anal epithelial cell line. J Gen Virol. 2018 05; 99(5):631-644.
  13. Yasen A, Herrera R, Rosbe K, Lien K, Tugizov SM. HIV internalization into oral and genital epithelial cells by endocytosis and macropinocytosis leads to viral sequestration in the vesicles. Virology. 2018 02; 515:92-107.
  14. Yasen A, Herrera R, Rosbe K, Lien K, Tugizov SM. Release of HIV-1 sequestered in the vesicles of oral and genital mucosal epithelial cells by epithelial-lymphocyte interaction. PLoS Pathog. 2017 02; 13(2):e1006247.
  15. Haga T, Efird JT, Tugizov S, Palefsky JM. Increased TNF-alpha and sTNFR2 levels are associated with high-grade anal squamous intraepithelial lesions in HIV-positive patients with low CD4 level. Papillomavirus Res. 2017 Jun; 3:1-6.
  16. Tugizov S. Human immunodeficiency virus-associated disruption of mucosal barriers and its role in HIV transmission and pathogenesis of HIV/AIDS disease. Tissue Barriers. 2016 Jul-Sep; 4(3):e1159276.
  17. Herrera R, Morris M, Rosbe K, Feng Z, Weinberg A, Tugizov S. Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cells. Virology. 2016 Jan; 487:172-87.
  18. Sufiawati I, Tugizov SM. HIV-associated disruption of tight and adherens junctions of oral epithelial cells facilitates HSV-1 infection and spread. PLoS One. 2014; 9(2):e88803.
  19. Shiboski CH, Chen H, Secours R, Lee A, Webster-Cyriaque J, Ghannoum M, Evans S, Bernard D, Reznik D, Dittmer DP, Hosey L, Sévère P, Aberg JA, Oral HIV/AIDS Research Alliance, Subcommittee of the AIDS Clinical Trial Group . High Accuracy of Common HIV-Related Oral Disease Diagnoses by Non-Oral Health Specialists in the AIDS Clinical Trial Group. PLoS One. 2015; 10(7):e0131001.
  20. Tugizov SM, Herrera R, Palefsky JM. Epstein-Barr virus transcytosis through polarized oral epithelial cells. J Virol. 2013 Jul; 87(14):8179-94.
  21. Sharof M. Tugizov, Rossana Herrera, Piri Veluppillai, Deborah Greenspan, Joel M. Palefsky. 46. HIV-induced epithelial–mesenchymal transition in mucosal epithelium facilitates HPV paracellular penetration. Sexual Health. 2013 Jan 1; 10(6):592.
  22. Erin Isaacson Wechsler, Sharof Tugizov, Joel Palefsky. 48. Cidofovir treatment prevents invasion of invasive HPV-16-positive anal keratinocytes. Sexual Health. 2013 Jan 1; 10(6):593.
  23. . Sargeant, S. Deverasetty, Y. Luo, A. Villahoz-Baleta, S. Zobrist, V. Rathnayake, J. Russo, M. Muesing, M. Schiller, R. Andrabi, R. Kumar, M. Bala, A. Nair, A. Biswas, N. Wig, P. Kumar, K. Luthra, N. Gonzalez, K. McKee, E. Yuste, J.R. Mascola, J. Alcamí, L. Vojnov, M. Martins, A. Bean, M. Veloso de Santana, J. Sacha, N. Wilson, M. Bonaldo, R. Galler, M. Stevenson, D. Watkins, M. Aziz, M. Mata, F. Mahmood, H. Durkin, C. Liu, R. Greenblatt, M. Nowicki, E. Golub, K. Anastos, A. French, L. Baum, V.S. Wacleche, N. Chomont, A. Gosselin, P. Monteiro, M. Goupil, H. Kared, C. Tremblay, N. Bernard, M.-R. Boulassel, J.-P. Routy, P. Ancuta, J. Jadlowsky, C. Baiduc, M. Richardson, A. Bennett, B. Jakobsen, J.L. Riley, B. Vingert, D. Benati, O. Lambotte, P. de Truchis, L. Slama, P. Jeannin, S. Perez-Patrigeon, F. Boufassa, W.W. Kwok, F. Lemaître, J.