Ruth Greenblatt, MD

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Ruth Greenblatt, MD

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Emeritus CFAR Mentor
Professor Emeritus, School of Pharmacy
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Biography

I am an Infectious Diseases trained Internist based in the Department of Clinical Pharmacy, in the UCSF School of Pharmacy. My research is focused on HIV infection in women, particularly the effects of gonadal aging and pharmacology. My group developed novel methods for assessing exposure to antiretroviral drugs using small samples of hair. I am one of three Principal Investigators of the Northern California site of the Women's Interagency HIV Study, which is the largest NIH-supported study of HIV among women, and one of the most diverse NIH-funded cohort studies. I am the founder of the UCSF WIHS consortium and the UCSF Women's HIV Practice. Within the School of Pharmacy, I am the Vice Chair for Research of the Department of Clinical Pharmacy (Lisa Kroon, PharmD is the Chair). I previously chaired the UCSF School of Pharmacy Faculty Council, and I am currently Vice Chair of the UCSF Academic Senate. With the School of Pharmacy Dean, B. Joseph Guglielmo, and Monica Gandhi, MD, I co-lead the UCSF Bridging Interdisciplinary Research Careers in Women's Health K-12 program for early career clinical scientists focused on Women's Health. I co-founded, with James Kahn, the UCSF/Gladstone Center for AIDS Research Mentoring Program.
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  1. Xie G, Moron-Lopez S, Siegel DA, Yin K, Polos A, Cohen J, Greenblatt RM, Tien PC, Lee SA, Yukl SA, Roan NR. Common and Divergent Features of T Cells from Blood, Gut, and Genital Tract of Antiretroviral Therapy-Treated HIV+ Women. J Immunol. 2022 04 01; 208(7):1790-1801.
  2. Moron-Lopez S, Xie G, Kim P, Siegel DA, Lee S, Wong JK, Price JC, Elnachef N, Greenblatt RM, Tien PC, Roan NR, Yukl SA. Tissue-specific differences in HIV DNA levels and mechanisms that govern HIV transcription in blood, gut, genital tract and liver in ART-treated women. J Int AIDS Soc. 2021 Jul; 24(7):e25738.
  3. Seidman D, Cavrois M, Hilton JF, Roan NR, Averbach S, Takeda M, Chang E, Raman N, Greenblatt R, Shacklett BL, Smith-McCune K. Reproductive tract immune cells from pregnant women or those using depot medroxyprogesterone acetate show no excess susceptibility to HIV-1: Results of an ex vivo fusion assay. Contraception. 2021 01; 103(1):44-47.
  4. Shanmugasundaram U, Critchfield JW, Giudice LC, Smith-McCune K, Greenblatt RM, Shacklett BL. Parallel studies of mucosal immunity in the reproductive and gastrointestinal mucosa of HIV-infected women. Am J Reprod Immunol. 2020 07; 84(1):e13246.
  5. Houshdaran S, Chen JC, Vallvé-Juanico J, Balayan S, Vo KC, Smith-McCune K, Greenblatt RM, Irwin JC, Giudice LC. Progestins Related to Progesterone and Testosterone Elicit Divergent Human Endometrial Transcriptomes and Biofunctions. Int J Mol Sci. 2020 Apr 09; 21(7).
  6. Tamraz B, Huang Y, French AL, Kassaye S, Anastos K, Nowicki MJ, Gange S, Gustafson DR, Bacchetti P, Greenblatt RM, Hysi PG, Aouizerat BE, Women's Interagency HIV Study . Association of Pharmacogenetic Markers With Atazanavir Exposure in HIV-Infected Women. Clin Pharmacol Ther. 2020 02; 107(2):315-318.
  7. Cavrois M, Hilton JF, Roan NR, Takeda M, Seidman D, Averbach S, Chang E, Raman N, Greenblatt R, Shacklett BL, Smith-McCune K. Effects of the levonorgestrel-containing intrauterine device, copper intrauterine device, and levonorgestrel-containing oral contraceptive on susceptibility of immune cells from cervix, endometrium and blood to HIV-1 fusion measured ex vivo. PLoS One. 2019; 14(8):e0221181.
  8. Greenblatt R, Bacchetti P, Boylan R, Kober K, Springer G, Anastos K, Busch M, Cohen M, Kassaye S, Gustafson D, Aouizerat B, Women’s Interagency HIV Study . Genetic and clinical predictors of CD4 lymphocyte recovery during suppressive antiretroviral therapy: Whole exome sequencing and antiretroviral therapy response phenotypes. PLoS One. 2019; 14(8):e0219201.
  9. Tamraz B, Reisner L, French AL, King ST, Fischl MA, Ofotokun I, Kashuba A, Milam J, Murphy K, Augenbraun M, Liu C, Finley PR, Aouizerat B, Cocohoba J, Gange S, Bacchetti P, Greenblatt RM. Association between Use of Methadone, Other Central Nervous System Depressants, and QTc Interval-Prolonging Medications and Risk of Mortality in a Large Cohort of Women Living with or at Risk for Human Immunodeficiency Virus Infection. Pharmacotherapy. 2019 09; 39(9):899-911.
