Gregory Lee, PhD

Email Gregory
(415) 476-8147

1700 4th St
San Francisco, CA 94158

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  • Specialist, UCSF School of Pharmacy

Displaying 1 - 25 of 25

  1. Gable JE, Lee GM, Acker TM, Hulce KR, Gonzalez ER, Schweigler P, Melkko S, Farady CJ, Craik CS. Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease. ChemMedChem. 2016 Apr 19; 11(8):862-9. View on Pubmed
  2. Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS. Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry. 2014 Jul 22; 53(28):4648-60. View on Pubmed
  3. Lee GM, Balouch E, Goetz DH, Lazic A, McKerrow JH, Craik CS. Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry. 2012 Dec 18; 51(50):10087-98. View on Pubmed
  4. Lee GM, Shahian T, Baharuddin A, Gable JE, Craik CS. Enzyme inhibition by allosteric capture of an inactive conformation. J Mol Biol. 2011 Sep 02; 411(5):999-1016. View on Pubmed
  5. Webb H, Tynan-Connolly BM, Lee GM, Farrell D, O'Meara F, Søndergaard CR, Teilum K, Hewage C, McIntosh LP, Nielsen JE. Remeasuring HEWL pK(a) values by NMR spectroscopy: methods, analysis, accuracy, and implications for theoretical pK(a) calculations. Proteins. 2011 Mar; 79(3):685-702. View on Pubmed
  6. Nelson ML, Kang HS, Lee GM, Blaszczak AG, Lau DK, McIntosh LP, Graves BJ. Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):10026-31. View on Pubmed
  7. Shahian T, Lee GM, Lazic A, Arnold LA, Velusamy P, Roels CM, Guy RK, Craik CS. Inhibition of a viral enzyme by a small-molecule dimer disruptor. Nat Chem Biol. 2009 Sep; 5(9):640-6. View on Pubmed
  8. Cort JR, Liu Z, Lee GM, Huggins KN, Janes S, Prickett K, Andersen NH. Solution state structures of human pancreatic amylin and pramlintide. Protein Eng Des Sel. 2009 Aug; 22(8):497-513. View on Pubmed
  9. Lee GM, Craik CS. Trapping moving targets with small molecules. Science. 2009 Apr 10; 324(5924):213-5. View on Pubmed
  10. Lee GM, Pufall MA, Meeker CA, Kang HS, Graves BJ, McIntosh LP. The affinity of Ets-1 for DNA is modulated by phosphorylation through transient interactions of an unstructured region. J Mol Biol. 2008 Oct 17; 382(4):1014-30. View on Pubmed
  11. Lakowski TM, Lee GM, Lelj-Garolla B, Okon M, Reid RE, McIntosh LP. Peptide binding by a fragment of calmodulin composed of EF-hands 2 and 3. Biochemistry. 2007 Jul 24; 46(29):8525-36. View on Pubmed
  12. Lakowski TM, Lee GM, Okon M, Reid RE, McIntosh LP. Calcium-induced folding of a fragment of calmodulin composed of EF-hands 2 and 3. Protein Sci. 2007 Jun; 16(6):1119-32. View on Pubmed
  13. Graves BJ, Pufall MA, Lee GM, and McIntosh LP. Compositions and methods for providing a Graded Response in a Protein. Patent WO/2007/005867. 2007. View on Pubmed
  14. Pufall MA, Lee GM, Nelson ML, Kang HS, Velyvis A, Kay LE, McIntosh LP, Graves BJ. Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. Science. 2005 Jul 01; 309(5731):142-5. View on Pubmed
  15. Lee GM, Donaldson LW, Pufall MA, Kang HS, Pot I, Graves BJ, McIntosh LP. The structural and dynamic basis of Ets-1 DNA binding autoinhibition. J Biol Chem. 2005 Feb 25; 280(8):7088-99. View on Pubmed
  16. Schärpf M, Connelly GP, Lee GM, Boraston AB, Warren RA, McIntosh LP. Site-specific characterization of the association of xylooligosaccharides with the CBM13 lectin-like xylan binding domain from Streptomyces lividans xylanase 10A by NMR spectroscopy. Biochemistry. 2002 Apr 02; 41(13):4255-63. View on Pubmed
  17. Yee A, Chang X, Pineda-Lucena A, Wu B, Semesi A, Le B, Ramelot T, Lee GM, Bhattacharyya S, Gutierrez P, Denisov A, Lee CH, Cort JR, Kozlov G, Liao J, Finak G, Chen L, Wishart D, Lee W, McIntosh LP, Gehring K, Kennedy MA, Edwards AM, Arrowsmith CH. An NMR approach to structural proteomics. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1825-30. View on Pubmed
  18. Lee GM, Edwards AM, Arrowsmith CH, McIntosh LP. NMR-based structure of the conserved protein MTH865 from the archaeon Methanobacterium thermoautotrophicum. J Biomol NMR. 2001 Sep; 21(1):63-6.
  19. Lee GM. Solution-State Conformational Analysis of Endothelin Analogs. University of Washington, Ph.D. Dissertation. 1999.
  20. Andersen NH, Neidigh JW, Harris SM, Lee GM, Liu Z, and Tong H. Extracting Information from the Temperature Gradients of Polypeptide NH Chemical Shifts. 1. The Importance of Conformational Averaging. J. Am. Chem. Soc. 1997; 36(119):8547–8561.
  21. Andersen NH, Chen C, and Lee GM. The Endothelin C-terminal Signal Fragment: Determinants of Conformational Equilibrium IN SITU and Detached. Prot. Pept. Lett. 1995; 4(1):215-222. View on Pubmed
  22. Lee GM, Chen C, Marschner TM, Andersen NH. Does the solid-state structure of endothelin-1 provide insights concerning the solution-state conformational equilibrium? FEBS Lett. 1994 Nov 28; 355(2):140-6.
  23. Cort J, Liu Z, Lee G, Harris SM, Prickett KS, Gaeta LSL, and Andersen NH. ß-Structure in Human Amylin and 2 Designer ß-Peptides: CD and NMR Spectroscopic Comparisons Suggest Soluble ß-Oligomers and the Absence of Significant Populations of ß-Strand Dimers. Biochem. Biophys. Res. Commun. 1994; 3(204):1088–1095.
  24. Searle PA, Jamal NM, Lee GM, and Moliski TF. Configurational analysis of new furanosesquiterpenes from Dysidea herbacea. Assignment of absolute stereochemistry. Tetrahedron. 1994; 13(50):3879–3888.
  25. Lee GM, and Molinski TF. Herbaceamide, a chlorinated N-acyl amino ester from the marine sponge, Dysidea herbacea. Tetrahedron Lett. 1992; 50(33):7671–7674.