Marielle Cavrois, PhD

Email Marielle
(415) 734-4824

1650 Owens St
San Francisco, CA 94107

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  • Assistant Professor, UCSF School of Medicine

Biography

Significance
Mucosal transmission of HIV is a major force driving expansion of the global AIDS epidemic. Understanding the initial events in the establishment of infection in a new host is key to developing an effective vaccine and microbicides.

Areas of Investigation
Our main focus is to understand HIV transmission: what cells HIV initially infects in the genital mucosa and what HIV features are critical for viral transmission from one person to another. We are particularly interested in the envelope protein encoded by HIV and how it mediates fusion, the initial step of the viral life cycle. We developed a fluorometric assay to identify the most susceptible cells in vivo and characterize the strains of HIV circulating in the population.

Displaying 1 - 17 of 17

  1. Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer MH, Lazarus NH, Jones JJ, Ochsenbauer C, McCune JM, Butcher EC, Arvin AM, Sen N, Greene WC, Roan NR. Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells. Cell Rep. 2017 Jul 25; 20(4):984-998. View on Pubmed
  2. Gesner M, Maiti M, Grant R, Cavrois M. Fluorescence-linked Antigen Quantification (FLAQ) Assay for Fast Quantification of HIV-1 p24Gag. Bio Protoc. 2014 Dec 20; 4(24). View on Pubmed
  3. Cavrois M, Neidleman J, Greene WC. HIV-1 Fusion Assay. Bio Protoc. 2014 Aug 20; 4(16). View on Pubmed
  4. Cavrois M, Neidleman J, Santiago ML, Derdeyn CA, Hunter E, Greene WC. Enhanced fusion and virion incorporation for HIV-1 subtype C envelope glycoproteins with compact V1/V2 domains. J Virol. 2014 Feb; 88(4):2083-94. View on Pubmed
  5. Roan NR, Cavrois M, Greene WC. [Role of semen-derived amyloid fibrils as facilitators of HIV infection]. Med Sci (Paris). 2012 Apr; 28(4):358-60. View on Pubmed
  6. Doitsh G, Cavrois M, Lassen KG, Zepeda O, Yang Z, Santiago ML, Hebbeler AM, Greene WC. Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue. Cell. 2010 Nov 24; 143(5):789-801. View on Pubmed
  7. Cavrois M, Neidleman J, Galloway N, Derdeyn CA, Hunter E, Greene WC. Measuring HIV fusion mediated by envelopes from primary viral isolates. Methods. 2011 Jan; 53(1):34-8. View on Pubmed
  8. Cavrois M, Neidleman J, Greene WC. The achilles heel of the trojan horse model of HIV-1 trans-infection. PLoS Pathog. 2008 Jun 27; 4(6):e1000051. View on Pubmed
  9. Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK. Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8718-23. View on Pubmed
  10. Cavrois M, Neidleman J, Kreisberg JF, Greene WC. In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions. PLoS Pathog. 2007 Jan; 3(1):e4. View on Pubmed
  11. Cavrois M, Neidleman J, Kreisberg JF, Fenard D, Callebaut C, Greene WC. Human immunodeficiency virus fusion to dendritic cells declines as cells mature. J Virol. 2006 Feb; 80(4):1992-9. View on Pubmed
  12. Fenard D, Yonemoto W, de Noronha C, Cavrois M, Williams SA, Greene WC. Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement. J Immunol. 2005 Nov 01; 175(9):6050-7. View on Pubmed
  13. Yonezawa A, Cavrois M, Greene WC. Studies of ebola virus glycoprotein-mediated entry and fusion by using pseudotyped human immunodeficiency virus type 1 virions: involvement of cytoskeletal proteins and enhancement by tumor necrosis factor alpha. J Virol. 2005 Jan; 79(2):918-26. View on Pubmed
  14. Cavrois M, Neidleman J, Yonemoto W, Fenard D, Greene WC. HIV-1 virion fusion assay: uncoating not required and no effect of Nef on fusion. Virology. 2004 Oct 10; 328(1):36-44. View on Pubmed
  15. Cavrois M, Neidleman J, Bigos M, Greene WC. Fluorescence resonance energy transfer-based HIV-1 virion fusion assay. Methods Mol Biol. 2004; 263:333-44. View on Pubmed
  16. Cavrois M, De Noronha C, Greene WC. A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes. Nat Biotechnol. 2002 Nov; 20(11):1151-4. View on Pubmed
  17. de Noronha CM, Sherman MP, Lin HW, Cavrois MV, Moir RD, Goldman RD, Greene WC. Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science. 2001 Nov 02; 294(5544):1105-8. View on Pubmed