  10. Kassaye SG, Wang C, Ocampo JMF, Wilson TE, Anastos K, Cohen M, Greenblatt RM, Fischl MA, Otofukun I, Adimora A, Kempf MC, Sharp GB, Young M, Plankey M. Viremia Trajectories of HIV in HIV-Positive Women in the United States, 1994-2017. JAMA Netw Open. 2019 05 03; 2(5):e193822.
  11. Robertson TE, Nouraie M, Qin S, Crothers KA, Kessinger CJ, McMahon D, Chandra D, Kingsley LA, Greenblatt RM, Huang L, Fitzpatrick ME, Morris A. HIV infection is an independent risk factor for decreased 6-minute walk test distance. PLoS One. 2019; 14(4):e0212975.
  12. Li Y, Nouraie SM, Kessinger C, Weinman R, Huang L, Greenblatt RM, Kleerup E, Kingsley L, McMahon D, Fitzpatrick M, Morris A. Factors Associated With Progression of Lung Function Abnormalities in HIV-Infected Individuals. J Acquir Immune Defic Syndr. 2018 Dec 01; 79(4):501-509.
  13. Qin S, Clausen E, Nouraie SM, Kingsley L, McMahon D, Kleerup E, Huang L, Ghedin E, Greenblatt RM, Morris A. Tropheryma whipplei colonization in HIV-infected individuals is not associated with lung function or inflammation. PLoS One. 2018; 13(10):e0205065.
  14. Cejtin HE, Evans CT, Greenblatt R, Minkoff H, Weber KM, Wright R, Colie C, Golub E, Massad LS. Prolonged Amenorrhea and Resumption of Menses in Women with HIV. J Womens Health (Larchmt). 2018 Sep 14.
  15. Rubin LH, Radtke KK, Eum S, Tamraz B, Kumanan KN, Springer G, Maki PM, Anastos K, Merenstein D, Karim R, Weber KM, Gustafson D, Greenblatt RM, Bishop JR. Cognitive Burden of Common Non-antiretroviral Medications in HIV-Infected Women. J Acquir Immune Defic Syndr. 2018 Sep 01; 79(1):83-91.
  16. Tipton L, Cuenco KT, Huang L, Greenblatt RM, Kleerup E, Sciurba F, Duncan SR, Donahoe MP, Morris A, Ghedin E. Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model. BioData Min. 2018; 11:12.
  17. Sharma A, Hoover DR, Shi Q, Tsao JCI, Cox C, Gustafson DR, Weber K, Greenblatt RM, Aouizerat BE, Plankey MW. Frequent Occurrence of Pain and Prescription Opioid Use for Treatment of Pain Among Women with and at Risk for HIV Infection. AIDS Behav. 2018 Jun; 22(6):2008-2017.
  18. Radtke KK, Bacchetti P, Anastos K, Merenstein D, Crystal H, Karim R, Weber KM, Edmonds A, Sheth AN, Fischl MA, Vance D, Greenblatt RM, Rubin LH. Use of Nonantiretroviral Medications That May Impact Neurocognition: Patterns and Predictors in a Large, Long-Term HIV Cohort Study. J Acquir Immune Defic Syndr. 2018 Jun 01; 78(2):202-208.
  19. Adimora AA, Ramirez C, Benning L, Greenblatt RM, Kempf MC, Tien PC, Kassaye SG, Anastos K, Cohen M, Minkoff H, Wingood G, Ofotokun I, Fischl MA, Gange S. Cohort Profile: The Women's Interagency HIV Study (WIHS). Int J Epidemiol. 2018 04 01; 47(2):393-394i.
  20. Tamraz B, Huang Y, French AL, Kassaye S, Anastos K, Nowicki MJ, Gange S, Gustafson DR, Bacchetti P, Greenblatt RM, Hysi PG, Aouizerat BE. A Genome-Wide Association Study Identifies a Candidate Gene Associated With Atazanavir Exposure Measured in Hair. Clin Pharmacol Ther. 2018 Nov; 104(5):949-956.
  21. Gingo MR, Nouraie M, Kessinger CJ, Greenblatt RM, Huang L, Kleerup EC, Kingsley L, McMahon DK, Morris A. Decreased Lung Function and All-Cause Mortality in HIV-infected Individuals. Ann Am Thorac Soc. 2018 02; 15(2):192-199.
  22. Baxi SM, Vittinghoff E, Bacchetti P, Huang Y, Chillag K, Wiegand R, Anderson PL, Grant R, Greenblatt RM, Buchbinder S, Gandhi M, Liu AY. Comparing pharmacologic measures of tenofovir exposure in a U.S. pre-exposure prophylaxis randomized trial. PLoS One. 2018; 13(1):e0190118.
  23. Graves JS, Henry RG, Cree BAC, Lambert-Messerlian G, Greenblatt RM, Waubant E, Cedars MI, Zhu A, Bacchetti P, Hauser SL, Oksenberg JR. Ovarian aging is associated with gray matter volume and disability in women with MS. Neurology. 2018 Jan 16; 90(3):e254-e260.
  24. Sarkar M, Dodge JL, Greenblatt RM, Kuniholm MH, DeHovitz J, Plankey M, Kovacs A, French AL, Seaberg EC, Ofotokun I, Fischl M, Overton E, Kelly E, Bacchetti P, Peters MG. Reproductive Aging and Hepatic Fibrosis Progression in Human Immunodeficiency Virus/Hepatitis C Virus-Coinfected Women. Clin Infect Dis. 2017 Oct 30; 65(10):1695-1702.
  25. Keating SM, Dodge JL, Norris PJ, Heitman J, Gange SJ, French AL, Glesby MJ, Edlin BR, Latham PS, Villacres MC, Greenblatt RM, Peters MG. The effect of HIV infection and HCV viremia on inflammatory mediators and hepatic injury-The Women's Interagency HIV Study. PLoS One. 2017; 12(9):e0181004.