-F. Delfraissy, J. Thèze, L.A. Chakrabarti, M. French, R. Center, K. Wilson, I. Fleyfel, S. Fernandez, A. Kelleher, P. An, J. Goedert, S. Donfield, S. Buchbinder, G. Kirk, R. Detels, C. Winkler, J. Lajoie, J. Juno, A. Burgener, S. Rahman, K. Mogk, C. Wachihi, J. Mwanjewe, F.A. Plummer, J. Kimani, T.B. Ball, K.R. Fowke, A. Burgener, J. Lajoie, C. Wachihi, J. Kimani, K. Fowke, F.A. Plummer, T.B. Ball, T.N. Dieye, A. Chentouffi, M. Camara, S. Sarr, M.V. Tran, M. Seydi, G. Dasgupta, M. Fall, G. Daneau, P.A. Diaw, L. Kestens, P.S. Sow, S. Mboup, L. Benmohamed, D.M. Asmuth, Z.-M. Ma, A. Albanese, S. Devaraj, E. Hodzic, J.-C. Garcia, T.H. Knight, N.M. Flynn, S. Mann, T. Yotter, E. Tsuchida, C.J. Miller, S. Pallikkuth, L. Micci, Z. Ende, R. Iriele, B. Cervasi, J. Else, G. Silvestri, F. Villinger, S. Pahwa, M. Paiardini, S. Solomon, K.G. Murugavel, R. Vignesh, D. Bella, R. Shoba, S. Poongulali, N. Kumarasamy, A. Landay, S.S. Solomon, C.R. Swathirajan, P. Balakrishnan, S. Cu-Uvin, K.H. Mayer, B.L. Shacklett, C.S. Palmer, J. Zhou, S. Saleh, L. Lam, A. Hearps, A. Maisa, C. Pereira, S. Lewin, A. Jaworowski, J.M. McCune, S. Crowe, G. Doitsh, N. Galloway, K. Monroe, Z. Yang, O. Zepeda, W.C. Greene, M. Patel, M.-A. Jenabian, B. Lebouché, M.-J. Brouillette, C. Tremblay, I. Kema, M.-R. Boulassel, J.-P. Routy, F. Al-Ghazawi, E. Faller, P. Parmar, J. Kakal, P. MacPherson, F. Al-Ghazawi, P. Parmar, E. Faller, S. Sugden, N. Sant, P. MacPherson, C. Vinton, J. Brenchley, B. Tabb, X.P. Hao, V.M. Hirsch, M. Paiardini, J. Lifson, G. Silvestri, J.D. Estes, F. Bushman, S. Sherrill-Mix, K. Ocwieja, R. Mukherjee, M. Brown, J. Chin, R. Custers-Allen, P. David, J. Olson, K. Travers, E. Schadt, M. Sánchez del Cojo, M.R. López-Huertas, E. Mateos, M. Coiras, J. Alcamí, G. Sampey, R. Van Duyne, I. Guendel, E. Gregg, N. Shafagati, M. Tyagi, R. Easely, Z. Klase, F. Romerio, M. Iglesias-Ussel, S. Nekhai, K. Kehn-Hall, F. Kashanchi, N. Kumar, V. Evans, S. Saleh, C.F. Pereira, P. Ellenberg, P.U. Cameron, S.R. Lewin, L. Gray, D. Cowley, E. Crespan, C. Welsh, C. Mackenzie, P. Gorry, S. Wesselingh, M. Churchill, M. Iglesias-Ussel, L. Marchionni, F. Romerio, S. Weber, H. Burger, K. Kemal, B. Weiser, K. Korn, K. Anastos, W. Doerfler, S. Saleh, D. Vatakis, P. Cameron, A. Harman, A. Cunningham, S. Lewin, D. Ma, A. Cillo, C.L. Xu, J. Kristoff, J. Fang, G. Haret-Richter, J. Mellors, I. Pandrea, C. Apetrei, B. Trinité, E. Ohlson, S. Rana, J. Alster, D.N. Levy, A.F.B. Victoriano, Y. Hibi, N. Tan Gana, K. Asamitsu, T. Okamoto, M. Marsden, M. Kovochich, N. Suree, S. Shimizu, R. Mehta, R. Cortado, G. Bristol, D.S. An, J. Zack, N. Madrid-Elena, B. Hernandez-Novoa, M. Lamas, L. Garcia-Bermejo, S. Moreno, T. Ruel, J. Achan, W. Huang, H. Cao, P. Li, L.A. Eller, M. Killian, E. Sinclair, E. Charlebois, D.V. Havlir, J. Wong, T.J. Henrich, G. Sciaranghella, J.Z. Li, S. Gallien, V. Ho, A.S. Lacasce, D.R. Kuritzkes, J. Lifson, G. Del Prete, R. Kiser, C.M. Trubey, J. Smedley, V. Coalter, K. Oswald, R. Shoemaker, R. Fast, Y. Li, A. Lara, A. Wiles, R. Wiles, R. Macallister, R. Sanchez, J. Wai, C. Tan, B. Keele, J. Estes, M. Piatakjr, D. Hazuda, J. Symons, S. Deeks. Track A Basic Science. Journal of the International AIDS Society. 2012 Oct 24; 15(Suppl 3):18438-01.
  24. Sharof M. Tugizov, Rossana Herrera, Piri Veluppillai, Deborah Greenspan, Joel M. Palefsky. 46. HIV-induced epithelial–mesenchymal transition in mucosal epithelium facilitates HPV paracellular penetration. Sexual Health. 2013 Jan 1; 10(6):592.
  25. Erin Isaacson Wechsler, Sharof Tugizov, Joel Palefsky. 48. Cidofovir treatment prevents invasion of invasive HPV-16-positive anal keratinocytes. Sexual Health. 2013 Jan 1; 10(6):593.